{"id":"https://openalex.org/W2160415437","doi":"https://doi.org/10.1074/mcp.m110.004390","title":"Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design","display_name":"Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design","publication_year":2010,"publication_date":"2010-11-17","ids":{"openalex":"https://openalex.org/W2160415437","doi":"https://doi.org/10.1074/mcp.m110.004390","mag":"2160415437","pmid":"https://pubmed.ncbi.nlm.nih.gov/21081668","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3047156"},"language":"en","primary_location":{"id":"doi:10.1074/mcp.m110.004390","doi":"https://doi.org/10.1074/mcp.m110.004390","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.m110.004390","pdf_url":null,"source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/mcp.m110.004390","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031544272","display_name":"Suguna Badireddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Suguna Badireddy","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore 117543","From the \u2021Department of Biological Sciences, National University of Singapore, Singapore 117543,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore 117543","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"From the \u2021Department of Biological Sciences, National University of Singapore, Singapore 117543,","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017911652","display_name":"G. Yunfeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Gao Yunfeng","raw_affiliation_strings":["From the \u2021Department of Biological Sciences, National University of Singapore, Singapore 117543,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the \u2021Department of Biological Sciences, National University of Singapore, Singapore 117543,","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037439169","display_name":"Mark A. Ritchie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Ritchie","raw_affiliation_strings":["\u00a7Waters Pacific Private Ltd., Singapore,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Waters Pacific Private Ltd., Singapore,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056514098","display_name":"Pearl Akamine","orcid":"https://orcid.org/0000-0002-6506-2267","observed_orcids":["https://orcid.org/0000-0002-6506-2267"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pearl Akamine","raw_affiliation_strings":["\u2016Department of Chemistry and Biochemistry and Howard Hughes Medical Institute, University of California San Diego, La Jolla, CA 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2016Department of Chemistry and Biochemistry and Howard Hughes Medical Institute, University of California San Diego, La Jolla, CA 92093","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010230212","display_name":"Jian Wu","orcid":"https://orcid.org/0000-0002-8031-9462","observed_orcids":["https://orcid.org/0000-0002-8031-9462"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Wu","raw_affiliation_strings":["\u2016Department of Chemistry and Biochemistry and Howard Hughes Medical Institute, University of California San Diego, La Jolla, CA 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2016Department of Chemistry and Biochemistry and Howard Hughes Medical Institute, University of California San Diego, La Jolla, CA 92093","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029610006","display_name":"Choel Kim","orcid":"https://orcid.org/0000-0002-3152-0020","observed_orcids":["https://orcid.org/0000-0002-3152-0020"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Choel W. Kim","raw_affiliation_strings":["\u00b6Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030,","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045962448","display_name":"Susan Serota Taylor","orcid":"https://orcid.org/0000-0002-7702-6108","observed_orcids":["https://orcid.org/0000-0002-7702-6108"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan S. Taylor","raw_affiliation_strings":["\u00b6Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030,","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006426839","display_name":"Qingsong Lin","orcid":"https://orcid.org/0000-0001-9117-8514","observed_orcids":["https://orcid.org/0000-0001-9117-8514"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lin Qingsong","raw_affiliation_strings":["From the \u2021Department of Biological Sciences, National University of Singapore, Singapore 117543,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the \u2021Department of Biological Sciences, National University of Singapore, Singapore 117543,","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082147626","display_name":"Kunchithapadam Swaminathan","orcid":"https://orcid.org/0000-0001-7940-1090","observed_orcids":["https://orcid.org/0000-0001-7940-1090"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Kunchithapadam Swaminathan","raw_affiliation_strings":["From the \u2021Department of Biological Sciences, National University of Singapore, Singapore 117543,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the \u2021Department of Biological Sciences, National University of Singapore, Singapore 117543,","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081786054","display_name":"Ganesh S. Anand","orcid":"https://orcid.org/0000-0001-8995-3067","observed_orcids":["https://orcid.org/0000-0001-8995-3067"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Ganesh S. Anand","raw_affiliation_strings":["From the \u2021Department of Biological Sciences, National University of Singapore, Singapore 117543,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the \u2021Department of Biological Sciences, National University of Singapore, Singapore 117543,","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5081786054","https://openalex.org/A5082147626"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.2138,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.77268077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"3","first_page":"M110.004390","last_page":"M110.004390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.20059999823570251,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.1388999968767166,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-a-regulatory-subunit","display_name":"protein kinase A regulatory subunit","score":0.9649999737739563},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.628000020980835},{"id":"https://openalex.org/keywords/rp-camps","display_name":"Rp-cAMPS","score":0.8889999985694885},{"id":"https://openalex.org/keywords/allosteric-inhibition","display_name":"allosteric inhibition","score":0.7390000224113464},{"id":"https://openalex.org/keywords/conformational-selection","display_name":"conformational selection","score":0.9980000257492065},{"id":"https://openalex.org/keywords/induced-fit","display_name":"induced fit","score":0.6949999928474426},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.7940000295639038},{"id":"https://openalex.org/keywords/amide-hydrogen-deuterium-exchange","display_name":"amide hydrogen/deuterium exchange","score":0.8740000128746033},{"id":"https://openalex.org/keywords/ion-mobility-mass-spectrometry","display_name":"ion mobility mass spectrometry","score":0.9319999814033508},{"id":"https://openalex.org/keywords/conformational-ensembles","display_name":"conformational ensembles","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.7462565898895264},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6882343292236328},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6798719167709351},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.48651355504989624},{"id":"https://openalex.org/C167569220","wikidata":"https://www.wikidata.org/wiki/Q5954985","display_name":"Hydrogen\u2013deuterium exchange","level":3,"score":0.4718836545944214},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4645886719226837},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4269999861717224},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.2634750008583069},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.252447247505188},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24792909622192383},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2416153848171234},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001051","descriptor_name":"Apoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001051","descriptor_name":"Apoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D041961","descriptor_name":"Deuterium Exchange Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1074/mcp.m110.004390","doi":"https://doi.org/10.1074/mcp.m110.004390","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.m110.004390","pdf_url":null,"source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2296560","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3047156","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3047156","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3047156","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Proteomics","raw_type":"Text"},{"id":"pmid:21081668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21081668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & cellular proteomics : MCP","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.662.5151","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.662.5151","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://susantaylorlab.ucsd.edu/Publications_PDF/Recent_Publications_2003_present_by_pubmed/21081668_Badireddy_cAMPanalogBlocks_11.pdf","raw_type":"text"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/113125","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/113125","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"mag:2767530903","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/1089726","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1074/mcp.m110.004390","doi":"https://doi.org/10.1074/mcp.m110.004390","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.m110.004390","pdf_url":null,"source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W112126394","https://openalex.org/W1520730837","https://openalex.org/W1539796472","https://openalex.org/W1570227839","https://openalex.org/W1643792176","https://openalex.org/W1965753868","https://openalex.org/W1967147564","https://openalex.org/W1975414887","https://openalex.org/W1975459052","https://openalex.org/W1978365857","https://openalex.org/W1979282739","https://openalex.org/W1979560481","https://openalex.org/W1981536086","https://openalex.org/W1983270588","https://openalex.org/W1991751920","https://openalex.org/W1993294731","https://openalex.org/W1995017064","https://openalex.org/W1995720011","https://openalex.org/W1997132172","https://openalex.org/W2001641653","https://openalex.org/W2005847898","https://openalex.org/W2011901471","https://openalex.org/W2013083986","https://openalex.org/W2015746168","https://openalex.org/W2019812098","https://openalex.org/W2022707619","https://openalex.org/W2024560766","https://openalex.org/W2031676031","https://openalex.org/W2050582664","https://openalex.org/W2052826095","https://openalex.org/W2059405249","https://openalex.org/W2063974082","https://openalex.org/W2066962978","https://openalex.org/W2069970306","https://openalex.org/W2071884490","https://openalex.org/W2072285092","https://openalex.org/W2079398727","https://openalex.org/W2083447174","https://openalex.org/W2085424227","https://openalex.org/W2101652741","https://openalex.org/W2104828842","https://openalex.org/W2105375733","https://openalex.org/W2107414468","https://openalex.org/W2115131377","https://openalex.org/W2116582554","https://openalex.org/W2127988771","https://openalex.org/W2132023176","https://openalex.org/W2135167483","https://openalex.org/W2156339041","https://openalex.org/W2167344126","https://openalex.org/W2230658567","https://openalex.org/W2410703791"],"related_works":["https://openalex.org/W7096116654","https://openalex.org/W1987890424","https://openalex.org/W2063974082","https://openalex.org/W7098575333","https://openalex.org/W2108174107","https://openalex.org/W7099360145","https://openalex.org/W7008853515","https://openalex.org/W1999908949","https://openalex.org/W2024560766","https://openalex.org/W2108317211"],"abstract_inverted_index":{"The":[0],"regulatory":[1],"(R)":[2],"subunit":[3],"of":[4,13,41,70,131,144,185,192,216,220,254],"protein":[5,14],"kinase":[6,15],"A":[7,16],"serves":[8],"to":[9,67,102,160,230],"modulate":[10],"the":[11,68,84,89,95,112,132,138,153,165,181,186,202,208,213,217,221],"activity":[12],"in":[17,23,83,94,111,224],"a":[18,48,71,234],"cAMP-dependent":[19],"manner":[20],"and":[21,26,33,61,76,128,155,195],"exists":[22,188],"two":[24],"distinct":[25],"structurally":[27],"dissimilar,":[28],"end":[29],"point":[30],"cAMP-bound":[31,81],"\"B\"":[32],"C-subunit-bound":[34],"\"H\"-conformations.":[35],"Here":[36],"we":[37,174],"report":[38,175],"mechanistic":[39],"details":[40],"cAMP":[42,73,168,199],"action":[43,169],"as":[44,115,141,189,245],"yet":[45],"unknown":[46],"through":[47,170],"unique":[49,214],"approach":[50,236],"combining":[51],"x-ray":[52],"crystallography":[53,79],"with":[54,147],"structural":[55],"proteomics":[56],"approaches,":[57],"amide":[58,118],"hydrogen/deuterium":[59],"exchange":[60,119],"ion":[62,135],"mobility":[63,136],"mass":[64,120],"spectrometry,":[65],"applied":[66],"study":[69],"stereospecific":[72],"phosphorothioate":[74],"analog":[75],"antagonist((Rp)-cAMPS).":[77],"X-ray":[78],"shows":[80],"R-subunit":[82,92,109,140,187],"B":[85,113,194,203,231],"form":[86,114,184],"but":[87,117],"surprisingly":[88],"antagonist":[90],"Rp-cAMPS-bound":[91],"crystallized":[93,110],"H":[96,196,209,229],"conformation,":[97,204],"which":[98],"was":[99],"previously":[100],"assumed":[101],"be":[103],"induced":[104],"only":[105],"by":[106,257],"C-subunit-binding.":[107],"Apo":[108],"well":[116],"spectrometry":[121],"showed":[122],"large":[123],"differences":[124],"between":[125],"apo,":[126],"agonist":[127,154],"antagonist-bound":[129,156],"states":[130],"R-subunit.":[133],"Further":[134],"reveals":[137,212],"apo":[139,183],"an":[142,190],"ensemble":[143,191],"multiple":[145],"conformations":[146,253],"collisional":[148],"cross-sectional":[149],"areas":[150],"spanning":[151],"both":[152,193],"states.":[157],"Thus":[158],"contrary":[159],"earlier":[161],"studies":[162],"that":[163,249],"explained":[164],"basis":[166],"for":[167,177,237,268],"\"induced":[171],"fit\"":[172],"alone,":[173],"evidence":[176],"conformational":[178,226,265],"selection,":[179],"where":[180],"ligand-free":[182],"conformations.":[197],"Although":[198],"preferentially":[200,250],"binds":[201,207],"Rp-cAMPS":[205,246],"interestingly":[206],"conformation.":[210],"This":[211],"importance":[215],"equatorial":[218],"oxygen":[219],"cyclic":[222],"phosphate":[223],"mediating":[225],"transitions":[227],"from":[228],"forms":[232],"highlighting":[233],"novel":[235],"rational":[238],"structure-based":[239],"drug":[240],"design.":[241],"Ideal":[242],"inhibitors":[243],"such":[244],"are":[247],"those":[248],"\"select\"":[251],"inactive":[252],"target":[255],"proteins":[256],"satisfying":[258],"all":[259],"\"binding\"":[260],"constraints":[261],"alone":[262],"without":[263],"inducing":[264],"changes":[266],"necessary":[267],"activation.":[269]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}