{"id":"https://openalex.org/W2160347316","doi":"https://doi.org/10.1016/j.cell.2015.01.036","title":"A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins","display_name":"A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins","publication_year":2015,"publication_date":"2015-03-01","ids":{"openalex":"https://openalex.org/W2160347316","doi":"https://doi.org/10.1016/j.cell.2015.01.036","mag":"2160347316","pmid":"https://pubmed.ncbi.nlm.nih.gov/25815993","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525717"},"language":"en","primary_location":{"id":"doi:10.1016/j.cell.2015.01.036","doi":"https://doi.org/10.1016/j.cell.2015.01.036","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2015.01.036","pdf_url":"http://www.cell.com/article/S0092867415000793/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0092867415000793/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058164552","display_name":"Joseph L. Goldstein","orcid":"https://orcid.org/0000-0002-1894-9463","observed_orcids":["https://orcid.org/0000-0002-1894-9463"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph\u00a0L. Goldstein","raw_affiliation_strings":["Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: joe.goldstein@utsouthwestern.edu","Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: joe.goldstein@utsouthwestern.edu","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079762911","display_name":"Michael S. Brown","orcid":"https://orcid.org/0000-0002-1324-152X","observed_orcids":["https://orcid.org/0000-0002-1324-152X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael\u00a0S. Brown","raw_affiliation_strings":["Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: mike.brown@utsouthwestern.edu","Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: mike.brown@utsouthwestern.edu","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058164552","https://openalex.org/A5079762911"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":13.5143,"has_fulltext":false,"cited_by_count":1279,"citation_normalized_percentile":{"value":0.9971449,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"161","issue":"1","first_page":"161","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.7919999957084656},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9459999799728394},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.7239999771118164},{"id":"https://openalex.org/keywords/ldlr-mutations","display_name":"LDLR mutations","score":0.800000011920929},{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.902999997138977},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.7919999957084656},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.7549999952316284},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.6068989634513855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5229490399360657},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.5053215622901917},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5042015314102173},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48432767391204834},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.45939087867736816},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.448140412569046},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.4446149468421936},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4156697690486908},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3887614607810974},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33206266164779663},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33030200004577637},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21434548497200012}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.cell.2015.01.036","doi":"https://doi.org/10.1016/j.cell.2015.01.036","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2015.01.036","pdf_url":"http://www.cell.com/article/S0092867415000793/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"pmid:25815993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25815993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3772904","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525717","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4525717","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525717","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.cell.2015.01.036","doi":"https://doi.org/10.1016/j.cell.2015.01.036","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2015.01.036","pdf_url":"http://www.cell.com/article/S0092867415000793/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7768474441","display_name":"Molecular Basis of Cholesterol Metabolism","funder_award_id":"P01HL020948","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160347316.pdf"},"referenced_works_count":114,"referenced_works":["https://openalex.org/W38523360","https://openalex.org/W57435778","https://openalex.org/W424467158","https://openalex.org/W597748064","https://openalex.org/W1524564445","https://openalex.org/W1528479054","https://openalex.org/W1532083370","https://openalex.org/W1534126065","https://openalex.org/W1543117447","https://openalex.org/W1549397399","https://openalex.org/W1556918753","https://openalex.org/W1558765348","https://openalex.org/W1603091820","https://openalex.org/W1607784649","https://openalex.org/W1650965741","https://openalex.org/W1676269880","https://openalex.org/W1977644047","https://openalex.org/W1978080134","https://openalex.org/W1981704568","https://openalex.org/W1983469573","https://openalex.org/W1984662248","https://openalex.org/W1986051194","https://openalex.org/W1989090236","https://openalex.org/W1989730880","https://openalex.org/W1990139485","https://openalex.org/W1992864925","https://openalex.org/W1995032745","https://openalex.org/W1996241166","https://openalex.org/W2003137291","https://openalex.org/W2004465970","https://openalex.org/W2007793689","https://openalex.org/W2007809519","https://openalex.org/W2020988004","https://openalex.org/W2021632088","https://openalex.org/W2023344829","https://openalex.org/W2023719883","https://openalex.org/W2023991608","https://openalex.org/W2028310816","https://openalex.org/W2028693103","https://openalex.org/W2030610610","https://openalex.org/W2031834612","https://openalex.org/W2031834725","https://openalex.org/W2033896075","https://openalex.org/W2034152285","https://openalex.org/W2037590835","https://openalex.org/W2039999119","https://openalex.org/W2040612932","https://openalex.org/W2040641918","https://openalex.org/W2041558851","https://openalex.org/W2045955618","https://openalex.org/W2051105453","https://openalex.org/W2054264938","https://openalex.org/W2054328698","https://openalex.org/W2056411372","https://openalex.org/W2058002657","https://openalex.org/W2067539811","https://openalex.org/W2068689195","https://openalex.org/W2071154679","https://openalex.org/W2072033965","https://openalex.org/W2074617391","https://openalex.org/W2077241694","https://openalex.org/W2078600472","https://openalex.org/W2080797731","https://openalex.org/W2081458493","https://openalex.org/W2081915217","https://openalex.org/W2084548092","https://openalex.org/W2084744450","https://openalex.org/W2086024671","https://openalex.org/W2086180480","https://openalex.org/W2086271423","https://openalex.org/W2088863232","https://openalex.org/W2089086088","https://openalex.org/W2091534448","https://openalex.org/W2094768566","https://openalex.org/W2097632838","https://openalex.org/W2098145494","https://openalex.org/W2100075764","https://openalex.org/W2100416355","https://openalex.org/W2102475173","https://openalex.org/W2103487568","https://openalex.org/W2115420718","https://openalex.org/W2117011155","https://openalex.org/W2118184073","https://openalex.org/W2122391469","https://openalex.org/W2125149319","https://openalex.org/W2127791131","https://openalex.org/W2129087692","https://openalex.org/W2138486337","https://openalex.org/W2144593277","https://openalex.org/W2146544786","https://openalex.org/W2146870449","https://openalex.org/W2151455751","https://openalex.org/W2152789823","https://openalex.org/W2152972819","https://openalex.org/W2154109643","https://openalex.org/W2156799866","https://openalex.org/W2162458714","https://openalex.org/W2168175864","https://openalex.org/W2171284332","https://openalex.org/W2195440880","https://openalex.org/W2313219886","https://openalex.org/W2322095705","https://openalex.org/W2327883350","https://openalex.org/W2478496979","https://openalex.org/W2957226098","https://openalex.org/W3021317847","https://openalex.org/W4230737044","https://openalex.org/W4234215706","https://openalex.org/W4246764494","https://openalex.org/W4249617443","https://openalex.org/W4252021281","https://openalex.org/W4285719527","https://openalex.org/W6607828777","https://openalex.org/W6672686642"],"related_works":["https://openalex.org/W2031834612","https://openalex.org/W2171458374","https://openalex.org/W2045201618","https://openalex.org/W2808137385","https://openalex.org/W2074855794","https://openalex.org/W4249150249","https://openalex.org/W4231843655","https://openalex.org/W2477400868","https://openalex.org/W1528479054","https://openalex.org/W2418375869"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":113},{"year":2025,"cited_by_count":138},{"year":2024,"cited_by_count":128},{"year":2023,"cited_by_count":127},{"year":2022,"cited_by_count":140},{"year":2021,"cited_by_count":153},{"year":2020,"cited_by_count":117},{"year":2019,"cited_by_count":106},{"year":2018,"cited_by_count":88},{"year":2017,"cited_by_count":85},{"year":2016,"cited_by_count":62},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}