{"id":"https://openalex.org/W2160345600","doi":"https://doi.org/10.5812/hepatmon.13173","title":"Drug-Resistance Associated Mutations in Polymerase (P) Gene of Hepatitis B Virus Isolated From Malaysian HBV Carriers","display_name":"Drug-Resistance Associated Mutations in Polymerase (P) Gene of Hepatitis B Virus Isolated From Malaysian HBV Carriers","publication_year":2014,"publication_date":"2014-01-05","ids":{"openalex":"https://openalex.org/W2160345600","doi":"https://doi.org/10.5812/hepatmon.13173","mag":"2160345600","pmid":"https://pubmed.ncbi.nlm.nih.gov/24497877","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3909636"},"language":"en","primary_location":{"id":"doi:10.5812/hepatmon.13173","doi":"https://doi.org/10.5812/hepatmon.13173","is_oa":true,"landing_page_url":"https://doi.org/10.5812/hepatmon.13173","pdf_url":"https://brieflands.com/articles/hepatmon-15320.pdf","source":{"id":"https://openalex.org/S151854748","display_name":"Hepatitis Monthly","issn_l":"1735-143X","issn":["1735-143X","1735-3408"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318596","host_organization_name":"Kowsar Publishing","host_organization_lineage":["https://openalex.org/P4310318596"],"host_organization_lineage_names":["Kowsar Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis Monthly","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://brieflands.com/articles/hepatmon-15320.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026862829","display_name":"Jeyanthi Suppiah","orcid":"https://orcid.org/0000-0002-4788-2149","observed_orcids":["https://orcid.org/0000-0002-4788-2149"]},"institutions":[{"id":"https://openalex.org/I4210130795","display_name":"Institute for Medical Research","ror":"https://ror.org/03bpc5f92","country_code":"MY","type":"facility","lineage":["https://openalex.org/I4210130795"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Jeyanthi Suppiah","raw_affiliation_strings":["Virology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I4210130795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020016479","display_name":"Rozainanee Mohd Zain","orcid":"https://orcid.org/0000-0002-5756-7660","observed_orcids":["https://orcid.org/0000-0002-5756-7660"]},"institutions":[{"id":"https://openalex.org/I2799421553","display_name":"Hospital Kuala Lumpur","ror":"https://ror.org/03n0nnh89","country_code":"MY","type":"healthcare","lineage":["https://openalex.org/I2799421553"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Rozainanee Mohd Zain","raw_affiliation_strings":["Microbiology Unit, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Unit, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I2799421553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112604183","display_name":"Salbiah Haji Nawi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799421553","display_name":"Hospital Kuala Lumpur","ror":"https://ror.org/03n0nnh89","country_code":"MY","type":"healthcare","lineage":["https://openalex.org/I2799421553"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Salbiah Haji Nawi","raw_affiliation_strings":["Microbiology Unit, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Unit, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I2799421553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044597769","display_name":"Norazlah Bahari","orcid":"https://orcid.org/0000-0003-0567-594X","observed_orcids":["https://orcid.org/0000-0003-0567-594X"]},"institutions":[{"id":"https://openalex.org/I4210132687","display_name":"Hospital Selayang","ror":"https://ror.org/03p43tq86","country_code":"MY","type":"healthcare","lineage":["https://openalex.org/I4210132687"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Norazlah Bahari","raw_affiliation_strings":["Pathology Unit, Selayang Hospital, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Unit, Selayang Hospital, Selangor, Malaysia","institution_ids":["https://openalex.org/I4210132687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071977871","display_name":"Zainah Saat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130795","display_name":"Institute for Medical Research","ror":"https://ror.org/03bpc5f92","country_code":"MY","type":"facility","lineage":["https://openalex.org/I4210130795"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Zainah Saat","raw_affiliation_strings":["Virology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I4210130795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026862829"],"corresponding_institution_ids":["https://openalex.org/I4210130795"],"apc_list":null,"apc_paid":null,"fwci":1.3511,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.77763082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"12","first_page":"e13173","last_page":"e13173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polymerase-gene","display_name":"polymerase gene","score":0.8600000143051147},{"id":"https://openalex.org/keywords/drug-resistance-mutations","display_name":"drug resistance mutations","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hbv-genotypes","display_name":"HBV genotypes","score":0.7039999961853027},{"id":"https://openalex.org/keywords/genotype-c","display_name":"genotype C","score":0.7879999876022339},{"id":"https://openalex.org/keywords/genotype-b","display_name":"genotype B","score":0.6499999761581421},{"id":"https://openalex.org/keywords/genotype-d","display_name":"genotype D","score":0.7689999938011169},{"id":"https://openalex.org/keywords/lamivudine-resistance","display_name":"lamivudine resistance","score":0.8709999918937683},{"id":"https://openalex.org/keywords/emtricitabine","display_name":"emtricitabine","score":0.8489999771118164},{"id":"https://openalex.org/keywords/telbivudine","display_name":"telbivudine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.8170753717422485},{"id":"https://openalex.org/C2781144229","wikidata":"https://www.wikidata.org/wiki/Q413621","display_name":"Telbivudine","level":5,"score":0.7733488082885742},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6993306279182434},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.664182186126709},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.641654372215271},{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.6315086483955383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.630020022392273},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5888810157775879},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.4812281131744385},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.422936350107193},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37170374393463135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2852988541126251},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18268951773643494}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.5812/hepatmon.13173","doi":"https://doi.org/10.5812/hepatmon.13173","is_oa":true,"landing_page_url":"https://doi.org/10.5812/hepatmon.13173","pdf_url":"https://brieflands.com/articles/hepatmon-15320.pdf","source":{"id":"https://openalex.org/S151854748","display_name":"Hepatitis Monthly","issn_l":"1735-143X","issn":["1735-143X","1735-3408"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318596","host_organization_name":"Kowsar Publishing","host_organization_lineage":["https://openalex.org/P4310318596"],"host_organization_lineage_names":["Kowsar Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis Monthly","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2898888","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3909636","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:24497877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24497877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis monthly","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3909636","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3909636/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepat Mon","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.5812/hepatmon.13173","doi":"https://doi.org/10.5812/hepatmon.13173","is_oa":true,"landing_page_url":"https://doi.org/10.5812/hepatmon.13173","pdf_url":"https://brieflands.com/articles/hepatmon-15320.pdf","source":{"id":"https://openalex.org/S151854748","display_name":"Hepatitis Monthly","issn_l":"1735-143X","issn":["1735-143X","1735-3408"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318596","host_organization_name":"Kowsar Publishing","host_organization_lineage":["https://openalex.org/P4310318596"],"host_organization_lineage_names":["Kowsar Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis Monthly","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160345600.pdf","grobid_xml":"https://content.openalex.org/works/W2160345600.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1506452965","https://openalex.org/W1532462036","https://openalex.org/W1587722496","https://openalex.org/W1975485577","https://openalex.org/W1976104517","https://openalex.org/W1985577568","https://openalex.org/W1987228840","https://openalex.org/W1990107312","https://openalex.org/W2027543203","https://openalex.org/W2046284114","https://openalex.org/W2048310429","https://openalex.org/W2065099361","https://openalex.org/W2068151431","https://openalex.org/W2068181941","https://openalex.org/W2090738619","https://openalex.org/W2096007448","https://openalex.org/W2100131352","https://openalex.org/W2108308364","https://openalex.org/W2114282730","https://openalex.org/W2131463612","https://openalex.org/W2146908231","https://openalex.org/W2152203386","https://openalex.org/W2155308616","https://openalex.org/W2155477672","https://openalex.org/W2171417088","https://openalex.org/W2188687066","https://openalex.org/W2396548226","https://openalex.org/W2399753891","https://openalex.org/W2460179693"],"related_works":["https://openalex.org/W7095746708","https://openalex.org/W2358535063","https://openalex.org/W4389333748","https://openalex.org/W2395276098","https://openalex.org/W2378300546","https://openalex.org/W2761644550","https://openalex.org/W2365746345","https://openalex.org/W2389170701","https://openalex.org/W4414651468","https://openalex.org/W3098743540"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mutations":[1],"in":[2,38,119,147,189],"the":[3,67,88,184,198],"polymerase":[4],"(P)":[5],"gene":[6,40,69],"of":[7,19,41,55,65,70,83,112,183,187,200,206],"hepatitis":[8,42,207],"B":[9,43,99,208],"virus":[10,44],"are":[11],"often":[12],"associated":[13,144],"with":[14,145,149,156],"drug":[15,114,153],"resistance.":[16,154],"The":[17],"pattern":[18],"mutations":[20,37,116,188],"varies":[21],"geographically,":[22],"thus":[23],"giving":[24],"rise":[25],"to":[26,35,170,195],"genotypes":[27],"diversity.":[28],"OBJECTIVES:":[29],"This":[30],"study":[31],"was":[32,73,91],"carried":[33],"out":[34],"detect":[36],"P":[39,68],"isolated":[45,71],"from":[46,78],"Malaysian":[47],"HBV":[48,72,190],"carriers.":[49,209],"MATERIALS":[50],"AND":[51],"METHODS:":[52],"A":[53,110],"total":[54],"58":[56],"sera":[57],"samples":[58,85],"were":[59,117,138,166],"analyzed":[60],"by":[61,97],"PCR":[62],"and":[63,76,102,131,136,143,151,159,173,181,203],"sequencing,":[64],"which":[66],"successfully":[74],"amplified":[75],"sequenced":[77],"40":[79],"samples.":[80],"RESULTS:":[81],"Genotyping":[82],"these":[84,164],"revealed":[86,162],"that":[87,163],"predominant":[89],"genotype":[90,92,98,107],"C":[93],"(22/40,":[94],"55.0%),":[95],"followed":[96],"(17/40,":[100],"42.5%),":[101],"only":[103],"1":[104],"sample":[105],"showed":[106],"D":[108],"(2.5%).":[109],"number":[111],"significant":[113,185],"resistant":[115],"found":[118],"five":[120],"patients":[121,165],"including":[122],"S202I,":[123],"N236T,":[124],"M250L,":[125],"L180M/V,":[126],"M204I,":[127],"A181T,":[128],"T184G,":[129],"M250V,":[130],"V173L.":[132],"Of":[133],"these,":[134],"L180M/V":[135],"M204I":[137],"most":[139],"frequently":[140],"detected":[141],"(80%)":[142],"lamivudine":[146],"combination":[148],"emtricitabine":[150],"telbivudine":[152],"Association":[155],"age,":[157],"sex,":[158],"clinical":[160],"symptoms":[161],"all":[167,175],"male,":[168],"mid":[169],"elderly":[171],"age":[172],"almost":[174],"hadcirrhotic":[176],"liver":[177],"disease.":[178],"CONCLUSIONS:":[179],"Detection":[180],"surveillance":[182],"sites":[186],"is":[191],"crucial":[192],"for":[193],"clinicians":[194],"decide":[196],"on":[197],"choice":[199],"antiviral":[201],"treatment":[202],"further":[204],"management":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
