{"id":"https://openalex.org/W2160320552","doi":"https://doi.org/10.3109/08982104.2010.498003","title":"Immunoglobulin immobilized liposomal constructs for transmucosal vaccination through nasal route","display_name":"Immunoglobulin immobilized liposomal constructs for transmucosal vaccination through nasal route","publication_year":2010,"publication_date":"2010-07-14","ids":{"openalex":"https://openalex.org/W2160320552","doi":"https://doi.org/10.3109/08982104.2010.498003","mag":"2160320552","pmid":"https://pubmed.ncbi.nlm.nih.gov/20626315"},"language":"en","primary_location":{"id":"doi:10.3109/08982104.2010.498003","doi":"https://doi.org/10.3109/08982104.2010.498003","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08982104.2010.498003","pdf_url":null,"source":{"id":"https://openalex.org/S158583779","display_name":"Journal of Liposome Research","issn_l":"0898-2104","issn":["0898-2104","1532-2394"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Liposome Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051577474","display_name":"B. V. Tiwari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8977528","display_name":"Dr. Hari Singh Gour University","ror":"https://ror.org/01xapxe37","country_code":"IN","type":"education","lineage":["https://openalex.org/I8977528"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Brajesh Tiwari","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr. H.S. Gour University, Sagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr. H.S. Gour University, Sagar, India","institution_ids":["https://openalex.org/I8977528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082641160","display_name":"Abhinav Agarwal","orcid":"https://orcid.org/0000-0002-9467-8511","observed_orcids":["https://orcid.org/0000-0002-9467-8511"]},"institutions":[{"id":"https://openalex.org/I8977528","display_name":"Dr. Hari Singh Gour University","ror":"https://ror.org/01xapxe37","country_code":"IN","type":"education","lineage":["https://openalex.org/I8977528"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhinav Agarwal","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr. H.S. Gour University, Sagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr. H.S. Gour University, Sagar, India","institution_ids":["https://openalex.org/I8977528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036753018","display_name":"Anil K. Kharya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8977528","display_name":"Dr. Hari Singh Gour University","ror":"https://ror.org/01xapxe37","country_code":"IN","type":"education","lineage":["https://openalex.org/I8977528"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anil K. Kharya","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr. H.S. Gour University, Sagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr. H.S. Gour University, Sagar, India","institution_ids":["https://openalex.org/I8977528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005907834","display_name":"Narendra Kumar Lariya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8977528","display_name":"Dr. Hari Singh Gour University","ror":"https://ror.org/01xapxe37","country_code":"IN","type":"education","lineage":["https://openalex.org/I8977528"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Narendra Lariya","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr. H.S. Gour University, Sagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr. H.S. Gour University, Sagar, India","institution_ids":["https://openalex.org/I8977528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023187631","display_name":"Gaurav Kant Saraogi","orcid":"https://orcid.org/0000-0003-1403-751X","observed_orcids":["https://orcid.org/0000-0003-1403-751X"]},"institutions":[{"id":"https://openalex.org/I8977528","display_name":"Dr. Hari Singh Gour University","ror":"https://ror.org/01xapxe37","country_code":"IN","type":"education","lineage":["https://openalex.org/I8977528"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gauravkant Saraogi","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr. H.S. Gour University, Sagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr. H.S. Gour University, Sagar, India","institution_ids":["https://openalex.org/I8977528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101691532","display_name":"Himanshu Agrawal","orcid":"https://orcid.org/0000-0001-6316-7199","observed_orcids":["https://orcid.org/0000-0001-6316-7199"]},"institutions":[{"id":"https://openalex.org/I110116418","display_name":"Maharaja Sayajirao University of Baroda","ror":"https://ror.org/01bx8ja67","country_code":"IN","type":"education","lineage":["https://openalex.org/I110116418"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Himanshu Agrawal","raw_affiliation_strings":["Pharmaceutics Research Laboratory, M.S. University of Baroda, Vadodara, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutics Research Laboratory, M.S. University of Baroda, Vadodara, India","institution_ids":["https://openalex.org/I110116418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013351312","display_name":"Govind Prasad Agrawal","orcid":"https://orcid.org/0000-0003-4486-8533","observed_orcids":["https://orcid.org/0000-0003-4486-8533"]},"institutions":[{"id":"https://openalex.org/I8977528","display_name":"Dr. Hari Singh Gour University","ror":"https://ror.org/01xapxe37","country_code":"IN","type":"education","lineage":["https://openalex.org/I8977528"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Govind P. Agrawal","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr. H.S. Gour University, Sagar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr. H.S. Gour University, Sagar, India","institution_ids":["https://openalex.org/I8977528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013351312"],"corresponding_institution_ids":["https://openalex.org/I8977528"],"apc_list":null,"apc_paid":null,"fwci":0.4421,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.58773451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"21","issue":"3","first_page":"181","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/intranasal-immunization","display_name":"intranasal immunization","score":0.7879999876022339},{"id":"https://openalex.org/keywords/mucosal-immunization","display_name":"mucosal immunization","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.9269999861717224},{"id":"https://openalex.org/keywords/immunoadjuvant","display_name":"immunoadjuvant","score":0.6980000138282776},{"id":"https://openalex.org/keywords/m-cells","display_name":"M cells","score":0.7429999709129333},{"id":"https://openalex.org/keywords/secretory-iga","display_name":"secretory IgA","score":0.7129999995231628},{"id":"https://openalex.org/keywords/humoral-and-cellular-immune-response","display_name":"humoral and cellular immune response","score":0.8730000257492065},{"id":"https://openalex.org/keywords/alum-comparison","display_name":"alum comparison","score":0.5839999914169312},{"id":"https://openalex.org/keywords/liposome-stability","display_name":"liposome stability","score":0.5070000290870667},{"id":"https://openalex.org/keywords/vesicular-carriers","display_name":"vesicular carriers","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.7646821737289429},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6091738939285278},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.5643845200538635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5149422287940979},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46241068840026855},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.37763547897338867},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3362114429473877},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1539018750190735}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/08982104.2010.498003","doi":"https://doi.org/10.3109/08982104.2010.498003","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08982104.2010.498003","pdf_url":null,"source":{"id":"https://openalex.org/S158583779","display_name":"Journal of Liposome Research","issn_l":"0898-2104","issn":["0898-2104","1532-2394"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Liposome Research","raw_type":"journal-article"},{"id":"pmid:20626315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20626315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of liposome research","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320736","display_name":"All India Council for Technical Education","ror":"https://ror.org/00xcd7y72"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1526823328","https://openalex.org/W1545622372","https://openalex.org/W1966796681","https://openalex.org/W1972431010","https://openalex.org/W1977908420","https://openalex.org/W1980095603","https://openalex.org/W1981786430","https://openalex.org/W1983363336","https://openalex.org/W1984415303","https://openalex.org/W1994327932","https://openalex.org/W2000694244","https://openalex.org/W2003614362","https://openalex.org/W2012610027","https://openalex.org/W2013009465","https://openalex.org/W2013833904","https://openalex.org/W2014813242","https://openalex.org/W2015304807","https://openalex.org/W2017690097","https://openalex.org/W2034347857","https://openalex.org/W2037372836","https://openalex.org/W2040192817","https://openalex.org/W2041190368","https://openalex.org/W2042858529","https://openalex.org/W2047131449","https://openalex.org/W2049248709","https://openalex.org/W2051977226","https://openalex.org/W2059453747","https://openalex.org/W2063013932","https://openalex.org/W2066659425","https://openalex.org/W2067749638","https://openalex.org/W2073326733","https://openalex.org/W2075278421","https://openalex.org/W2077547071","https://openalex.org/W2089479233","https://openalex.org/W2092706112","https://openalex.org/W2093694770","https://openalex.org/W2108663560","https://openalex.org/W2113447602","https://openalex.org/W2118965097","https://openalex.org/W2122859063","https://openalex.org/W2128006934","https://openalex.org/W2138778274","https://openalex.org/W2143990576","https://openalex.org/W2156640546","https://openalex.org/W2158507587","https://openalex.org/W2167107393","https://openalex.org/W2167912705"],"related_works":["https://openalex.org/W4415726852","https://openalex.org/W1964348171","https://openalex.org/W1981876008","https://openalex.org/W2030617439","https://openalex.org/W2003596458","https://openalex.org/W4414078613","https://openalex.org/W2098523823","https://openalex.org/W2004446948","https://openalex.org/W2042921192","https://openalex.org/W2077547071"],"abstract_inverted_index":{"The":[0,37,96,144],"aim":[1],"of":[2,11,29,45,105,175],"the":[3,9,19,27,43,102,132,171,179],"present":[4],"investigation":[5],"was":[6,24,89,108],"to":[7,77,169],"evaluate":[8],"prospective":[10],"surface-engineered":[12],"vesicular":[13],"carriers":[14,168],"for":[15,65,197],"mucosal":[16,141],"immunization":[17],"via":[18,186],"nasal":[20,129,198],"route.":[21],"IgG":[22,161],"antibody":[23],"immobilized":[25],"on":[26,42],"surface":[28,32],"hepatitis":[30],"B":[31],"antigen":[33,67,134,176],"(HBsAg)":[34],"antigen-loaded":[35],"liposomes.":[36,113],"developed":[38],"formulations":[39,61],"were":[40,62,75],"characterized":[41],"basis":[44],"physicochemical":[46],"parameters,":[47],"such":[48],"as":[49,166,193],"morphology,":[50],"particle":[51],"size,":[52],"polydispersity":[53],"index,":[54],"entrapment":[55],"efficiency,":[56],"and":[57,69,83,122,124,155],"zeta":[58],"potential.":[59],"Liposomal":[60],"then":[63],"evaluated":[64],"in-process":[66],"stability":[68],"storage":[70],"stability.":[71],"In":[72,85],"vivo":[73],"studies":[74],"conducted":[76],"visualize":[78],"targeting":[79],"potential,":[80],"localization":[81],"pattern,":[82],"immunogenicity.":[84],"addition,":[86],"immune":[87,126,173],"response":[88,174],"compared":[90],"with":[91],"alum-HBsAg":[92],"vaccine":[93],"injected":[94],"intramuscularly.":[95],"serum":[97],"anti-HBsAg":[98],"titer,":[99],"obtained":[100],"from":[101],"postnasal":[103],"administration":[104],"IgG-coupled":[106,115],"liposomes,":[107,180],"significantly":[109],"higher":[110],"than":[111],"plain":[112],"Moreover,":[114],"liposomes":[116,163],"generated":[117],"both":[118],"humoral":[119],"(i.e.,":[120],"systemic":[121],"mucosal)":[123],"cellular":[125,137],"responses":[127],"upon":[128],"administration,":[130],"while":[131],"alum-adsorbed":[133],"displayed":[135,147],"neither":[136],"(cytokine":[138],"level)":[139],"nor":[140],"(IgA)":[142],"response.":[143],"formulation":[145],"also":[146],"enhanced":[148],"transmucosal":[149],"transport,":[150],"improved":[151],"in":[152,178],"vitro":[153],"stability,":[154],"effective":[156],"immunoadjuvant":[157],"property.":[158],"To":[159],"conclude,":[160],"antibody-coupled":[162],"may":[164],"serve":[165],"novel":[167],"augment":[170],"secretory":[172],"encapsulated":[177],"apparently":[181],"by":[182],"escalating":[183],"liposome":[184],"uptake":[185],"M":[187],"cells,":[188],"thereby":[189],"rationalizing":[190],"their":[191],"use":[192],"a":[194],"carrier":[195],"adjuvant":[196],"subunit":[199],"vaccines.":[200]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}