{"id":"https://openalex.org/W2160249491","doi":"https://doi.org/10.1136/gut.19.7.655","title":"Gastrointestinal somatostatin: extraction and radioimmunoassay in different species.","display_name":"Gastrointestinal somatostatin: extraction and radioimmunoassay in different species.","publication_year":1978,"publication_date":"1978-07-01","ids":{"openalex":"https://openalex.org/W2160249491","doi":"https://doi.org/10.1136/gut.19.7.655","mag":"2160249491","pmid":"https://pubmed.ncbi.nlm.nih.gov/680597","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1412086"},"language":"en","primary_location":{"id":"doi:10.1136/gut.19.7.655","doi":"https://doi.org/10.1136/gut.19.7.655","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.19.7.655","pdf_url":"https://gut.bmj.com/content/gutjnl/19/7/655.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://gut.bmj.com/content/gutjnl/19/7/655.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111557732","display_name":"Christopher H.S. McIntosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C McIntosh","raw_affiliation_strings":["From the Department of Medicine, Division of Gastroenterology and Metabolism, University of Gdttingen, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Division of Gastroenterology and Metabolism, University of Gdttingen, Federal Republic of Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109944301","display_name":"R. Arnold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Arnold","raw_affiliation_strings":["From the Department of Medicine, Division of Gastroenterology and Metabolism, University of Gdttingen, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Division of Gastroenterology and Metabolism, University of Gdttingen, Federal Republic of Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070626719","display_name":"Elisabeth Bothe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E Bothe","raw_affiliation_strings":["From the Department of Medicine, Division of Gastroenterology and Metabolism, University of Gdttingen, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Division of Gastroenterology and Metabolism, University of Gdttingen, Federal Republic of Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112289372","display_name":"H. Dieter Becker","orcid":"https://orcid.org/0000-0002-4102-7520","observed_orcids":["https://orcid.org/0000-0002-4102-7520"]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Becker","raw_affiliation_strings":["From the Department of Medicine, Division of Gastroenterology and Metabolism, University of Gdttingen, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Division of Gastroenterology and Metabolism, University of Gdttingen, Federal Republic of Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114165418","display_name":"Johannes K\u00f6bberling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Kobberling","raw_affiliation_strings":["From the Department of Medicine, Division of Gastroenterology and Metabolism, University of Gdttingen, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Division of Gastroenterology and Metabolism, University of Gdttingen, Federal Republic of Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006244909","display_name":"W. Creutzfeldt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W Creutzfeldt","raw_affiliation_strings":["From the Department of Medicine, Division of Gastroenterology and Metabolism, University of Gdttingen, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Division of Gastroenterology and Metabolism, University of Gdttingen, Federal Republic of Germany","institution_ids":["https://openalex.org/I74656192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74656192"],"apc_list":null,"apc_paid":null,"fwci":3.257,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.92937451,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"7","first_page":"655","last_page":"663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7099999785423279,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7099999785423279,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.241799995303154,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/radioimmunoassay","display_name":"radioimmunoassay","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tissue-extraction","display_name":"tissue extraction","score":0.6269999742507935},{"id":"https://openalex.org/keywords/duodenal-ulcer","display_name":"duodenal ulcer","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pancreas","display_name":"pancreas","score":0.6610000133514404},{"id":"https://openalex.org/keywords/neonatal-hypoglycemia","display_name":"neonatal hypoglycemia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tetradecapeptide","display_name":"tetradecapeptide","score":0.7680000066757202},{"id":"https://openalex.org/keywords/species-comparison","display_name":"species comparison","score":0.6140000224113464},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.6119999885559082},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.7549999952316284},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.8935462236404419},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.867733359336853},{"id":"https://openalex.org/C131253125","wikidata":"https://www.wikidata.org/wiki/Q609361","display_name":"Antrum","level":3,"score":0.8049010038375854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6211114525794983},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5823338031768799},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5350868105888367},{"id":"https://openalex.org/C2778108375","wikidata":"https://www.wikidata.org/wiki/Q246978","display_name":"Pancreatic polypeptide","level":4,"score":0.4809964597225189},{"id":"https://openalex.org/C3017563778","wikidata":"https://www.wikidata.org/wiki/Q290248","display_name":"Gastric antrum","level":4,"score":0.4394480288028717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4283527135848999},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.42378634214401245},{"id":"https://openalex.org/C2910480513","wikidata":"https://www.wikidata.org/wiki/Q290248","display_name":"Pyloric Antrum","level":4,"score":0.4143137037754059},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41003769636154175},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3373410701751709},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32861441373825073},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.2864927649497986},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.21228989958763123},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.08975815773010254},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.08582097291946411}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004064","descriptor_name":"Digestive System","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004381","descriptor_name":"Duodenal Ulcer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1136/gut.19.7.655","doi":"https://doi.org/10.1136/gut.19.7.655","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.19.7.655","pdf_url":"https://gut.bmj.com/content/gutjnl/19/7/655.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1412086","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1412086","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Text"},{"id":"pmid:680597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/680597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.840.5628","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.840.5628","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://gut.bmj.com/content/19/7/655.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1136/gut.19.7.655","doi":"https://doi.org/10.1136/gut.19.7.655","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.19.7.655","pdf_url":"https://gut.bmj.com/content/gutjnl/19/7/655.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160249491.pdf","grobid_xml":"https://content.openalex.org/works/W2160249491.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W49246689","https://openalex.org/W603160594","https://openalex.org/W609768702","https://openalex.org/W1499345514","https://openalex.org/W1893651774","https://openalex.org/W1966713680","https://openalex.org/W1979967316","https://openalex.org/W1984904625","https://openalex.org/W1986509353","https://openalex.org/W1987394161","https://openalex.org/W1996070097","https://openalex.org/W1996876777","https://openalex.org/W1997138984","https://openalex.org/W2012020661","https://openalex.org/W2020518605","https://openalex.org/W2026421902","https://openalex.org/W2033208469","https://openalex.org/W2039214641","https://openalex.org/W2039393841","https://openalex.org/W2044938590","https://openalex.org/W2047809413","https://openalex.org/W2057289630","https://openalex.org/W2057537453","https://openalex.org/W2058979305","https://openalex.org/W2059926597","https://openalex.org/W2070423174","https://openalex.org/W2074580268","https://openalex.org/W2076685145","https://openalex.org/W2086285989","https://openalex.org/W2092759696","https://openalex.org/W2102653087","https://openalex.org/W2150445591","https://openalex.org/W2166468225","https://openalex.org/W2168498803","https://openalex.org/W2410499703","https://openalex.org/W2415696916","https://openalex.org/W2415704404","https://openalex.org/W2416327809","https://openalex.org/W2418867580","https://openalex.org/W2424179643"],"related_works":["https://openalex.org/W2161504149","https://openalex.org/W1992747294","https://openalex.org/W2414062703","https://openalex.org/W2342313391","https://openalex.org/W2090913861","https://openalex.org/W2330408909","https://openalex.org/W2419443470","https://openalex.org/W2061156170","https://openalex.org/W1966154775","https://openalex.org/W4300175464"],"abstract_inverted_index":{"A":[0],"radioimmunoassay":[1],"capable":[2],"of":[3,13,29,35,43,105,119],"detecting":[4],"300":[5],"fg":[6],"somatostatin":[7,121],"has":[8],"been":[9,25],"developed":[10],"and":[11,22,32,65,71,127],"levels":[12],"the":[14,108,117,124],"polypeptide":[15],"in":[16,40,59,79,93,102],"gastrointestinal":[17],"tissues":[18],"from":[19,61],"man,":[20],"dog,":[21],"rat":[23],"have":[24],"measured.":[26],"Rapid":[27],"freezing":[28],"collected":[30],"samples":[31],"careful":[33],"control":[34,66],"extraction":[36],"is":[37],"necessary.":[38],"Concentrations":[39],"different":[41],"regions":[42],"dog":[44,94],"antrum":[45,60],"(425":[46],"+/-":[47,51,69,73,85,97],"50":[48],"to":[49,57],"773":[50],"254":[52],"ng/g":[53,75,87,99,112],"tissue)":[54,88],"are":[55,89],"similar":[56],"those":[58,92],"duodenal":[62],"ulcer":[63],"patients":[64],"subjects:":[67],"614":[68],"125":[70],"465":[72],"104":[74],"tissue":[76],"respectively.":[77],"Levels":[78],"histologically":[80],"normal":[81],"human":[82],"pancreas":[83,95],"(253":[84],"43":[86],"comparable":[90],"with":[91],"(333":[96],"66":[98],"tissue),":[100],"whereas":[101],"two":[103],"cases":[104],"neonatal":[106],"hypoglycaemia":[107],"concentration":[109],"exceeded":[110],"3000":[111],"tissue.":[113],"On":[114],"gel":[115],"chromatography":[116],"majority":[118],"immunoreactive":[120],"elutes":[122],"as":[123,131],"synthetic":[125],"tetradecapeptide":[126],"a":[128,132],"small":[129],"fraction":[130],"larger":[133],"species.":[134]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}