{"id":"https://openalex.org/W2160220616","doi":"https://doi.org/10.7897/2277-4343.054103","title":"TRANSDERMAL PERMEATION ENHANCEMENT OF IBUPROFEN AND ITS SOLID DISPERSIONS","display_name":"TRANSDERMAL PERMEATION ENHANCEMENT OF IBUPROFEN AND ITS SOLID DISPERSIONS","publication_year":2014,"publication_date":"2014-09-16","ids":{"openalex":"https://openalex.org/W2160220616","doi":"https://doi.org/10.7897/2277-4343.054103","mag":"2160220616"},"language":"en","primary_location":{"id":"doi:10.7897/2277-4343.054103","doi":"https://doi.org/10.7897/2277-4343.054103","is_oa":true,"landing_page_url":"https://doi.org/10.7897/2277-4343.054103","pdf_url":"https://doi.org/10.7897/2277-4343.054103","source":{"id":"https://openalex.org/S2764692968","display_name":"International Journal of Research in Ayurveda and Pharmacy","issn_l":"2229-3566","issn":["2229-3566","2277-4343"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4360969348","host_organization_name":"Moksha Publishing House","host_organization_lineage":["https://openalex.org/P4360969348"],"host_organization_lineage_names":["Moksha Publishing House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research in Ayurveda &amp; Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.7897/2277-4343.054103","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081327376","display_name":"K Rajitha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263311","display_name":"G. Pulla Reddy College of Pharmacy","ror":"https://ror.org/053xha254","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405263311"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajitha K","raw_affiliation_strings":["Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India","Head of the department, Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India","institution_ids":["https://openalex.org/I4405263311"]},{"raw_affiliation_string":"Head of the department, Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India","institution_ids":["https://openalex.org/I4405263311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112971911","display_name":"P K Lakshmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263311","display_name":"G. Pulla Reddy College of Pharmacy","ror":"https://ror.org/053xha254","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405263311"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Lakshmi P K","raw_affiliation_strings":["Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India","institution_ids":["https://openalex.org/I4405263311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070152122","display_name":"Pranitha Akula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263311","display_name":"G. Pulla Reddy College of Pharmacy","ror":"https://ror.org/053xha254","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405263311"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pranitha Akula","raw_affiliation_strings":["Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India","Head of the department, Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India","institution_ids":["https://openalex.org/I4405263311"]},{"raw_affiliation_string":"Head of the department, Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India","institution_ids":["https://openalex.org/I4405263311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103325513","display_name":"D Prasanthi","orcid":"https://orcid.org/0000-0002-3856-814X","observed_orcids":["https://orcid.org/0000-0002-3856-814X"]},"institutions":[{"id":"https://openalex.org/I4405263311","display_name":"G. Pulla Reddy College of Pharmacy","ror":"https://ror.org/053xha254","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405263311"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prasanthi D","raw_affiliation_strings":["Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India","Head of the department, Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India","institution_ids":["https://openalex.org/I4405263311"]},{"raw_affiliation_string":"Head of the department, Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, India","institution_ids":["https://openalex.org/I4405263311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405263311"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"5","issue":"4","first_page":"508","last_page":"514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":0.9700000286102295},{"id":"https://openalex.org/keywords/terpenes","display_name":"terpenes","score":0.8629999756813049},{"id":"https://openalex.org/keywords/solid-dispersion","display_name":"solid dispersion","score":0.8320000171661377},{"id":"https://openalex.org/keywords/farnesol","display_name":"farnesol","score":0.9850000143051147},{"id":"https://openalex.org/keywords/geraniol","display_name":"geraniol","score":0.9150000214576721},{"id":"https://openalex.org/keywords/limonene","display_name":"limonene","score":0.9990000128746033},{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.5929999947547913},{"id":"https://openalex.org/keywords/drug-flux","display_name":"drug flux","score":0.4970000088214874},{"id":"https://openalex.org/keywords/permeability-coefficient","display_name":"permeability coefficient","score":0.8209999799728394},{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.7670000195503235},{"id":"https://openalex.org/keywords/higuchi-kinetics","display_name":"Higuchi model","score":0.8740000128746033},{"id":"https://openalex.org/keywords/non-fickian-diffusion","display_name":"non-Fickian diffusion","score":0.8610000014305115},{"id":"https://openalex.org/keywords/topical-gel-formulation","display_name":"topical gel formulation","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.823359489440918},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.810187578201294},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.8058878779411316},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39977914094924927},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3669372797012329},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36544740200042725},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.32532480359077454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2522631287574768},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.086497962474823},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7897/2277-4343.054103","doi":"https://doi.org/10.7897/2277-4343.054103","is_oa":true,"landing_page_url":"https://doi.org/10.7897/2277-4343.054103","pdf_url":"https://doi.org/10.7897/2277-4343.054103","source":{"id":"https://openalex.org/S2764692968","display_name":"International Journal of Research in Ayurveda and Pharmacy","issn_l":"2229-3566","issn":["2229-3566","2277-4343"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4360969348","host_organization_name":"Moksha Publishing House","host_organization_lineage":["https://openalex.org/P4360969348"],"host_organization_lineage_names":["Moksha Publishing House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research in Ayurveda &amp; Pharmacy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.7897/2277-4343.054103","doi":"https://doi.org/10.7897/2277-4343.054103","is_oa":true,"landing_page_url":"https://doi.org/10.7897/2277-4343.054103","pdf_url":"https://doi.org/10.7897/2277-4343.054103","source":{"id":"https://openalex.org/S2764692968","display_name":"International Journal of Research in Ayurveda and Pharmacy","issn_l":"2229-3566","issn":["2229-3566","2277-4343"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4360969348","host_organization_name":"Moksha Publishing House","host_organization_lineage":["https://openalex.org/P4360969348"],"host_organization_lineage_names":["Moksha Publishing House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research in Ayurveda &amp; Pharmacy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160220616.pdf","grobid_xml":"https://content.openalex.org/works/W2160220616.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1989928156","https://openalex.org/W2016581182","https://openalex.org/W2024452031","https://openalex.org/W2057820363","https://openalex.org/W2060930604","https://openalex.org/W2067857128","https://openalex.org/W2070776842","https://openalex.org/W2072655318","https://openalex.org/W2080430067","https://openalex.org/W2090506086","https://openalex.org/W2095526712","https://openalex.org/W2102467849","https://openalex.org/W2123085000","https://openalex.org/W2186925697","https://openalex.org/W2288610988","https://openalex.org/W2515384166","https://openalex.org/W4211054789","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W182379229","https://openalex.org/W2409833063","https://openalex.org/W2186701775","https://openalex.org/W2388000525","https://openalex.org/W1989606484","https://openalex.org/W2031057832","https://openalex.org/W2057820363","https://openalex.org/W2169086805","https://openalex.org/W2353331465","https://openalex.org/W1966675721"],"abstract_inverted_index":{"Terpenes":[0],"are":[1],"the":[2,11,78,83,97,102,128,170,237],"most":[3],"promising":[4],"natural":[5],"chemical":[6],"enhancers":[7],"used":[8],"to":[9,134,176],"amplify":[10],"transdermal":[12],"permeation":[13,61,80,99],"of":[14,27,42,86,105,111,140,148,151,182,190,194,199,202,219,245],"drugs,":[15],"among":[16],"them":[17],"monoterpenes":[18],"and":[19,47,63,70,73,93,130,145,172,187,217,241],"sesquiterpenes":[20],"have":[21,66],"been":[22],"widely":[23],"suggested.Permeation":[24],"enhancement":[25,81,100,195],"effect":[26,196],"various":[28,40],"terpenes":[29,203],"(nerolidol,":[30],"farnesol,":[31],"limonene,":[32],"linalool,":[33],"menthol,":[34],"geraniol,":[35],"carvone,":[36],"fenchone":[37],"etc.)":[38],"in":[39,197],"combinations":[41],"preparations":[43],"on":[44,82,101],"ibuprofen":[45,87,106,112,152,205,220],"(IBU)":[46],"its":[48],"solid":[49,107,153,221],"dispersions":[50],"(IBUSD1)":[51],"from":[52],"Carbopol":[53],"941":[54],"gel":[55,113,155,206,223],"formulations":[56,235],"(0.9":[57],"%)":[58,72,76,95],"were":[59],"studied.Skin":[60],"studies":[62,110],"release":[64,84,103,239],"kinetics":[65,240],"shown":[67],"farnesol":[68,116,208],"(2.5":[69,75,89,92],"5":[71,94],"geraniol":[74,91,213,230],"had":[77,96],"best":[79,98],"rate":[85,104,139,181],"gel.Limonene":[88],"%),":[90],"dispersion":[108,154,222],"gel.Ex-vivo":[109],"revealed":[114,156],"that":[115,157,218],"with":[117,136,159,178],"highest":[118,160],"lipophilicity":[119,161],"(log":[120,162],"P":[121,163],"5.31)":[122],"significantly":[123,165],"(p":[124,166],"<":[125,167],"0.0001)":[126,168],"increased":[127,169],"flux":[129,138,171,180],"permeability":[131,146,173,188],"coefficient":[132,147,174,189],"compared":[133,175],"control,":[135],"a":[137,179],"605.6":[141],"\u03bcg/cm":[142,184],"2":[143,185],"/hr":[144],"6.2":[149],"cm/h.Studies":[150],"limonene":[158,225],"4.58)":[164],"control":[177],"738.6":[183],"/h":[186],"8.86":[191],"cm/h.Rank":[192],"order":[193],"terms":[198],"boiling":[200],"point":[201],"for":[204],"was":[207,224],"(111":[209],"o":[210,215,227,232],"C)":[211,216,228],">":[212,229],"(230":[214,231],"(176":[226],"C).All":[233],"optimized":[234],"obeyed":[236],"Higuchi":[238],"non":[242],"fickian":[243],"type":[244],"diffusion.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}