{"id":"https://openalex.org/W2160215386","doi":"https://doi.org/10.1084/jem.20050341","title":"T cell aging","display_name":"T cell aging","publication_year":2005,"publication_date":"2005-03-21","ids":{"openalex":"https://openalex.org/W2160215386","doi":"https://doi.org/10.1084/jem.20050341","mag":"2160215386","pmid":"https://pubmed.ncbi.nlm.nih.gov/15781575","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2213096"},"language":"en","primary_location":{"id":"doi:10.1084/jem.20050341","doi":"https://doi.org/10.1084/jem.20050341","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20050341","pdf_url":"https://rupress.org/jem/article-pdf/201/6/837/1718026/jem2016837.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/201/6/837/1718026/jem2016837.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036273449","display_name":"Janko Nikolich\u2010\u017dugich","orcid":"https://orcid.org/0000-0001-5830-5323","observed_orcids":["https://orcid.org/0000-0001-5830-5323"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Janko Nikolich-Z\u030cugich","raw_affiliation_strings":["J.N.-Z\u030c. is at Oregon Health and Science University, Beaverton, OR 97006"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J.N.-Z\u030c. is at Oregon Health and Science University, Beaverton, OR 97006","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036273449"],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":null,"apc_paid":null,"fwci":0.653,"has_fulltext":true,"cited_by_count":104,"citation_normalized_percentile":{"value":0.58726592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"201","issue":"6","first_page":"837","last_page":"840"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-senescence","display_name":"T cell senescence","score":0.9319999814033508},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-homeostasis","display_name":"T cell homeostasis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/t-cell-homeostatic-proliferation","display_name":"T cell homeostatic proliferation","score":0.5550000071525574},{"id":"https://openalex.org/keywords/age-related-immune-decline","display_name":"age-related immune decline","score":0.6240000128746033},{"id":"https://openalex.org/keywords/aged-mice","display_name":"aged mice","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.8977341055870056},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7400918006896973},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6527259945869446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5777780413627625},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5249630808830261},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4809498190879822},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4124501943588257},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.351046621799469},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3349938690662384}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1084/jem.20050341","doi":"https://doi.org/10.1084/jem.20050341","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20050341","pdf_url":"https://rupress.org/jem/article-pdf/201/6/837/1718026/jem2016837.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1368863","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC2213096","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2213096","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2213096","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:15781575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15781575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.282.2979","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.2979","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0e/3e/J_Exp_Med_2005_Mar_21_201(6)_837-840.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1084/jem.20050341","doi":"https://doi.org/10.1084/jem.20050341","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20050341","pdf_url":"https://rupress.org/jem/article-pdf/201/6/837/1718026/jem2016837.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2167771296","display_name":null,"funder_award_id":"RR-0163","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2291313450","display_name":null,"funder_award_id":"AG 20719","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3160859834","display_name":"SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER","funder_award_id":"P51RR000163","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3517345373","display_name":"Vaccination and immune senescence in primates","funder_award_id":"P01AG023664","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6733631288","display_name":"T cell Homeostasis and Function in Immune Senescence","funder_award_id":"R01AG020719","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6879629834","display_name":"Caloric restrictions and immune senescence","funder_award_id":"U01AG021384","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7524207001","display_name":"REPRODUCTIVE STEROIDS AND EXPERIMENTAL STROKE","funder_award_id":"K01RR000163","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8279388581","display_name":null,"funder_award_id":"RR0163","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160215386.pdf","grobid_xml":"https://content.openalex.org/works/W2160215386.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1517279365","https://openalex.org/W1531762153","https://openalex.org/W1543352581","https://openalex.org/W1966642421","https://openalex.org/W1976493250","https://openalex.org/W1982538054","https://openalex.org/W1991601117","https://openalex.org/W1997196319","https://openalex.org/W2004769751","https://openalex.org/W2016430734","https://openalex.org/W2021969295","https://openalex.org/W2038378952","https://openalex.org/W2039414848","https://openalex.org/W2043464691","https://openalex.org/W2046825776","https://openalex.org/W2062781335","https://openalex.org/W2082291199","https://openalex.org/W2089342737","https://openalex.org/W2091600573","https://openalex.org/W2094076010","https://openalex.org/W2094712265","https://openalex.org/W2103059589","https://openalex.org/W2103411171","https://openalex.org/W2136616293","https://openalex.org/W2150244918","https://openalex.org/W2156461461","https://openalex.org/W2156829804","https://openalex.org/W2158574195","https://openalex.org/W2188294308","https://openalex.org/W2208393701","https://openalex.org/W2324837225","https://openalex.org/W4246769581"],"related_works":["https://openalex.org/W7100915322","https://openalex.org/W2058168972","https://openalex.org/W2075245809","https://openalex.org/W2056436868","https://openalex.org/W2041586952","https://openalex.org/W1995239001","https://openalex.org/W168341218","https://openalex.org/W3134712194","https://openalex.org/W2336942609","https://openalex.org/W2048088192"],"abstract_inverted_index":{"The":[0,10,35],"immune":[1,29,50],"system":[2],"exhibits":[3],"profound":[4],"age-related":[5],"changes,":[6],"collectively":[7],"termed":[8],"immunosenescence.":[9],"most":[11],"visible":[12],"of":[13,27,37,43],"these":[14,38],"is":[15,40],"the":[16],"decline":[17],"in":[18],"protective":[19],"immunity,":[20],"which":[21],"results":[22],"from":[23],"a":[24,41],"complex":[25],"interaction":[26],"primary":[28],"defects":[30],"and":[31,70],"compensatory":[32],"homeostatic":[33],"mechanisms.":[34],"sum":[36],"changes":[39],"dysregulation":[42],"many":[44],"processes":[45],"that":[46,55],"normally":[47],"ensure":[48],"optimal":[49],"function.":[51],"Recent":[52],"advances":[53],"suggest":[54],"old":[56],"mice":[57],"can":[58],"produce":[59],"fully":[60],"functional":[61],"new":[62],"T":[63],"cells,":[64],"opening":[65],"both":[66],"intriguing":[67],"inquiry":[68],"avenues":[69],"raising":[71],"critical":[72],"questions":[73],"to":[74],"be":[75],"pursued.":[76]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}