{"id":"https://openalex.org/W2160151168","doi":"https://doi.org/10.1136/bjo.2010.196907","title":"Retinal nerve fibre layer and visual function loss in glaucoma: the tipping point","display_name":"Retinal nerve fibre layer and visual function loss in glaucoma: the tipping point","publication_year":2011,"publication_date":"2011-04-08","ids":{"openalex":"https://openalex.org/W2160151168","doi":"https://doi.org/10.1136/bjo.2010.196907","mag":"2160151168","pmid":"https://pubmed.ncbi.nlm.nih.gov/21478200","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3193885"},"language":"en","primary_location":{"id":"doi:10.1136/bjo.2010.196907","doi":"https://doi.org/10.1136/bjo.2010.196907","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo.2010.196907","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/96/1/47.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://bjo.bmj.com/content/bjophthalmol/96/1/47.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090027463","display_name":"Gadi Wollstein","orcid":"https://orcid.org/0000-0001-7036-2726","observed_orcids":["https://orcid.org/0000-0001-7036-2726"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gadi Wollstein","raw_affiliation_strings":["Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, 203 Lothrop Street, Eye and Ear Institute, Pittsburgh, PA 15213, USA","Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, 203 Lothrop Street, Eye and Ear Institute, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046179209","display_name":"Larry E. Kagemann","orcid":"https://orcid.org/0000-0001-8961-0187","observed_orcids":["https://orcid.org/0000-0001-8961-0187"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry Kagemann","raw_affiliation_strings":["Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030921212","display_name":"Richard A. Bilonick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A Bilonick","raw_affiliation_strings":["Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061044862","display_name":"Hiroshi Ishikawa","orcid":"https://orcid.org/0000-0001-6310-5748","observed_orcids":["https://orcid.org/0000-0001-6310-5748"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroshi Ishikawa","raw_affiliation_strings":["Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004981616","display_name":"Lindsey S. Folio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsey S Folio","raw_affiliation_strings":["Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113480065","display_name":"Michelle L. Gabriele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle L Gabriele","raw_affiliation_strings":["Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047817244","display_name":"Allison K. Ungar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison K Ungar","raw_affiliation_strings":["Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018213798","display_name":"Jay S. Duker","orcid":"https://orcid.org/0000-0002-5482-4844","observed_orcids":["https://orcid.org/0000-0002-5482-4844"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay S Duker","raw_affiliation_strings":["New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019768182","display_name":"James G. Fujimoto","orcid":"https://orcid.org/0000-0002-0828-4357","observed_orcids":["https://orcid.org/0000-0002-0828-4357"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James G Fujimoto","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030747987","display_name":"Joel S. Schuman","orcid":"https://orcid.org/0000-0002-8885-3766","observed_orcids":["https://orcid.org/0000-0002-8885-3766"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joel S Schuman","raw_affiliation_strings":["Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","The McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, 203 Lothrop Street, Eye and Ear Institute, Suite 816, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"The McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]},{"raw_affiliation_string":"Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, 203 Lothrop Street, Eye and Ear Institute, Suite 816, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5030747987"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"],"apc_list":null,"apc_paid":null,"fwci":9.0488,"has_fulltext":true,"cited_by_count":175,"citation_normalized_percentile":{"value":0.98457888,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"96","issue":"1","first_page":"47","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/retinal-nerve-fiber-layer-thickness","display_name":"retinal nerve fiber layer thickness","score":0.9959999918937683},{"id":"https://openalex.org/keywords/visual-field-defects","display_name":"visual field defects","score":0.8339999914169312},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.8939999938011169},{"id":"https://openalex.org/keywords/regime-shifts","display_name":"tipping points","score":0.9100000262260437},{"id":"https://openalex.org/keywords/visual-field-threshold","display_name":"visual field threshold","score":0.6349999904632568},{"id":"https://openalex.org/keywords/structural-loss","display_name":"structural loss","score":0.32100000977516174},{"id":"https://openalex.org/keywords/visual-function-loss","display_name":"visual function loss","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.7912206649780273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7726690769195557},{"id":"https://openalex.org/C2780592520","wikidata":"https://www.wikidata.org/wiki/Q4423908","display_name":"Nerve fiber layer","level":3,"score":0.7546629309654236},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6606606245040894},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.644927978515625},{"id":"https://openalex.org/C2776058522","wikidata":"https://www.wikidata.org/wiki/Q2364768","display_name":"Visual field","level":2,"score":0.6359610557556152},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.5407573580741882},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.3347064256668091}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014786","descriptor_name":"Vision Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014786","descriptor_name":"Vision Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014794","descriptor_name":"Visual Fields","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1136/bjo.2010.196907","doi":"https://doi.org/10.1136/bjo.2010.196907","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo.2010.196907","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/96/1/47.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmid:21478200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21478200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2257729","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3193885","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3193885","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3193885","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Br J Ophthalmol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1013.4631","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1013.4631","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bjo.bmj.com/content/96/1/47.full.pdf","raw_type":"text"},{"id":"pmh:oai:dspace.mit.edu:1721.1/70600","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/70600","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ","raw_type":"Article"},{"id":"pmh:oai:open-archive.highwire.org:bjophthalmol:bjo.2010.196907v1","doi":null,"is_oa":false,"landing_page_url":"http://bjo.bmj.com/cgi/content/short/bjo.2010.196907v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"mag:2245824214","doi":null,"is_oa":false,"landing_page_url":"http://dspace.mit.edu/handle/1721.1/70600","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"BMJ","raw_type":null}],"best_oa_location":{"id":"doi:10.1136/bjo.2010.196907","doi":"https://doi.org/10.1136/bjo.2010.196907","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo.2010.196907","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/96/1/47.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1970662503","display_name":null,"funder_award_id":"EY08098","funder_id":"https://openalex.org/F4320306811","funder_display_name":"Research to Prevent Blindness"},{"id":"https://openalex.org/G3799663561","display_name":"Novel Optical Diagnostics with Optical Coherence Tomography","funder_award_id":"R01EY011289","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000090013","display_name":null,"funder_award_id":"EY 08098","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000873517","display_name":"Interdisciplinary Visual Sciences (IVS) Training Program","funder_award_id":"T32EY017271","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000874969","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY008098","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000892384","display_name":"Novel Glaucoma Diagnostics for Structure and Function.","funder_award_id":"R01EY013178","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320309369","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44"},{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320321502","display_name":"Carl Zeiss Meditec AG","ror":"https://ror.org/02mp31p96"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160151168.pdf","grobid_xml":"https://content.openalex.org/works/W2160151168.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W206489706","https://openalex.org/W1594870591","https://openalex.org/W1820257239","https://openalex.org/W1968169793","https://openalex.org/W2000642633","https://openalex.org/W2013674507","https://openalex.org/W2018784944","https://openalex.org/W2029335553","https://openalex.org/W2031297029","https://openalex.org/W2035696983","https://openalex.org/W2041927024","https://openalex.org/W2045931594","https://openalex.org/W2052673688","https://openalex.org/W2057172039","https://openalex.org/W2071921468","https://openalex.org/W2076673551","https://openalex.org/W2102640376","https://openalex.org/W2131940376","https://openalex.org/W2136464549","https://openalex.org/W2159305204","https://openalex.org/W2582743722","https://openalex.org/W2748268306"],"related_works":["https://openalex.org/W1974700163","https://openalex.org/W4247229728","https://openalex.org/W2025931400","https://openalex.org/W3085731832","https://openalex.org/W7165734614","https://openalex.org/W1994572558","https://openalex.org/W2123411566","https://openalex.org/W2029350273","https://openalex.org/W1126312001","https://openalex.org/W2139672720"],"abstract_inverted_index":{"AIMS:":[0],"To":[1],"determine":[2],"the":[3,109,115,122,128,141,172,175,192,203,206,238],"retinal":[4],"nerve":[5],"fibre":[6],"layer":[7],"(RNFL)":[8],"thickness":[9,111,148,165,179],"at":[10,83,91],"which":[11],"visual":[12],"field":[13,59],"(VF)":[14],"damage":[15],"becomes":[16],"detectable":[17,236],"and":[18,31,47,61,69,87,104,132,139,180,190,219],"associated":[19,120],"with":[20,73,121],"structural":[21,123,224],"loss.":[22],"METHODS:":[23],"In":[24],"a":[25,78,88,162],"prospective":[26],"cross-sectional":[27],"study,":[28],"72":[29],"healthy":[30],"40":[32],"glaucoma":[33],"subjects":[34],"(one":[35],"eye":[36],"per":[37],"subject)":[38],"recruited":[39],"from":[40,167],"an":[41],"academic":[42],"institution":[43],"had":[44],"VF":[45,74,116,151],"examinations":[46],"spectral":[48],"domain":[49],"optical":[50],"coherence":[51],"tomography":[52],"(SD-OCT)":[53],"optic":[54],"disc":[55],"cube":[56],"scans":[57],"(Humphrey":[58],"analyser":[60],"Cirrus":[62],"HD-OCT,":[63],"respectively).":[64],"Comparison":[65],"of":[66,80],"global":[67,103],"mean":[68,146],"sectoral":[70,105],"RNFL":[71,85,93,110,147,164,178],"thicknesses":[72,86],"threshold":[75,81,117,149,181],"values":[76,82,118],"showed":[77],"plateau":[79],"high":[84],"sharp":[89],"decrease":[90],"lower":[92],"thicknesses.":[94],"A":[95,212],"'broken":[96],"stick'":[97],"statistical":[98],"model":[99],"was":[100,134,153,183,196,208,215],"fitted":[101],"to":[102,107,159,188,201,228,234],"data":[106,137],"estimate":[108],"'tipping":[112],"point'":[113],"where":[114],"become":[119],"measurements.":[124],"The":[125,145],"slope":[126,176],"for":[127,136,150,177,217,231],"association":[129],"between":[130,205],"structure":[131],"function":[133],"computed":[135],"above":[138],"below":[140,191],"tipping":[142,173,193],"point.":[143],"RESULTS:":[144],"loss":[152,166,225,233],"75.3":[154],"\u03bcm":[155],"(95%":[156],"CI:":[157],"68.9":[158],"81.8),":[160],"reflecting":[161],"17.3%":[163],"age-matched":[168],"normative":[169],"value.":[170],"Above":[171],"point,":[174,194],"value":[182],"0.03":[184],"dB/\u03bcm":[185,198],"(CI:":[186,199],"-0.02":[187],"0.08)":[189],"it":[195],"0.28":[197],"0.18":[200],"0.38);":[202],"difference":[204],"slopes":[207],"statistically":[209],"significant":[210],"(p<0.001).":[211],"similar":[213],"pattern":[214],"observed":[216],"quadrant":[218],"clock-hour":[220],"analysis.":[221],"CONCLUSIONS:":[222],"Substantial":[223],"(\u223c17%)":[226],"appears":[227],"be":[229,235],"necessary":[230],"functional":[232],"using":[237],"current":[239],"testing":[240],"methods.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
