{"id":"https://openalex.org/W2160052372","doi":null,"title":"Calcitonin effects on growth and on selective activation of type II isoenzyme of cyclic adenosine 3':5'-monophosphate-dependent protein kinase in T 47D human breast cancer cells.","display_name":"Calcitonin effects on growth and on selective activation of type II isoenzyme of cyclic adenosine 3':5'-monophosphate-dependent protein kinase in T 47D human breast cancer cells.","publication_year":1983,"publication_date":"1983-02-01","ids":{"openalex":"https://openalex.org/W2160052372","mag":"2160052372","pmid":"https://pubmed.ncbi.nlm.nih.gov/6184157"},"language":"en","primary_location":{"id":"pmid:6184157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6184157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042563072","display_name":"Ng Kw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K W Ng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110395187","display_name":"Livesey Sa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Livesey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113774129","display_name":"Larkins Rg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R G Larkins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110265061","display_name":"TJ Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T J Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1368,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.88281866,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"43","issue":"2","first_page":"794","last_page":"800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.17970000207424164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.17970000207424164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.15299999713897705,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcitonin","display_name":"calcitonin","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6710000038146973},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.5690000057220459},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.8080000281333923},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8360000252723694},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9340000152587891},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.9520000219345093},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mitogenesis","display_name":"mitogenesis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/calcitonin-receptor","display_name":"calcitonin receptor","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.8832406997680664},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7501654624938965},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.742983341217041},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.46031755208969116},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.4441503584384918},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43709808588027954},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.37634778022766113},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36051541566848755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34211570024490356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2563493847846985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18207094073295593}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011458","descriptor_name":"Prostaglandins E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015056","descriptor_name":"1-Methyl-3-isobutylxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6184157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6184157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2160052372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6184157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W19150501","https://openalex.org/W177271203","https://openalex.org/W1486660821","https://openalex.org/W1495754095","https://openalex.org/W1498071142","https://openalex.org/W1558611508","https://openalex.org/W1561853718","https://openalex.org/W1567964079","https://openalex.org/W1579335674","https://openalex.org/W1595366583","https://openalex.org/W1775749144","https://openalex.org/W1923601914","https://openalex.org/W1928687819","https://openalex.org/W1964500142","https://openalex.org/W1966505162","https://openalex.org/W1971202273","https://openalex.org/W1977078805","https://openalex.org/W1985317756","https://openalex.org/W1989789536","https://openalex.org/W2005630438","https://openalex.org/W2007753723","https://openalex.org/W2013216313","https://openalex.org/W2016620410","https://openalex.org/W2017919338","https://openalex.org/W2021895364","https://openalex.org/W2023838194","https://openalex.org/W2026967502","https://openalex.org/W2052522791","https://openalex.org/W2057456583","https://openalex.org/W2066239175","https://openalex.org/W2082559281","https://openalex.org/W2100351315","https://openalex.org/W2108746469","https://openalex.org/W2110223847","https://openalex.org/W2141449078","https://openalex.org/W2143310581","https://openalex.org/W2152691788","https://openalex.org/W2222836159","https://openalex.org/W2317050701","https://openalex.org/W2415109070","https://openalex.org/W2423031113"],"related_works":["https://openalex.org/W2005466470","https://openalex.org/W1987302979","https://openalex.org/W1928687819","https://openalex.org/W2107012598","https://openalex.org/W2086608129","https://openalex.org/W2015475881","https://openalex.org/W2375543440","https://openalex.org/W1978308998","https://openalex.org/W2036358227","https://openalex.org/W2323105555"],"abstract_inverted_index":{"The":[0,248],"influence":[1,159],"of":[2,41,51,65,76,85,107,111,117,121,137,154,172,198,211,217,238,250,255,265,267,269,273],"calcitonin":[3,25,43,66,138,147,188,229,256],"on":[4,139],"cell":[5,14,46,68,100,109,242],"growth":[6,47,163,171,221],"was":[7,59,78,143,179,184],"examined":[8],"in":[9,83,151,204,223,244,282],"the":[10,35,49,73,152,170,205,235,239,251,263,283],"human":[11,146],"breast":[12],"cancer":[13,224],"line,":[15],"T":[16,36,140,173,206,245],"47D.":[17],"These":[18],"cells":[19,113,142],"possess":[20],"specific":[21],"high-affinity":[22],"receptors":[23],"for":[24],"as":[26,28],"well":[27,98],"a":[29,115],"sensitive":[30],"calcitonin-responsive":[31],"adenylate":[32,160],"cyclase.":[33,161],"In":[34,209],"47D":[37,141,174,207,246],"cells,":[38,175,225],"low":[39],"doses":[40],"salmon":[42,187],"initially":[44],"stimulated":[45,169],"and":[48,81,94,148,166],"incorporation":[50],"[3H]thymidine":[52],"into":[53],"acid-insoluble":[54],"macromolecules.":[55],"This":[56,134],"initial":[57],"stimulation":[58,266],"followed":[60],"by":[61,145],"an":[62],"inhibitory":[63,236],"effect":[64,136,178,237,254],"upon":[67,241,257],"proliferation,":[69],"which":[70,157],"occurred":[71],"during":[72],"log":[74],"phase":[75],"growth,":[77],"dose":[79],"dependent,":[80],"resulted":[82],"prolongation":[84],"doubling":[86],"time":[87],"from":[88],"36":[89],"to":[90,104,132,220,228,234],"90":[91],"hr.":[92],"DNA":[93],"protein":[95,202,275],"content":[96],"correlated":[97],"with":[99,156,186],"number.":[101],"By":[102],"7":[103],"9":[105],"days":[106],"treatment,":[108],"numbers":[110],"calcitonin-treated":[112],"reached":[114],"mean":[116],"66.5":[118],"+/-":[119],"3.7%":[120],"control":[122],"(p":[123],"less":[124],"than":[125],"0.001,":[126],"n":[127],"=":[128],"8)":[129],"(range,":[130],"51.3":[131],"82.9%).":[133],"biphasic":[135],"reproduced":[144],"prostaglandin":[149],"E2":[150],"order":[153],"potency":[155],"they":[158],"Epidermal":[162],"factor":[164],"(10(-9)M)":[165,168],"insulin":[167],"but":[176],"this":[177,218,226],"abolished":[180],"when":[181],"either":[182],"hormone":[183,240],"combined":[185],"(3":[189],"x":[190],"10(-10)M).":[191],"Calcitonin":[192],"specifically":[193],"activated":[194],"type":[195,270],"II":[196],"isoenzyme":[197,219,272],"cyclic":[199],"adenosine":[200],"3':5'-monophosphate-dependent":[201],"kinase":[203,276],"cells.":[208,247],"view":[210],"other":[212],"published":[213],"data":[214],"relating":[215],"activation":[216],"regression":[222],"response":[227],"may":[230],"be":[231],"causally":[232],"related":[233],"replication":[243],"mechanism":[249],"early":[252],"stimulatory":[253],"mitogenesis":[258],"is":[259],"not":[260,278],"explained,":[261],"although":[262],"possibility":[264],"activity":[268],"I":[271],"cAMP-dependent":[274],"has":[277],"been":[279],"entirely":[280],"excluded":[281],"present":[284],"experiments.":[285]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
