{"id":"https://openalex.org/W2160050879","doi":null,"title":"6q- is an early and persistent chromosomal aberration in CD3-CD4+ T-cell clones associated with the lymphocytic variant of hypereosinophilic syndrome.","display_name":"6q- is an early and persistent chromosomal aberration in CD3-CD4+ T-cell clones associated with the lymphocytic variant of hypereosinophilic syndrome.","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W2160050879","mag":"2160050879","pmid":"https://pubmed.ncbi.nlm.nih.gov/15951288"},"language":"en","primary_location":{"id":"pmid:15951288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15951288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2078.1/26691","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072930110","display_name":"Marie Ravoet","orcid":"https://orcid.org/0000-0002-0900-9947","observed_orcids":["https://orcid.org/0000-0002-0900-9947"]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marie Ravoet","raw_affiliation_strings":["Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010084016","display_name":"Catherine Sibille","orcid":"https://orcid.org/0000-0001-5766-093X","observed_orcids":["https://orcid.org/0000-0001-5766-093X"]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Catherine Sibille","raw_affiliation_strings":["Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072613674","display_name":"Florence E. Roufosse","orcid":"https://orcid.org/0000-0002-5288-0375","observed_orcids":["https://orcid.org/0000-0002-5288-0375","https://orcid.org/0000-0001-8825-8126"]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Florence Roufosse","raw_affiliation_strings":["Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075029399","display_name":"Hugues Duvillier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hugues Duvillier","raw_affiliation_strings":["Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022586486","display_name":"Christos Sotiriou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Christos Sotiriou","raw_affiliation_strings":["Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030002732","display_name":"Liliane Schanden\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Liliane Schanden\u00e9","raw_affiliation_strings":["Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109985989","display_name":"Philippe Martiat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Philippe Martiat","raw_affiliation_strings":["Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016249576","display_name":"Michel Goldman","orcid":"https://orcid.org/0000-0003-0222-7287","observed_orcids":["https://orcid.org/0000-0003-0222-7287"]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Michel Goldman","raw_affiliation_strings":["Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048023873","display_name":"Karen E Willard-Gallo","orcid":"https://orcid.org/0000-0002-1150-1295","observed_orcids":["https://orcid.org/0000-0002-1150-1295"]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Karen E Willard-Gallo","raw_affiliation_strings":["Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics, Cliniques Universitaires St Luc UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1315288073"],"apc_list":null,"apc_paid":null,"fwci":1.4149,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.81069238,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"90","issue":"6","first_page":"753","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/6q-deletion","display_name":"6q deletion","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cd3-cd4-t-cells","display_name":"CD3+CD4+ T cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/t-cell-lymphoma","display_name":"T-cell lymphoma","score":0.8429999947547913},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.8289999961853027},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cytogenetic-markers","display_name":"cytogenetic markers","score":0.6890000104904175},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.6104822754859924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5985381603240967},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.5170907974243164},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.49553143978118896},{"id":"https://openalex.org/C2777621362","wikidata":"https://www.wikidata.org/wiki/Q2551272","display_name":"Hypereosinophilic syndrome","level":3,"score":0.48402756452560425},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4545130729675293},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.448917418718338},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4463549554347992},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4444941282272339},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.4251987040042877},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.29835599660873413},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2712722420692444},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2401195466518402},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.23765090107917786},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22164225578308105},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.1847859025001526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16262727975845337},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.15967398881912231}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002879","descriptor_name":"Chromosomes, Human, Pair 10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002896","descriptor_name":"Chromosomes, Human, Pair 6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022202","descriptor_name":"Chromosomes, Artificial, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"pmid:15951288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15951288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.318.9611","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.318.9611","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.haematologica.org/content/90/6/753.full.pdf","raw_type":"text"},{"id":"pmh:oai:dial.uclouvain.be:boreal:26691","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/26691","pdf_url":null,"source":{"id":"https://openalex.org/S4306401974","display_name":"DIAL (Catholic University of Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol. 90, no. 6, p. 753-65 (2005)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/50932","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50932","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, 90 (6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:c3a1b4247266464b88e0f37ea0d5d9c7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c3a1b4247266464b88e0f37ea0d5d9c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 90, Iss 6 (2005)","raw_type":"article"},{"id":"mag:2160050879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15951288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:dial.uclouvain.be:boreal:26691","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/26691","pdf_url":null,"source":{"id":"https://openalex.org/S4306401974","display_name":"DIAL (Catholic University of Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol. 90, no. 6, p. 753-65 (2005)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W17630750","https://openalex.org/W167225159","https://openalex.org/W196756575","https://openalex.org/W1525811283","https://openalex.org/W1731209109","https://openalex.org/W1791188340","https://openalex.org/W1967330066","https://openalex.org/W1968572217","https://openalex.org/W1972581653","https://openalex.org/W1989157965","https://openalex.org/W1994171871","https://openalex.org/W1997985068","https://openalex.org/W2002835770","https://openalex.org/W2006432362","https://openalex.org/W2012952884","https://openalex.org/W2025690484","https://openalex.org/W2032808719","https://openalex.org/W2047074802","https://openalex.org/W2049219444","https://openalex.org/W2049772811","https://openalex.org/W2050728254","https://openalex.org/W2056156489","https://openalex.org/W2057496292","https://openalex.org/W2058240442","https://openalex.org/W2062062840","https://openalex.org/W2066304917","https://openalex.org/W2069900852","https://openalex.org/W2085908488","https://openalex.org/W2094768479","https://openalex.org/W2099364141","https://openalex.org/W2104521784","https://openalex.org/W2106931266","https://openalex.org/W2110681386","https://openalex.org/W2110952739","https://openalex.org/W2133339616","https://openalex.org/W2133339791","https://openalex.org/W2134812217","https://openalex.org/W2136851976","https://openalex.org/W2137739534","https://openalex.org/W2140422307","https://openalex.org/W2141324982","https://openalex.org/W2170989872","https://openalex.org/W2172112558","https://openalex.org/W2212033819","https://openalex.org/W2263704514","https://openalex.org/W2264143004","https://openalex.org/W2280063724","https://openalex.org/W2281850830","https://openalex.org/W2306041162","https://openalex.org/W2330754503","https://openalex.org/W2342251757","https://openalex.org/W3023846844","https://openalex.org/W4293245940"],"related_works":["https://openalex.org/W1655597475","https://openalex.org/W7093856210","https://openalex.org/W1992578435","https://openalex.org/W1894893591","https://openalex.org/W1938176571","https://openalex.org/W7171522689","https://openalex.org/W4400825501","https://openalex.org/W1965564689","https://openalex.org/W2020341107","https://openalex.org/W2066304917"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,67,224],"OBJECTIVES:":[2],"The":[3,69],"lymphocytic":[4],"variant":[5],"of":[6,19,30,53,60,106,121,165],"hypereosinophilic":[7],"syndrome":[8],"(LV-HES)":[9],"is":[10,25,37,184],"an":[11,234],"underrated":[12],"disease":[13,24,142,221],"defined":[14],"by":[15,27,82],"the":[16,61,74,104,119,135,155,163,177,181,190,196,200,207,217,230],"monoclonal":[17],"proliferation":[18],"interleukin-5":[20],"secreting":[21],"T-cells.":[22],"This":[23],"distinguished":[26],"a":[28,39,51,98,166],"period":[29],"chronic":[31,141,191,218],"lymphoproliferation":[32],"without":[33],"clinical":[34,110],"transformation,":[35],"which":[36],"frequently":[38],"precursor":[40],"to":[41,55,102,117,162,206],"T-cell":[42,168,239],"lymphoma.":[43],"In":[44],"this":[45],"study,":[46],"LV-HES":[47,137],"was":[48,91,115,132,148],"used":[49,116],"as":[50,195],"model":[52],"pre-malignancy":[54],"identify":[56],"specific":[57],"marker(s)":[58],"predictive":[59],"potential":[62],"for":[63,238],"malignant":[64,220],"transformation.":[65,240],"DESIGN":[66],"METHODS:":[68],"karyotypic":[70],"abnormalities":[71],"detected":[72,133],"in":[73,84,134,152,158,199,216],"abnormal":[75],"CD3-CD4+":[76,167],"T":[77],"cells":[78],"were":[79],"further":[80],"characterized":[81],"fluorescent":[83],"situ":[85],"hybridization.":[86],"A":[87,129],"multi-step":[88],"retrospective":[89],"analysis":[90,114],"performed":[92],"on":[93,125],"successive":[94],"blood":[95],"samples":[96],"during":[97,139],"six-year":[99],"follow":[100],"up":[101],"correlate":[103],"evolution":[105],"cytogenetic":[107,236],"changes":[108],"with":[109,154],"progression.":[111],"Expression":[112],"array":[113],"investigate":[118],"effect":[120],"these":[122],"chromosomal":[123],"aberrations":[124],"gene":[126,212],"expression.":[127],"RESULTS:":[128],"6q":[130,156,178,231],"deletion":[131,147,183,232],"two":[136],"patients":[138],"their":[140],"phase.":[143],"An":[144],"additional":[145],"10p":[146,182],"found":[149],"alone":[150],"or":[151],"association":[153],"defect":[157],"one":[159],"patient":[160],"prior":[161],"development":[164],"lymphoma":[169,201],"six":[170],"years":[171],"after":[172],"diagnosis.":[173],"We":[174],"show":[175],"that":[176,229],"but":[179],"not":[180],"both":[185,215],"stable":[186],"and":[187,219],"persistent":[188],"throughout":[189],"disease,":[192],"finally":[193],"emerging":[194],"predominant":[197],"aberration":[198],"cells.":[202],"Six":[203],"genes":[204],"mapped":[205],"6q-deleted":[208],"region":[209],"displayed":[210],"altered":[211],"expression":[213],"profiles":[214],"phases.":[222],"INTERPRETATION":[223],"CONCLUSIONS:":[225],"Our":[226],"data":[227],"suggest":[228],"represents":[233],"early":[235],"marker":[237]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}