{"id":"https://openalex.org/W2159931986","doi":"https://doi.org/10.1002/ajh.21503","title":"Quality of life and use of red cell transfusion in patients with myelodysplastic syndromes. A systematic review","display_name":"Quality of life and use of red cell transfusion in patients with myelodysplastic syndromes. A systematic review","publication_year":2009,"publication_date":"2009-07-17","ids":{"openalex":"https://openalex.org/W2159931986","doi":"https://doi.org/10.1002/ajh.21503","mag":"2159931986","pmid":"https://pubmed.ncbi.nlm.nih.gov/19705430"},"language":"en","primary_location":{"id":"doi:10.1002/ajh.21503","doi":"https://doi.org/10.1002/ajh.21503","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajh.21503","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.21503","source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.21503","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038965525","display_name":"Deborah J. Pinchon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800993931","display_name":"Hull Royal Infirmary","ror":"https://ror.org/02njpkz73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800043709","https://openalex.org/I2800993931"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Deborah J. Pinchon","raw_affiliation_strings":["Pathology Department, Hull Royal Infirmary, Hull, United Kingdom","Transfusion Nurse Specialist, Pathology Department, Hull Royal Infirmary, Hull, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Department, Hull Royal Infirmary, Hull, United Kingdom","institution_ids":["https://openalex.org/I2800993931"]},{"raw_affiliation_string":"Transfusion Nurse Specialist, Pathology Department, Hull Royal Infirmary, Hull, United Kingdom","institution_ids":["https://openalex.org/I2800993931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018342534","display_name":"Simon J. Stanworth","orcid":"https://orcid.org/0000-0002-7414-4950","observed_orcids":["https://orcid.org/0000-0002-7414-4950","https://orcid.org/0000-0001-6371-5079"]},"institutions":[{"id":"https://openalex.org/I1307946715","display_name":"NHS Blood and Transplant","ror":"https://ror.org/0227qpa16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307946715"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon J. Stanworth","raw_affiliation_strings":["Consultant Haematologist, NHSBT/Oxford Radcliffe Hospitals Trust, John Radcliffe Hospital, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Haematologist, NHSBT/Oxford Radcliffe Hospitals Trust, John Radcliffe Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I1307946715","https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009756710","display_name":"Carolyn J. Doree","orcid":"https://orcid.org/0000-0001-6955-7497","observed_orcids":["https://orcid.org/0000-0001-6955-7497"]},"institutions":[{"id":"https://openalex.org/I1307946715","display_name":"NHS Blood and Transplant","ror":"https://ror.org/0227qpa16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307946715"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carolyn Dor\u00e9e","raw_affiliation_strings":["Systematic Reviews Initiative, NHSBT, John Radcliffe Hospital, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systematic Reviews Initiative, NHSBT, John Radcliffe Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I1307946715","https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083450977","display_name":"Susan J Brunskill","orcid":"https://orcid.org/0000-0002-0329-7677","observed_orcids":["https://orcid.org/0000-0002-0329-7677"]},"institutions":[{"id":"https://openalex.org/I1307946715","display_name":"NHS Blood and Transplant","ror":"https://ror.org/0227qpa16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307946715"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Susan Brunskill","raw_affiliation_strings":["Systematic Reviews Initiative, NHSBT, John Radcliffe Hospital, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systematic Reviews Initiative, NHSBT, John Radcliffe Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I1307946715","https://openalex.org/I2802742124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111521547","display_name":"D. R. Norfolk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307946715","display_name":"NHS Blood and Transplant","ror":"https://ror.org/0227qpa16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307946715"]},{"id":"https://openalex.org/I2799390153","display_name":"Leeds Teaching Hospitals NHS Trust","ror":"https://ror.org/00v4dac24","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Derek R. Norfolk","raw_affiliation_strings":["Consultant Haematologist, NHSBT and Leeds Teaching Hospitals NHS Trust, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant Haematologist, NHSBT and Leeds Teaching Hospitals NHS Trust, United Kingdom","institution_ids":["https://openalex.org/I1307946715","https://openalex.org/I2799390153"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111521547"],"corresponding_institution_ids":["https://openalex.org/I1307946715","https://openalex.org/I2799390153"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":0.3224,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.3616419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"84","issue":"10","first_page":"671","last_page":"677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.4738999903202057,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.4738999903202057,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.17399999499320984,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.1289999932050705,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":1.0},{"id":"https://openalex.org/keywords/red-blood-cell-transfusion","display_name":"red blood cell transfusion","score":0.8090000152587891},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.9629999995231628},{"id":"https://openalex.org/keywords/chronic-anemia","display_name":"chronic anemia","score":0.7459999918937683},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.9129999876022339},{"id":"https://openalex.org/keywords/quality-of-life-instruments","display_name":"quality of life instruments","score":0.7260000109672546},{"id":"https://openalex.org/keywords/facts","display_name":"facts","score":0.515999972820282},{"id":"https://openalex.org/keywords/eortc-qlq-c30","display_name":"EORTC QLQ-C30","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8500993251800537},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.8008444309234619},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.6712716817855835},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5327114462852478},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.47200700640678406},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41787245869636536},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4097154438495636},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3785077929496765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2786308228969574},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017707","descriptor_name":"Erythrocyte Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ajh.21503","doi":"https://doi.org/10.1002/ajh.21503","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajh.21503","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.21503","source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},{"id":"pmid:19705430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19705430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hematology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/ajh.21503","doi":"https://doi.org/10.1002/ajh.21503","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ajh.21503","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.21503","source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159931986.pdf","grobid_xml":"https://content.openalex.org/works/W2159931986.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W147324995","https://openalex.org/W1986544757","https://openalex.org/W1987694020","https://openalex.org/W1990415065","https://openalex.org/W1996887331","https://openalex.org/W1997543621","https://openalex.org/W2002385564","https://openalex.org/W2017514019","https://openalex.org/W2028635896","https://openalex.org/W2050299158","https://openalex.org/W2058820265","https://openalex.org/W2070939442","https://openalex.org/W2071586909","https://openalex.org/W2078443896","https://openalex.org/W2080361105","https://openalex.org/W2081279521","https://openalex.org/W2091771435","https://openalex.org/W2106292925","https://openalex.org/W2149564130","https://openalex.org/W2156870897","https://openalex.org/W2159156084","https://openalex.org/W2167571044","https://openalex.org/W2170954997","https://openalex.org/W2217205218","https://openalex.org/W2607083742","https://openalex.org/W2992010020","https://openalex.org/W4233274666"],"related_works":["https://openalex.org/W3162929023","https://openalex.org/W2070939442","https://openalex.org/W3180351622","https://openalex.org/W3002741063","https://openalex.org/W2156166039","https://openalex.org/W4205422453","https://openalex.org/W2534077863","https://openalex.org/W2338359559","https://openalex.org/W3169097194","https://openalex.org/W4280568269"],"abstract_inverted_index":{"The":[0],"main":[1],"treatment":[2],"for":[3,115,154],"many":[4],"patients":[5,63],"with":[6,64],"Myelodysplastic":[7],"Syndromes":[8],"(MDS)":[9],"remains":[10],"red":[11],"cell":[12],"transfusion":[13,175],"to":[14,43,51,142,177,205],"attenuate":[15],"the":[16,38,57,104,112,133,163,173,197,206],"symptoms":[17],"of":[18,29,37,41,59,68,103,107,119,123,139,156,160,165,201,214],"chronic":[19],"anemia.":[20],"Fatigue":[21],"can":[22],"reduce":[23],"a":[24,137,190],"patient's":[25],"health":[26],"related":[27],"quality":[28],"life":[30],"(HRQoL),":[31],"but":[32,79],"there":[33],"is":[34,169,189],"little":[35],"understanding":[36],"optimal":[39,174],"use":[40,58],"transfusions":[42],"improve":[44,178],"this.":[45],"A":[46,66],"systematic":[47],"review":[48],"was":[49,88],"performed":[50],"identify":[52],"and":[53,111,117,150],"appraise":[54],"publications":[55],"reporting":[56],"HRQoL":[60,77,85,93,157,179,186],"instruments":[61,94],"in":[62,99,132,180],"MDS.":[65,182],"total":[67],"17":[69],"separate":[70],"studies":[71],"were":[72,95,130],"identified":[73,131],"that":[74,199],"used":[75,98],"14":[76],"instruments,":[78],"only":[80],"one":[81],"MDS":[82,100,188],"disease":[83],"specific":[84],"instrument":[86],"(QOL-E)":[87],"reported.":[89],"Two":[90],"well":[91,209],"established":[92],"most":[96,202],"often":[97],"research":[101,184],"(variants":[102],"Functional":[105],"Assessment":[106],"Cancer":[108,120],"Therapy":[109],"(FACT)":[110],"European":[113],"Organisation":[114],"Research":[116],"Treatment":[118],"Core":[121],"Quality":[122],"Life":[124],"Questionnaire":[125],"(QLQ-C30)).":[126],"Several":[127],"common":[128],"problems":[129],"published":[134],"literature":[135],"including":[136],"lack":[138],"power":[140],"calculations":[141],"detect":[143],"clinically":[144],"relevant":[145],"changes,":[146],"small":[147],"sample":[148],"sizes":[149],"significant":[151],"attrition":[152],"rates":[153],"completion":[155],"assessments,":[158],"all":[159],"which":[161],"limit":[162],"strength":[164],"any":[166],"conclusions.":[167],"There":[168],"no":[170],"consensus":[171],"on":[172,196],"regimen":[176],"transfusion-dependent":[181],"Future":[183],"into":[185],"within":[187],"pressing":[191],"requirement.":[192],"Studies":[193],"should":[194],"focus":[195],"domains":[198],"are":[200],"clinical":[203],"importance":[204],"patient":[207],"as":[208,210],"traditional":[211],"quantitative":[212],"changes":[213],"hemoglobin":[215],"concentration.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}