{"id":"https://openalex.org/W2159832667","doi":"https://doi.org/10.1007/10_2008_45","title":"Totipotency, Pluripotency and Nuclear Reprogramming","display_name":"Totipotency, Pluripotency and Nuclear Reprogramming","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2159832667","doi":"https://doi.org/10.1007/10_2008_45","mag":"2159832667","pmid":"https://pubmed.ncbi.nlm.nih.gov/19343304","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2752493"},"language":"en","primary_location":{"id":"doi:10.1007/10_2008_45","doi":"https://doi.org/10.1007/10_2008_45","is_oa":false,"landing_page_url":"https://doi.org/10.1007/10_2008_45","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Engineering of Stem Cells","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W47598260","display_name":"Engineering of Stem Cells"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2752493","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037802716","display_name":"Shoukhrat M. Mitalipov","orcid":"https://orcid.org/0000-0003-0937-6146","observed_orcids":["https://orcid.org/0000-0003-0937-6146"]},"institutions":[{"id":"https://openalex.org/I102507086","display_name":"Oregon National Primate Research Center","ror":"https://ror.org/05fcfqq67","country_code":"US","type":"facility","lineage":["https://openalex.org/I102507086"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shoukhrat Mitalipov","raw_affiliation_strings":["Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, 505 N.W. 185th Avenue, Beaverton, Oregon, 97006, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, 505 N.W. 185th Avenue, Beaverton, Oregon, 97006, USA","institution_ids":["https://openalex.org/I102507086","https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069135894","display_name":"Don P. Wolf","orcid":"https://orcid.org/0000-0001-6900-2045","observed_orcids":["https://orcid.org/0000-0001-6900-2045"]},"institutions":[{"id":"https://openalex.org/I102507086","display_name":"Oregon National Primate Research Center","ror":"https://ror.org/05fcfqq67","country_code":"US","type":"facility","lineage":["https://openalex.org/I102507086"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Don Wolf","raw_affiliation_strings":["Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, 505 N.W. 185th Avenue, Beaverton, Oregon, 97006, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, 505 N.W. 185th Avenue, Beaverton, Oregon, 97006, USA","institution_ids":["https://openalex.org/I102507086","https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":16.5549,"has_fulltext":false,"cited_by_count":264,"citation_normalized_percentile":{"value":0.99515205,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"114","issue":null,"first_page":"185","last_page":"199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/totipotency","display_name":"totipotency","score":0.996999979019165},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":1.0},{"id":"https://openalex.org/keywords/nuclear-reprogramming","display_name":"nuclear reprogramming","score":0.9959999918937683},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/somatic-cell-nuclear-transfer","display_name":"somatic cell nuclear transfer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/direct-reprogramming","display_name":"direct reprogramming","score":0.9100000262260437},{"id":"https://openalex.org/keywords/somatic-cell-reprogramming","display_name":"somatic cell reprogramming","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cell-replacement-therapy","display_name":"cell replacement therapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/immune-rejection","display_name":"immune rejection","score":0.44200000166893005},{"id":"https://openalex.org/keywords/germ-layers","display_name":"germ layers","score":0.5899999737739563},{"id":"https://openalex.org/keywords/inner-cell-mass","display_name":"inner cell mass","score":0.7020000219345093},{"id":"https://openalex.org/keywords/trophectoderm","display_name":"trophectoderm","score":0.9100000262260437},{"id":"https://openalex.org/keywords/zygote","display_name":"zygote","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.9193706512451172},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7807357907295227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.722495436668396},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.7158272862434387},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6576116681098938},{"id":"https://openalex.org/C2910790502","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Totipotent","level":4,"score":0.6534491777420044},{"id":"https://openalex.org/C27390768","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Cell potency","level":5,"score":0.5928546786308289},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5518593788146973},{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.5488543510437012},{"id":"https://openalex.org/C18155467","wikidata":"https://www.wikidata.org/wiki/Q660498","display_name":"Germ layer","level":5,"score":0.5036179423332214},{"id":"https://openalex.org/C2779329299","wikidata":"https://www.wikidata.org/wiki/Q272474","display_name":"Ectoderm","level":4,"score":0.45032089948654175},{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.44749897718429565},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.42160600423812866},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29008251428604126},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24140256643295288},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.23316776752471924},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.12205010652542114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039901","descriptor_name":"Totipotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D039901","descriptor_name":"Totipotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053652","descriptor_name":"Nuclear Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/10_2008_45","doi":"https://doi.org/10.1007/10_2008_45","is_oa":false,"landing_page_url":"https://doi.org/10.1007/10_2008_45","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Engineering of Stem Cells","raw_type":"book-chapter"},{"id":"pmid:19343304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19343304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in biochemical engineering/biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2752493","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2752493","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Biochem Eng Biotechnol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2752493","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2752493","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Biochem Eng Biotechnol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1316683064","display_name":"Histocompatible Primate Embryonic Stem Cells","funder_award_id":"R01HD057121","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3160859834","display_name":"SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER","funder_award_id":"P51RR000163","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6494800041","display_name":"Genetically Modified Rhesus Monkeys","funder_award_id":"R01NS044330","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000261679","display_name":"New England Primate Research Center Base Grant","funder_award_id":"P51RR000168","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1487014009","https://openalex.org/W1585827177","https://openalex.org/W1662624624","https://openalex.org/W1819540738","https://openalex.org/W1912369993","https://openalex.org/W1916885428","https://openalex.org/W1969525909","https://openalex.org/W1969770877","https://openalex.org/W1970894097","https://openalex.org/W1976493174","https://openalex.org/W1978173381","https://openalex.org/W1980506633","https://openalex.org/W1982480043","https://openalex.org/W1992525863","https://openalex.org/W1993205220","https://openalex.org/W1994144105","https://openalex.org/W1995539279","https://openalex.org/W2002179012","https://openalex.org/W2003701368","https://openalex.org/W2008013782","https://openalex.org/W2012305943","https://openalex.org/W2014650591","https://openalex.org/W2015554554","https://openalex.org/W2019818957","https://openalex.org/W2020532383","https://openalex.org/W2021836117","https://openalex.org/W2021952728","https://openalex.org/W2029252362","https://openalex.org/W2031721014","https://openalex.org/W2032512845","https://openalex.org/W2035047199","https://openalex.org/W2036831198","https://openalex.org/W2040404307","https://openalex.org/W2041695960","https://openalex.org/W2043173210","https://openalex.org/W2043952117","https://openalex.org/W2045899482","https://openalex.org/W2052245690","https://openalex.org/W2053482584","https://openalex.org/W2053911973","https://openalex.org/W2057159461","https://openalex.org/W2065784422","https://openalex.org/W2067789711","https://openalex.org/W2068196702","https://openalex.org/W2069512527","https://openalex.org/W2072872182","https://openalex.org/W2086943348","https://openalex.org/W2091373909","https://openalex.org/W2092806325","https://openalex.org/W2093626923","https://openalex.org/W2101863334","https://openalex.org/W2102974928","https://openalex.org/W2104063770","https://openalex.org/W2104978512","https://openalex.org/W2122214027","https://openalex.org/W2122694737","https://openalex.org/W2123475048","https://openalex.org/W2123829995","https://openalex.org/W2125987139","https://openalex.org/W2126536572","https://openalex.org/W2131912679","https://openalex.org/W2138977668","https://openalex.org/W2142046859","https://openalex.org/W2143658931","https://openalex.org/W2144281534","https://openalex.org/W2153824299","https://openalex.org/W2157087132","https://openalex.org/W2157635332","https://openalex.org/W2160220798","https://openalex.org/W2166649689","https://openalex.org/W2244361787","https://openalex.org/W2739174192","https://openalex.org/W3004979616","https://openalex.org/W4253651752"],"related_works":["https://openalex.org/W2122214027","https://openalex.org/W189938518","https://openalex.org/W7095866629","https://openalex.org/W2483751664","https://openalex.org/W7098001986","https://openalex.org/W2027744379","https://openalex.org/W2063135302","https://openalex.org/W1983494917","https://openalex.org/W98200394","https://openalex.org/W2108241558"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":40},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":19}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}