{"id":"https://openalex.org/W2159822285","doi":null,"title":"Small Circular DNAs in Human Pathology.","display_name":"Small Circular DNAs in Human Pathology.","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W2159822285","mag":"2159822285","pmid":"https://pubmed.ncbi.nlm.nih.gov/25246831","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4163554"},"language":"en","primary_location":{"id":"pmid:25246831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25246831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Malaysian journal of medical sciences : MJMS","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4163554/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071872387","display_name":"Stephany C. Barreto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephany Carolina Barreto","raw_affiliation_strings":["Saint James School of Medicine, Albert Lake Drive, The Quarter AI 2640, Anguilla, British West Indies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint James School of Medicine, Albert Lake Drive, The Quarter AI 2640, Anguilla, British West Indies","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077009063","display_name":"Madhuri Uppalapati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhuri Uppalapati","raw_affiliation_strings":["Saint James School of Medicine, Albert Lake Drive, The Quarter AI 2640, Anguilla, British West Indies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint James School of Medicine, Albert Lake Drive, The Quarter AI 2640, Anguilla, British West Indies","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101624471","display_name":"Amitabha Ray","orcid":"https://orcid.org/0000-0003-1240-6887","observed_orcids":["https://orcid.org/0000-0003-1240-6887"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amitabha Ray","raw_affiliation_strings":["Saint James School of Medicine, Albert Lake Drive, The Quarter AI 2640, Anguilla, British West Indies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint James School of Medicine, Albert Lake Drive, The Quarter AI 2640, Anguilla, British West Indies","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1101,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.41010733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"21","issue":"3","first_page":"4","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.20960000157356262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.20960000157356262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.09780000150203705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.08749999850988388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmids","display_name":"plasmids","score":0.8040000200271606},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.6790000200271606},{"id":"https://openalex.org/keywords/anelloviruses","display_name":"anelloviruses","score":0.8240000009536743},{"id":"https://openalex.org/keywords/papillomavirus","display_name":"papillomavirus","score":0.9789999723434448},{"id":"https://openalex.org/keywords/polyomavirus","display_name":"polyomavirus","score":0.996999979019165},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/high-risk-hpv","display_name":"high-risk HPV","score":0.6510000228881836},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5090000033378601},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.46299999952316284},{"id":"https://openalex.org/keywords/mtdna-mutations","display_name":"mitochondrial DNA mutations","score":0.7239999771118164},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.7510063648223877},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.738895058631897},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.7153670787811279},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.656294584274292},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6105838418006897},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5495213866233826},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5455136299133301},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4417967200279236}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:25246831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25246831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Malaysian journal of medical sciences : MJMS","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4163554","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4163554/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malays J Med Sci","raw_type":"Text"},{"id":"pmh:cria:bioline:mj:mj14029","doi":null,"is_oa":true,"landing_page_url":"http://www.bioline.org.br/abstract?id=mj14029","pdf_url":"http://www.bioline.org.br/abstract?id=mj14029","source":{"id":"https://openalex.org/S4306402188","display_name":"Bioline International (Bioline International)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Malaysian Journal of Medical Sciences (ISSN: 1394-195X) Vol 21 Num 3","raw_type":"RA"},{"id":"mag:2159822285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25246831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4163554","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4163554/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Malays J Med Sci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159822285.pdf","grobid_xml":"https://content.openalex.org/works/W2159822285.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W64539847","https://openalex.org/W113333611","https://openalex.org/W135685900","https://openalex.org/W195092054","https://openalex.org/W1583633471","https://openalex.org/W1628177336","https://openalex.org/W1928042840","https://openalex.org/W1952527768","https://openalex.org/W1953332264","https://openalex.org/W1963888311","https://openalex.org/W1966522008","https://openalex.org/W1971377807","https://openalex.org/W1975848530","https://openalex.org/W1978346502","https://openalex.org/W1980671310","https://openalex.org/W1981927400","https://openalex.org/W1983225564","https://openalex.org/W1984808365","https://openalex.org/W1986922319","https://openalex.org/W1987792884","https://openalex.org/W1990240344","https://openalex.org/W1992115370","https://openalex.org/W1992694822","https://openalex.org/W1996543107","https://openalex.org/W1998091937","https://openalex.org/W1998736939","https://openalex.org/W1999412929","https://openalex.org/W2003402437","https://openalex.org/W2006377432","https://openalex.org/W2009515210","https://openalex.org/W2010486441","https://openalex.org/W2010495285","https://openalex.org/W2013720812","https://openalex.org/W2014160736","https://openalex.org/W2017514272","https://openalex.org/W2021806578","https://openalex.org/W2022726996","https://openalex.org/W2024944975","https://openalex.org/W2027181440","https://openalex.org/W2027296250","https://openalex.org/W2032117338","https://openalex.org/W2032276273","https://openalex.org/W2034074217","https://openalex.org/W2034321092","https://openalex.org/W2038031276","https://openalex.org/W2038264706","https://openalex.org/W2040246495","https://openalex.org/W2041307935","https://openalex.org/W2049160937","https://openalex.org/W2050711948","https://openalex.org/W2051899889","https://openalex.org/W2055914778","https://openalex.org/W2056658581","https://openalex.org/W2056882100","https://openalex.org/W2057495929","https://openalex.org/W2058123255","https://openalex.org/W2059494962","https://openalex.org/W2060862586","https://openalex.org/W2062376481","https://openalex.org/W2063231482","https://openalex.org/W2064300165","https://openalex.org/W2069912181","https://openalex.org/W2070811342","https://openalex.org/W2070922929","https://openalex.org/W2071009029","https://openalex.org/W2071880161","https://openalex.org/W2071917362","https://openalex.org/W2073050084","https://openalex.org/W2073061430","https://openalex.org/W2073432014","https://openalex.org/W2075710067","https://openalex.org/W2077798840","https://openalex.org/W2078364131","https://openalex.org/W2081194505","https://openalex.org/W2084077405","https://openalex.org/W2089017407","https://openalex.org/W2090899702","https://openalex.org/W2097492854","https://openalex.org/W2099277370","https://openalex.org/W2103170242","https://openalex.org/W2109614163","https://openalex.org/W2118913456","https://openalex.org/W2119853807","https://openalex.org/W2126938735","https://openalex.org/W2129145321","https://openalex.org/W2132492411","https://openalex.org/W2133623475","https://openalex.org/W2135294004","https://openalex.org/W2137019827","https://openalex.org/W2140489687","https://openalex.org/W2146665116","https://openalex.org/W2151897047","https://openalex.org/W2154226051","https://openalex.org/W2156928776","https://openalex.org/W2158992333","https://openalex.org/W2160558336","https://openalex.org/W2163069284","https://openalex.org/W2166664098","https://openalex.org/W2171661826","https://openalex.org/W2321828406","https://openalex.org/W2786774014","https://openalex.org/W3190527813","https://openalex.org/W4210652211","https://openalex.org/W4236306046","https://openalex.org/W4317523535"],"related_works":["https://openalex.org/W188157039","https://openalex.org/W2060372825","https://openalex.org/W2621874717","https://openalex.org/W1980779505","https://openalex.org/W2098493029","https://openalex.org/W2783521900","https://openalex.org/W4234190962","https://openalex.org/W7100020194","https://openalex.org/W4205827027","https://openalex.org/W4214623619"],"abstract_inverted_index":{"In":[0],"general,":[1],"human":[2,144,276],"pathogen-related":[3],"small":[4,22,96,151,252,299],"circular":[5,23,97,152,231,253,300],"deoxyribonucleic":[6],"acid":[7],"(DNA)":[8],"molecules":[9,154,302],"are":[10,20,26,35,48,74,104,119,233,256],"bacterial":[11],"plasmids":[12,47,73],"and":[13,34,70,92,138,179,215,261,265,268],"a":[14,38,111,127,226,283],"group":[15],"of":[16,28,31,40,52,60,75,89,95,113,131,150,163,170,188,247,251,295,298,313],"viral":[17,263],"genomes.":[18],"Plasmids":[19],"extra-chromosomal":[21,230,270],"DNAs":[24,232,254],"that":[25,166,255],"capable":[27],"replicating":[29],"independently":[30,187],"the":[32,53,141,171,189,296],"host,":[33,54],"present":[36,257],"throughout":[37],"variety":[39],"different":[41],"microorganisms,":[42],"most":[43],"notably":[44],"bacteria.":[45],"While":[46],"not":[49],"essential":[50],"components":[51],"they":[55],"can":[56,185,223],"impart":[57],"an":[58,245],"assortment":[59],"survival":[61],"enhancing":[62],"genes":[63,165],"such":[64],"as":[65,225],"for":[66,106,168,195],"fertility,":[67],"drug":[68],"resistance,":[69],"toxins.":[71],"Furthermore,":[72,221],"particular":[76],"interest":[77],"to":[78,84,123,203,243,275,305],"molecular":[79],"biology":[80],"especially":[81,134],"in":[82,110,200,212,236,258,310],"relation":[83],"gene-cloning.":[85],"Among":[86],"viruses,":[87],"genomes":[88],"anelloviruses,":[90],"papillomaviruses,":[91],"polyomaviruses":[93],"consist":[94],"DNA.":[98],"The":[99,159],"latter":[100],"two":[101],"virus":[102],"families":[103],"known":[105],"their":[107],"potential":[108],"roles":[109],"number":[112],"pathogenic":[114],"processes.":[115],"Human":[116],"papillomaviruses":[117],"(HPV)":[118],"now":[120],"widely":[121],"recognised":[122],"be":[124],"associated":[125],"with":[126,217,273],"greatly":[128],"increased":[129],"risk":[130],"cervical":[132],"cancer,":[133],"oncogenic":[135],"strains":[136],"16":[137],"18.":[139],"On":[140],"other":[142,269],"hand,":[143],"cells":[145],"may":[146],"contain":[147],"several":[148,196,213],"types":[149],"DNA":[153,157,192,301],"including":[155],"mitochondrial":[156,160,197],"(mtDNA).":[158],"genome":[161],"consists":[162],"37":[164],"encode":[167,194],"proteins":[169],"oxidation":[172],"phosphorylation":[173],"system,":[174],"transfer":[175],"ribonucleic":[176],"acids":[177],"(tRNAs),":[178],"ribosomal":[180],"RNAs":[181],"(rRNAs).":[182],"Though":[183],"mitochondria":[184],"replicate":[186],"host;":[190],"nuclear":[191],"does":[193],"proteins.":[198],"Mutations":[199],"mtDNA":[201,208,222],"contribute":[202],"some":[204],"well":[205],"characterised":[206],"diseases;":[207],"is":[209,241,303],"also":[210],"implicated":[211],"diseases":[214],"malignancies":[216],"poorly":[218],"elucidated":[219],"aetiologies.":[220],"function":[224],"diagnostic":[227],"tool.":[228],"Other":[229],"usually":[234],"detected":[235],"cancer.":[237,279],"This":[238],"review":[239],"article":[240],"intended":[242],"provide":[244],"overview":[246],"four":[248],"broad":[249],"categories":[250],"non-eukaryotic":[259],"(plasmids":[260],"relevant":[262],"genomes)":[264],"eukaryotic":[266],"(mtDNA":[267],"DNAs)":[271],"systems":[272],"reference":[274],"diseases,":[277],"particularly":[278],"For":[280],"this":[281],"purpose,":[282],"literature":[284],"search":[285],"has":[286],"been":[287],"carried":[288],"out":[289],"mainly":[290],"from":[291],"PubMed.":[292],"Improved":[293],"understanding":[294],"significance":[297],"expected":[304],"have":[306],"far":[307],"reaching":[308],"implications":[309],"many":[311],"fields":[312],"medicine.":[314]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
