{"id":"https://openalex.org/W2159792874","doi":null,"title":"Thromboembolism following orthopaedic surgery : Outcome and diagnostic procedures after prophylaxis in lower limb injuries","display_name":"Thromboembolism following orthopaedic surgery : Outcome and diagnostic procedures after prophylaxis in lower limb injuries","publication_year":2007,"publication_date":"2007-03-02","ids":{"openalex":"https://openalex.org/W2159792874","mag":"2159792874"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26908498","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Thromboembolism_following_orthopaedic_surgery_outcome_and_diagnostic_procedures_after_prophylaxis_in_lower_limb_injuries/26908498","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/38514","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017501377","display_name":"Lasse J. Lapidus","orcid":"https://orcid.org/0000-0002-7852-9890","observed_orcids":["https://orcid.org/0000-0002-7852-9890"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lasse J. Lapidus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7852-9890","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017501377"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9300000071525574},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pulmonary-embolism","display_name":"pulmonary embolism","score":1.0},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/orthopedic-surgery","display_name":"orthopedic surgery","score":0.9150000214576721},{"id":"https://openalex.org/keywords/lower-limb-injuries","display_name":"lower limb injuries","score":0.6520000100135803},{"id":"https://openalex.org/keywords/ankle-fractures","display_name":"ankle fractures","score":0.8339999914169312},{"id":"https://openalex.org/keywords/venography","display_name":"venography","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pelvic-fracture-surgery","display_name":"pelvic fracture surgery","score":0.5429999828338623},{"id":"https://openalex.org/keywords/knee-arthroplasty","display_name":"knee arthroplasty","score":0.9459999799728394},{"id":"https://openalex.org/keywords/achilles-tendon-repair","display_name":"Achilles tendon repair","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.3709999918937683},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.5370000004768372},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.4779999852180481},{"id":"https://openalex.org/keywords/plaster-cast-immobilization","display_name":"plaster immobilization","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9627469778060913},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.6948545575141907},{"id":"https://openalex.org/C2776265017","wikidata":"https://www.wikidata.org/wiki/Q220570","display_name":"Pulmonary embolism","level":2,"score":0.6885890960693359},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6698182225227356},{"id":"https://openalex.org/C2778959117","wikidata":"https://www.wikidata.org/wiki/Q430892","display_name":"Deep vein","level":3,"score":0.6584500670433044},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.6484082937240601},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5552809834480286},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.49864625930786133},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4858857989311218},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26908498","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Thromboembolism_following_orthopaedic_surgery_outcome_and_diagnostic_procedures_after_prophylaxis_in_lower_limb_injuries/26908498","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/38514","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38514","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2159792874","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/10616/38514/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/38514","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38514","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":141,"referenced_works":["https://openalex.org/W39302253","https://openalex.org/W70359381","https://openalex.org/W80314944","https://openalex.org/W90676001","https://openalex.org/W105094744","https://openalex.org/W106153730","https://openalex.org/W107707933","https://openalex.org/W121099259","https://openalex.org/W1501210932","https://openalex.org/W1531281563","https://openalex.org/W1554127422","https://openalex.org/W1778892396","https://openalex.org/W1827635769","https://openalex.org/W1916870232","https://openalex.org/W1928520489","https://openalex.org/W1949136765","https://openalex.org/W1961525230","https://openalex.org/W1969379131","https://openalex.org/W1973312374","https://openalex.org/W1975547544","https://openalex.org/W1978696511","https://openalex.org/W1978869621","https://openalex.org/W1981403806","https://openalex.org/W1982894405","https://openalex.org/W1986135590","https://openalex.org/W1989964518","https://openalex.org/W1993602774","https://openalex.org/W1998785253","https://openalex.org/W2000130043","https://openalex.org/W2001863291","https://openalex.org/W2002526547","https://openalex.org/W2003149127","https://openalex.org/W2003413907","https://openalex.org/W2004782936","https://openalex.org/W2004964926","https://openalex.org/W2006153614","https://openalex.org/W2007510426","https://openalex.org/W2007797365","https://openalex.org/W2009309113","https://openalex.org/W2010127823","https://openalex.org/W2010599049","https://openalex.org/W2012426748","https://openalex.org/W2012519169","https://openalex.org/W2014037058","https://openalex.org/W2015732515","https://openalex.org/W2017630438","https://openalex.org/W2018351334","https://openalex.org/W2019095425","https://openalex.org/W2021891071","https://openalex.org/W2022932023","https://openalex.org/W2025589840","https://openalex.org/W2026113470","https://openalex.org/W2029826104","https://openalex.org/W2031015217","https://openalex.org/W2032235952","https://openalex.org/W2033226766","https://openalex.org/W2036407748","https://openalex.org/W2038557221","https://openalex.org/W2045716011","https://openalex.org/W2047247186","https://openalex.org/W2048792123","https://openalex.org/W2050951414","https://openalex.org/W2051087080","https://openalex.org/W2051710211","https://openalex.org/W2053150430","https://openalex.org/W2054324054","https://openalex.org/W2059549685","https://openalex.org/W2062075388","https://openalex.org/W2062272588","https://openalex.org/W2064131658","https://openalex.org/W2064562336","https://openalex.org/W2065379041","https://openalex.org/W2066160685","https://openalex.org/W2066681685","https://openalex.org/W2066701117","https://openalex.org/W2067354653","https://openalex.org/W2068256592","https://openalex.org/W2071155706","https://openalex.org/W2072975396","https://openalex.org/W2076844096","https://openalex.org/W2076932332","https://openalex.org/W2077510454","https://openalex.org/W2078035232","https://openalex.org/W2083205711","https://openalex.org/W2083592362","https://openalex.org/W2085655431","https://openalex.org/W2087462313","https://openalex.org/W2088494721","https://openalex.org/W2107146099","https://openalex.org/W2108333893","https://openalex.org/W2109060049","https://openalex.org/W2109933981","https://openalex.org/W2110192993","https://openalex.org/W2111297541","https://openalex.org/W2111945846","https://openalex.org/W2122477702","https://openalex.org/W2123357614","https://openalex.org/W2123604057","https://openalex.org/W2127596246","https://openalex.org/W2130518609","https://openalex.org/W2131728148","https://openalex.org/W2132576859","https://openalex.org/W2138478053","https://openalex.org/W2143230270","https://openalex.org/W2147383560","https://openalex.org/W2148870814","https://openalex.org/W2150121055","https://openalex.org/W2151759300","https://openalex.org/W2151880534","https://openalex.org/W2152900444","https://openalex.org/W2157625865","https://openalex.org/W2161023907","https://openalex.org/W2162631927","https://openalex.org/W2163723714","https://openalex.org/W2165244071","https://openalex.org/W2166287849","https://openalex.org/W2170524066","https://openalex.org/W2171555235","https://openalex.org/W2173203919","https://openalex.org/W2184113413","https://openalex.org/W2187118985","https://openalex.org/W2288281507","https://openalex.org/W2298398889","https://openalex.org/W2301096497","https://openalex.org/W2311465682","https://openalex.org/W2312814626","https://openalex.org/W2333206452","https://openalex.org/W2335152594","https://openalex.org/W2335520675","https://openalex.org/W2400178228","https://openalex.org/W2402580414","https://openalex.org/W2411698854","https://openalex.org/W2413730566","https://openalex.org/W2415542074","https://openalex.org/W2424887566","https://openalex.org/W2468000182","https://openalex.org/W2558779320","https://openalex.org/W3025809664","https://openalex.org/W4297918267","https://openalex.org/W4323283678","https://openalex.org/W4324113883"],"related_works":["https://openalex.org/W2401571855","https://openalex.org/W2063313016","https://openalex.org/W2497492430","https://openalex.org/W2024136699","https://openalex.org/W2605178118","https://openalex.org/W4237829896","https://openalex.org/W2527645564","https://openalex.org/W1965950013","https://openalex.org/W2151611575","https://openalex.org/W187639498"],"abstract_inverted_index":{"Deep":[0],"vein":[1],"thrombosis":[2,526],"(DVT)":[3],"and":[4,19,23,49,54,71,96,101,133,137,157,175,180,183,207,225,255,322,334,378,398,410,436,455,501],"pulmonary":[5],"embolism":[6],"(PE)":[7],"frequently":[8],"occur":[9],"after":[10,68,154,158,202,218,345,368,412,438,445,451,528,560,595],"major":[11,61,147,446],"orthopaedic":[12,62,129,439],"surgery.":[13,63,348,440,485],"The":[14,172,189,211,223,310,385],"clinical":[15],"assessment":[16],"of":[17,75,83,91,108,121,135,150,192,227,233,253,260,295,305,316,342,422,434,464,467,490,598],"DVT":[18,92,136,174,273,314,372,390],"PE":[20,37,138,176],"is":[21,38,66,267,443],"unreliable":[22],"most":[24],"cases":[25],"are":[26,55],"asymptomatic.":[27],"However,":[28],"even":[29],"in":[30,58,235,318,324,394,400,525],"asymptomatic":[31],"DVTs,":[32],"the":[33,76,88,106,131,151,184,197,262,319,325,335,340,389,395,401,420,462],"risk":[34,463],"for":[35,51,87,247,270,274,289],"a":[36,143,236,251,256,278,313,565,602],"considerable.":[39],"Low-molecular-weight":[40],"heparins":[41],"(LMWHs)":[42,164],"have":[43,104],"been":[44],"shown":[45],"to":[46,169],"be":[47,417],"safe":[48],"effective":[50],"this":[52],"purpose":[53],"used":[56],"especially":[57],"patients":[59,125,244,286,496],"undergoing":[60,128],"Whether":[64],"prophylaxis":[65,199,215,307,428,450],"necessary":[67],"minor":[69],"surgery":[70,130,149,156,205,454,563],"plaster":[72],"cast":[73],"immobilization":[74,367,559],"lower":[77,152,159],"limb":[78,160],"still":[79],"remains":[80,430],"an":[81,118,290,431],"issue":[82],"debate.":[84],"Available":[85],"techniques":[86],"objective":[89],"diagnosis":[90],"include":[93],"both":[94],"invasive":[95],"non-invasive":[97,109],"methods.":[98],"Technical":[99],"advances":[100],"increased":[102],"experience":[103],"improved":[105],"accuracy":[107],"methods":[110],"such":[111],"as":[112],"colour":[113],"duplex":[114,523],"sonography":[115,524],"(CDS).":[116],"In":[117,277,349,425],"observational":[119],"study":[120,282,353],"30":[122,493],"816":[123],"consecutive":[124,243,495],"(Paper":[126,239,283,354],"I)":[127],"mortality":[132,186,437],"incidence":[134,177,191,213,315,391],"was":[139,165,178,187,200,216,300,330,362,374,392,406],"recorded":[140],"prospectively":[141],"during":[142,167,359,366,558],"6-week":[144,185,488],"follow-up.":[145],"After":[146],"joint":[148],"extremity,":[153],"spinal":[155],"fracture":[161,204,347,453,530,562],"surgery,":[162],"thromboprophylaxis":[163,344,356,411,442,555,592],"administered":[166],"7":[168],"10":[170],"days.":[171],"overall":[173],"1.0%":[179],"0.3%,":[181],"respectively,":[182],"2.3%.":[188],"highest":[190,212],"venous":[193],"thromboembolism":[194,482],"(VTE)":[195],"with":[196,231,241,298,357,364,376,383,521,556,593],"LMWH":[198],"seen":[201],"pelvic":[203],"(13.0%)":[206],"knee":[208],"replacement":[209],"(3.5%).":[210],"without":[214],"found":[217],"Achilles":[219,369,413,456],"tendon":[220,370,414,457,600],"repair":[221,415,458],"(7.0%).":[222],"sensitivity":[224,252,520],"specificity":[226],"CDS":[228,266,377],"were":[229,381],"compared":[230,363],"that":[232,265,388],"phlebography":[234,311,386],"prospective":[237,487],"trial":[238],"II)":[240],"180":[242],"surgically":[245,287,497],"treated":[246,288,498],"ankle":[248,291,346,452,529,561],"fracture.":[249],"With":[250],"96%":[254],"negative":[257],"predictive":[258],"value":[259],"99%,":[261],"results":[263,336],"showed":[264],"highly":[268],"reliable":[269],"ruling":[271],"out":[272],"screening":[275,373,527],"purposes.":[276],"randomized":[279,351,566],"placebo-controlled":[280,352,604],"double-blind":[281],"III)":[284],"on":[285,419],"fracture,":[292],"one":[293],"week":[294],"open-labeled":[296],"treatment":[297,396,597],"dalteparin":[299,306,320,358,557,594],"followed":[301],"by":[302],"5":[303],"weeks":[304,361],"or":[308],"placebo.":[309],"verified":[312,387],"21%":[317],"group":[321,397],"28%":[323],"placebo":[326,365,402],"group.":[327,403],"This":[328,404],"difference":[329,405],"not":[331,338,407,460],"statistically":[332,408],"significant":[333,409],"do":[337],"support":[339],"use":[341],"prolonged":[343,449],"another":[350],"IV),":[355],"6":[360],"repair.":[371],"performed":[375],"all":[379],"DVTs":[380],"confirmed":[382],"phlebography.":[384],"34%":[393],"36%":[399],"cannot":[416],"recommended":[418],"basis":[421],"these":[423],"results.":[424],"summary,":[426],"despite":[427],"VTE":[429],"important":[432],"cause":[433],"morbidity":[435],"Adequate":[441],"essential":[444],"procedures":[447],"although":[448],"did":[459],"reduce":[461],"DVT.":[465],"List":[466],"scientific":[468],"papers":[469],"I.":[470],"Lapidus":[471,505,538,575],"L,":[472,506,539],"Ponzer":[473,510,540,579],"S,":[474,511,541,549,578,580],"Pettersson":[475],"H,":[476],"de":[477,507,550,587],"Bri":[478,508,551,588],"E":[479,552,589],"(2007).":[480,553,590],"\"Venous":[481],"following":[483],"orthopedic":[484],"A":[486],"follow-up":[489],"more":[491],"than":[492],"000":[494],"between":[499],"1996":[500],"2003.\"":[502],"[Manuscript]":[503],"II.":[504],"E,":[509],"Elvin":[512,542,583],"A,":[513,515,543,584],"Noren":[514],"Rosfors":[516,548,577],"S":[517],"(2006).":[518],"\"High":[519],"color":[522],"surgery.\"":[531],"J":[532,606],"Thromb":[533],"Haemost":[534],"4(4):807-12.":[535],"https://doi.org/10.1111/j.1538-7836.2006.01832.x":[536],"III.":[537],"Levander":[544,581],"C,":[545,582],"Larfors":[546],"G,":[547,586],"\"Prolonged":[554,591],"-":[564],"placebo-controlled,":[567],"double-blinded":[568],"study.\"":[569,605],"Acts":[570],"Orthopaedica.":[571],"[Accepted]":[572],"https://doi.org/10.1080/17453670710014185":[573],"IV.":[574],"LJ,":[576],"Larfars":[585],"surgical":[596],"achilles":[599],"rupture:":[601],"randomized,":[603],"Orthop":[607],"Trauma":[608],"21(1):":[609],"52-7.":[610],"https://doi.org/10.1097/01.bot.0000250741.65003.14":[611]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}