{"id":"https://openalex.org/W2159776706","doi":"https://doi.org/10.1002/pro.2465","title":"Crystal structure of toxin HP0892 from Helicobacter pylori with two Zn(II) at 1.8 \u00c5 resolution","display_name":"Crystal structure of toxin HP0892 from Helicobacter pylori with two Zn(II) at 1.8 \u00c5 resolution","publication_year":2014,"publication_date":"2014-03-27","ids":{"openalex":"https://openalex.org/W2159776706","doi":"https://doi.org/10.1002/pro.2465","mag":"2159776706","pmid":"https://pubmed.ncbi.nlm.nih.gov/24677509","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4093957"},"language":"en","primary_location":{"id":"doi:10.1002/pro.2465","doi":"https://doi.org/10.1002/pro.2465","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.2465","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2465","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2465","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110165466","display_name":"Hookang Im","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hookang Im","raw_affiliation_strings":["Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742 Korea","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742 Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015465896","display_name":"Sunbok Jang","orcid":"https://orcid.org/0000-0001-7371-0124","observed_orcids":["https://orcid.org/0000-0001-7371-0124"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun\u2010Bok Jang","raw_affiliation_strings":["Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742 Korea","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742 Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069424933","display_name":"Chinar Pathak","orcid":"https://orcid.org/0000-0002-6410-7208","observed_orcids":["https://orcid.org/0000-0002-6410-7208"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chinar Pathak","raw_affiliation_strings":["Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742 Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742 Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005922432","display_name":"Yeon\u2010Jin Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeon\u2010Jin Yang","raw_affiliation_strings":["Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742 Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742 Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032095282","display_name":"Hye\u2010Jin Yoon","orcid":"https://orcid.org/0000-0003-4724-4208","observed_orcids":["https://orcid.org/0000-0003-4724-4208"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye\u2010Jin Yoon","raw_affiliation_strings":["Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, 151-742 Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, 151-742 Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064187965","display_name":"Tae\u2010Kyung Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae\u2010Kyung Yu","raw_affiliation_strings":["Department of Agricultural Biotechnology, Seoul National University, Seoul, 151-921 Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Biotechnology, Seoul National University, Seoul, 151-921 Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013198280","display_name":"Jeong\u2010Yong Suh","orcid":"https://orcid.org/0000-0001-8720-3844","observed_orcids":["https://orcid.org/0000-0001-8720-3844"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong\u2010Yong Suh","raw_affiliation_strings":["Department of Agricultural Biotechnology, Seoul National University, Seoul, 151-921 Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Biotechnology, Seoul National University, Seoul, 151-921 Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086369397","display_name":"Bong\u2010Jin Lee","orcid":"https://orcid.org/0000-0001-7896-2961","observed_orcids":["https://orcid.org/0000-0001-7896-2961"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Bong\u2010Jin Lee","raw_affiliation_strings":["Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742 Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742 Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086369397"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.1637,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.44612001,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"23","issue":"6","first_page":"819","last_page":"832"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.05169999971985817,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxin-antitoxin-systems","display_name":"toxin-antitoxin systems","score":0.921999990940094},{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.9950000047683716},{"id":"https://openalex.org/keywords/zinc-binding","display_name":"zinc binding","score":0.6850000023841858},{"id":"https://openalex.org/keywords/rnase-activity","display_name":"ribonuclease activity","score":0.5379999876022339},{"id":"https://openalex.org/keywords/metal-ion-catalysis","display_name":"metal ion catalysis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/substrate-binding","display_name":"substrate binding","score":0.7099999785423279},{"id":"https://openalex.org/keywords/sequence-recognition","display_name":"sequence recognition","score":0.492000013589859},{"id":"https://openalex.org/keywords/phosphate-binding","display_name":"phosphate binding","score":0.6050000190734863},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.641751766204834},{"id":"https://openalex.org/C2778973234","wikidata":"https://www.wikidata.org/wiki/Q584135","display_name":"Antitoxin","level":3,"score":0.6398466229438782},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5914833545684814},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.5309531092643738},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4888977110385895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.485358864068985},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.48432791233062744},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.4680105447769165},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.4624178111553192},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.42708820104599},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.42501503229141235},{"id":"https://openalex.org/C2776376580","wikidata":"https://www.wikidata.org/wiki/Q407355","display_name":"Transferase","level":3,"score":0.42158347368240356},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.4170669913291931},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3693695068359375},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.1590484380722046},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/pro.2465","doi":"https://doi.org/10.1002/pro.2465","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.2465","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2465","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmid:24677509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24677509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4093957","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4093957/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/pro.2465","doi":"https://doi.org/10.1002/pro.2465","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.2465","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2465","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1673135703","display_name":null,"funder_award_id":"2012R1A2A1A01003569","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4931492489","display_name":null,"funder_award_id":"20070056817","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6810166653","display_name":null,"funder_award_id":"2008-355-E00019","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320337308","display_name":"National Institute for International Education","ror":"https://ror.org/04xbpez43"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159776706.pdf","grobid_xml":"https://content.openalex.org/works/W2159776706.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1511212618","https://openalex.org/W1539796472","https://openalex.org/W1604915411","https://openalex.org/W1964051028","https://openalex.org/W1976507253","https://openalex.org/W1979283674","https://openalex.org/W1982148012","https://openalex.org/W1985347638","https://openalex.org/W1989869773","https://openalex.org/W1992192767","https://openalex.org/W1996607909","https://openalex.org/W1996804832","https://openalex.org/W2001304252","https://openalex.org/W2001406683","https://openalex.org/W2012016148","https://openalex.org/W2014051550","https://openalex.org/W2014694459","https://openalex.org/W2015442594","https://openalex.org/W2015642465","https://openalex.org/W2021197152","https://openalex.org/W2022115313","https://openalex.org/W2038840577","https://openalex.org/W2039437333","https://openalex.org/W2041699785","https://openalex.org/W2045114886","https://openalex.org/W2046219181","https://openalex.org/W2060809301","https://openalex.org/W2073574973","https://openalex.org/W2075518131","https://openalex.org/W2082176639","https://openalex.org/W2084168858","https://openalex.org/W2084637336","https://openalex.org/W2085035258","https://openalex.org/W2085319475","https://openalex.org/W2091426267","https://openalex.org/W2092500470","https://openalex.org/W2092867234","https://openalex.org/W2093814623","https://openalex.org/W2096792353","https://openalex.org/W2099207146","https://openalex.org/W2099326312","https://openalex.org/W2101828342","https://openalex.org/W2109560282","https://openalex.org/W2109572234","https://openalex.org/W2115328763","https://openalex.org/W2115921407","https://openalex.org/W2120772351","https://openalex.org/W2123355026","https://openalex.org/W2124026197","https://openalex.org/W2126573196","https://openalex.org/W2126622794","https://openalex.org/W2127322768","https://openalex.org/W2127372563","https://openalex.org/W2132629607","https://openalex.org/W2134705864","https://openalex.org/W2136833370","https://openalex.org/W2152301430","https://openalex.org/W2154714625","https://openalex.org/W2157378009","https://openalex.org/W2165885624","https://openalex.org/W2166474344","https://openalex.org/W2167970541","https://openalex.org/W2168332319","https://openalex.org/W2168404136","https://openalex.org/W2169821755","https://openalex.org/W2171112077","https://openalex.org/W2416418190","https://openalex.org/W4234562195"],"related_works":["https://openalex.org/W2084637336","https://openalex.org/W2558862887","https://openalex.org/W2001304252","https://openalex.org/W2092867234","https://openalex.org/W2042777786","https://openalex.org/W1964437900","https://openalex.org/W4391075666","https://openalex.org/W2550961289","https://openalex.org/W3214747461","https://openalex.org/W7223392337"],"abstract_inverted_index":{"Antibiotic":[0],"resistance":[1],"and":[2,11,44,49,88,93,109,113,146,160,162,175,182,192,198,205],"microorganism":[3],"virulence":[4],"have":[5],"been":[6],"consistently":[7],"exhibited":[8],"by":[9,99],"bacteria":[10],"archaea,":[12],"which":[13],"survive":[14],"in":[15,125,150,171,179,189,202],"conditions":[16],"of":[17,30,53,63,73,121,194],"environmental":[18],"stress":[19],"through":[20],"toxin-antitoxin":[21],"(TA)":[22],"systems.":[23],"The":[24,40,82,132],"HP0892-HP0893":[25],"TA":[26,34,55],"system":[27],"is":[28,187,200],"one":[29],"the":[31,46,51,54,60,64,76,94,103,107,110,119,122,195],"two":[32],"known":[33],"systems":[35],"belonging":[36],"to":[37,140],"Helicobacter":[38],"pylori.":[39],"antitoxin,":[41],"HP0893,":[42],"binds":[43],"inhibits":[45],"HP0892":[47,66],"toxin":[48,67],"regulates":[50],"transcription":[52],"operon.":[56],"Here,":[57],"we":[58],"present":[59],"crystal":[61],"structure":[62],"zinc-bound":[65],"at":[68,75],"1.8":[69],"\u00c5":[70],"resolution.":[71],"Reorientation":[72],"residues":[74],"mRNase":[77,126],"active":[78,127],"site":[79,128],"was":[80,97],"shown.":[81],"involved":[83,149,178,188,201],"residues,":[84],"namely":[85],"E58A,":[86],"H86A,":[87],"H58A/":[89],"H60A,":[90],"were":[91],"mutated":[92],"binding":[95,152,181,191],"affinity":[96],"monitored":[98],"ITC":[100],"studies.":[101],"Through":[102],"structural":[104],"difference":[105],"between":[106],"apo":[108],"metal-bound":[111],"state,":[112,197],"using":[114],"a":[115,157,168],"homology":[116],"modeling":[117],"tool,":[118],"involvement":[120],"metal":[123,151],"ion":[124],"could":[129],"be":[130],"identified.":[131],"most":[133],"catalytically":[134],"important":[135],"residue,":[136],"His86,":[137],"reorients":[138],"itself":[139],"exhibit":[141],"RNase":[142],"activity.":[143,173],"His47,":[144],"Glu58,":[145],"His60":[147,163],"are":[148,177],"where":[153],"Glu58":[154,174],"acts":[155],"as":[156,167],"general":[158,169],"base":[159,203],"His47":[161],"may":[164],"also":[165],"act":[166],"acid":[170],"enzymatic":[172],"Asp64":[176],"substrate":[180,206],"specific":[183],"sequence":[184],"recognition.":[185],"Arg83":[186],"phosphate":[190],"stabilization":[193],"transition":[196],"Phe90":[199],"packing":[204],"orientation.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
