{"id":"https://openalex.org/W2159762439","doi":"https://doi.org/10.1146/annurev-biophys-060414-034236","title":"Single-Cell Physiology","display_name":"Single-Cell Physiology","publication_year":2015,"publication_date":"2015-03-06","ids":{"openalex":"https://openalex.org/W2159762439","doi":"https://doi.org/10.1146/annurev-biophys-060414-034236","mag":"2159762439","pmid":"https://pubmed.ncbi.nlm.nih.gov/25747591","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5672912"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-biophys-060414-034236","doi":"https://doi.org/10.1146/annurev-biophys-060414-034236","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-biophys-060414-034236","pdf_url":null,"source":{"id":"https://openalex.org/S4157722","display_name":"Annual Review of Biophysics","issn_l":"1936-122X","issn":["1936-122X","1936-1238"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Biophysics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5672912","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049203945","display_name":"Sattar Taheri-Araghi","orcid":"https://orcid.org/0000-0001-8736-1893","observed_orcids":["https://orcid.org/0000-0001-8736-1893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sattar Taheri-Araghi","raw_affiliation_strings":["Department of Physics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019407143","display_name":"Steven D. Brown","orcid":"https://orcid.org/0000-0002-9281-3898","observed_orcids":["https://orcid.org/0000-0002-9281-3898"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven D. Brown","raw_affiliation_strings":["Department of Physics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006194159","display_name":"John T. Sauls","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John T. Sauls","raw_affiliation_strings":["Department of Physics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088952648","display_name":"Dustin B. McIntosh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dustin B. McIntosh","raw_affiliation_strings":["Department of Physics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083736833","display_name":"Suckjoon Jun","orcid":"https://orcid.org/0000-0002-0139-4297","observed_orcids":["https://orcid.org/0000-0002-0139-4297"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suckjoon Jun","raw_affiliation_strings":["Department of Physics,","Section of Molecular Biology, Division of Biological Science, University of California, San Diego, La Jolla, California 92093;","Department of Physics,; Section of Molecular Biology, Division of Biological Science, University of California, San Diego, La Jolla, California 92093;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics,","institution_ids":[]},{"raw_affiliation_string":"Section of Molecular Biology, Division of Biological Science, University of California, San Diego, La Jolla, California 92093;","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Physics,; Section of Molecular Biology, Division of Biological Science, University of California, San Diego, La Jolla, California 92093;","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7814,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.62770563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"44","issue":"1","first_page":"123","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.48660001158714294,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.48660001158714294,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.2660999894142151,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.1340000033378601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microbial-physiology","display_name":"microbial physiology","score":0.9380000233650208},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.7440000176429749},{"id":"https://openalex.org/keywords/genetically-encoded-fluorescent-reporters","display_name":"genetically encoded fluorescent reporters","score":0.7210000157356262},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bacterial-growth","display_name":"bacterial growth","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cell-size","display_name":"cell size","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C52069626","wikidata":"https://www.wikidata.org/wiki/Q4692","display_name":"The Renaissance","level":2,"score":0.5744568109512329},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5202661752700806},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4489172101020813},{"id":"https://openalex.org/C191141034","wikidata":"https://www.wikidata.org/wiki/Q3087369","display_name":"Cell physiology","level":3,"score":0.43853700160980225},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.4170762300491333},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3758704662322998},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3619942367076874},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.34574633836746216},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3363193869590759},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2683607339859009},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21858498454093933},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09202656149864197},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0855531096458435},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.08431625366210938},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C52119013","wikidata":"https://www.wikidata.org/wiki/Q50637","display_name":"Art history","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1146/annurev-biophys-060414-034236","doi":"https://doi.org/10.1146/annurev-biophys-060414-034236","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-biophys-060414-034236","pdf_url":null,"source":{"id":"https://openalex.org/S4157722","display_name":"Annual Review of Biophysics","issn_l":"1936-122X","issn":["1936-122X","1936-1238"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Biophysics","raw_type":"journal-article"},{"id":"pmid:25747591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25747591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of biophysics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5672912","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5672912","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Biophys","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8p06z4zk","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8p06z4zk","pdf_url":"https://escholarship.org/uc/item/8p06z4zk","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annual Review of Biophysics, vol 44, iss 1","raw_type":"article"},{"id":"pmh:qt8p06z4zk","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/8p06z4zk","pdf_url":"http://www.escholarship.org/uc/item/8p06z4zk","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Taheri-Araghi, S; Brown, SD; Sauls, JT; McIntosh, DB; & Jun, S. (2015). Single-Cell Physiology. Annual Review of Biophysics, 44, 123 - 142. doi: 10.1146/annurev-biophys-060414-034236. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/8p06z4zk","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt8p06z4zk","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8p06z4zk","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annual review of biophysics, vol 44, iss 1","raw_type":"article"},{"id":"pmh:oai:scholarworks.calstate.edu:10211.3/197610","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10211.3/197610","pdf_url":null,"source":{"id":"https://openalex.org/S7407064448","display_name":"California State University ScholarWorks (system-wide DSpace)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5672912","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5672912","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Biophys","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4956102834","display_name":"Graduate Training Program in Bioinformatics","funder_award_id":"T32GM008806","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310812","display_name":"Allen Foundation","ror":"https://ror.org/036jq7b41"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159762439.pdf","grobid_xml":"https://content.openalex.org/works/W2159762439.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W193644956","https://openalex.org/W1512447155","https://openalex.org/W1591091640","https://openalex.org/W1604804653","https://openalex.org/W1763857691","https://openalex.org/W1871973308","https://openalex.org/W1925839400","https://openalex.org/W1943394565","https://openalex.org/W1966062610","https://openalex.org/W1971945173","https://openalex.org/W1972358559","https://openalex.org/W1974326595","https://openalex.org/W1976991065","https://openalex.org/W1981892387","https://openalex.org/W1984571004","https://openalex.org/W1988343344","https://openalex.org/W1988691705","https://openalex.org/W1992663222","https://openalex.org/W1995636525","https://openalex.org/W1996341957","https://openalex.org/W1996666978","https://openalex.org/W1997265483","https://openalex.org/W1997572817","https://openalex.org/W1997803921","https://openalex.org/W1999777663","https://openalex.org/W2000332508","https://openalex.org/W2001649355","https://openalex.org/W2003375107","https://openalex.org/W2004452302","https://openalex.org/W2004801113","https://openalex.org/W2017909074","https://openalex.org/W2020438216","https://openalex.org/W2024526152","https://openalex.org/W2027126615","https://openalex.org/W2032619610","https://openalex.org/W2032759622","https://openalex.org/W2043856392","https://openalex.org/W2045610672","https://openalex.org/W2047453261","https://openalex.org/W2049433285","https://openalex.org/W2049821596","https://openalex.org/W2053207647","https://openalex.org/W2055926450","https://openalex.org/W2058077403","https://openalex.org/W2059725783","https://openalex.org/W2059905849","https://openalex.org/W2060603511","https://openalex.org/W2064483836","https://openalex.org/W2067652815","https://openalex.org/W2070068738","https://openalex.org/W2071051512","https://openalex.org/W2071311642","https://openalex.org/W2071351067","https://openalex.org/W2072227605","https://openalex.org/W2075234068","https://openalex.org/W2082578449","https://openalex.org/W2084403652","https://openalex.org/W2086187432","https://openalex.org/W2086861259","https://openalex.org/W2087242711","https://openalex.org/W2090232842","https://openalex.org/W2090363184","https://openalex.org/W2091967952","https://openalex.org/W2093657008","https://openalex.org/W2094506363","https://openalex.org/W2095658523","https://openalex.org/W2098145231","https://openalex.org/W2099412396","https://openalex.org/W2099530052","https://openalex.org/W2101870905","https://openalex.org/W2102670556","https://openalex.org/W2103726483","https://openalex.org/W2105776288","https://openalex.org/W2107554012","https://openalex.org/W2109367383","https://openalex.org/W2111967267","https://openalex.org/W2113372755","https://openalex.org/W2114085934","https://openalex.org/W2114853176","https://openalex.org/W2117179092","https://openalex.org/W2122773355","https://openalex.org/W2123999282","https://openalex.org/W2124480752","https://openalex.org/W2125454468","https://openalex.org/W2127377673","https://openalex.org/W2134153749","https://openalex.org/W2134910569","https://openalex.org/W2136133782","https://openalex.org/W2137055458","https://openalex.org/W2137943250","https://openalex.org/W2138538544","https://openalex.org/W2140055375","https://openalex.org/W2143094150","https://openalex.org/W2144683622","https://openalex.org/W2148323109","https://openalex.org/W2150473143","https://openalex.org/W2151007518","https://openalex.org/W2152022069","https://openalex.org/W2158622675","https://openalex.org/W2161861781","https://openalex.org/W2163707541","https://openalex.org/W2167460696","https://openalex.org/W2170158942","https://openalex.org/W2171280873","https://openalex.org/W2172229929","https://openalex.org/W2181989021","https://openalex.org/W2609912642","https://openalex.org/W4236463097","https://openalex.org/W4247419735"],"related_works":["https://openalex.org/W2757658034","https://openalex.org/W2992151120","https://openalex.org/W7205016386","https://openalex.org/W2551393443","https://openalex.org/W1562919182","https://openalex.org/W4229011321","https://openalex.org/W2774849165","https://openalex.org/W1567520642","https://openalex.org/W3025406617","https://openalex.org/W2747930756"],"abstract_inverted_index":{"Single-cell":[0],"techniques":[1,109],"have":[2,28],"a":[3,31,104],"long":[4],"history":[5],"of":[6,20,57,74,89,112],"unveiling":[7],"fundamental":[8],"paradigms":[9],"in":[10,14,34,39,85,100],"biology.":[11],"Recent":[12],"improvements":[13],"the":[15,71,87,108],"throughput,":[16],"resolution,":[17],"and":[18,24,54,83,115,120],"availability":[19],"microfluidics,":[21],"computational":[22],"power,":[23],"genetically":[25],"encoded":[26],"fluorescence":[27],"led":[29],"to":[30,78,107],"modern":[32],"renaissance":[33],"microbial":[35],"physiology.":[36],"This":[37],"resurgence":[38],"research":[40],"activity":[41],"has":[42],"offered":[43],"new":[44],"perspectives":[45],"on":[46],"physiological":[47],"processes":[48,82],"such":[49,60],"as":[50,61],"growth,":[51],"cell":[52,55],"cycle,":[53],"size":[56],"model":[58],"organisms":[59],"Escherichia":[62],"coli.":[63],"We":[64],"expect":[65],"these":[66],"single-cell":[67,101],"techniques,":[68],"coupled":[69],"with":[70],"molecular":[72],"revolution":[73],"biology's":[75],"recent":[76],"half-century,":[77],"continue":[79],"illuminating":[80],"unforeseen":[81],"patterns":[84],"microorganisms,":[86],"bedrock":[88],"biological":[90],"science.":[91],"In":[92],"this":[93],"article":[94],"we":[95],"review":[96],"major":[97],"open":[98],"questions":[99],"physiology,":[102],"provide":[103],"brief":[105],"introduction":[106],"for":[110],"scientists":[111],"diverse":[113],"backgrounds,":[114],"highlight":[116],"some":[117],"pervasive":[118],"issues":[119],"their":[121],"solutions.":[122]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}