{"id":"https://openalex.org/W2159755902","doi":null,"title":"Expression of angiopoietins and its clinical significance in non-small cell lung cancer.","display_name":"Expression of angiopoietins and its clinical significance in non-small cell lung cancer.","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W2159755902","mag":"2159755902","pmid":"https://pubmed.ncbi.nlm.nih.gov/12460935"},"language":"en","primary_location":{"id":"pmid:12460935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12460935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015471387","display_name":"Fumihiro Tanaka","orcid":"https://orcid.org/0000-0003-4692-6151","observed_orcids":["https://orcid.org/0000-0003-4692-6151"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumihiro Tanaka","raw_affiliation_strings":["Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, 606-8507 Japan. ftanaka@kuhp.kyoto-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, 606-8507 Japan. ftanaka@kuhp.kyoto-u.ac.jp","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100855855","display_name":"Shinya Ishikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shinya Ishikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017546556","display_name":"Kazuhiro Yanagihara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuhiro Yanagihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111583307","display_name":"Ryo Miyahara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryo Miyahara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113570827","display_name":"Yozo Kawano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yozo Kawano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025219643","display_name":"Mio Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mio Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109899839","display_name":"Yosuke Otake","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yosuke Otake","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049226902","display_name":"Hiromi Wada","orcid":"https://orcid.org/0000-0001-6171-1963","observed_orcids":["https://orcid.org/0000-0001-6171-1963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiromi Wada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8242,"has_fulltext":false,"cited_by_count":150,"citation_normalized_percentile":{"value":0.94890822,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"62","issue":"23","first_page":"7124","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiopoietin-1","display_name":"angiopoietin-1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9120000004768372},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tumor-microvessel-density","display_name":"tumor microvessel density","score":0.9319999814033508},{"id":"https://openalex.org/keywords/endoglin","display_name":"CD105","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.9660000205039978},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7820000052452087},{"id":"https://openalex.org/keywords/postoperative-survival","display_name":"postoperative survival","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pathological-stage","display_name":"pathological stage","score":0.42100000381469727},{"id":"https://openalex.org/keywords/prognostic-score","display_name":"prognostic score","score":0.3799999952316284},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.49799999594688416},{"id":"https://openalex.org/keywords/tumor-infiltrating-macrophages","display_name":"tumor-infiltrating macrophages","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C6061869","wikidata":"https://www.wikidata.org/wiki/Q18250377","display_name":"Endoglin","level":4,"score":0.8816037178039551},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.6725268363952637},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6204385757446289},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6160857677459717},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5862445831298828},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5720255374908447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5671442747116089},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4884394705295563},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4658665657043457},{"id":"https://openalex.org/C2779094623","wikidata":"https://www.wikidata.org/wiki/Q539710","display_name":"Angiopoietin","level":4,"score":0.4127240777015686},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4114683270454407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2583422362804413},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21947714686393738},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.17014974355697632},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.08701947331428528},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042683","descriptor_name":"Angiopoietin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042702","descriptor_name":"Angiopoietin-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043925","descriptor_name":"Angiogenesis Inducing Agents","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:12460935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12460935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.319.3041","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.319.3041","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/62/23/7124.full.pdf","raw_type":"text"},{"id":"mag:2159755902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12460935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1498167302","https://openalex.org/W1514053247","https://openalex.org/W1530073529","https://openalex.org/W1783580437","https://openalex.org/W1959188680","https://openalex.org/W1966879486","https://openalex.org/W1970614272","https://openalex.org/W1985528986","https://openalex.org/W1993312546","https://openalex.org/W1998405343","https://openalex.org/W2012255417","https://openalex.org/W2028572934","https://openalex.org/W2066888615","https://openalex.org/W2073497814","https://openalex.org/W2077746894","https://openalex.org/W2093117205","https://openalex.org/W2099084546","https://openalex.org/W2133718654","https://openalex.org/W2135924006","https://openalex.org/W2152215024","https://openalex.org/W2166119177","https://openalex.org/W2169544817","https://openalex.org/W2170124424","https://openalex.org/W2170201138","https://openalex.org/W2170770755","https://openalex.org/W2278422521"],"related_works":["https://openalex.org/W2361307844","https://openalex.org/W937119198","https://openalex.org/W1983577722","https://openalex.org/W2082426855","https://openalex.org/W4285181242","https://openalex.org/W2375906600","https://openalex.org/W7099387942","https://openalex.org/W65436151","https://openalex.org/W1981937442","https://openalex.org/W1973498312"],"abstract_inverted_index":{"Angiopoietin":[0],"(Ang)-1":[1],"and":[2,85,100,109,122,200,210,236,241,276,289,299,303,310],"-2":[3],"have":[4],"been":[5,31],"recently":[6],"identified":[7],"as":[8,283,293,304,326,328],"potent":[9],"angiogenic":[10,152],"factors":[11],"which":[12,247],"function":[13],"in":[14,41,106,332,338],"concert":[15],"with":[16,52,74,285,295,306,322,329],"vascular":[17],"endothelial":[18,93],"growth":[19],"factor":[20,223],"(VEGF),":[21],"but":[22],"no":[23,116],"detailed":[24],"clinical":[25,36],"study":[26],"on":[27,259],"Ang":[28,39],"expression":[29,40,97,121,161,166,191,215,266,318],"has":[30],"reported.":[32],"To":[33],"assess":[34],"the":[35,128,169,194,207,271,339],"significance":[37],"of":[38,49,60,81,91,98,102,154,216,256,274,341],"non-small":[42],"cell":[43],"lung":[44],"cancer":[45],"(NSCLC),":[46],"a":[47,79,89,221,226,251,323],"total":[48],"236":[50],"patients":[51,111,235,238,278,291,301,312],"pathological":[53],"stage-I-IIIA":[54],"disease":[55],"were":[56,104,205,239],"retrospectively":[57],"reviewed.":[58],"Expression":[59],"Ang-1,":[61,219],"Ang-2,":[62,217],"or":[63,124],"VEGF":[64,160,165,190,265,343],"was":[65,72,115,134,156,162,167,175,192,220,248,262,267,279,319,336],"examined":[66,73],"immunohistochemically;":[67],"intratumoral":[68],"microvessel":[69],"density":[70],"(IMVD)":[71],"immunohistochemical":[75],"staining":[76],"against":[77,87],"CD34,":[78],"marker":[80,90],"pan-endothelial":[82],"cells":[83,94],"(CD34-IMVD),":[84],"that":[86,101,138,179,201,286,296,307,335],"CD105,":[88],"proliferative":[92],"(CD105-IMVD).":[95],"Positive":[96],"Ang-1":[99,120],"Ang-2":[103,155,257,317],"seen":[105,157],"101":[107],"(42.8%)":[108],"40":[110],"(16.9%),":[112],"respectively.":[113],"There":[114],"significant":[117,222],"correlation":[118],"between":[119],"CD34-IMVD":[123],"CD105-IMVD.":[125],"In":[126,314],"contrast,":[127],"average":[129,170,195],"CD105-IMVD":[130,171,196],"for":[131,139,172,180,197,202,233,287,297,308],"Ang-2-positive":[132,173,198,234,275,298],"tumor":[133,141,174,182,199,204],"significantly":[135,176,320],"higher":[136,177],"than":[137,178],"Ang-2-negative":[140,181,203,288,309],"(56.7":[142],"versus":[143,184],"38.5;":[144],"P":[145,186,244],"=":[146,187,245],"0.032).":[147],"More":[148],"interestingly,":[149],"such":[150],"an":[151],"effect":[153],"only":[158],"when":[159,164,189,264],"high;":[163],"high,":[168],"(89.1":[183],"63.6;":[185],"0.045);":[188],"low,":[193],"almost":[206],"same":[208],"(27.4":[209],"27.1,":[211],"respectively).":[212],"Moreover,":[213],"positive":[214,316],"not":[218],"to":[224],"predict":[225],"poor":[227,324],"postoperative":[228,260],"survival":[229,231,261,273],"(5-year":[230],"rates":[232],"-negative":[237],"53.5":[240],"70.3%,":[242],"respectively;":[243],"0.027),":[246],"confirmed":[249],"by":[250],"multivariate":[252],"analysis.":[253],"The":[254],"influence":[255],"status":[258],"enhanced":[263,337],"high.":[268],"That":[269],"said,":[270],"5-year":[272],"VEGF-high":[277],"extremely":[280],"low":[281],"(41.4%)":[282],"compared":[284,294,305],"VEGF-low":[290,300,311],"(66.6%),":[292],"(63.6%),":[302],"(71.8%).":[313],"conclusion,":[315],"correlated":[321],"prognosis,":[325],"well":[327],"aggressive":[330],"angiogenesis":[331],"resected":[333],"NSCLC":[334],"presence":[340],"high":[342],"expression.":[344]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}