{"id":"https://openalex.org/W2159748639","doi":"https://doi.org/10.1042/bj20131412","title":"Physiological expression of the PI3K-activating mutation Pik3caH1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice","display_name":"Physiological expression of the PI3K-activating mutation Pik3caH1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice","publication_year":2013,"publication_date":"2013-12-10","ids":{"openalex":"https://openalex.org/W2159748639","doi":"https://doi.org/10.1042/bj20131412","mag":"2159748639","pmid":"https://pubmed.ncbi.nlm.nih.gov/24320611"},"language":"en","primary_location":{"id":"doi:10.1042/bj20131412","doi":"https://doi.org/10.1042/bj20131412","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20131412","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11343/123670","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003472573","display_name":"Lauren Hare","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lauren\u00a0M. Hare","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia","Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067834126","display_name":"Toby James Phesse","orcid":"https://orcid.org/0000-0001-9568-4916","observed_orcids":["https://orcid.org/0000-0001-9568-4916"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Toby\u00a0J. Phesse","raw_affiliation_strings":["Cell Signalling and Cell Death Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia","Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signalling and Cell Death Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101694634","display_name":"Paul Michael Waring","orcid":"https://orcid.org/0000-0002-9848-1310","observed_orcids":["https://orcid.org/0000-0002-9848-1310"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul\u00a0M. Waring","raw_affiliation_strings":["Department of Pathology, University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075288083","display_name":"Karen G. Montgomery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Karen\u00a0G. Montgomery","raw_affiliation_strings":["Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027252584","display_name":"Kathryn M. Kinross","orcid":"https://orcid.org/0000-0001-8397-828X","observed_orcids":["https://orcid.org/0000-0001-8397-828X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kathryn\u00a0M. Kinross","raw_affiliation_strings":["Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia","The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kevin Mills","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Kevin Mills","raw_affiliation_strings":["Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057084365","display_name":"Vincent Roh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Vincent Roh","raw_affiliation_strings":["Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012092459","display_name":"Joan K. Heath","orcid":"https://orcid.org/0000-0001-6955-232X","observed_orcids":["https://orcid.org/0000-0001-6955-232X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Joan\u00a0K. Heath","raw_affiliation_strings":["Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia","Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037001639","display_name":"Robert George Ramsay","orcid":"https://orcid.org/0000-0001-5003-0433","observed_orcids":["https://orcid.org/0000-0001-5003-0433"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robert\u00a0G. Ramsay","raw_affiliation_strings":["Differentiation and Transcription Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia","The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Differentiation and Transcription Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067242663","display_name":"Matthias Ernst","orcid":"https://orcid.org/0000-0002-6399-1177","observed_orcids":["https://orcid.org/0000-0002-6399-1177"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthias Ernst","raw_affiliation_strings":["Cell Signalling and Cell Death Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia","Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signalling and Cell Death Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025138822","display_name":"Wayne Allen Phillips","orcid":"https://orcid.org/0000-0002-7961-638X","observed_orcids":["https://orcid.org/0000-0002-7961-638X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Wayne\u00a0A. Phillips","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia","Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia","The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5057084365"],"corresponding_institution_ids":["https://openalex.org/I2800555584"],"apc_list":null,"apc_paid":null,"fwci":0.7462,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.71580485,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"458","issue":"2","first_page":"251","last_page":"258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.8410000205039978},{"id":"https://openalex.org/keywords/apc-loss","display_name":"APC loss","score":0.824999988079071},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9570000171661377},{"id":"https://openalex.org/keywords/intestinal-adenocarcinoma","display_name":"intestinal adenocarcinoma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.609000027179718},{"id":"https://openalex.org/keywords/intestinal-tumorigenesis","display_name":"intestinal tumorigenesis","score":0.7289999723434448},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.8270000219345093},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5649999976158142},{"id":"https://openalex.org/keywords/small-intestine-neoplasms","display_name":"small intestine neoplasms","score":0.49399998784065247},{"id":"https://openalex.org/keywords/large-bowel-cancer","display_name":"large bowel cancer","score":0.9729999899864197}],"concepts":[{"id":"https://openalex.org/C2781465904","wikidata":"https://www.wikidata.org/wiki/Q14887700","display_name":"P110\u03b1","level":4,"score":0.7151569128036499},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6799014210700989},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6483030319213867},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6474491357803345},{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.6315578818321228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5819957852363586},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5597622394561768},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.543203592300415},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.49767211079597473},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.48280584812164307},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4808395802974701},{"id":"https://openalex.org/C2780814781","wikidata":"https://www.wikidata.org/wiki/Q1369011","display_name":"Familial adenomatous polyposis","level":4,"score":0.46781110763549805},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33043724298477173},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2667708396911621},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20856371521949768},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.193004310131073},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055879","descriptor_name":"Gene Knock-In Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057507","descriptor_name":"Mice, 129 Strain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1042/bj20131412","doi":"https://doi.org/10.1042/bj20131412","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20131412","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:24320611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24320611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/123670","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/123670","pdf_url":"http://hdl.handle.net/11343/123670","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:91562","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/91562/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/41940","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11343/41940","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/123670","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/123670","pdf_url":"http://hdl.handle.net/11343/123670","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1910558476","display_name":"PI3K mutations in gastrointestinal cancer","funder_award_id":"628621","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G7204137587","display_name":"gp130-Stat3 promotes Wnt-beta catenin induced intestinal tumourigenesis","funder_award_id":"603127","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320322467","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159748639.pdf","grobid_xml":"https://content.openalex.org/works/W2159748639.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1768274470","https://openalex.org/W1967187359","https://openalex.org/W1981989535","https://openalex.org/W1990606472","https://openalex.org/W2001258296","https://openalex.org/W2026035216","https://openalex.org/W2029596323","https://openalex.org/W2038608495","https://openalex.org/W2053731598","https://openalex.org/W2055808017","https://openalex.org/W2058043554","https://openalex.org/W2059813946","https://openalex.org/W2064054320","https://openalex.org/W2067911884","https://openalex.org/W2068085420","https://openalex.org/W2082416335","https://openalex.org/W2097018007","https://openalex.org/W2102457333","https://openalex.org/W2129172946","https://openalex.org/W2135900256","https://openalex.org/W2145607651","https://openalex.org/W2150172589","https://openalex.org/W2150625137","https://openalex.org/W2153403424","https://openalex.org/W2154692501","https://openalex.org/W2262414037","https://openalex.org/W6660044814"],"related_works":["https://openalex.org/W1529351760","https://openalex.org/W2569816987","https://openalex.org/W2038608495","https://openalex.org/W1965357540","https://openalex.org/W2324425855","https://openalex.org/W2955351166","https://openalex.org/W6969565193","https://openalex.org/W2256481962","https://openalex.org/W2114352903","https://openalex.org/W4402892422"],"abstract_inverted_index":{"PIK3CA,":[0],"the":[1,4,23,29,36,47,50,53,61,86,109,113,123,131,149],"gene":[2],"encoding":[3],"p110\u03b1":[5],"catalytic":[6],"subunit":[7],"of":[8,17,25,31,49,65,88,99,115,130,151],"PI3K":[9,165],"(phosphoinositide":[10],"3-kinase),":[11],"is":[12,78,95],"mutated":[13],"in":[14,28,58,85,97,105,121,142],"approximately":[15],"20%":[16],"sporadic":[18],"CRCs":[19,100],"(colorectal":[20],"cancers),":[21],"but":[22],"role":[24,48],"these":[26],"mutations":[27],"pathogenesis":[30],"CRC":[32],"remains":[33],"unclear.":[34],"In":[35],"present":[37,132],"study":[38,133],"we":[39],"used":[40],"a":[41],"novel":[42],"mouse":[43],"model":[44],"to":[45,80,147,161],"investigate":[46],"Pik3caH1047R":[51,110],"mutation,":[52],"most":[54],"common":[55],"PIK3CA":[56],"mutation":[57,111,139],"CRC,":[59],"during":[60],"development":[62,114],"and":[63,101,118,125,154],"progression":[64,150],"intestinal":[66,82,107],"cancer.":[67],"Our":[68],"results":[69,104,129],"demonstrate":[70],"that":[71,135],"Pik3caH1047R,":[72],"when":[73],"expressed":[74],"at":[75],"physiological":[76],"levels,":[77],"insufficient":[79],"initiate":[81],"tumorigenesis;":[83],"however,":[84],"context":[87],"Apc":[89,145],"(adenomatous":[90],"polyposis":[91],"coli)":[92],"loss,":[93],"which":[94],"observed":[96],"80%":[98],"by":[102],"itself":[103],"benign":[106],"adenomas,":[108],"promotes":[112],"highly":[116],"aggressive":[117],"invasive":[119],"adenocarcinomas":[120],"both":[122],"small":[124],"large":[126],"intestines.":[127],"The":[128],"show":[134],"an":[136],"activating":[137],"Pik3ca":[138],"can":[140],"act":[141],"tandem":[143],"with":[144],"loss":[146],"drive":[148],"gastrointestinal":[152],"cancer":[153],"thus":[155],"this":[156],"disease":[157],"may":[158],"be":[159],"susceptible":[160],"therapeutic":[162],"targeting":[163],"using":[164],"pathway":[166],"inhibitors.":[167]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
