{"id":"https://openalex.org/W2159649486","doi":"https://doi.org/10.1002/eji.201444500","title":"Acute myeloid leukemia impairs natural killer cells through the formation of a deficient cytotoxic immunological synapse","display_name":"Acute myeloid leukemia impairs natural killer cells through the formation of a deficient cytotoxic immunological synapse","publication_year":2014,"publication_date":"2014-07-15","ids":{"openalex":"https://openalex.org/W2159649486","doi":"https://doi.org/10.1002/eji.201444500","mag":"2159649486","pmid":"https://pubmed.ncbi.nlm.nih.gov/25041786"},"language":"en","primary_location":{"id":"doi:10.1002/eji.201444500","doi":"https://doi.org/10.1002/eji.201444500","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.201444500","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.201444500","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.201444500","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050855608","display_name":"Zena Khaznadar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4403386632","display_name":"Ecotaxie, Microenvironnement et d\u00e9veloppement lymphocytaire","ror":"https://ror.org/04t9v8r67","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4403386632"]},{"id":"https://openalex.org/I4405259871","display_name":"Institut Universitaire d'H\u00e9matologie","ror":"https://ror.org/02w653772","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4405259871"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Zena Khaznadar","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM UMRS 1160)  Paris France","Institut Universitaire d'H\u00e9matologie Univ Paris Diderot  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM UMRS 1160)  Paris France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4403386632"]},{"raw_affiliation_string":"Institut Universitaire d'H\u00e9matologie Univ Paris Diderot  Paris France","institution_ids":["https://openalex.org/I4405259871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022842438","display_name":"Guylaine Henry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guylaine Henry","raw_affiliation_strings":["Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP) H\u00f4pital Saint\u2010Louis Laboratoire d'Immunologie et Histocompatibilit\u00e9  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP) H\u00f4pital Saint\u2010Louis Laboratoire d'Immunologie et Histocompatibilit\u00e9  Paris France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008693390","display_name":"Niclas Setterblad","orcid":"https://orcid.org/0000-0002-1899-5435","observed_orcids":["https://orcid.org/0000-0002-1899-5435"]},"institutions":[{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]},{"id":"https://openalex.org/I4405259871","display_name":"Institut Universitaire d'H\u00e9matologie","ror":"https://ror.org/02w653772","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4405259871"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Niclas Setterblad","raw_affiliation_strings":["D\u00e9partement d'Imagerie Institut Universitaire d'H\u00e9matologie Univ Paris Diderot  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement d'Imagerie Institut Universitaire d'H\u00e9matologie Univ Paris Diderot  Paris France","institution_ids":["https://openalex.org/I4387154366","https://openalex.org/I4405259871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019953605","display_name":"Sophie Agaugu\u00e9","orcid":"https://orcid.org/0000-0001-6642-2810","observed_orcids":["https://orcid.org/0000-0001-6642-2810"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4403386632","display_name":"Ecotaxie, Microenvironnement et d\u00e9veloppement lymphocytaire","ror":"https://ror.org/04t9v8r67","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4403386632"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Agaugue","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM UMRS 1160)  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM UMRS 1160)  Paris France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4403386632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064103067","display_name":"Emmanuel Raffoux","orcid":"https://orcid.org/0000-0003-3925-7391","observed_orcids":["https://orcid.org/0000-0003-3925-7391"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuel Raffoux","raw_affiliation_strings":["Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP) H\u00f4pital Saint\u2010Louis Service d'H\u00e9matologie Adulte  Paris France","Facult\u00e9 de M\u00e9decine, Univ Paris Diderot  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP) H\u00f4pital Saint\u2010Louis Service d'H\u00e9matologie Adulte  Paris France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Univ Paris Diderot  Paris France","institution_ids":["https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076973611","display_name":"Nicolas Boissel","orcid":"https://orcid.org/0000-0003-2091-7927","observed_orcids":["https://orcid.org/0000-0003-2091-7927"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Boissel","raw_affiliation_strings":["Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP) H\u00f4pital Saint\u2010Louis Service d'H\u00e9matologie Adulte  Paris France","Facult\u00e9 de M\u00e9decine, Univ Paris Diderot  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP) H\u00f4pital Saint\u2010Louis Service d'H\u00e9matologie Adulte  Paris France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Univ Paris Diderot  Paris France","institution_ids":["https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000436961","display_name":"Herv\u00e9 Dombret","orcid":"https://orcid.org/0000-0002-5454-6768","observed_orcids":["https://orcid.org/0000-0002-5454-6768","https://orcid.org/0000-0003-4824-3880"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Dombret","raw_affiliation_strings":["Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP) H\u00f4pital Saint\u2010Louis Service d'H\u00e9matologie Adulte  Paris France","Facult\u00e9 de M\u00e9decine, Univ Paris Diderot  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP) H\u00f4pital Saint\u2010Louis Service d'H\u00e9matologie Adulte  Paris France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"raw_affiliation_string":"Facult\u00e9 de M\u00e9decine, Univ Paris Diderot  Paris France","institution_ids":["https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000888675","display_name":"Antoine Toubert","orcid":"https://orcid.org/0000-0002-7308-7317","observed_orcids":["https://orcid.org/0000-0002-7308-7317"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4403386632","display_name":"Ecotaxie, Microenvironnement et d\u00e9veloppement lymphocytaire","ror":"https://ror.org/04t9v8r67","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4403386632"]},{"id":"https://openalex.org/I4405259871","display_name":"Institut Universitaire d'H\u00e9matologie","ror":"https://ror.org/02w653772","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4405259871"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antoine Toubert","raw_affiliation_strings":["Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP) H\u00f4pital Saint\u2010Louis Laboratoire d'Immunologie et Histocompatibilit\u00e9  Paris France","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM UMRS 1160)  Paris France","Institut Universitaire d'H\u00e9matologie Univ Paris Diderot  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP) H\u00f4pital Saint\u2010Louis Laboratoire d'Immunologie et Histocompatibilit\u00e9  Paris France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM UMRS 1160)  Paris France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4403386632"]},{"raw_affiliation_string":"Institut Universitaire d'H\u00e9matologie Univ Paris Diderot  Paris France","institution_ids":["https://openalex.org/I4405259871"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071449715","display_name":"Nicolas Dulphy","orcid":"https://orcid.org/0000-0002-1243-6456","observed_orcids":["https://orcid.org/0000-0002-1243-6456"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4403386632","display_name":"Ecotaxie, Microenvironnement et d\u00e9veloppement lymphocytaire","ror":"https://ror.org/04t9v8r67","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4403386632"]},{"id":"https://openalex.org/I4405259871","display_name":"Institut Universitaire d'H\u00e9matologie","ror":"https://ror.org/02w653772","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4405259871"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Nicolas Dulphy","raw_affiliation_strings":["Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP) H\u00f4pital Saint\u2010Louis Laboratoire d'Immunologie et Histocompatibilit\u00e9  Paris France","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM UMRS 1160)  Paris France","Institut Universitaire d'H\u00e9matologie Univ Paris Diderot  Paris France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP) H\u00f4pital Saint\u2010Louis Laboratoire d'Immunologie et Histocompatibilit\u00e9  Paris France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM UMRS 1160)  Paris France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4403386632"]},{"raw_affiliation_string":"Institut Universitaire d'H\u00e9matologie Univ Paris Diderot  Paris France","institution_ids":["https://openalex.org/I4405259871"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5071449715"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210097159","https://openalex.org/I4210144610","https://openalex.org/I4403386632","https://openalex.org/I4405259871"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":3.57,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.93916717,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"44","issue":"10","first_page":"3068","last_page":"3080"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.9160000085830688},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.777999997138977},{"id":"https://openalex.org/keywords/lfa-1","display_name":"LFA-1","score":0.8140000104904175},{"id":"https://openalex.org/keywords/lenalidomide","display_name":"lenalidomide","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cytokine-induction","display_name":"cytokine induction","score":0.7979999780654907},{"id":"https://openalex.org/keywords/adoptive-nk-cell-therapy","display_name":"adoptive NK cell therapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/allogeneic-nk-cells","display_name":"allogeneic NK cells","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8634998202323914},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.8023608326911926},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.772621750831604},{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.7652201652526855},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5200173854827881},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4998455047607422},{"id":"https://openalex.org/C2994430510","wikidata":"https://www.wikidata.org/wiki/Q3270846","display_name":"Myeloid cells","level":3,"score":0.47301366925239563},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.46302667260169983},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.4259505569934845},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3528019189834595},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34366822242736816},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.21255651116371155},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.168439120054245},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.058708757162094116},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.04216820001602173}],"mesh":[{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054992","descriptor_name":"Immunological Synapses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/eji.201444500","doi":"https://doi.org/10.1002/eji.201444500","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.201444500","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.201444500","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:25041786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25041786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-03664884v1","doi":null,"is_oa":true,"landing_page_url":"https://u-paris.hal.science/hal-03664884","pdf_url":"https://u-paris.hal.science/hal-03664884/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Immunology, 2014, 43 (5), pp.3068-3080. ⟨10.1002/eji.201444500⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/eji.201444500","doi":"https://doi.org/10.1002/eji.201444500","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.201444500","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.201444500","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7200158272","display_name":null,"funder_award_id":"DOC20100600956","funder_id":"https://openalex.org/F4320309749","funder_display_name":"Association pour la Recherche sur le Cancer"},{"id":"https://openalex.org/G8074790634","display_name":null,"funder_award_id":"RPT12008HHA","funder_id":"https://openalex.org/F4320323807","funder_display_name":"Institut National Du Cancer"}],"funders":[{"id":"https://openalex.org/F4320309749","display_name":"Association pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322646","display_name":"Fondation de France","ror":"https://ror.org/02zkxjz73"},{"id":"https://openalex.org/F4320323807","display_name":"Institut National Du Cancer","ror":"https://ror.org/03m8vkq32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159649486.pdf","grobid_xml":"https://content.openalex.org/works/W2159649486.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W14441452","https://openalex.org/W1514772132","https://openalex.org/W1617995910","https://openalex.org/W1669828090","https://openalex.org/W1964982854","https://openalex.org/W1965393381","https://openalex.org/W1969900447","https://openalex.org/W1970610464","https://openalex.org/W1971222772","https://openalex.org/W1979309423","https://openalex.org/W1980068016","https://openalex.org/W1985322758","https://openalex.org/W1992908671","https://openalex.org/W1997849135","https://openalex.org/W2008693616","https://openalex.org/W2011977826","https://openalex.org/W2014349052","https://openalex.org/W2022069273","https://openalex.org/W2023101543","https://openalex.org/W2030669661","https://openalex.org/W2044835347","https://openalex.org/W2045054311","https://openalex.org/W2051233096","https://openalex.org/W2052502668","https://openalex.org/W2054218102","https://openalex.org/W2062508345","https://openalex.org/W2063022052","https://openalex.org/W2064008845","https://openalex.org/W2064733298","https://openalex.org/W2071065868","https://openalex.org/W2084896925","https://openalex.org/W2089697869","https://openalex.org/W2090083883","https://openalex.org/W2095491662","https://openalex.org/W2098150432","https://openalex.org/W2099427002","https://openalex.org/W2103897906","https://openalex.org/W2108526881","https://openalex.org/W2112633838","https://openalex.org/W2118143380","https://openalex.org/W2129391478","https://openalex.org/W2131014265","https://openalex.org/W2133010132","https://openalex.org/W2133184513","https://openalex.org/W2138265677","https://openalex.org/W2153385228","https://openalex.org/W2154518608","https://openalex.org/W2158469499","https://openalex.org/W2159319189","https://openalex.org/W2162494273","https://openalex.org/W2162583751","https://openalex.org/W2165813814","https://openalex.org/W2167279371","https://openalex.org/W2168459600","https://openalex.org/W2168663010","https://openalex.org/W2409920374"],"related_works":["https://openalex.org/W2320033921","https://openalex.org/W2595780152","https://openalex.org/W2586302305","https://openalex.org/W745642808","https://openalex.org/W1535296185","https://openalex.org/W2470200249","https://openalex.org/W2799438446","https://openalex.org/W2332407955","https://openalex.org/W2008693616","https://openalex.org/W4407798040"],"abstract_inverted_index":{"Acute":[0],"myeloid":[1],"leukemia":[2],"(AML)":[3],"cells":[4,14,37,148,186,194],"are":[5],"killed":[6],"by":[7,143],"allogeneic":[8,192],"NK":[9,13,34,147,185,193],"cells.":[10],"However,":[11],"autologous":[12,184],"from":[15],"AML":[16,36,50,82,122,158,180],"patients":[17],"express":[18],"decreased":[19],"levels":[20],"of":[21,41,68,80,92,96,115,134,146,157,191],"activating":[22],"receptors,":[23],"and":[24,35,53,73,85,111,176,187],"show":[25,48],"reduced":[26],"cytotoxicity.":[27],"Here,":[28],"we":[29],"investigated":[30],"how":[31],"interactions":[32,87],"between":[33],"might":[38],"cause":[39],"loss":[40],"NK-cell":[42,58,86,97],"activity":[43,190],"in":[44,103,195],"patients.":[45],"Our":[46],"results":[47],"that":[49,172],"cell":[51,83,123,129,159,181],"lines":[52,124,160],"primary":[54,119],"blasts":[55,120],"alter":[56],"the":[57,162,189],"phenotype,":[59],"reducing":[60],"their":[61],"cytotoxic":[62],"potential":[63],"upon":[64],"prolonged":[65],"contact.":[66],"Downregulation":[67],"NK-cell-activating":[69],"receptors":[70],"was":[71,125],"contact-dependent":[72],"correlated":[74],"with":[75,161],"conjugate":[76,150],"formation.":[77,106],"Time-lapse":[78],"imaging":[79],"HL60":[81],"line":[84,130],"showed":[88,132],"a":[89,101],"high":[90],"proportion":[91],"noncytolytic":[93],"contacts.":[94],"Studies":[95],"immunological":[98],"synapses":[99,131],"revealed":[100],"defect":[102],"lytic":[104,116],"synapse":[105,141],"Namely,":[107],"despite":[108],"correct":[109,139],"F-actin":[110],"LFA-1":[112],"recruitment,":[113],"polarization":[114],"granules":[117],"toward":[118],"or":[121],"reduced.":[126],"The":[127],"NK-AML":[128],"impairment":[133],"CD3\u03b6":[135],"recruitment.":[136],"Attempts":[137],"to":[138,183],"these":[140],"defects":[142],"cytokine":[144],"stimulation":[145],"improved":[149],"formation,":[151],"but":[152],"not":[153],"granule":[154,168],"polarization.":[155,169],"Pretreatment":[156],"immunomodulating":[163],"molecule":[164],"lenalidomide":[165],"significantly":[166],"enhanced":[167],"We":[170],"speculate":[171],"combining":[173],"immunomodulatory":[174],"drugs":[175],"cytokines":[177],"could":[178],"increase":[179],"sensitivity":[182],"reinforce":[188],"adoptive":[196],"immunotherapy.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}