{"id":"https://openalex.org/W2159586303","doi":"https://doi.org/10.1126/science.1091176","title":"The Proteasome of Mycobacterium tuberculosis Is Required for Resistance to Nitric Oxide","display_name":"The Proteasome of Mycobacterium tuberculosis Is Required for Resistance to Nitric Oxide","publication_year":2003,"publication_date":"2003-12-11","ids":{"openalex":"https://openalex.org/W2159586303","doi":"https://doi.org/10.1126/science.1091176","mag":"2159586303","pmid":"https://pubmed.ncbi.nlm.nih.gov/14671303"},"language":"en","primary_location":{"id":"doi:10.1126/science.1091176","doi":"https://doi.org/10.1126/science.1091176","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1091176","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030020521","display_name":"K. Heran Darwin","orcid":"https://orcid.org/0000-0002-5043-7548","observed_orcids":["https://orcid.org/0000-0002-5043-7548"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405270001","display_name":"Takeda Oncology (United States)","ror":"https://ror.org/05vm7p871","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Heran Darwin","raw_affiliation_strings":["Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA","Millennium Pharmaceuticals, 75 Sidney Street, Cambridge, MA 02139, USA","Programs in Immunology and Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Millennium Pharmaceuticals, 75 Sidney Street, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I4405270001"]},{"raw_affiliation_string":"Programs in Immunology and Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023886894","display_name":"Sabine Ehrt","orcid":"https://orcid.org/0000-0002-7951-2310","observed_orcids":["https://orcid.org/0000-0002-7951-2310"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405270001","display_name":"Takeda Oncology (United States)","ror":"https://ror.org/05vm7p871","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabine Ehrt","raw_affiliation_strings":["Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA","Millennium Pharmaceuticals, 75 Sidney Street, Cambridge, MA 02139, USA","Programs in Immunology and Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Millennium Pharmaceuticals, 75 Sidney Street, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I4405270001"]},{"raw_affiliation_string":"Programs in Immunology and Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108682426","display_name":"Jos\u00e9-Carlos Gutierrez-Ramos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405270001","display_name":"Takeda Oncology (United States)","ror":"https://ror.org/05vm7p871","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose\u0301-Carlos Gutierrez-Ramos","raw_affiliation_strings":["Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA","Millennium Pharmaceuticals, 75 Sidney Street, Cambridge, MA 02139, USA","Programs in Immunology and Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Millennium Pharmaceuticals, 75 Sidney Street, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I4405270001"]},{"raw_affiliation_string":"Programs in Immunology and Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111768797","display_name":"Nadine S. Weich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405270001","display_name":"Takeda Oncology (United States)","ror":"https://ror.org/05vm7p871","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadine Weich","raw_affiliation_strings":["Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA","Millennium Pharmaceuticals, 75 Sidney Street, Cambridge, MA 02139, USA","Programs in Immunology and Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Millennium Pharmaceuticals, 75 Sidney Street, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I4405270001"]},{"raw_affiliation_string":"Programs in Immunology and Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000793262","display_name":"Carl Nathan","orcid":"https://orcid.org/0000-0002-7744-8896","observed_orcids":["https://orcid.org/0000-0002-7744-8896"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405270001","display_name":"Takeda Oncology (United States)","ror":"https://ror.org/05vm7p871","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270001"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carl F. Nathan","raw_affiliation_strings":["Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA","Millennium Pharmaceuticals, 75 Sidney Street, Cambridge, MA 02139, USA","Programs in Immunology and Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Millennium Pharmaceuticals, 75 Sidney Street, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I4405270001"]},{"raw_affiliation_string":"Programs in Immunology and Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000793262"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405270001"],"apc_list":null,"apc_paid":null,"fwci":9.0433,"has_fulltext":false,"cited_by_count":535,"citation_normalized_percentile":{"value":0.98622964,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"302","issue":"5652","first_page":"1963","last_page":"1966"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.9649999737739563},{"id":"https://openalex.org/keywords/nitric-oxide-resistance","display_name":"nitric oxide resistance","score":0.9760000109672546},{"id":"https://openalex.org/keywords/reactive-nitrogen-intermediates","display_name":"reactive nitrogen intermediates","score":0.9980000257492065},{"id":"https://openalex.org/keywords/transposon-mutants","display_name":"transposon mutants","score":0.8519999980926514},{"id":"https://openalex.org/keywords/uvrb","display_name":"UvrB","score":0.7519999742507935},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.8849999904632568},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8510000109672546},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.6688960790634155},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6566733121871948},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6484463214874268},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6100419759750366},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5914566516876221},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47895199060440063},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4583122432231903},{"id":"https://openalex.org/C2779525624","wikidata":"https://www.wikidata.org/wiki/Q225595","display_name":"Reactive nitrogen species","level":3,"score":0.43731629848480225},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.362186998128891},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3039151430130005},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.2558215856552124},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07364606857299805},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015169","descriptor_name":"Colony Count, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019732","descriptor_name":"Amide Synthases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1091176","doi":"https://doi.org/10.1126/science.1091176","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1091176","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:14671303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14671303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4479830101","display_name":null,"funder_award_id":"AI055549","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5661516315","display_name":"Immunology and Microbial Pathogenesis Research Training Program","funder_award_id":"T32AI007621","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6773307923","display_name":"MYCOBACTERIAL RESISTANCE TO REACTIVE NITROGEN/OXYGEN","funder_award_id":"R01HL061241","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1549438168","https://openalex.org/W1586874910","https://openalex.org/W1978839418","https://openalex.org/W1987547898","https://openalex.org/W1994303699","https://openalex.org/W1995045090","https://openalex.org/W2000886019","https://openalex.org/W2019255399","https://openalex.org/W2046299226","https://openalex.org/W2047670590","https://openalex.org/W2053450572","https://openalex.org/W2068696470","https://openalex.org/W2080063823","https://openalex.org/W2095681652","https://openalex.org/W2101334702","https://openalex.org/W2124001620","https://openalex.org/W2128482141","https://openalex.org/W2147379467","https://openalex.org/W2149200346","https://openalex.org/W2158023121","https://openalex.org/W2161034058"],"related_works":["https://openalex.org/W7096530354","https://openalex.org/W1974129529","https://openalex.org/W2171814990","https://openalex.org/W4243952280","https://openalex.org/W2146569411","https://openalex.org/W1971184861","https://openalex.org/W2158070227","https://openalex.org/W2084395135","https://openalex.org/W2042360733","https://openalex.org/W4210920975"],"abstract_inverted_index":{"The":[0],"production":[1],"of":[2,64,70],"nitric":[3],"oxide":[4],"and":[5,26,67,96],"other":[6],"reactive":[7],"nitrogen":[8],"intermediates":[9],"(RNI)":[10],"by":[11,17],"macrophages":[12],"helps":[13],"to":[14,35,46,98,106],"control":[15],"infection":[16,27],"Mycobacterium":[18],"tuberculosis":[19],"(Mtb).":[20],"However,":[21],"the":[22,62,68,109],"protection":[23],"is":[24],"imperfect":[25],"persists.":[28],"To":[29],"identify":[30],"genes":[31,57],"that":[32],"Mtb":[33,41,83,105],"requires":[34],"resist":[36],"RNI,":[37],"we":[38],"screened":[39],"10,100":[40],"transposon":[42],"mutants":[43,52,76],"for":[44],"hypersusceptibility":[45],"acidified":[47],"nitrite.":[48],"We":[49],"found":[50],"12":[51],"with":[53],"insertions":[54,78],"in":[55,79,86,94],"seven":[56],"representing":[58],"six":[59],"pathways,":[60],"including":[61],"repair":[63],"DNA":[65],"(uvrB)":[66],"synthesis":[69],"a":[71,87,114],"flavin":[72],"cofactor":[73],"(fbiC).":[74],"Five":[75],"had":[77],"proteasome-associated":[80],"genes.":[81],"An":[82],"mutant":[84],"deficient":[85],"presumptive":[88],"proteasomal":[89,99],"adenosine":[90],"triphosphatase":[91],"was":[92],"attenuated":[93],"mice,":[95],"exposure":[97],"protease":[100],"inhibitors":[101],"markedly":[102],"sensitized":[103],"wild-type":[104],"RNI.":[107],"Thus,":[108],"mycobacterial":[110],"proteasome":[111],"serves":[112],"as":[113],"defense":[115],"against":[116],"oxidative":[117],"or":[118],"nitrosative":[119],"stress.":[120]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":43},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":39},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}