{"id":"https://openalex.org/W2159583302","doi":"https://doi.org/10.1042/bj20080868","title":"High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial functionin vivo","display_name":"High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial functionin vivo","publication_year":2008,"publication_date":"2008-08-28","ids":{"openalex":"https://openalex.org/W2159583302","doi":"https://doi.org/10.1042/bj20080868","mag":"2159583302","pmid":"https://pubmed.ncbi.nlm.nih.gov/18752470","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2637578"},"language":"en","primary_location":{"id":"doi:10.1042/bj20080868","doi":"https://doi.org/10.1042/bj20080868","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20080868","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2637578/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013004448","display_name":"Sudheer Kumar Mantena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudheer\u00a0K. Mantena","raw_affiliation_strings":["Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022993524","display_name":"Denty Paul Vaughn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denty\u00a0Paul Vaughn","raw_affiliation_strings":["Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048931760","display_name":"Kelly K. Andringa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly\u00a0K. Andringa","raw_affiliation_strings":["Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042963735","display_name":"Heather B. Eccleston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather\u00a0B. Eccleston","raw_affiliation_strings":["Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054821659","display_name":"Adrienne Lester King","orcid":"https://orcid.org/0000-0002-6434-9039","observed_orcids":["https://orcid.org/0000-0002-6434-9039"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrienne\u00a0L. King","raw_affiliation_strings":["Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069199501","display_name":"Gary A. Abrams","orcid":"https://orcid.org/0000-0001-8036-3861","observed_orcids":["https://orcid.org/0000-0001-8036-3861"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary\u00a0A. Abrams","raw_affiliation_strings":["Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109165427","display_name":"Jeannette E. Doeller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeannette\u00a0E. Doeller","raw_affiliation_strings":["Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111520062","display_name":"David W. Kraus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David\u00a0W. Kraus","raw_affiliation_strings":["Department of Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062506120","display_name":"Victor M. Darley-Usmar","orcid":"https://orcid.org/0000-0001-8921-7086","observed_orcids":["https://orcid.org/0000-0001-8921-7086"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor\u00a0M. Darley-Usmar","raw_affiliation_strings":["Department of Pathology, Molecular and Cellular Division, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Molecular and Cellular Division, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047734216","display_name":"Shannon M. Bailey","orcid":"https://orcid.org/0000-0003-0002-3424","observed_orcids":["https://orcid.org/0000-0003-0002-3424"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shannon\u00a0M. Bailey","raw_affiliation_strings":["Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, U.S.A","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047734216"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":10.8595,"has_fulltext":true,"cited_by_count":274,"citation_normalized_percentile":{"value":0.98564044,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"417","issue":"1","first_page":"183","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.8939999938011169},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hepatic-hypoxia","display_name":"hepatic hypoxia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/oxygen-gradients","display_name":"oxygen gradients","score":0.703000009059906},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9589999914169312},{"id":"https://openalex.org/keywords/reactive-nitrogen-species","display_name":"reactive nitrogen species","score":0.7630000114440918},{"id":"https://openalex.org/keywords/3-nitrotyrosine","display_name":"nitrotyrosine","score":0.9240000247955322},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cyp2e1","display_name":"CYP2E1","score":0.8989999890327454},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.8330000042915344},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7879999876022339},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7508839964866638},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6466820240020752},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4874453842639923},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.48514828085899353},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4764143228530884},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4410080313682556},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43726351857185364},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4216325283050537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3760259747505188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1923089325428009},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09221246838569641},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019069","descriptor_name":"Cell Respiration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019392","descriptor_name":"Cytochrome P-450 CYP2E1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj20080868","doi":"https://doi.org/10.1042/bj20080868","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20080868","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2637578","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2637578/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2637578/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:1625984","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2637578","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:18752470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18752470","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2637578","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2637578/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2637578/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3317630481","display_name":"Ethanol Hepatotoxicity and NO-Dependent Mitochondrial Dysfunction","funder_award_id":"R01AA013395","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G3391971522","display_name":"Redox Modification of Thiols in Alcohol Hepatotoxicity","funder_award_id":"R01AA015172","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G4378483056","display_name":"Proteomics of Oxidant-Induced Mitochondrial Damage in an Animal Model of NASH","funder_award_id":"R21DK073775","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000897483","display_name":"UAB Nutrition Obesity Research Center (NORC)","funder_award_id":"P30DK056336","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159583302.pdf","grobid_xml":"https://content.openalex.org/works/W2159583302.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W962061814","https://openalex.org/W1528220495","https://openalex.org/W1778687422","https://openalex.org/W1926012349","https://openalex.org/W1967216895","https://openalex.org/W1975497281","https://openalex.org/W1977194186","https://openalex.org/W1980608195","https://openalex.org/W1982513877","https://openalex.org/W1999098395","https://openalex.org/W2018170506","https://openalex.org/W2018205667","https://openalex.org/W2021304489","https://openalex.org/W2022763702","https://openalex.org/W2027048243","https://openalex.org/W2034919439","https://openalex.org/W2034976767","https://openalex.org/W2039579730","https://openalex.org/W2040949761","https://openalex.org/W2047257800","https://openalex.org/W2048626265","https://openalex.org/W2053023042","https://openalex.org/W2053331006","https://openalex.org/W2058062846","https://openalex.org/W2060263803","https://openalex.org/W2066050507","https://openalex.org/W2080195958","https://openalex.org/W2082185635","https://openalex.org/W2084382398","https://openalex.org/W2086251702","https://openalex.org/W2087561593","https://openalex.org/W2090267115","https://openalex.org/W2091337145","https://openalex.org/W2096458076","https://openalex.org/W2116630862","https://openalex.org/W2131656539","https://openalex.org/W2133362207","https://openalex.org/W2134466661","https://openalex.org/W2138780460","https://openalex.org/W2142137775","https://openalex.org/W2155557800","https://openalex.org/W2157677850","https://openalex.org/W2162051951","https://openalex.org/W2163200614","https://openalex.org/W2164325911","https://openalex.org/W2165103770","https://openalex.org/W2166884462","https://openalex.org/W2167213027","https://openalex.org/W2275889189"],"related_works":["https://openalex.org/W2979433614","https://openalex.org/W1998980938","https://openalex.org/W2065239370","https://openalex.org/W7135057774","https://openalex.org/W2167878661","https://openalex.org/W3157607097","https://openalex.org/W4378648377","https://openalex.org/W2889225561","https://openalex.org/W2384966164","https://openalex.org/W3164012322"],"abstract_inverted_index":{"NAFLD":[0,34],"(non-alcoholic":[1,45],"fatty":[2],"liver":[3,68,115,247],"disease),":[4],"associated":[5,72],"with":[6,73,187],"obesity":[7],"and":[8,36,69,93,97,114,125,155,162,200,229,249,256],"the":[9,39,167,171,175,195,213,244],"cardiometabolic":[10],"syndrome,":[11],"is":[12,71],"an":[13],"important":[14],"medical":[15],"problem":[16],"affecting":[17],"up":[18],"to":[19,38,56,63,181,239,253],"20%":[20],"of":[21,43,123,130,170,184,192,246,260],"western":[22],"populations.":[23],"Evidence":[24],"indicates":[25],"that":[26,50,236],"mitochondrial":[27,51,117,206,230,261],"dysfunction":[28],"plays":[29],"a":[30,57,64,90,128,138,240],"critical":[31],"role":[32],"in":[33,67,166,198,205],"initiation":[35],"progression":[37],"more":[40],"serious":[41],"condition":[42],"NASH":[44],"steatohepatitis).":[46],"Herein":[47],"we":[48],"hypothesize":[49],"defects":[52],"induced":[53,143],"by":[54,77,133,147],"exposure":[55,238],"HFD":[58,94,139,176,214,241],"(high":[59],"fat":[60,107],"diet)":[61],"contribute":[62],"hypoxic":[65,254],"state":[66,220],"this":[70,84,250],"increased":[74,150,179,204],"protein":[75,131],"modification":[76,132,259],"RNS":[78],"(reactive":[79],"nitrogen":[80],"species).":[81],"To":[82],"test":[83],"concept,":[85],"C57BL/6":[86],"mice":[87,211],"were":[88,135,203],"pair-fed":[89],"control":[91,122],"diet":[92],"containing":[95],"35%":[96],"71%":[98],"total":[99],"calories":[100],"(1":[101],"cal":[102],"approximately":[103],"4.184":[104],"J)":[105],"from":[106,174,210],"respectively,":[108],"for":[109,140,215],"8":[110],"or":[111],"16":[112,141,216],"weeks":[113,142,217],"hypoxia,":[116],"bioenergetics,":[118],"NO":[119],"(nitric":[120],"oxide)-dependent":[121],"respiration,":[124,222,224],"3-NT":[126,193,201],"(3-nitrotyrosine),":[127],"marker":[129],"RNS,":[134],"examined.":[136],"Feeding":[137],"NASH-like":[144],"pathology":[145],"accompanied":[146],"elevated":[148],"triacylglycerols,":[149],"CYP2E1":[151],"(cytochrome":[152],"P450":[153],"2E1)":[154],"iNOS":[156],"(inducible":[157],"nitric":[158],"oxide":[159],"synthase)":[160],"protein,":[161],"significantly":[163],"enhanced":[164],"hypoxia":[165,196],"pericentral":[168],"region":[169],"liver.":[172],"Mitochondria":[173],"group":[177],"showed":[178],"sensitivity":[180],"NO-dependent":[182,258],"inhibition":[183],"respiration":[185],"compared":[186],"controls.":[188],"In":[189],"addition,":[190],"accumulation":[191],"paralleled":[194],"gradient":[197],"vivo":[199],"levels":[202],"proteins.":[207,262],"Liver":[208],"mitochondria":[209,248],"fed":[212],"exhibited":[218],"depressed":[219],"3":[221],"uncoupled":[223],"cytochrome":[225],"c":[226],"oxidase":[227],"activity,":[228],"membrane":[231],"potential.":[232],"These":[233],"findings":[234],"indicate":[235],"chronic":[237],"negatively":[242],"affects":[243],"bioenergetics":[245],"probably":[251],"contributes":[252],"stress":[255],"deleterious":[257]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}