{"id":"https://openalex.org/W2159575889","doi":"https://doi.org/10.1158/0008-5472.can-13-0594","title":"Loss of Androgen Receptor Expression Promotes a Stem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling","display_name":"Loss of Androgen Receptor Expression Promotes a Stem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2159575889","doi":"https://doi.org/10.1158/0008-5472.can-13-0594","mag":"2159575889","pmid":"https://pubmed.ncbi.nlm.nih.gov/24177177","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4539262"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-13-0594","doi":"https://doi.org/10.1158/0008-5472.can-13-0594","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-13-0594","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2159575889"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4539262/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057097411","display_name":"Anne Schroeder","orcid":"https://orcid.org/0000-0001-7442-1527","observed_orcids":["https://orcid.org/0000-0001-7442-1527"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Anne Schroeder","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4210120689","https://openalex.org/I4387156432","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andreas Herrmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Andreas Herrmann","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4210120689","https://openalex.org/I4387156432","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059624504","display_name":"Gregory Allan Cherryholmes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Gregory Cherryholmes","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4210120689","https://openalex.org/I4387156432","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025245155","display_name":"Claudia M. Kowolik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Claudia Kowolik","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4210120689","https://openalex.org/I4387156432","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112456022","display_name":"Ralf Buettner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Ralf Buettner","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4210120689","https://openalex.org/I4387156432","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041033274","display_name":"Sumanta Kumar Pal","orcid":"https://orcid.org/0000-0002-1712-0848","observed_orcids":["https://orcid.org/0000-0002-1712-0848"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Sumanta Pal","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4210120689","https://openalex.org/I4387156432","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012334511","display_name":"Hua Yu","orcid":"https://orcid.org/0000-0003-0931-1000","observed_orcids":["https://orcid.org/0000-0003-0931-1000"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Hua Yu","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4210120689","https://openalex.org/I4387156432","https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036852859","display_name":"Gerhard M\u00fcller\u2010Newen","orcid":"https://orcid.org/0000-0002-0820-7693","observed_orcids":["https://orcid.org/0000-0002-0820-7693"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Gerhard M\u00fcller-Newen","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4210120689","https://openalex.org/I4387156432","https://openalex.org/I887968799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022795218","display_name":"Richard Jove","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Richard Jove","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Molecular Medicine, 2Cancer Immunotherapy and Tumor Immunology, and 3Medical Oncology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California; and 4Institute for Biochemistry and Molecular Biology, Universit\u00e4tsklinikum RWTH Aachen, Aachen, Germany","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4210120689","https://openalex.org/I4387156432","https://openalex.org/I887968799"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5022795218"],"corresponding_institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4210120689","https://openalex.org/I4387156432","https://openalex.org/I887968799"],"apc_list":null,"apc_paid":null,"fwci":4.9691,"has_fulltext":false,"cited_by_count":200,"citation_normalized_percentile":{"value":0.96690477,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"74","issue":"4","first_page":"1227","last_page":"1237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9800000190734863},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.828000009059906},{"id":"https://openalex.org/keywords/cancer-stem-like-cells","display_name":"cancer stem-like cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.9940000176429749},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9440000057220459},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy-resistance","display_name":"androgen deprivation therapy resistance","score":0.671999990940094},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.844537615776062},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.7652537822723389},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6806502342224121},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6566969752311707},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6018365025520325},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.586450457572937},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.48762980103492737},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4716571867465973},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4515232443809509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4142736792564392},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34383857250213623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29683196544647217},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28833872079849243},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1441291868686676},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-13-0594","doi":"https://doi.org/10.1158/0008-5472.can-13-0594","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-13-0594","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:24177177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24177177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4539262","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4539262/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},{"id":"pmh:oai:publications.rwth-aachen.de:231496","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/record/231496","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer research 74(4), 1227-1237 (2014). doi:10.1158/0008-5472.CAN-13-0594","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4539262","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4539262/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4850162710","display_name":"Inhibitors in Src Signaling for Antitumor Therapy","funder_award_id":"R01CA115674","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1548640328","https://openalex.org/W1889152575","https://openalex.org/W1970733036","https://openalex.org/W1980714336","https://openalex.org/W1991997331","https://openalex.org/W2004624656","https://openalex.org/W2005658600","https://openalex.org/W2007278160","https://openalex.org/W2019491391","https://openalex.org/W2023457562","https://openalex.org/W2024282024","https://openalex.org/W2028401452","https://openalex.org/W2029275361","https://openalex.org/W2044227662","https://openalex.org/W2046510888","https://openalex.org/W2053298425","https://openalex.org/W2055438460","https://openalex.org/W2062069198","https://openalex.org/W2062165914","https://openalex.org/W2066235353","https://openalex.org/W2066647113","https://openalex.org/W2073069369","https://openalex.org/W2073100248","https://openalex.org/W2074356752","https://openalex.org/W2081748846","https://openalex.org/W2084748836","https://openalex.org/W2086840459","https://openalex.org/W2090496954","https://openalex.org/W2098016561","https://openalex.org/W2115585914","https://openalex.org/W2118310862","https://openalex.org/W2121826958","https://openalex.org/W2124224257","https://openalex.org/W2125200489","https://openalex.org/W2126913564","https://openalex.org/W2131078803","https://openalex.org/W2134987819","https://openalex.org/W2135177247","https://openalex.org/W2135454149","https://openalex.org/W2137958038","https://openalex.org/W2139520473","https://openalex.org/W2144713347","https://openalex.org/W2153086428","https://openalex.org/W2153382986","https://openalex.org/W2154052817","https://openalex.org/W2161347865","https://openalex.org/W2165469857","https://openalex.org/W2783142245","https://openalex.org/W6639300012","https://openalex.org/W6681285637"],"related_works":["https://openalex.org/W2061893006","https://openalex.org/W759487224","https://openalex.org/W7207907757","https://openalex.org/W2143211793","https://openalex.org/W2069303628","https://openalex.org/W2296373146","https://openalex.org/W2326837970","https://openalex.org/W2566324110","https://openalex.org/W1488407600","https://openalex.org/W4403953257"],"abstract_inverted_index":{"Androgen":[0],"receptor":[1,89],"(AR)":[2],"signaling":[3],"is":[4,77],"important":[5],"for":[6],"prostate":[7,33,43,53,100,117],"cancer":[8,34,44,57],"progression.":[9],"However,":[10],"androgen-deprivation":[11],"and/or":[12],"AR":[13,26,36,71,73,113],"targeting-based":[14],"therapies":[15],"often":[16],"lead":[17],"to":[18,40],"resistance.":[19],"Here,":[20],"we":[21],"demonstrate":[22],"that":[23],"loss":[24],"of":[25,42,112],"expression":[27],"results":[28],"in":[29,32,95,116],"STAT3":[30,67,75,94,115],"activation":[31,76],"cells.":[35],"downregulation":[37],"further":[38],"leads":[39],"development":[41],"stem-like":[45,58],"cells":[46,64,97],"(CSC),":[47],"which":[48],"requires":[49],"STAT3.":[50],"In":[51],"human":[52],"tumor":[54,96,101],"tissues,":[55],"elevated":[56],"cell":[59],"markers":[60],"coincide":[61],"with":[62,86],"those":[63],"exhibiting":[65],"high":[66],"activity":[68],"and":[69,103,114],"low":[70],"expression.":[72,83],"downregulation-induced":[74],"mediated":[78],"through":[79],"increased":[80],"interleukin":[81],"(IL)-6":[82],"Treating":[84],"mice":[85],"soluble":[87],"IL-6":[88],"fusion":[90],"protein":[91],"or":[92],"silencing":[93],"significantly":[98],"reduced":[99],"growth":[102],"CSCs.":[104],"Together,":[105],"these":[106],"findings":[107],"indicate":[108],"an":[109],"opposing":[110],"role":[111],"CSC":[118],"development.":[119]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":13}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}