{"id":"https://openalex.org/W2159498952","doi":"https://doi.org/10.1634/theoncologist.2009-0058","title":"Prognostic Significance of Epidermal Growth Factor Receptor Phosphorylation and Mutation in Head and Neck Squamous Cell Carcinoma","display_name":"Prognostic Significance of Epidermal Growth Factor Receptor Phosphorylation and Mutation in Head and Neck Squamous Cell Carcinoma","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W2159498952","doi":"https://doi.org/10.1634/theoncologist.2009-0058","mag":"2159498952","pmid":"https://pubmed.ncbi.nlm.nih.gov/19726454"},"language":"en","primary_location":{"id":"doi:10.1634/theoncologist.2009-0058","doi":"https://doi.org/10.1634/theoncologist.2009-0058","is_oa":false,"landing_page_url":"https://doi.org/10.1634/theoncologist.2009-0058","pdf_url":null,"source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024944463","display_name":"Takanori Hama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Hama","raw_affiliation_strings":["Department of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan","Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","aDivision of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","bDepartment of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"aDivision of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"bDepartment of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083825319","display_name":"Yuki Yuza","orcid":"https://orcid.org/0009-0003-6475-3394","observed_orcids":["https://orcid.org/0009-0003-6475-3394"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Yuza","raw_affiliation_strings":["Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan","cDepartment of Pediatrics, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"cDepartment of Pediatrics, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112208946","display_name":"Yoshimichi Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]},{"id":"https://openalex.org/I23172683","display_name":"Meiji Pharmaceutical University","ror":"https://ror.org/00wm7p047","country_code":"JP","type":"education","lineage":["https://openalex.org/I23172683"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimichi Saito","raw_affiliation_strings":["Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","Meiji Pharmaceutical University, Tokyo, Japan","aDivision of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","gMeiji Pharmaceutical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Meiji Pharmaceutical University, Tokyo, Japan","institution_ids":["https://openalex.org/I23172683"]},{"raw_affiliation_string":"aDivision of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"gMeiji Pharmaceutical University, Tokyo, Japan","institution_ids":["https://openalex.org/I23172683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019491267","display_name":"Jin O\u2010Uchi","orcid":"https://orcid.org/0000-0001-7566-5400","observed_orcids":["https://orcid.org/0000-0001-7566-5400","https://orcid.org/0000-0003-1890-3518"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jin O-uchi","raw_affiliation_strings":["Department of Physiology, Jikei University School of Medicine, Tokyo, Japan","dDepartment of Physiology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"dDepartment of Physiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024331685","display_name":"Shu Kondo","orcid":"https://orcid.org/0000-0002-4625-8379","observed_orcids":["https://orcid.org/0000-0002-4625-8379"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shu Kondo","raw_affiliation_strings":["Department of Anatomy, Jikei University School of Medicine, Tokyo, Japan","eDepartment of Anatomy, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"eDepartment of Anatomy, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063677770","display_name":"Masataka Okabe","orcid":"https://orcid.org/0000-0002-8618-6859","observed_orcids":["https://orcid.org/0000-0002-8618-6859"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masataka Okabe","raw_affiliation_strings":["Department of Anatomy, Jikei University School of Medicine, Tokyo, Japan","eDepartment of Anatomy, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"eDepartment of Anatomy, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019965481","display_name":"Hisashi Yamada","orcid":"https://orcid.org/0000-0002-0933-2330","observed_orcids":["https://orcid.org/0000-0002-0933-2330"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisashi Yamada","raw_affiliation_strings":["DNA Medicine Institute, Jikei University School of Medicine, Tokyo, Japan","fDNA Medicine Institute, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DNA Medicine Institute, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"fDNA Medicine Institute, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112148979","display_name":"Takakuni Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takakuni Kato","raw_affiliation_strings":["Department of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan","bDepartment of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"bDepartment of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019800005","display_name":"Hiroshi Moriyama","orcid":"https://orcid.org/0000-0002-9985-924X","observed_orcids":["https://orcid.org/0000-0002-9985-924X","https://orcid.org/0000-0003-4293-9297"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Moriyama","raw_affiliation_strings":["Department of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan","bDepartment of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"bDepartment of Oto-Rhino-Laryngology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037344196","display_name":"Satoshi Kurihara","orcid":"https://orcid.org/0009-0001-4374-4814","observed_orcids":["https://orcid.org/0009-0001-4374-4814"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Kurihara","raw_affiliation_strings":["Department of Physiology, Jikei University School of Medicine, Tokyo, Japan","dDepartment of Physiology, Jikei University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"dDepartment of Physiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075947539","display_name":"Mitsuyoshi Urashima","orcid":"https://orcid.org/0000-0002-7395-5831","observed_orcids":["https://orcid.org/0000-0002-7395-5831"]},"institutions":[{"id":"https://openalex.org/I115498069","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22","country_code":"JP","type":"education","lineage":["https://openalex.org/I115498069"]},{"id":"https://openalex.org/I23172683","display_name":"Meiji Pharmaceutical University","ror":"https://ror.org/00wm7p047","country_code":"JP","type":"education","lineage":["https://openalex.org/I23172683"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mitsuyoshi Urashima","raw_affiliation_strings":["Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","Meiji Pharmaceutical University, Tokyo, Japan","aDivision of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","gMeiji Pharmaceutical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"Meiji Pharmaceutical University, Tokyo, Japan","institution_ids":["https://openalex.org/I23172683"]},{"raw_affiliation_string":"aDivision of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I115498069"]},{"raw_affiliation_string":"gMeiji Pharmaceutical University, Tokyo, Japan","institution_ids":["https://openalex.org/I23172683"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075947539"],"corresponding_institution_ids":["https://openalex.org/I115498069","https://openalex.org/I23172683"],"apc_list":{"value":3852,"currency":"USD","value_usd":3852},"apc_paid":null,"fwci":8.1715,"has_fulltext":false,"cited_by_count":131,"citation_normalized_percentile":{"value":0.98228248,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"14","issue":"9","first_page":"900","last_page":"908"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.5371000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.5371000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.38530001044273376,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/egfr-phosphorylation","display_name":"EGFR phosphorylation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7670000195503235},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9210000038146973},{"id":"https://openalex.org/keywords/egfrviii","display_name":"EGFRvIII","score":0.5809999704360962},{"id":"https://openalex.org/keywords/egfr-l858r-mutation","display_name":"L858R mutation","score":0.800000011920929},{"id":"https://openalex.org/keywords/metastatic-lymph-nodes","display_name":"metastatic lymph nodes","score":0.7379999756813049},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.6830000281333923},{"id":"https://openalex.org/keywords/egfr-overexpression","display_name":"EGFR overexpression","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.8177142143249512},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7198306322097778},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6571242809295654},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5807377696037292},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5768935084342957},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5625510811805725},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5383530259132385},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5098568797111511},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5012073516845703},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.49735215306282043},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4463983178138733},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.418915331363678},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4120030701160431},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37130382657051086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19418060779571533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17502731084823608},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1634/theoncologist.2009-0058","doi":"https://doi.org/10.1634/theoncologist.2009-0058","is_oa":false,"landing_page_url":"https://doi.org/10.1634/theoncologist.2009-0058","pdf_url":null,"source":{"id":"https://openalex.org/S15523509","display_name":"The Oncologist","issn_l":"1083-7159","issn":["1083-7159","1549-490X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316295","host_organization_name":"AlphaMed Press","host_organization_lineage":["https://openalex.org/P4310316295"],"host_organization_lineage_names":["AlphaMed Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Oncologist","raw_type":"journal-article"},{"id":"pmid:19726454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19726454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The oncologist","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.977.9713","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.977.9713","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://theoncologist.alphamedpress.org/content/14/9/900.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320324809","display_name":"Jikei University School of Medicine","ror":"https://ror.org/039ygjf22"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1981138318","https://openalex.org/W2005204942","https://openalex.org/W2009193372","https://openalex.org/W2011603871","https://openalex.org/W2023532383","https://openalex.org/W2031981401","https://openalex.org/W2043696829","https://openalex.org/W2056082272","https://openalex.org/W2061446835","https://openalex.org/W2065251641","https://openalex.org/W2075264134","https://openalex.org/W2080373512","https://openalex.org/W2102639464","https://openalex.org/W2118135682","https://openalex.org/W2140407529","https://openalex.org/W2142845167","https://openalex.org/W2143171062","https://openalex.org/W2149447281","https://openalex.org/W2152332206","https://openalex.org/W2155384808","https://openalex.org/W2161821474","https://openalex.org/W2162291351","https://openalex.org/W2164738374","https://openalex.org/W2288483565","https://openalex.org/W6684057760"],"related_works":["https://openalex.org/W7098382493","https://openalex.org/W2049723491","https://openalex.org/W2116123484","https://openalex.org/W2149412903","https://openalex.org/W3155814144","https://openalex.org/W2102639464","https://openalex.org/W2050161865","https://openalex.org/W2078805504","https://openalex.org/W2067608199","https://openalex.org/W1999427737"],"abstract_inverted_index":{"The":[0],"molecular":[1,56,86],"status":[2,40,57],"of":[3,32,41,97,140,164,169,174,185,226,245],"the":[4,30,38,42,98,137,162,172,194,230],"epidermal":[5],"growth":[6],"factor":[7],"receptor":[8],"(EGFR)":[9],"has":[10],"not":[11,81,132],"been":[12,82],"as":[13,24,35,37,143,151,153],"well":[14,36,152],"studied":[15],"in":[16,25,45,118,124,136,145,248],"head":[17],"and":[18,58,61,71,93,95,112,114,149,178,224],"neck":[19],"squamous":[20],"cell":[21],"carcinoma":[22],"(HNSCC)":[23],"lung":[26,119],"cancer.":[27],"We":[28],"examined":[29],"frequencies":[31],"EGFR":[33,43,55,85,90,99,190,206,227,238],"mutations":[34,108,135,159,191,240],"expression/phosphorylation":[39],"protein":[44,100,228],"HNSCC":[46,126],"patients.":[47],"Moreover,":[48],"we":[49,130],"tried":[50],"to":[51,156],"elucidate":[52],"associations":[53],"between":[54],"patient":[59,170],"characteristics":[60],"disease-free":[62],"survival.":[63],"In":[64,167,235],"this":[65,146],"prospective":[66],"cohort":[67],"study,":[68],"clinical":[69],"data":[70],"samples":[72,127,203],"were":[73,101,122,181],"obtained":[74],"from":[75],"82":[76],"consecutive":[77],"patients":[78,188,200,249],"who":[79],"had":[80],"treated":[83],"with":[84,183,189,250],"targeting":[87],"therapy.":[88],"Full-length":[89],"was":[91,217],"sequenced,":[92],"expression":[94],"phosphorylation":[96,184],"measured":[102],"by":[103],"Western":[104],"blotting.":[105],"Four":[106],"novel":[107],"(E709K,":[109],"V765G,":[110],"Ins770G,":[111],"G1022S)":[113],"one":[115],"mutation":[116,223],"well-known":[117],"cancer":[120],"(L858R)":[121],"identified":[123],"six":[125],"(7%),":[128],"but":[129],"could":[131],"find":[133],"any":[134],"extracellular":[138],"domain":[139],"EGFR,":[141],"such":[142],"EGFRvIII,":[144],"study.":[147],"E709K":[148],"Ins770G":[150],"L858R":[154],"appear":[155],"be":[157,242],"functional":[158],"based":[160],"on":[161],"use":[163],"Ba/F3":[165],"cells.":[166],"terms":[168],"characteristics,":[171],"number":[173],"metastatic":[175],"lymph":[176],"nodes":[177],"node":[179],"stage":[180],"associated":[182],"EGFR.":[186,214],"No":[187],"relapsed":[192,207],"during":[193],"study":[195],"period.":[196],"Excluding":[197],"mutated":[198],"cases,":[199],"whose":[201],"tumor":[202],"showed":[204],"phosphorylated":[205,213,237],"significantly":[208],"earlier":[209],"than":[210],"those":[211],"without":[212,239],"This":[215],"finding":[216],"still":[218],"significant":[219],"after":[220],"adjusting":[221],"for":[222],"overexpression":[225],"using":[229],"Cox":[231],"proportional":[232],"hazard":[233],"model.":[234],"conclusion,":[236],"may":[241],"a":[243],"marker":[244],"poor":[246],"prognosis":[247],"HNSCC.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
