{"id":"https://openalex.org/W2159495568","doi":"https://doi.org/10.1242/jcs.082271","title":"Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity","display_name":"Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity","publication_year":2011,"publication_date":"2011-04-12","ids":{"openalex":"https://openalex.org/W2159495568","doi":"https://doi.org/10.1242/jcs.082271","mag":"2159495568","pmid":"https://pubmed.ncbi.nlm.nih.gov/21486942","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3078814"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.082271","doi":"https://doi.org/10.1242/jcs.082271","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.082271","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3078814","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062499279","display_name":"Jamie R. Privratsky","orcid":"https://orcid.org/0000-0003-3598-4911","observed_orcids":["https://orcid.org/0000-0003-3598-4911"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie R. Privratsky","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA","Department of Pharmacology, Medical College of Wisconsin, Milwaukee, WI 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Medical College of Wisconsin, Milwaukee, WI 53226, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076149795","display_name":"Cathy M. Paddock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cathy M. Paddock","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033694495","display_name":"Oliver Florey","orcid":"https://orcid.org/0000-0002-1075-7424","observed_orcids":["https://orcid.org/0000-0002-1075-7424"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oliver Florey","raw_affiliation_strings":["Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-3008, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-3008, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041058094","display_name":"Debra K. Newman","orcid":"https://orcid.org/0000-0001-9674-0801","observed_orcids":["https://orcid.org/0000-0001-9674-0801"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra K. Newman","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA","Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA","Department of Pharmacology, Medical College of Wisconsin, Milwaukee, WI 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Pharmacology, Medical College of Wisconsin, Milwaukee, WI 53226, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043301854","display_name":"William A. M\u00fcller","orcid":"https://orcid.org/0000-0002-4802-2757","observed_orcids":["https://orcid.org/0000-0002-4802-2757"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Muller","raw_affiliation_strings":["Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-3008, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-3008, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043749891","display_name":"Peter J. Newman","orcid":"https://orcid.org/0000-0001-8853-7707","observed_orcids":["https://orcid.org/0000-0001-8853-7707"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter J. Newman","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA","Department of Cellular Biology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA","Department of Pharmacology, Medical College of Wisconsin, Milwaukee, WI 53226, USA","The Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53201, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Pharmacology, Medical College of Wisconsin, Milwaukee, WI 53226, USA","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"The Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043749891"],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":null,"apc_paid":null,"fwci":5.0346,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.95037739,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"124","issue":"9","first_page":"1477","last_page":"1485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.996999979019165},{"id":"https://openalex.org/keywords/endothelial-barrier-integrity","display_name":"endothelial barrier integrity","score":0.777999997138977},{"id":"https://openalex.org/keywords/homophilic-adhesion","display_name":"homophilic adhesion","score":0.8149999976158142},{"id":"https://openalex.org/keywords/endothelial-junctions","display_name":"endothelial junctions","score":0.8809999823570251},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8382300138473511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7399841547012329},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.6565470695495605},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5267488360404968},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5091277956962585},{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.4796907603740692},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.4508190453052521},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.4432125389575958},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4370521008968353},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4282287359237671},{"id":"https://openalex.org/C2781380885","wikidata":"https://www.wikidata.org/wiki/Q17859848","display_name":"VE-cadherin","level":4,"score":0.4199771285057068},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3503261208534241},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.18421882390975952},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12072640657424927},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.08626940846443176},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07265430688858032},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06991517543792725}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019408","descriptor_name":"Platelet Endothelial Cell Adhesion Molecule-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019408","descriptor_name":"Platelet Endothelial Cell Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1242/jcs.082271","doi":"https://doi.org/10.1242/jcs.082271","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.082271","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2344239","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3078814","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3078814","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3078814","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Sci","raw_type":"Text"},{"id":"pmid:21486942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21486942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2344239","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3078814","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1898485612","display_name":null,"funder_award_id":"HL-40926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G274113493","display_name":"The Roles of Endothelial PECAM and the LBRC in Leukocyte Transmigration","funder_award_id":"R01HL046849","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2848816873","display_name":"Beyond PECAM: Mechanisms of Transendothelial Migration","funder_award_id":"R37HL064774","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3962194529","display_name":null,"funder_award_id":"HL 46849","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6237039664","display_name":"Molecular Biology and Function of PECAM-1","funder_award_id":"R01HL040926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W274441265","https://openalex.org/W1511482735","https://openalex.org/W1535701012","https://openalex.org/W1544261227","https://openalex.org/W1553909464","https://openalex.org/W1578101184","https://openalex.org/W1603593764","https://openalex.org/W1739820884","https://openalex.org/W1873722097","https://openalex.org/W1901517851","https://openalex.org/W1938205630","https://openalex.org/W1964079012","https://openalex.org/W1969448383","https://openalex.org/W1970143570","https://openalex.org/W1973054747","https://openalex.org/W1982687474","https://openalex.org/W1986070215","https://openalex.org/W1991558659","https://openalex.org/W2001456643","https://openalex.org/W2014993261","https://openalex.org/W2018587071","https://openalex.org/W2019055633","https://openalex.org/W2026252047","https://openalex.org/W2027995863","https://openalex.org/W2030385020","https://openalex.org/W2033546665","https://openalex.org/W2037150903","https://openalex.org/W2037188857","https://openalex.org/W2038628992","https://openalex.org/W2039710381","https://openalex.org/W2040322459","https://openalex.org/W2049760106","https://openalex.org/W2049866297","https://openalex.org/W2055755227","https://openalex.org/W2056027939","https://openalex.org/W2056337748","https://openalex.org/W2058067037","https://openalex.org/W2061235037","https://openalex.org/W2061344749","https://openalex.org/W2063975983","https://openalex.org/W2074466423","https://openalex.org/W2076544464","https://openalex.org/W2078219311","https://openalex.org/W2079583982","https://openalex.org/W2083052252","https://openalex.org/W2084147384","https://openalex.org/W2086905823","https://openalex.org/W2088220499","https://openalex.org/W2092590506","https://openalex.org/W2095828707","https://openalex.org/W2100454870","https://openalex.org/W2102015925","https://openalex.org/W2117560579","https://openalex.org/W2120691494","https://openalex.org/W2128214001","https://openalex.org/W2128428920","https://openalex.org/W2131882767","https://openalex.org/W2133885225","https://openalex.org/W2137997760","https://openalex.org/W2139660045","https://openalex.org/W2141908703","https://openalex.org/W2148245148","https://openalex.org/W2148511071","https://openalex.org/W2152364499","https://openalex.org/W2152532559","https://openalex.org/W2153909067","https://openalex.org/W2158323899","https://openalex.org/W2159265736","https://openalex.org/W2166833739","https://openalex.org/W2167532406","https://openalex.org/W2169778726","https://openalex.org/W2189322842","https://openalex.org/W2400600154","https://openalex.org/W2417318333","https://openalex.org/W4229609280","https://openalex.org/W6645797160","https://openalex.org/W6712589528"],"related_works":["https://openalex.org/W2008447781","https://openalex.org/W2177456672","https://openalex.org/W2317982666","https://openalex.org/W2083052252","https://openalex.org/W2979660149","https://openalex.org/W2005345468","https://openalex.org/W1997146483","https://openalex.org/W2546387251","https://openalex.org/W2160811005","https://openalex.org/W4200295300"],"abstract_inverted_index":{"PECAM-1":[0,25,59,120,137,153],"(CD31)":[1],"is":[2,10],"a":[3,131],"cellular":[4],"adhesion":[5,61],"and":[6,124],"signaling":[7,185],"receptor":[8],"that":[9,64,176],"highly":[11],"expressed":[12],"at":[13],"endothelial":[14,77,80,102,192],"cell-cell":[15,128],"junctions":[16],"in":[17,26,147,161],"confluent":[18],"vascular":[19,30],"beds.":[20],"Previous":[21],"studies":[22,174],"have":[23],"implicated":[24],"the":[27,34,47,54,101,117,189],"maintenance":[28],"of":[29,46,58,94,100,107,119,136,191],"barrier":[31,38,69,86,95,109,143,169],"integrity;":[32],"however,":[33],"mechanisms":[35],"behind":[36],"PECAM-1-mediated":[37,108,162],"protection":[39,110],"are":[40,180],"still":[41],"poorly":[42],"understood.":[43],"The":[44,105],"goal":[45],"present":[48],"study,":[49],"therefore,":[50],"was":[51,111,138],"to":[52,67,113,116,121,127,140,158,167],"examine":[53],"pertinent":[55],"biological":[56],"properties":[57],"(i.e.":[60],"and/or":[62],"signaling)":[63],"allow":[65],"it":[66],"support":[68,141],"integrity.":[70,170],"We":[71],"found":[72,112],"that,":[73],"compared":[74],"with":[75],"PECAM-1-deficient":[76],"cells,":[78],"PECAM-1-expressing":[79],"cell":[81,103,193],"monolayers":[82],"exhibit":[83],"increased":[84],"steady-state":[85],"function,":[87],"as":[88,90],"well":[89],"more":[91,181],"rapid":[92],"restoration":[93],"integrity":[96,190],"following":[97],"thrombin-induced":[98],"perturbation":[99],"monolayer.":[104],"majority":[106],"be":[114,159],"due":[115],"ability":[118],"interact":[122],"homophilically":[123],"become":[125],"localized":[126],"junctions,":[129],"because":[130],"homophilic":[132,178],"binding-crippled":[133],"mutant":[134],"form":[135],"unable":[139],"efficient":[142],"function":[144,186],"when":[145],"re-expressed":[146],"cells.":[148],"By":[149],"contrast,":[150],"cells":[151],"expressing":[152],"variants":[154],"lacking":[155],"residues":[156],"known":[157],"involved":[160],"signal":[163],"transduction":[164],"exhibited":[165],"normal":[166],"near-normal":[168],"Taken":[171],"together,":[172],"these":[173],"suggest":[175],"PECAM-1-PECAM-1":[177],"interactions":[179],"important":[182],"than":[183],"its":[184],"for":[187],"maintaining":[188],"junctions.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
