{"id":"https://openalex.org/W2159488456","doi":"https://doi.org/10.1186/s12931-015-0225-3","title":"Accelerated extracellular matrix turnover during exacerbations of COPD","display_name":"Accelerated extracellular matrix turnover during exacerbations of COPD","publication_year":2015,"publication_date":"2015-06-10","ids":{"openalex":"https://openalex.org/W2159488456","doi":"https://doi.org/10.1186/s12931-015-0225-3","mag":"2159488456","pmid":"https://pubmed.ncbi.nlm.nih.gov/26062683","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4491243"},"language":"en","primary_location":{"id":"doi:10.1186/s12931-015-0225-3","doi":"https://doi.org/10.1186/s12931-015-0225-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-015-0225-3","pdf_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-015-0225-3","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-015-0225-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076601121","display_name":"Jannie Marie B\u00fclow Sand","orcid":"https://orcid.org/0000-0002-3239-0934","observed_orcids":["https://orcid.org/0000-0002-3239-0934"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Jannie M. B. Sand","raw_affiliation_strings":["Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark. jsa@nordicbioscience.com","Section of Social Medicine, Institute of Public Health, University of Copenhagen, Oester Farimagsgade 5, 1014, Copenhagen K, Denmark. jsa@nordicbioscience.com","Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark. jsa@nordicbioscience.com","institution_ids":["https://openalex.org/I4210142214"]},{"raw_affiliation_string":"Section of Social Medicine, Institute of Public Health, University of Copenhagen, Oester Farimagsgade 5, 1014, Copenhagen K, Denmark. jsa@nordicbioscience.com","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071572427","display_name":"Alan J. Knox","orcid":"https://orcid.org/0000-0002-5906-4143","observed_orcids":["https://orcid.org/0000-0002-5906-4143"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan J. Knox","raw_affiliation_strings":["Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK. alan.knox@nottingham.ac.uk","Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK. alan.knox@nottingham.ac.uk","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003111166","display_name":"Peter Lange","orcid":"https://orcid.org/0000-0003-0401-0081","observed_orcids":["https://orcid.org/0000-0003-0401-0081"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter Lange","raw_affiliation_strings":["Section of Respiratory Medicine, Hvidovre Hospital, Kettegaards Alle 30, 2650, Hvidovre, Denmark. peter.lange@sund.ku.dk","Section of Social Medicine, Institute of Public Health, University of Copenhagen, Oester Farimagsgade 5, 1014, Copenhagen K, Denmark. peter.lange@sund.ku.dk","Section of Social Medicine, Institute of Public Health, University of Copenhagen, Oester Farimagsgade 5, 1014, Copenhagen K, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Respiratory Medicine, Hvidovre Hospital, Kettegaards Alle 30, 2650, Hvidovre, Denmark. peter.lange@sund.ku.dk","institution_ids":["https://openalex.org/I2801942218"]},{"raw_affiliation_string":"Section of Social Medicine, Institute of Public Health, University of Copenhagen, Oester Farimagsgade 5, 1014, Copenhagen K, Denmark. peter.lange@sund.ku.dk","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Section of Social Medicine, Institute of Public Health, University of Copenhagen, Oester Farimagsgade 5, 1014, Copenhagen K, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087875931","display_name":"Shu Sun","orcid":"https://orcid.org/0000-0002-2477-8904","observed_orcids":["https://orcid.org/0000-0002-2477-8904"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Shu Sun","raw_affiliation_strings":["Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark. ssu@nordicbioscience.com","Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark. ssu@nordicbioscience.com","institution_ids":["https://openalex.org/I4210142214"]},{"raw_affiliation_string":"Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048746698","display_name":"Jacob Hull Kristensen","orcid":"https://orcid.org/0000-0002-8467-0989","observed_orcids":["https://orcid.org/0000-0002-8467-0989"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jacob H. Kristensen","raw_affiliation_strings":["Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark. jhk@nordicbioscience.com","Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark. jhk@nordicbioscience.com","institution_ids":["https://openalex.org/I4210142214"]},{"raw_affiliation_string":"Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054029103","display_name":"Diana Julie Leeming","orcid":"https://orcid.org/0000-0002-4256-140X","observed_orcids":["https://orcid.org/0000-0002-4256-140X"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Diana J. Leeming","raw_affiliation_strings":["Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark. djl@nordicbioscience.com","Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark. djl@nordicbioscience.com","institution_ids":["https://openalex.org/I4210142214"]},{"raw_affiliation_string":"Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063475809","display_name":"M.A. Karsdal","orcid":"https://orcid.org/0000-0001-5026-8740","observed_orcids":["https://orcid.org/0000-0001-5026-8740"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten A. Karsdal","raw_affiliation_strings":["Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark. mk@nordicbioscience.com","Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark. mk@nordicbioscience.com","institution_ids":["https://openalex.org/I4210142214"]},{"raw_affiliation_string":"Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 207, 2730, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064580984","display_name":"Charlotte E. Bolton","orcid":"https://orcid.org/0000-0002-9578-2249","observed_orcids":["https://orcid.org/0000-0002-9578-2249"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charlotte E. Bolton","raw_affiliation_strings":["Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK. charlotte.bolton@nottingham.ac.uk","Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK. charlotte.bolton@nottingham.ac.uk","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017673380","display_name":"Simon R. Johnson","orcid":"https://orcid.org/0000-0002-9837-2763","observed_orcids":["https://orcid.org/0000-0002-9837-2763"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon R. Johnson","raw_affiliation_strings":["Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK. simon.johnson@nottingham.ac.uk","Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK. simon.johnson@nottingham.ac.uk","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"Division of Respiratory Medicine and Nottingham Respiratory Research Unit, University of Nottingham, Hucknall Road, Nottingham, NG5 1 PB, UK","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076601121"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I4210142214"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":8.3749,"has_fulltext":true,"cited_by_count":101,"citation_normalized_percentile":{"value":0.98238101,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"16","issue":"1","first_page":"69","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.8889999985694885},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.9459999799728394},{"id":"https://openalex.org/keywords/extracellular-matrix-turnover","display_name":"extracellular matrix turnover","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-remodeling","display_name":"lung remodeling","score":0.4909999966621399},{"id":"https://openalex.org/keywords/disease-activity-markers","display_name":"disease activity markers","score":0.8690000176429749},{"id":"https://openalex.org/keywords/type-iii-collagen","display_name":"type III collagen","score":0.7110000252723694},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.9929999709129333},{"id":"https://openalex.org/keywords/collagen-vi","display_name":"collagen VI","score":0.9990000128746033},{"id":"https://openalex.org/keywords/elastin-degradation","display_name":"elastin degradation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/versican","display_name":"versican","score":0.9520000219345093},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6469611525535583},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.6013080477714539},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3967520594596863},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37890899181365967},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3353763818740845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2896820306777954},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25845539569854736}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12931-015-0225-3","doi":"https://doi.org/10.1186/s12931-015-0225-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-015-0225-3","pdf_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-015-0225-3","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3455968","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4491243","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4491243","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4491243","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respir Res","raw_type":"Text"},{"id":"pmid:26062683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26062683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory research","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/28165c1b-7b97-4802-9521-513a55c07aa8","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/28165c1b-7b97-4802-9521-513a55c07aa8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sand, J M B, Knox, A J, Lange, P, Sun, S, Kristensen, J H, Leeming, D J, Karsdal, M A, Bolton, C E & Johnson, S R 2015, 'Accelerated extracellular matrix turnover during exacerbations of COPD', Respiratory research, vol. 16, no. 69, 69, pp. 1-8. https://doi.org/10.1186/s12931-015-0225-3","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12931-015-0225-3","doi":"https://doi.org/10.1186/s12931-015-0225-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-015-0225-3","pdf_url":"https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-015-0225-3","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G6015288888","display_name":"Nottingham Molecular Pathology Node (NMPN) for Integrated Multi-platform Biomarker Research and Knowledge Transfer","funder_award_id":"MR/N005953/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320324","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58"},{"id":"https://openalex.org/F4320333848","display_name":"Forsknings- og Innovationsstyrelsen","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334770","display_name":"Danish Agency for Science and Higher Education","ror":"https://ror.org/03ge1nb22"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159488456.pdf","grobid_xml":"https://content.openalex.org/works/W2159488456.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W15077488","https://openalex.org/W169268049","https://openalex.org/W1586233199","https://openalex.org/W1877809213","https://openalex.org/W1893181623","https://openalex.org/W1964731186","https://openalex.org/W1965451386","https://openalex.org/W1973087217","https://openalex.org/W1994863837","https://openalex.org/W2002726093","https://openalex.org/W2007777985","https://openalex.org/W2030993607","https://openalex.org/W2046246972","https://openalex.org/W2049422998","https://openalex.org/W2052792098","https://openalex.org/W2065752901","https://openalex.org/W2069533740","https://openalex.org/W2087244516","https://openalex.org/W2094653660","https://openalex.org/W2094874764","https://openalex.org/W2102920083","https://openalex.org/W2103392464","https://openalex.org/W2103883318","https://openalex.org/W2112162293","https://openalex.org/W2117837864","https://openalex.org/W2123084333","https://openalex.org/W2127301082","https://openalex.org/W2127951128","https://openalex.org/W2128446020","https://openalex.org/W2129238234","https://openalex.org/W2136037247","https://openalex.org/W2137284441","https://openalex.org/W2149849734","https://openalex.org/W2156754528","https://openalex.org/W2163457429","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2518126672","https://openalex.org/W3096406805","https://openalex.org/W2560026523","https://openalex.org/W2810183781","https://openalex.org/W2575124789","https://openalex.org/W1988889902","https://openalex.org/W7165778779","https://openalex.org/W2776472883","https://openalex.org/W2621093525","https://openalex.org/W2526809150"],"abstract_inverted_index":{"BACKGROUND:":[0],"Exacerbations":[1,211],"of":[2,33,51,58,66,74,111,133,144,156,192,212,218,221,229],"chronic":[3],"obstructive":[4],"pulmonary":[5],"disease":[6,11,34,38,59,230,249],"(COPD)":[7],"contribute":[8],"significantly":[9],"to":[10,160,248],"progression.":[12,39,250],"However,":[13],"the":[14,64,107],"effect":[15],"on":[16],"tissue":[17],"structure":[18],"and":[19,48,89,109,116,122,125,128,131,136,138,149,176,202,204],"turnover":[20,43,53,65,241],"is":[21,26],"not":[22],"well":[23],"described.":[24],"There":[25],"an":[27,83,154],"urgent":[28],"clinical":[29],"need":[30],"for":[31,82,91,198,206],"biomarkers":[32,57],"activity":[35,45],"associated":[36],"with":[37,79,236],"Extracellular":[40],"matrix":[41],"(ECM)":[42],"reflects":[44],"in":[46,102,215],"tissues":[47],"consequently":[49],"assessment":[50],"ECM":[52,68,240],"may":[54,225,245],"serve":[55,226],"as":[56,158,227],"activity.":[60,231],"We":[61],"hypothesized":[62],"that":[63,234],"lung":[67],"proteins":[69],"were":[70,85,151,168,174,180,188,196],"altered":[71],"during":[72,153,182,242],"exacerbations":[73,243],"COPD.":[75],"METHODS:":[76],"69":[77],"patients":[78,235],"COPD":[80,157,213,237],"hospitalised":[81],"exacerbation":[84,155,183],"recruited":[86],"at":[87],"admission":[88],"returned":[90],"a":[92],"4":[93],"weeks":[94],"follow-up.":[95],"Competitive":[96],"ELISAs":[97],"measuring":[98],"circulating":[99,219],"protein":[100],"fragments":[101,220],"serum":[103],"or":[104],"plasma":[105],"assessed":[106],"formation":[108],"degradation":[110,132],"collagen":[112,199,207],"types":[113,200],"III":[114,201],"(Pro-C3":[115],"C3M,":[117,145],"respectively),":[118,124,130],"IV":[119],"(P4NP":[120],"7S":[121,178],"C4M,":[123,146],"VI":[126,203],"(Pro-C6":[127],"C6M,":[129,147],"elastin":[134],"(ELM7":[135],"EL-NE)":[137],"versican":[139],"(VCANM).":[140],"RESULTS:":[141],"Circulating":[142],"levels":[143,167,173,179,187,217],"ELM7,":[148],"EL-NE":[150],"elevated":[152,181,216],"compared":[159],"follow-up":[161],"(all":[162],"P":[163],"<0.0001),":[164],"while":[165],"VCANM":[166],"decreased":[169,175,205],"(P":[170,184],"<0.0001).":[171,185],"Pro-C6":[172],"P4NP":[177],"Pro-C3":[186],"unchanged.":[189],"At":[190],"time":[191],"exacerbation,":[193],"degradation/formation":[194],"ratios":[195],"increased":[197],"type":[208],"IV.":[209],"CONCLUSIONS:":[210],"resulted":[214],"structural":[222],"proteins,":[223],"which":[224,244],"markers":[228],"This":[232],"suggests":[233],"have":[238],"accelerated":[239],"be":[246],"related":[247]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}