{"id":"https://openalex.org/W2159478263","doi":"https://doi.org/10.1183/09031936.00067307","title":"Use of a T-cell interferon-\u03b3 release assay for the diagnosis of tuberculous pleurisy","display_name":"Use of a T-cell interferon-\u03b3 release assay for the diagnosis of tuberculous pleurisy","publication_year":2007,"publication_date":"2007-08-22","ids":{"openalex":"https://openalex.org/W2159478263","doi":"https://doi.org/10.1183/09031936.00067307","mag":"2159478263","pmid":"https://pubmed.ncbi.nlm.nih.gov/17715165"},"language":"en","primary_location":{"id":"doi:10.1183/09031936.00067307","doi":"https://doi.org/10.1183/09031936.00067307","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.00067307","pdf_url":"https://erj.ersjournals.com/content/erj/30/6/1173.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://erj.ersjournals.com/content/erj/30/6/1173.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067394201","display_name":"Monica Losi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210094195","display_name":"Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda","ror":"https://ror.org/00htrxv69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094195"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Losi","raw_affiliation_strings":["Dept of Oncology and Hematology, University of Modena and Reggio Emilia, Italy","Dept of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, \"","Emerging Bacterial Pathogen Unit, San Raffaele Hospital, Milan, Italy,","Niguarda Hospital,","Section of Respiratory Disease,","TB Reg. Ref. Centre, Villa Marelli,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Oncology and Hematology, University of Modena and Reggio Emilia, Italy","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Dept of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, \"","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Emerging Bacterial Pathogen Unit, San Raffaele Hospital, Milan, Italy,","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"Niguarda Hospital,","institution_ids":["https://openalex.org/I4210094195"]},{"raw_affiliation_string":"Section of Respiratory Disease,","institution_ids":[]},{"raw_affiliation_string":"TB Reg. Ref. Centre, Villa Marelli,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108567406","display_name":"Aik W. J. Bossink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. Bossink","raw_affiliation_strings":["Depts of Pulmonary Diseases and Tuberculosis and e Medical Microbiology and Immunology, Diakonessenhuis Utrecht, Utrecht, The Netherlands,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depts of Pulmonary Diseases and Tuberculosis and e Medical Microbiology and Immunology, Diakonessenhuis Utrecht, Utrecht, The Netherlands,","institution_ids":["https://openalex.org/I4210106388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078276517","display_name":"Luigi Ruffo Codecasa","orcid":"https://orcid.org/0000-0001-6825-2050","observed_orcids":["https://orcid.org/0000-0001-6825-2050"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L. Codecasa","raw_affiliation_strings":["European Tuberculosis Network TBNET","Division of Clinical Infectious Diseases Medical Clinic Research Center Borstel Borstel Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Tuberculosis Network TBNET","institution_ids":[]},{"raw_affiliation_string":"Division of Clinical Infectious Diseases Medical Clinic Research Center Borstel Borstel Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083364006","display_name":"Claudia Jafari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Jafari","raw_affiliation_strings":["Division of Clinical Infectious Diseases , and","Division of Clinical Infectious Diseases,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Infectious Diseases , and","institution_ids":[]},{"raw_affiliation_string":"Division of Clinical Infectious Diseases,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056150399","display_name":"Martin Ernst","orcid":"https://orcid.org/0000-0001-9003-3823","observed_orcids":["https://orcid.org/0000-0001-9003-3823"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Ernst","raw_affiliation_strings":["Immune-cell Analytics, Research Center Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune-cell Analytics, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066494790","display_name":"Steven F. T. Thijsen","orcid":"https://orcid.org/0009-0000-8411-1653","observed_orcids":["https://orcid.org/0009-0000-8411-1653"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Thijsen","raw_affiliation_strings":["AFFILIATIONS","Division of Clinical Infectious Diseases Medical Clinic Research Center Borstel Borstel Germany","European Tuberculosis Network TBNET"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AFFILIATIONS","institution_ids":[]},{"raw_affiliation_string":"Division of Clinical Infectious Diseases Medical Clinic Research Center Borstel Borstel Germany","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"European Tuberculosis Network TBNET","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090984399","display_name":"Daniela Mar\u00eda Cirillo","orcid":"https://orcid.org/0000-0001-6415-1535","observed_orcids":["https://orcid.org/0000-0001-6415-1535"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Cirillo","raw_affiliation_strings":["Division of Clinical Infectious Diseases Medical Clinic Research Center Borstel Borstel Germany","European Tuberculosis Network TBNET"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Infectious Diseases Medical Clinic Research Center Borstel Borstel Germany","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"European Tuberculosis Network TBNET","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014722811","display_name":"Maurizio Ferrarese","orcid":"https://orcid.org/0009-0006-0760-9304","observed_orcids":["https://orcid.org/0009-0006-0760-9304"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Ferrarese","raw_affiliation_strings":["European Tuberculosis Network TBNET","Division of Clinical Infectious Diseases Medical Clinic Research Center Borstel Borstel Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Tuberculosis Network TBNET","institution_ids":[]},{"raw_affiliation_string":"Division of Clinical Infectious Diseases Medical Clinic Research Center Borstel Borstel Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090699293","display_name":"Ulf Greinert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U. Greinert","raw_affiliation_strings":["European Tuberculosis Network TBNET","Division of Clinical Infectious Diseases,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Tuberculosis Network TBNET","institution_ids":[]},{"raw_affiliation_string":"Division of Clinical Infectious Diseases,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010278392","display_name":"Leonardo Michele Fabbri","orcid":"https://orcid.org/0000-0001-8894-1689","observed_orcids":["https://orcid.org/0000-0001-8894-1689"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210094195","display_name":"Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda","ror":"https://ror.org/00htrxv69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094195"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. M. Fabbri","raw_affiliation_strings":["Emerging Bacterial Pathogen Unit, San Raffaele Hospital, Milan, Italy,","Section of Respiratory Disease,","Dept of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, \"","Niguarda Hospital,","TB Reg. Ref. Centre, Villa Marelli,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emerging Bacterial Pathogen Unit, San Raffaele Hospital, Milan, Italy,","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"Section of Respiratory Disease,","institution_ids":[]},{"raw_affiliation_string":"Dept of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, \"","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Niguarda Hospital,","institution_ids":["https://openalex.org/I4210094195"]},{"raw_affiliation_string":"TB Reg. Ref. Centre, Villa Marelli,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019441565","display_name":"Luca Richeldi","orcid":"https://orcid.org/0000-0001-8594-1448","observed_orcids":["https://orcid.org/0000-0001-8594-1448"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210094195","display_name":"Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda","ror":"https://ror.org/00htrxv69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094195"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Richeldi","raw_affiliation_strings":["Emerging Bacterial Pathogen Unit, San Raffaele Hospital, Milan, Italy,","Section of Respiratory Disease,","Dept of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, \"","Niguarda Hospital,","TB Reg. Ref. Centre, Villa Marelli,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emerging Bacterial Pathogen Unit, San Raffaele Hospital, Milan, Italy,","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"Section of Respiratory Disease,","institution_ids":[]},{"raw_affiliation_string":"Dept of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, \"","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Niguarda Hospital,","institution_ids":["https://openalex.org/I4210094195"]},{"raw_affiliation_string":"TB Reg. Ref. Centre, Villa Marelli,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057051062","display_name":"Christoph G. Lange","orcid":"https://orcid.org/0000-0002-9691-4741","observed_orcids":["https://orcid.org/0000-0002-9691-4741"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"C. Lange","raw_affiliation_strings":["Division of Clinical Infectious Diseases , and","Division of Clinical Infectious Diseases,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Infectious Diseases , and","institution_ids":[]},{"raw_affiliation_string":"Division of Clinical Infectious Diseases,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5057051062"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.7608,"has_fulltext":true,"cited_by_count":147,"citation_normalized_percentile":{"value":0.98849221,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"30","issue":"6","first_page":"1173","last_page":"1179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases","score":0.15719999372959137,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.04170000180602074,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculous-pleurisy","display_name":"pleural tuberculosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/interferon-gamma-release-assay","display_name":"interferon-gamma release assay","score":0.9549999833106995},{"id":"https://openalex.org/keywords/t-spot-tb","display_name":"T-SPOT.TB","score":0.9940000176429749},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/latent-tuberculosis-infection","display_name":"latent tuberculosis infection","score":0.7519999742507935},{"id":"https://openalex.org/keywords/elispot","display_name":"ELISPOT","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8945780992507935},{"id":"https://openalex.org/C2779053233","wikidata":"https://www.wikidata.org/wiki/Q731235","display_name":"ELISPOT","level":4,"score":0.8008394241333008},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7609706521034241},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.7530795335769653},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6363292932510376},{"id":"https://openalex.org/C2779634585","wikidata":"https://www.wikidata.org/wiki/Q1334541","display_name":"Pleural effusion","level":2,"score":0.6126464605331421},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.5064646005630493},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47436437010765076},{"id":"https://openalex.org/C2778679867","wikidata":"https://www.wikidata.org/wiki/Q1881705","display_name":"Nontuberculous mycobacteria","level":4,"score":0.41112959384918213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3704235553741455},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35529547929763794},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2962876558303833},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.29330092668533325},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.23639193177223206},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.062254875898361206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05778506398200989},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003955","descriptor_name":"Diagnostic Tests, Routine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014396","descriptor_name":"Tuberculosis, Pleural","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1183/09031936.00067307","doi":"https://doi.org/10.1183/09031936.00067307","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.00067307","pdf_url":"https://erj.ersjournals.com/content/erj/30/6/1173.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},{"id":"pmid:17715165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17715165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European respiratory journal","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.561.9832","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.561.9832","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://erj.ersjournals.com/content/30/6/1173.full.pdf","raw_type":"text"},{"id":"pmh:oai:eprints.soton.ac.uk:368971","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/368971/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:iris.unimore.it:11380/613201","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/613201","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1183/09031936.00067307","doi":"https://doi.org/10.1183/09031936.00067307","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.00067307","pdf_url":"https://erj.ersjournals.com/content/erj/30/6/1173.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159478263.pdf","grobid_xml":"https://content.openalex.org/works/W2159478263.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W114376087","https://openalex.org/W1662338722","https://openalex.org/W1966409189","https://openalex.org/W1972638223","https://openalex.org/W1975159750","https://openalex.org/W1987531965","https://openalex.org/W1989604051","https://openalex.org/W1992043122","https://openalex.org/W1998502795","https://openalex.org/W2003321223","https://openalex.org/W2008333878","https://openalex.org/W2022159086","https://openalex.org/W2024898836","https://openalex.org/W2025537386","https://openalex.org/W2037014631","https://openalex.org/W2037492436","https://openalex.org/W2039683552","https://openalex.org/W2041635532","https://openalex.org/W2045047237","https://openalex.org/W2051161288","https://openalex.org/W2052426477","https://openalex.org/W2056108991","https://openalex.org/W2064099553","https://openalex.org/W2079051706","https://openalex.org/W2081402205","https://openalex.org/W2083871152","https://openalex.org/W2088438813","https://openalex.org/W2090481685","https://openalex.org/W2093371474","https://openalex.org/W2095467108","https://openalex.org/W2097640558","https://openalex.org/W2099439029","https://openalex.org/W2100757327","https://openalex.org/W2101528550","https://openalex.org/W2104577284","https://openalex.org/W2106477727","https://openalex.org/W2107357004","https://openalex.org/W2117885943","https://openalex.org/W2121472628","https://openalex.org/W2124329945","https://openalex.org/W2124510438","https://openalex.org/W2139099450","https://openalex.org/W2140606215","https://openalex.org/W2145673483","https://openalex.org/W2147175623","https://openalex.org/W2148214927","https://openalex.org/W2153285588","https://openalex.org/W2154596732","https://openalex.org/W2159022800","https://openalex.org/W2160669976","https://openalex.org/W2160881227","https://openalex.org/W2163897987","https://openalex.org/W2301871817","https://openalex.org/W2419409870","https://openalex.org/W2472631886","https://openalex.org/W4234419448","https://openalex.org/W4240016487","https://openalex.org/W4249909393","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7097823101","https://openalex.org/W2142145502","https://openalex.org/W2356446905","https://openalex.org/W2054124785","https://openalex.org/W2157996399","https://openalex.org/W2417136933","https://openalex.org/W1907931255","https://openalex.org/W2912802766","https://openalex.org/W2600157254","https://openalex.org/W2093880315"],"abstract_inverted_index":{"The":[0,56],"diagnosis":[1,88,168,207],"of":[2,9,29,79,89,91,108,121,133,155,164,169,208],"pleural":[3,10,46,186,209],"tuberculosis":[4,34],"(plTB)":[5],"by":[6,190],"the":[7,23,27,99,167],"analysis":[8],"effusions":[11],"(PEs)":[12],"with":[13,53,73,86,111,149],"standard":[14],"diagnostic":[15],"tools":[16],"is":[17,192],"difficult.":[18],"In":[19,103],"routine":[20,195],"clinical":[21,75,196],"practice,":[22],"present":[24],"authors":[25],"evaluated":[26],"performance":[28],"a":[30,74,87,203],"commercially":[31],"available":[32],"Mycobacterium":[33,182],"(MTB)-specific":[35],"enzyme-linked":[36],"immunospot":[37],"assay":[38],"on":[39,66,115,123,139,159,174],"peripheral":[40],"blood":[41],"mononuclear":[42,48,188],"cells":[43,49,189],"(PBMCs)":[44],"and":[45,68,76,81,117,151,162,178,198,205],"effusion":[47,187],"(PEMCs)":[50],"in":[51,70,82,98,130,185,194],"patients":[52,72,110,136,142],"suspect":[54,78],"plTB.":[55],"T-SPOT.TB":[57,127,165],"test":[58],"(Oxford":[59],"Immunotec":[60],"Ltd,":[61],"Abingdon,":[62],"UK)":[63],"was":[64,128],"performed":[65,138,158,173],"PBMCs":[67,116,140],"PEMCs":[69,175],"20":[71,109,122],"radiological":[77],"plTB":[80,112,171],"21":[83,134,156],"control":[84],"subjects":[85],"PE":[90],"nontuberculous":[92],"origin":[93],"at":[94],"four":[95],"centres":[96],"participating":[97],"European":[100],"Tuberculosis":[101],"Network.":[102],"total,":[104],"18":[105],"(90%)":[106],"out":[107,120,132,154],"tested":[113],"T-SPOT.TB-positive":[114],"19":[118],"(95%)":[119],"PEMCs.":[124,160],"Among":[125],"controls,":[126],"positive":[129],"seven":[131],"(33%)":[135],"when":[137,157,172],"(these":[141],"were":[143,176],"assumed":[144],"to":[145],"be":[146,200],"latently":[147],"infected":[148],"MTB)":[150],"five":[152],"(23%)":[153],"Sensitivity":[161],"specificity":[163],"for":[166,202],"active":[170],"95":[177],"76%,":[179],"respectively.":[180],"Enumerating":[181],"tuberculosis-specific":[183],"T-cells":[184],"ELISPOT":[191],"feasible":[193],"practice":[197],"may":[199],"useful":[201],"rapid":[204],"accurate":[206],"tuberculosis.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}