{"id":"https://openalex.org/W2159478018","doi":"https://doi.org/10.1111/j.1399-6576.2006.01174.x","title":"Assessing the depth of dexmedetomidine\u2010induced sedation with electroencephalogram (EEG)\u2010based spectral entropy","display_name":"Assessing the depth of dexmedetomidine\u2010induced sedation with electroencephalogram (EEG)\u2010based spectral entropy","publication_year":2006,"publication_date":"2006-10-31","ids":{"openalex":"https://openalex.org/W2159478018","doi":"https://doi.org/10.1111/j.1399-6576.2006.01174.x","mag":"2159478018","pmid":"https://pubmed.ncbi.nlm.nih.gov/17073855"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-6576.2006.01174.x","doi":"https://doi.org/10.1111/j.1399-6576.2006.01174.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-6576.2006.01174.x","pdf_url":null,"source":{"id":"https://openalex.org/S177321322","display_name":"Acta Anaesthesiologica Scandinavica","issn_l":"0001-5172","issn":["0001-5172","1399-6576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Anaesthesiologica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027018357","display_name":"Anu T. Maksimow","orcid":"https://orcid.org/0000-0002-8682-1605","observed_orcids":["https://orcid.org/0000-0002-8682-1605"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]},{"id":"https://openalex.org/I4210105428","display_name":"Turku PET Centre","ror":"https://ror.org/01761e930","country_code":"FI","type":"facility","lineage":["https://openalex.org/I130217899","https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"A. Maksimow","raw_affiliation_strings":["Turku PET Centre, University of Turku, Turku, Finland. Anu.Maksimow@utu.fi","1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Turku PET Centre, University of Turku, Turku, Finland. Anu.Maksimow@utu.fi","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I4210105428"]},{"raw_affiliation_string":"1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076533776","display_name":"Amir Snapir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]},{"id":"https://openalex.org/I4210105428","display_name":"Turku PET Centre","ror":"https://ror.org/01761e930","country_code":"FI","type":"facility","lineage":["https://openalex.org/I130217899","https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"A. Snapir","raw_affiliation_strings":["1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072295824","display_name":"Mika O. K. S\u00e4rkel\u00e4","orcid":"https://orcid.org/0000-0001-6817-2093","observed_orcids":["https://orcid.org/0000-0001-6817-2093"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]},{"id":"https://openalex.org/I4210105428","display_name":"Turku PET Centre","ror":"https://ror.org/01761e930","country_code":"FI","type":"facility","lineage":["https://openalex.org/I130217899","https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"M. S\u00e4rkel\u00e4","raw_affiliation_strings":["1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. Kentala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]},{"id":"https://openalex.org/I4210105428","display_name":"Turku PET Centre","ror":"https://ror.org/01761e930","country_code":"FI","type":"facility","lineage":["https://openalex.org/I130217899","https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"E. Kentala","raw_affiliation_strings":["1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042943293","display_name":"Juha W. Koskenvuo","orcid":"https://orcid.org/0000-0002-2306-2883","observed_orcids":["https://orcid.org/0000-0002-2306-2883"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]},{"id":"https://openalex.org/I4210105428","display_name":"Turku PET Centre","ror":"https://ror.org/01761e930","country_code":"FI","type":"facility","lineage":["https://openalex.org/I130217899","https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J. Koskenvuo","raw_affiliation_strings":["1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063237156","display_name":"Jussi P. Posti","orcid":"https://orcid.org/0000-0002-5925-5193","observed_orcids":["https://orcid.org/0000-0002-5925-5193"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]},{"id":"https://openalex.org/I4210105428","display_name":"Turku PET Centre","ror":"https://ror.org/01761e930","country_code":"FI","type":"facility","lineage":["https://openalex.org/I130217899","https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J. Posti","raw_affiliation_strings":["1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079799861","display_name":"S. K. Ja\u0308a\u0308skela\u0308inen","orcid":"https://orcid.org/0000-0002-7844-3966","observed_orcids":["https://orcid.org/0000-0002-7844-3966"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]},{"id":"https://openalex.org/I4210105428","display_name":"Turku PET Centre","ror":"https://ror.org/01761e930","country_code":"FI","type":"facility","lineage":["https://openalex.org/I130217899","https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"S. K. J\u00e4\u00e4skel\u00e4inen","raw_affiliation_strings":["1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045617855","display_name":"Susanna Hinkka\u2010Yli\u2010Salom\u00e4ki","orcid":"https://orcid.org/0000-0001-7785-9196","observed_orcids":["https://orcid.org/0000-0001-7785-9196"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]},{"id":"https://openalex.org/I4210105428","display_name":"Turku PET Centre","ror":"https://ror.org/01761e930","country_code":"FI","type":"facility","lineage":["https://openalex.org/I130217899","https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"S. Hinkka\u2010Yli\u2010Salom\u00e4ki","raw_affiliation_strings":["1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078460231","display_name":"Mika Scheinin","orcid":"https://orcid.org/0000-0001-7579-9126","observed_orcids":["https://orcid.org/0000-0001-7579-9126"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]},{"id":"https://openalex.org/I4210105428","display_name":"Turku PET Centre","ror":"https://ror.org/01761e930","country_code":"FI","type":"facility","lineage":["https://openalex.org/I130217899","https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"M. Scheinin","raw_affiliation_strings":["1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037429588","display_name":"Harry Scheinin","orcid":"https://orcid.org/0000-0002-1171-3511","observed_orcids":["https://orcid.org/0000-0002-1171-3511"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]},{"id":"https://openalex.org/I4210105428","display_name":"Turku PET Centre","ror":"https://ror.org/01761e930","country_code":"FI","type":"facility","lineage":["https://openalex.org/I130217899","https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"H. Scheinin","raw_affiliation_strings":["1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Turku PET Centre and 2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, 3GE Healthcare Finland Oy, Helsinki, Departments of 4Anaesthesiology and Intensive Care Unit, 5Clinical Physiology and Nuclear Medicine and 6Clinical Neurophysiology, Turku University Hospital, Turku and 7Department of Biostatistics, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027018357"],"corresponding_institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007","https://openalex.org/I4210105428"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":4.8279,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.94656929,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"51","issue":"1","first_page":"22","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sedation-depth-monitoring","display_name":"sedation depth monitoring","score":0.8330000042915344},{"id":"https://openalex.org/keywords/spectral-entropy","display_name":"spectral entropy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/alpha-2-adrenergic-agonists","display_name":"alpha-2 adrenergic agonists","score":0.8159999847412109},{"id":"https://openalex.org/keywords/loss-of-consciousness","display_name":"loss of consciousness","score":0.7680000066757202},{"id":"https://openalex.org/keywords/icu-sedation","display_name":"intensive care unit sedation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2781302539","wikidata":"https://www.wikidata.org/wiki/Q412133","display_name":"Dexmedetomidine","level":3,"score":0.9779301881790161},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.9197167158126831},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.837957501411438},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6911939382553101},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.6492211818695068},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.6137170791625977},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.5364786982536316},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.47324472665786743},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.42259398102760315},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2424565851688385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20104053616523743},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.09170818328857422},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003243","descriptor_name":"Consciousness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016292","descriptor_name":"Procedural Sedation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1399-6576.2006.01174.x","doi":"https://doi.org/10.1111/j.1399-6576.2006.01174.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-6576.2006.01174.x","pdf_url":null,"source":{"id":"https://openalex.org/S177321322","display_name":"Acta Anaesthesiologica Scandinavica","issn_l":"0001-5172","issn":["0001-5172","1399-6576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Anaesthesiologica Scandinavica","raw_type":"journal-article"},{"id":"pmid:17073855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17073855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta anaesthesiologica Scandinavica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1497351237","https://openalex.org/W1971101248","https://openalex.org/W1975496410","https://openalex.org/W1977891902","https://openalex.org/W1980461684","https://openalex.org/W1981844489","https://openalex.org/W1985086414","https://openalex.org/W1986966459","https://openalex.org/W1991037983","https://openalex.org/W1993485702","https://openalex.org/W1999621642","https://openalex.org/W2008333898","https://openalex.org/W2012543775","https://openalex.org/W2022106209","https://openalex.org/W2033017054","https://openalex.org/W2039710554","https://openalex.org/W2041322579","https://openalex.org/W2045278770","https://openalex.org/W2063443539","https://openalex.org/W2065737200","https://openalex.org/W2084444573","https://openalex.org/W2087084537","https://openalex.org/W2088885898","https://openalex.org/W2101991988","https://openalex.org/W2102587390","https://openalex.org/W2104167586","https://openalex.org/W2110858892","https://openalex.org/W2112101180","https://openalex.org/W2123098876","https://openalex.org/W2125062005","https://openalex.org/W2129401965","https://openalex.org/W2134210134","https://openalex.org/W2143009766","https://openalex.org/W2153230907","https://openalex.org/W2167021426","https://openalex.org/W2322707526","https://openalex.org/W3192141250"],"related_works":["https://openalex.org/W4312065127","https://openalex.org/W4312113237","https://openalex.org/W2809143545","https://openalex.org/W2078660465","https://openalex.org/W4384282881","https://openalex.org/W2382273907","https://openalex.org/W4293107910","https://openalex.org/W3156027005","https://openalex.org/W2142704787","https://openalex.org/W2546648033"],"abstract_inverted_index":{"BACKGROUND:":[0],"Adequate":[1],"sedation":[2,18,50,230],"of":[3,10,17,28,31,51,59,74,109,114,165,186,203,222,228],"critically":[4],"ill":[5],"patients":[6],"improves":[7],"the":[8,20,49,57,72,112,115,223],"outcome":[9],"intensive":[11,21],"care.":[12],"Maintaining":[13],"an":[14],"optimal":[15],"level":[16],"in":[19,243],"care":[22],"unit":[23],"(ICU)":[24],"is":[25],"difficult":[26],"because":[27],"a":[29,40,218,244],"lack":[30],"appropriate":[32],"monitoring":[33,64],"methods":[34],"to":[35,134,149,177,194],"guide":[36],"drug":[37],"dosing.":[38],"Dexmedetomidine,":[39],"selective":[41],"alpha(2)-adrenoceptor":[42],"agonist,":[43],"has":[44],"recently":[45],"been":[46],"introduced":[47],"for":[48,71],"ICU":[52],"patients.":[53],"This":[54],"study":[55],"investigated":[56],"utility":[58],"electroencephalogram":[60],"(EEG)-based":[61],"spectral":[62,236],"entropy":[63,94,128],"(with":[65],"M-ENTROPY,":[66],"GE":[67],"Healthcare,":[68],"Helsinki,":[69],"Finland)":[70],"assessment":[73],"dexmedetomidine-induced":[75,229],"sedation.":[76],"METHODS:":[77],"Eleven":[78],"healthy,":[79],"non-smoking":[80],"men,":[81],"aged":[82],"23.9":[83],"+/-":[84,88,132,136,147,151,174,179,192,196],"2.5":[85],"years":[86],"(mean":[87],"standard":[89],"deviation),":[90],"were":[91,118,167,207],"recruited.":[92],"Spectral":[93,127],"was":[95],"recorded":[96],"before":[97,176],"and":[98,103,123,144,163,188,214],"during":[99,140,156,161],"low":[100,141],"(0.5":[101],"ng/ml)":[102,106],"high":[104,157,219],"(5":[105],"plasma":[107],"concentrations":[108],"dexmedetomidine.":[110],"At":[111],"end":[113],"infusion,":[116],"subjects":[117],"awakened":[119],"by":[120],"verbal":[121],"command":[122],"light":[124],"shaking.":[125],"RESULTS:":[126],"decreased":[129,171],"from":[130,145,172,190],"84":[131,146],"5":[133,148],"66":[135],"16":[137],"(P=":[138],"0.029)":[139],"dexmedetomidine":[142,158],"levels":[143],"20":[150],"12":[152],"(P":[153,181,198],"<":[154,182,199],"0.001)":[155,183,200],"levels.":[159],"Transitions":[160],"loss":[162,185],"regaining":[164,202],"consciousness":[166],"analysed":[168],"separately.":[169],"Entropy":[170],"76":[173],"8":[175],"43":[178],"10":[180],"after":[184],"consciousness,":[187],"increased":[189],"14":[191],"4":[193],"63":[195],"13":[197],"on":[201],"consciousness.":[204],"These":[205,238],"changes":[206],"consistent":[208],"across":[209],"all":[210],"subjects.":[211],"Prediction":[212],"probability":[213],"sensitivity":[215],"values":[216],"indicated":[217],"predictive":[220],"performance":[221],"method.":[224],"CONCLUSION:":[225],"The":[226],"depth":[227],"can":[231],"be":[232,241],"monitored":[233],"with":[234],"EEG-based":[235],"entropy.":[237],"results":[239],"should":[240],"confirmed":[242],"clinical":[245],"setting.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
