{"id":"https://openalex.org/W2159463683","doi":null,"title":"Osteoprotegerin, Rank ve Rank Ligandi","display_name":"Osteoprotegerin, Rank ve Rank Ligandi","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2159463683","mag":"2159463683"},"language":"en","primary_location":{"id":"mag:2159463683","doi":null,"is_oa":false,"landing_page_url":"https://app.trdizin.gov.tr/makale/T0RFMk1USXk/osteoprotegerin-rank-ve-rank-ligand","pdf_url":null,"source":{"id":"https://openalex.org/S4210194879","display_name":"Turkish Journal of Biochemistry","issn_l":"0250-4685","issn":["0250-4685","1303-829X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Turkish Journal of Biochemistry","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028050195","display_name":"Sevil Kurban","orcid":"https://orcid.org/0000-0001-5443-0442","observed_orcids":["https://orcid.org/0000-0001-5443-0442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sevil Kurban","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5443-0442","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065368150","display_name":"\u0130dris Mehmeto\u011flu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0130dris Mehmeto\u011flu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":750,"currency":"EUR","value_usd":848},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.1598502,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"32","issue":"4","first_page":"178","last_page":"184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13328","display_name":"Osteomyelitis and Bone Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rank","display_name":"RANK","score":0.8360000252723694},{"id":"https://openalex.org/keywords/rank-ligand","display_name":"RANK ligand","score":0.9089999794960022},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.9380000233650208},{"id":"https://openalex.org/keywords/immune-system","display_name":"immune system","score":0.7670000195503235},{"id":"https://openalex.org/keywords/arterial-calcification","display_name":"arterial calcification","score":0.9810000061988831},{"id":"https://openalex.org/keywords/metabolic-bone-disease","display_name":"metabolic bone disease","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.9357295036315918},{"id":"https://openalex.org/C2909639871","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANK Ligand","level":5,"score":0.5731922388076782},{"id":"https://openalex.org/C2779179475","wikidata":"https://www.wikidata.org/wiki/Q3545649","display_name":"Decoy","level":3,"score":0.5284557342529297},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5160017013549805},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5110917687416077},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.4769143760204315},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4080316424369812},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38361087441444397},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3667213022708893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34510937333106995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3040796220302582}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2159463683","doi":null,"is_oa":false,"landing_page_url":"https://app.trdizin.gov.tr/makale/T0RFMk1USXk/osteoprotegerin-rank-ve-rank-ligand","pdf_url":null,"source":{"id":"https://openalex.org/S4210194879","display_name":"Turkish Journal of Biochemistry","issn_l":"0250-4685","issn":["0250-4685","1303-829X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-4","tr-dizin"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Turkish Journal of Biochemistry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1510237891","https://openalex.org/W1534645474","https://openalex.org/W1549053710","https://openalex.org/W1577265851","https://openalex.org/W1639934123","https://openalex.org/W1650001464","https://openalex.org/W1937290251","https://openalex.org/W1964066819","https://openalex.org/W1971448100","https://openalex.org/W1977114282","https://openalex.org/W1977830503","https://openalex.org/W1980418071","https://openalex.org/W1984673297","https://openalex.org/W1992159640","https://openalex.org/W1997504364","https://openalex.org/W1999985403","https://openalex.org/W2000647744","https://openalex.org/W2014225480","https://openalex.org/W2025128018","https://openalex.org/W2029051823","https://openalex.org/W2031808440","https://openalex.org/W2038340127","https://openalex.org/W2041702088","https://openalex.org/W2046390154","https://openalex.org/W2046675807","https://openalex.org/W2048299560","https://openalex.org/W2048346627","https://openalex.org/W2050104200","https://openalex.org/W2051255001","https://openalex.org/W2051320963","https://openalex.org/W2058262190","https://openalex.org/W2061026306","https://openalex.org/W2062776506","https://openalex.org/W2063676540","https://openalex.org/W2065226530","https://openalex.org/W2072050034","https://openalex.org/W2074255445","https://openalex.org/W2076721956","https://openalex.org/W2076904776","https://openalex.org/W2081263818","https://openalex.org/W2092065668","https://openalex.org/W2100359187","https://openalex.org/W2106433656","https://openalex.org/W2106766464","https://openalex.org/W2118835331","https://openalex.org/W2120837197","https://openalex.org/W2122303350","https://openalex.org/W2128791904","https://openalex.org/W2139996507","https://openalex.org/W2140813706","https://openalex.org/W2144698989","https://openalex.org/W2146217561","https://openalex.org/W2151480907","https://openalex.org/W2155874884","https://openalex.org/W2156467557","https://openalex.org/W2158299560","https://openalex.org/W2158694622","https://openalex.org/W2163247322","https://openalex.org/W2168451480","https://openalex.org/W2411814225","https://openalex.org/W2887937198"],"related_works":["https://openalex.org/W1790164244","https://openalex.org/W2121778907","https://openalex.org/W1898125913","https://openalex.org/W2076904776","https://openalex.org/W7042328862","https://openalex.org/W1978994647","https://openalex.org/W2026698859","https://openalex.org/W2155352301","https://openalex.org/W2057082971","https://openalex.org/W3015993188"],"abstract_inverted_index":{"The":[0],"discovery":[1],"of":[2,7,15,21,35,47,70,101,112,115,121,143],"the":[3,45,67,93,110,141],"osteoprotegerin,":[4],"receptor":[5,13,33,65,68,113,119],"activator":[6,14,34,69,114,120],"nuclear":[8,16,36,71,116,122],"factor-kappa":[9,17,37,72,117,123],"B":[10,18,38,73,124],"ligand":[11,39,74,125],"and":[12,19,49,98,126,133,136],"identification":[20],"their":[22,51,138],"role":[23],"in":[24,30,85,92,128,140],"osteoclastogenesis":[25],"provided":[26],"a":[27,62,99],"major":[28],"advance":[29],"bone":[31,58,77,86,103,129],"biology.":[32],"binds":[40],"to":[41,57,81],"its":[42],"receptors":[43],"on":[44],"surface":[46],"preosteoclasts":[48],"stimulates":[50],"differentiation":[52],"into":[53],"active":[54],"osteoclasts,":[55],"leading":[56],"resorption.":[59,78],"Osteoprotegerin":[60],"is":[61],"soluble":[63],"decoy":[64],"for":[66],"thereby":[75],"inhibiting":[76],"In":[79,105],"addition":[80],"providing":[82],"fundamental":[83],"insights":[84],"biology,":[87],"they":[88],"may":[89],"be":[90],"involved":[91],"immune":[94,131],"system,":[95],"arterial":[96,134],"calcification":[97,135],"number":[100],"metabolic":[102],"diseases.":[104,145],"this":[106],"review,":[107],"we":[108],"summarize":[109],"roles":[111],"B,":[118],"osteoprotegerin":[127],"metabolism,":[130],"system":[132],"discuss":[137],"potential":[139],"treatment":[142],"these":[144]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}