{"id":"https://openalex.org/W2159449648","doi":"https://doi.org/10.1128/aem.70.3.1514-1521.2004","title":"Construction of a Functional S-Layer Fusion Protein Comprising an Immunoglobulin G-Binding Domain for Development of Specific Adsorbents for Extracorporeal Blood Purification","display_name":"Construction of a Functional S-Layer Fusion Protein Comprising an Immunoglobulin G-Binding Domain for Development of Specific Adsorbents for Extracorporeal Blood Purification","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W2159449648","doi":"https://doi.org/10.1128/aem.70.3.1514-1521.2004","mag":"2159449648","pmid":"https://pubmed.ncbi.nlm.nih.gov/15006773","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/368406"},"language":"en","primary_location":{"id":"doi:10.1128/aem.70.3.1514-1521.2004","doi":"https://doi.org/10.1128/aem.70.3.1514-1521.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aem.70.3.1514-1521.2004","pdf_url":null,"source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC368406/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010676318","display_name":"Christine Voellenkle","orcid":"https://orcid.org/0000-0003-0824-060X","observed_orcids":["https://orcid.org/0000-0003-0824-060X"]},"institutions":[{"id":"https://openalex.org/I92869138","display_name":"BOKU University","ror":"https://ror.org/057ff4y42","country_code":"AT","type":"education","lineage":["https://openalex.org/I92869138"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christine V\u00f6llenkle","raw_affiliation_strings":["Center for Ultrastructure Research and Ludwig Boltzmann Institute for Molecular Nanotechnology, University of Natural Resources and Applied Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Ultrastructure Research and Ludwig Boltzmann Institute for Molecular Nanotechnology, University of Natural Resources and Applied Life Sciences","institution_ids":["https://openalex.org/I92869138"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stefan Weigert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Weigert","raw_affiliation_strings":["Nano S Biotechnology GmbH, Vienna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nano S Biotechnology GmbH, Vienna","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081882023","display_name":"Nicola Ilk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92869138","display_name":"BOKU University","ror":"https://ror.org/057ff4y42","country_code":"AT","type":"education","lineage":["https://openalex.org/I92869138"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Nicola Ilk","raw_affiliation_strings":["Center for Ultrastructure Research and Ludwig Boltzmann Institute for Molecular Nanotechnology, University of Natural Resources and Applied Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Ultrastructure Research and Ludwig Boltzmann Institute for Molecular Nanotechnology, University of Natural Resources and Applied Life Sciences","institution_ids":["https://openalex.org/I92869138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109930741","display_name":"Eva Maria Egelseer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92869138","display_name":"BOKU University","ror":"https://ror.org/057ff4y42","country_code":"AT","type":"education","lineage":["https://openalex.org/I92869138"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Eva Egelseer","raw_affiliation_strings":["Center for Ultrastructure Research and Ludwig Boltzmann Institute for Molecular Nanotechnology, University of Natural Resources and Applied Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Ultrastructure Research and Ludwig Boltzmann Institute for Molecular Nanotechnology, University of Natural Resources and Applied Life Sciences","institution_ids":["https://openalex.org/I92869138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052098760","display_name":"Viktoria Weber","orcid":"https://orcid.org/0000-0002-3963-9077","observed_orcids":["https://orcid.org/0000-0002-3963-9077"]},"institutions":[{"id":"https://openalex.org/I132976966","display_name":"Universit\u00e4t f\u00fcr Weiterbildung Krems","ror":"https://ror.org/03ef4a036","country_code":"AT","type":"education","lineage":["https://openalex.org/I132976966"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Viktoria Weber","raw_affiliation_strings":["Christian Doppler Laboratory for Specific Adsorption Technologies in Medicine, Centre for Biomedical Technology, Danube University, Krems, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Specific Adsorption Technologies in Medicine, Centre for Biomedical Technology, Danube University, Krems, Austria","institution_ids":["https://openalex.org/I132976966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022151173","display_name":"F. Loth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128116","display_name":"Fraunhofer Institute for Applied Polymer Research","ror":"https://ror.org/02yhs7m71","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210128116","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fritz Loth","raw_affiliation_strings":["Fraunhofer Institute for Applied Polymer Research, Golm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Applied Polymer Research, Golm, Germany","institution_ids":["https://openalex.org/I4210128116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060607786","display_name":"Dieter Falkenhagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132976966","display_name":"Universit\u00e4t f\u00fcr Weiterbildung Krems","ror":"https://ror.org/03ef4a036","country_code":"AT","type":"education","lineage":["https://openalex.org/I132976966"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Dieter Falkenhagen","raw_affiliation_strings":["Christian Doppler Laboratory for Specific Adsorption Technologies in Medicine, Centre for Biomedical Technology, Danube University, Krems, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Specific Adsorption Technologies in Medicine, Centre for Biomedical Technology, Danube University, Krems, Austria","institution_ids":["https://openalex.org/I132976966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020717643","display_name":"Uwe B. Sleytr","orcid":"https://orcid.org/0000-0002-1425-9860","observed_orcids":["https://orcid.org/0000-0002-1425-9860"]},"institutions":[{"id":"https://openalex.org/I92869138","display_name":"BOKU University","ror":"https://ror.org/057ff4y42","country_code":"AT","type":"education","lineage":["https://openalex.org/I92869138"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Uwe B. Sleytr","raw_affiliation_strings":["Center for Ultrastructure Research and Ludwig Boltzmann Institute for Molecular Nanotechnology, University of Natural Resources and Applied Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Ultrastructure Research and Ludwig Boltzmann Institute for Molecular Nanotechnology, University of Natural Resources and Applied Life Sciences","institution_ids":["https://openalex.org/I92869138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111736757","display_name":"Margit S\u00e1ra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92869138","display_name":"BOKU University","ror":"https://ror.org/057ff4y42","country_code":"AT","type":"education","lineage":["https://openalex.org/I92869138"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Margit S\u00e1ra","raw_affiliation_strings":["Center for Ultrastructure Research and Ludwig Boltzmann Institute for Molecular Nanotechnology, University of Natural Resources and Applied Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Ultrastructure Research and Ludwig Boltzmann Institute for Molecular Nanotechnology, University of Natural Resources and Applied Life Sciences","institution_ids":["https://openalex.org/I92869138"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111736757"],"corresponding_institution_ids":["https://openalex.org/I92869138"],"apc_list":null,"apc_paid":null,"fwci":3.3183,"has_fulltext":false,"cited_by_count":108,"citation_normalized_percentile":{"value":0.93752412,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"70","issue":"3","first_page":"1514","last_page":"1521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.7440999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.1754000037908554,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-layer-proteins","display_name":"S-layer proteins","score":0.8820000290870667},{"id":"https://openalex.org/keywords/lysinibacillus-sphaericus","display_name":"Bacillus sphaericus","score":0.9750000238418579},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.7269999980926514},{"id":"https://openalex.org/keywords/immunoglobulin-g-binding","display_name":"immunoglobulin G binding","score":0.824999988079071},{"id":"https://openalex.org/keywords/extracorporeal-blood-purification","display_name":"extracorporeal blood purification","score":0.859000027179718},{"id":"https://openalex.org/keywords/adsorbents","display_name":"adsorbents","score":0.7319999933242798},{"id":"https://openalex.org/keywords/protein-self-assembly","display_name":"protein self-assembly","score":0.6759999990463257},{"id":"https://openalex.org/keywords/autoantibody-removal","display_name":"autoantibody removal","score":0.7870000004768372},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.7609999775886536},{"id":"https://openalex.org/C114883478","wikidata":"https://www.wikidata.org/wiki/Q418821","display_name":"S-layer","level":3,"score":0.6854567527770996},{"id":"https://openalex.org/C2779000548","wikidata":"https://www.wikidata.org/wiki/Q425941","display_name":"Protein A","level":3,"score":0.6419878602027893},{"id":"https://openalex.org/C135604509","wikidata":"https://www.wikidata.org/wiki/Q424403","display_name":"Protein G","level":3,"score":0.6063743829727173},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5189095139503479},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5135433673858643},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.48902878165245056},{"id":"https://openalex.org/C88001094","wikidata":"https://www.wikidata.org/wiki/Q7251453","display_name":"Protein adsorption","level":3,"score":0.4366304874420166},{"id":"https://openalex.org/C106847996","wikidata":"https://www.wikidata.org/wiki/Q898756","display_name":"Surface plasmon resonance","level":3,"score":0.42113959789276123},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34066125750541687},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.32641172409057617},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3262976408004761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2325117588043213},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.16690665483474731},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.13630664348602295},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1294129490852356},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09546148777008057},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.08486714959144592},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007164","descriptor_name":"Immunosorbents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/aem.70.3.1514-1521.2004","doi":"https://doi.org/10.1128/aem.70.3.1514-1521.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aem.70.3.1514-1521.2004","pdf_url":null,"source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},{"id":"pmid:15006773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15006773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and environmental microbiology","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:368406","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC368406/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Appl Environ Microbiol","raw_type":"Text"},{"id":"pmh:oai:fraunhofer.de:N-29571","doi":null,"is_oa":false,"landing_page_url":"http://publica.fraunhofer.de/documents/N-29571.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400801","display_name":"Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fraunhofer IAP","raw_type":"Journal Article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/207046","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/207046","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:368406","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC368406/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Appl Environ Microbiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6000000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1531451570","https://openalex.org/W1775749144","https://openalex.org/W1906164074","https://openalex.org/W1927693978","https://openalex.org/W1980604167","https://openalex.org/W1985675014","https://openalex.org/W1986106933","https://openalex.org/W1993179235","https://openalex.org/W1993870692","https://openalex.org/W1994271463","https://openalex.org/W2005351153","https://openalex.org/W2007967052","https://openalex.org/W2008105528","https://openalex.org/W2014453046","https://openalex.org/W2035728933","https://openalex.org/W2037317073","https://openalex.org/W2042820114","https://openalex.org/W2054468570","https://openalex.org/W2055554679","https://openalex.org/W2055938935","https://openalex.org/W2056498966","https://openalex.org/W2062967109","https://openalex.org/W2063968553","https://openalex.org/W2086115755","https://openalex.org/W2091304595","https://openalex.org/W2100837269","https://openalex.org/W2102042443","https://openalex.org/W2144027922","https://openalex.org/W2145008115","https://openalex.org/W2154897636","https://openalex.org/W2162019435","https://openalex.org/W2165256578","https://openalex.org/W2167876305","https://openalex.org/W2408878165","https://openalex.org/W4232534952","https://openalex.org/W4256211321"],"related_works":["https://openalex.org/W2045325949","https://openalex.org/W1985675014","https://openalex.org/W2342112216","https://openalex.org/W2061193766","https://openalex.org/W2026038151","https://openalex.org/W1979509744","https://openalex.org/W2005413549","https://openalex.org/W2014453046","https://openalex.org/W1973543697","https://openalex.org/W2386689560"],"abstract_inverted_index":{"The":[0,34,56,123],"chimeric":[1],"gene":[2],"encoding":[3],"a":[4,37,200],"C-terminally-truncated":[5],"form":[6],"of":[7,20,40,43,47,52,65,106,119,126,155,163,184,194,199,223,234,252],"the":[8,21,41,49,62,66,88,93,97,103,107,111,116,120,127,156,161,164,167,195,207,230,235,258],"S-layer":[9,57,67,94,108,157,236],"protein":[10,44,59,68,95,121],"SbpA":[11],"from":[12,221,226],"Bacillus":[13],"sphaericus":[14],"CCM":[15],"2177":[16],"and":[17,27,74,192],"two":[18],"copies":[19],"Fc-binding":[22],"Z-domain":[23,35],"was":[24,135,173,186,240],"constructed,":[25],"cloned,":[26],"heterologously":[28],"expressed":[29],"in":[30,72,96,206,257],"Escherichia":[31],"coli":[32],"HMS174(DE3).":[33],"is":[36,87],"synthetic":[38],"analogue":[39],"B-domain":[42],"A,":[45],"capable":[46],"binding":[48,124,168,232],"Fc":[50],"part":[51],"immunoglobulin":[53],"G":[54],"(IgG).":[55],"fusion":[58,109,158,237],"rSbpA(31-1068)/ZZ":[60],"retained":[61],"specific":[63],"properties":[64],"moiety":[69],"to":[70,75,102,190,212,218],"self-assemble":[71],"suspension":[73],"recrystallize":[76],"on":[77,115],"supports":[78],"precoated":[79],"with":[80,179],"secondary":[81],"cell":[82,99],"wall":[83],"polymer":[84],"(SCWP),":[85],"which":[86],"natural":[89],"anchoring":[90],"molecule":[91],"for":[92,132,153,170,203],"bacterial":[98],"wall.":[100],"Due":[101],"construction":[104],"principle":[105],"protein,":[110],"ZZ-domains":[112],"remained":[113],"exposed":[114],"outermost":[117],"surface":[118,138,202],"lattice.":[122],"capacity":[125,169,198,233],"native":[128,165],"or":[129],"cross-linked":[130],"monolayer":[131],"human":[133,171],"IgG":[134,172,231],"determined":[136],"by":[137],"plasmon":[139],"resonance":[140],"measurements.":[141],"For":[142,246],"batch":[143],"adsorption":[144],"experiments,":[145],"3-microm-diameter,":[146],"biocompatible":[147],"cellulose-based,":[148],"SCWP-coated":[149],"microbeads":[150,239,253],"were":[151],"used":[152,215],"recrystallization":[154],"protein.":[159],"In":[160],"case":[162],"monolayer,":[166],"5.1":[174],"ng/mm(2),":[175],"whereas":[176],"after":[177],"cross-linking":[178],"dimethyl":[180],"pimelimidate,":[181],"4.4":[182],"ng":[183],"IgG/mm(2)":[185],"bound.":[187],"This":[188],"corresponded":[189],"78":[191],"65%":[193],"theoretical":[196],"saturation":[197],"planar":[201],"IgGs":[204],"aligned":[205],"upright":[208],"position,":[209],"respectively.":[210],"Compared":[211],"commercial":[213],"particles":[214],"as":[216],"immunoadsorbents":[217],"remove":[219],"autoantibodies":[220],"sera":[222],"patients":[224],"suffering":[225],"an":[227],"autoimmune":[228],"disease,":[229],"protein-coated":[238],"at":[241],"least":[242],"20":[243],"times":[244],"higher.":[245],"that":[247],"reason,":[248],"this":[249],"novel":[250],"type":[251],"should":[254],"find":[255],"application":[256],"microsphere-based":[259],"detoxification":[260],"system.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}