{"id":"https://openalex.org/W2159448420","doi":null,"title":"Tissue ACE inhibition and sodium status in left ventricular dysfunction","display_name":"Tissue ACE inhibition and sodium status in left ventricular dysfunction","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2159448420","mag":"2159448420"},"language":"en","primary_location":{"id":"pmh:oai:pure.rug.nl:openaire/5d35df44-cb03-4883-8cb0-8708b5c0f11b","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/5d35df44-cb03-4883-8cb0-8708b5c0f11b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Westendorp, B 2005, 'Tissue ACE inhibition and sodium status in left ventricular dysfunction', Doctor of Philosophy.","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.rug.nl/en/publications/5d35df44-cb03-4883-8cb0-8708b5c0f11b","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020772605","display_name":"Bart Westendorp","orcid":"https://orcid.org/0000-0003-1043-3638","observed_orcids":["https://orcid.org/0000-0003-1043-3638"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bart Westendorp","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1043-3638","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5020772605"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.8647000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.10939999669790268,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/left-ventricular-dysfunction","display_name":"left ventricular dysfunction","score":0.7749999761581421},{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/low-sodium-diet","display_name":"sodium restriction","score":0.8289999961853027},{"id":"https://openalex.org/keywords/sodium-balance","display_name":"sodium balance","score":0.8669999837875366},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system","display_name":"renin-angiotensin-aldosterone system","score":0.984000027179718},{"id":"https://openalex.org/keywords/renin","display_name":"renin","score":0.6700000166893005},{"id":"https://openalex.org/keywords/myocardial-function","display_name":"myocardial function","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8473998308181763},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7798061370849609},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7392051219940186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7013618350028992},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.5922661423683167},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5777243375778198},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.49791955947875977},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4537321925163269},{"id":"https://openalex.org/C2993469949","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Cardiac dysfunction","level":3,"score":0.44868648052215576},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.3923361599445343},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2083805501461029}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pure.rug.nl:openaire/5d35df44-cb03-4883-8cb0-8708b5c0f11b","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/5d35df44-cb03-4883-8cb0-8708b5c0f11b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Westendorp, B 2005, 'Tissue ACE inhibition and sodium status in left ventricular dysfunction', Doctor of Philosophy.","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:rug:oai:pure.rug.nl:publications/5d35df44-cb03-4883-8cb0-8708b5c0f11b","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/5d35df44-cb03-4883-8cb0-8708b5c0f11b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2159448420","doi":null,"is_oa":false,"landing_page_url":"https://pure.rug.nl/ws/files/2905401/titlecon.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pure.rug.nl:openaire/5d35df44-cb03-4883-8cb0-8708b5c0f11b","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/5d35df44-cb03-4883-8cb0-8708b5c0f11b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Westendorp, B 2005, 'Tissue ACE inhibition and sodium status in left ventricular dysfunction', Doctor of Philosophy.","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":201,"referenced_works":["https://openalex.org/W13516814","https://openalex.org/W59436057","https://openalex.org/W82086764","https://openalex.org/W147216824","https://openalex.org/W1499839181","https://openalex.org/W1538192513","https://openalex.org/W1546802604","https://openalex.org/W1564985705","https://openalex.org/W1819973517","https://openalex.org/W1964714332","https://openalex.org/W1965434560","https://openalex.org/W1967785796","https://openalex.org/W1968355808","https://openalex.org/W1970068637","https://openalex.org/W1970664393","https://openalex.org/W1973067074","https://openalex.org/W1973423274","https://openalex.org/W1973783771","https://openalex.org/W1976062999","https://openalex.org/W1976555160","https://openalex.org/W1977966187","https://openalex.org/W1978443570","https://openalex.org/W1979695692","https://openalex.org/W1979709872","https://openalex.org/W1980870055","https://openalex.org/W1980952557","https://openalex.org/W1984717781","https://openalex.org/W1984827835","https://openalex.org/W1985146730","https://openalex.org/W1985265801","https://openalex.org/W1986644699","https://openalex.org/W1988045585","https://openalex.org/W1990332139","https://openalex.org/W1990423948","https://openalex.org/W1994734582","https://openalex.org/W1995065492","https://openalex.org/W1995261217","https://openalex.org/W1995262353","https://openalex.org/W1996067394","https://openalex.org/W1996482544","https://openalex.org/W1997062534","https://openalex.org/W1997916285","https://openalex.org/W2000844053","https://openalex.org/W2001237673","https://openalex.org/W2003563752","https://openalex.org/W2005228376","https://openalex.org/W2005747721","https://openalex.org/W2007338020","https://openalex.org/W2008993087","https://openalex.org/W2011563843","https://openalex.org/W2012489893","https://openalex.org/W2014739371","https://openalex.org/W2016151911","https://openalex.org/W2018394333","https://openalex.org/W2020152126","https://openalex.org/W2021231932","https://openalex.org/W2022661671","https://openalex.org/W2024189638","https://openalex.org/W2025266397","https://openalex.org/W2026291585","https://openalex.org/W2026421997","https://openalex.org/W2028167921","https://openalex.org/W2028414806","https://openalex.org/W2031008864","https://openalex.org/W2032647797","https://openalex.org/W2032748094","https://openalex.org/W2033946030","https://openalex.org/W2034182021","https://openalex.org/W2037834217","https://openalex.org/W2038368135","https://openalex.org/W2040725416","https://openalex.org/W2043550752","https://openalex.org/W2043884187","https://openalex.org/W2044280833","https://openalex.org/W2045472431","https://openalex.org/W2046383587","https://openalex.org/W2048228293","https://openalex.org/W2049023692","https://openalex.org/W2050664579","https://openalex.org/W2050700980","https://openalex.org/W2051185167","https://openalex.org/W2052530868","https://openalex.org/W2054521115","https://openalex.org/W2055123579","https://openalex.org/W2055880019","https://openalex.org/W2055951155","https://openalex.org/W2060614175","https://openalex.org/W2060633147","https://openalex.org/W2061139485","https://openalex.org/W2061846540","https://openalex.org/W2067165584","https://openalex.org/W2067739148","https://openalex.org/W2068033616","https://openalex.org/W2068110268","https://openalex.org/W2070820723","https://openalex.org/W2070933263","https://openalex.org/W2075516836","https://openalex.org/W2075577088","https://openalex.org/W2075653842","https://openalex.org/W2075868324","https://openalex.org/W2076048176","https://openalex.org/W2078374154","https://openalex.org/W2079545779","https://openalex.org/W2079740085","https://openalex.org/W2082069148","https://openalex.org/W2082151580","https://openalex.org/W2082690341","https://openalex.org/W2083143372","https://openalex.org/W2083152534","https://openalex.org/W2083529118","https://openalex.org/W2085367013","https://openalex.org/W2086793695","https://openalex.org/W2087060187","https://openalex.org/W2089695853","https://openalex.org/W2091113770","https://openalex.org/W2093369326","https://openalex.org/W2093791985","https://openalex.org/W2094727696","https://openalex.org/W2094845846","https://openalex.org/W2095317470","https://openalex.org/W2096875294","https://openalex.org/W2097362788","https://openalex.org/W2097399918","https://openalex.org/W2097971039","https://openalex.org/W2098780362","https://openalex.org/W2099744476","https://openalex.org/W2103810068","https://openalex.org/W2108548563","https://openalex.org/W2108914217","https://openalex.org/W2111936495","https://openalex.org/W2111945961","https://openalex.org/W2113212881","https://openalex.org/W2114231586","https://openalex.org/W2114547396","https://openalex.org/W2116763228","https://openalex.org/W2119031278","https://openalex.org/W2119313387","https://openalex.org/W2120309176","https://openalex.org/W2121369013","https://openalex.org/W2121456619","https://openalex.org/W2122625788","https://openalex.org/W2122747902","https://openalex.org/W2124728065","https://openalex.org/W2126896570","https://openalex.org/W2127642431","https://openalex.org/W2132161051","https://openalex.org/W2132798941","https://openalex.org/W2132853131","https://openalex.org/W2133641279","https://openalex.org/W2135139460","https://openalex.org/W2135856179","https://openalex.org/W2136423707","https://openalex.org/W2138046394","https://openalex.org/W2139905714","https://openalex.org/W2140766694","https://openalex.org/W2142182263","https://openalex.org/W2144391460","https://openalex.org/W2144543119","https://openalex.org/W2145797508","https://openalex.org/W2146897448","https://openalex.org/W2151705191","https://openalex.org/W2152094259","https://openalex.org/W2153322945","https://openalex.org/W2154295247","https://openalex.org/W2155980675","https://openalex.org/W2157476464","https://openalex.org/W2157479809","https://openalex.org/W2161347199","https://openalex.org/W2162319002","https://openalex.org/W2163632142","https://openalex.org/W2168777122","https://openalex.org/W2171593092","https://openalex.org/W2171717217","https://openalex.org/W2214898436","https://openalex.org/W2280830285","https://openalex.org/W2306712501","https://openalex.org/W2314029408","https://openalex.org/W2319017470","https://openalex.org/W2321494583","https://openalex.org/W2321649236","https://openalex.org/W2323458614","https://openalex.org/W2326354230","https://openalex.org/W2327729773","https://openalex.org/W2329803254","https://openalex.org/W2333271497","https://openalex.org/W2334994616","https://openalex.org/W2338262993","https://openalex.org/W2405368086","https://openalex.org/W2412820952","https://openalex.org/W2413451592","https://openalex.org/W2415480648","https://openalex.org/W2418532825","https://openalex.org/W2472705290","https://openalex.org/W2476254916","https://openalex.org/W2512763345","https://openalex.org/W2518540974","https://openalex.org/W2585382523","https://openalex.org/W2587559762","https://openalex.org/W3144354822","https://openalex.org/W4255518427","https://openalex.org/W4300983020"],"related_works":["https://openalex.org/W2132798941","https://openalex.org/W2225727432","https://openalex.org/W2032513508","https://openalex.org/W2127454792","https://openalex.org/W148310438","https://openalex.org/W2067338876","https://openalex.org/W2140519331","https://openalex.org/W2085290574","https://openalex.org/W1541376187","https://openalex.org/W2026291585"],"abstract_inverted_index":{"Left":[0],"ventricular":[1,69],"(LV)":[2],"dysfunction":[3,70,96],"is":[4,28,140],"characterized":[5],"by":[6,137],"a":[7,61,115],"progressive":[8],"loss":[9],"of":[10,21,37,67,94,155],"cardiac":[11,81],"pump":[12],"function,":[13],"which":[14],"eventually":[15],"leads":[16],"to":[17,107,112,147,159,168],"the":[18,43,65,91,151,163],"clinical":[19],"syndrome":[20],"chronic":[22,72],"heart":[23,38,73],"failure":[24,27,39],"(CHF).":[25],"Heart":[26],"associated":[29],"with":[30,162],"high":[31],"morbidity":[32,85],"and":[33,83,86],"mortality.":[34,87],"The":[35,122],"incidence":[36],"has":[40],"increased":[41],"during":[42],"last":[44],"decades,":[45],"mainly":[46],"because":[47],"improved":[48],"survival":[49],"after":[50],"acute":[51],"myocardial":[52,95],"infarction.":[53],"Renin":[54],"angiotensin":[55],"aldosterone":[56],"system":[57],"(RAAS)":[58],"activation":[59],"plays":[60],"major":[62],"role":[63],"in":[64,166],"progression":[66,93],"left":[68],"towards":[71,97],"failure.":[74],"Angiotensinconverting":[75],"enzyme":[76],"(ACE)":[77],"inhibition":[78,114],"therapy":[79,110],"improves":[80],"function":[82],"reduces":[84],"Although":[88],"ACE-inhibition":[89],"slows":[90],"gradual":[92],"overt":[98],"CHF,":[99],"it":[100],"does":[101],"not":[102],"prevent":[103],"it.":[104],"In":[105],"order":[106,167],"reach":[108],"maximal":[109],"response":[111,146],"ACE":[113,148],"low":[116],"sodium":[117,138,164],"intake":[118],"may":[119],"be":[120],"required.":[121],"expected":[123],"underlyingmechanism":[124],"was":[125,158],"that":[126],"an":[127,143],"activated":[128],"RAAS":[129],"\u2013":[130,135],"i.e.":[131],"elevated":[132],"renin":[133],"production":[134],"induced":[136],"restriction":[139],"required":[141],"for":[142],"optimal":[144],"therapeutic":[145],"inhibition.":[149],"Hence,":[150],"first":[152],"main":[153],"subject":[154],"this":[156],"thesis":[157],"study":[160],"intervention":[161],"balance":[165],"optimize":[169],"ACE-I":[170],"therapy.":[171]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}