{"id":"https://openalex.org/W2159433698","doi":null,"title":"Neuroprotective effect of vitamin D3 toward apoptosis induced by ethanol in CA1 pyramidal cells of rat hippocampus","display_name":"Neuroprotective effect of vitamin D3 toward apoptosis induced by ethanol in CA1 pyramidal cells of rat hippocampus","publication_year":2015,"publication_date":"2015-11-18","ids":{"openalex":"https://openalex.org/W2159433698","mag":"2159433698"},"language":"en","primary_location":{"id":"pmh:oai:journal.ugm.ac.id:article/3266","doi":null,"is_oa":true,"landing_page_url":"https://journal.ugm.ac.id/bik/article/view/3266","pdf_url":"https://journal.ugm.ac.id/bik/article/download/3266/2868","source":{"id":"https://openalex.org/S2764828112","display_name":"Journal of the Medical Sciences (Berkala Ilmu Kedokteran)","issn_l":"0126-1312","issn":["0126-1312","2356-3931"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314959","host_organization_name":"Gadjah Mada University","host_organization_lineage":["https://openalex.org/P4310314959"],"host_organization_lineage_names":["Gadjah Mada University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2356-3931","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journal.ugm.ac.id/bik/article/download/3266/2868","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053166262","display_name":"Junaedy Yunus Djoko Prakosa Dwi Cahyani Ratna Sari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Junaedy Yunus Djoko Prakosa Dwi Cahyani Ratna Sari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053166262"],"corresponding_institution_ids":[],"apc_list":{"value":50,"currency":"USD","value_usd":50},"apc_paid":{"value":50,"currency":"USD","value_usd":50},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.39989998936653137,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.39989998936653137,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.19509999454021454,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12494","display_name":"Alcoholism and Thiamine Deficiency","score":0.10570000112056732,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ethanol-neurotoxicity","display_name":"ethanol neurotoxicity","score":0.9300000071525574},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.8690000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9629999995231628},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.740352213382721},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7182409763336182},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6516066789627075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6464216113090515},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.6022171974182129},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5697104930877686},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5631726980209351},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5279176235198975},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5272749066352844},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.5045560598373413},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4504488706588745},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.4339732825756073},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3968031704425812},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3500216007232666},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2099718451499939},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18804305791854858}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:journal.ugm.ac.id:article/3266","doi":null,"is_oa":true,"landing_page_url":"https://journal.ugm.ac.id/bik/article/view/3266","pdf_url":"https://journal.ugm.ac.id/bik/article/download/3266/2868","source":{"id":"https://openalex.org/S2764828112","display_name":"Journal of the Medical Sciences (Berkala Ilmu Kedokteran)","issn_l":"0126-1312","issn":["0126-1312","2356-3931"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314959","host_organization_name":"Gadjah Mada University","host_organization_lineage":["https://openalex.org/P4310314959"],"host_organization_lineage_names":["Gadjah Mada University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2356-3931","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:jurnal.ugm.ac.id:article/3266","doi":null,"is_oa":true,"landing_page_url":"http://jurnal.ugm.ac.id/bik/article/view/3266","pdf_url":"http://jurnal.ugm.ac.id/bik/article/view/3266","source":{"id":"https://openalex.org/S4306400707","display_name":"Indonesian Journal of Biotechnology (Universitas Gadjah Mada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165230279","host_organization_name":"Universitas Gadjah Mada","host_organization_lineage":["https://openalex.org/I165230279"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Medical Sciences (Berkala ilmu Kedokteran); Vol 44, No 01 (2012)","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2159433698","doi":null,"is_oa":true,"landing_page_url":"http://perpustakaan.litbang.kemkes.go.id/index.php?p=show_detail&id=34540","pdf_url":null,"source":{"id":"https://openalex.org/S2764828112","display_name":"Journal of the Medical Sciences (Berkala Ilmu Kedokteran)","issn_l":"0126-1312","issn":["0126-1312","2356-3931"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314959","host_organization_name":"Gadjah Mada University","host_organization_lineage":["https://openalex.org/P4310314959"],"host_organization_lineage_names":["Gadjah Mada University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Medical Sciences (Berkala Ilmu Kedokteran)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:journal.ugm.ac.id:article/3266","doi":null,"is_oa":true,"landing_page_url":"https://journal.ugm.ac.id/bik/article/view/3266","pdf_url":"https://journal.ugm.ac.id/bik/article/download/3266/2868","source":{"id":"https://openalex.org/S2764828112","display_name":"Journal of the Medical Sciences (Berkala Ilmu Kedokteran)","issn_l":"0126-1312","issn":["0126-1312","2356-3931"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314959","host_organization_name":"Gadjah Mada University","host_organization_lineage":["https://openalex.org/P4310314959"],"host_organization_lineage_names":["Gadjah Mada University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2356-3931","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327626","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159433698.pdf","grobid_xml":"https://content.openalex.org/works/W2159433698.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W32923551","https://openalex.org/W1495456524","https://openalex.org/W1601723864","https://openalex.org/W1965514557","https://openalex.org/W1969048004","https://openalex.org/W1971618371","https://openalex.org/W1993788286","https://openalex.org/W1995292150","https://openalex.org/W1997208169","https://openalex.org/W2000981671","https://openalex.org/W2014585682","https://openalex.org/W2017219584","https://openalex.org/W2020584531","https://openalex.org/W2025186743","https://openalex.org/W2025983577","https://openalex.org/W2028613340","https://openalex.org/W2028764252","https://openalex.org/W2029860755","https://openalex.org/W2057855533","https://openalex.org/W2071924459","https://openalex.org/W2074988843","https://openalex.org/W2075894833","https://openalex.org/W2085143181","https://openalex.org/W2092859716","https://openalex.org/W2108935850","https://openalex.org/W2110342945","https://openalex.org/W2111405228","https://openalex.org/W2277663001","https://openalex.org/W2495832169"],"related_works":["https://openalex.org/W7097714707","https://openalex.org/W2139112165","https://openalex.org/W2903910461","https://openalex.org/W2029860755","https://openalex.org/W2265777866","https://openalex.org/W2336301141","https://openalex.org/W3212766834","https://openalex.org/W2013146071","https://openalex.org/W2056016579","https://openalex.org/W2093659420"],"abstract_inverted_index":{"As":[0],"an":[1,22,236,263],"antioxidant,":[2],"Vitamin":[3,231],"D3":[4,56,106,110,192,232,249,256],"can":[5],"protect":[6],"neurons":[7],"from":[8],"damage":[9],"caused":[10],"by":[11,20,39,67,138,276],"oxidative":[12,25],"stress.Ethanol":[13],"is":[14,32,41],"known":[15],"to":[16,35,50,225,261,271],"have":[17],"neurotoxic":[18,36,273],"effects":[19,37,54,274],"inducing":[21],"increase":[23,206,237,264],"in":[24,57,61,114,208,216,217,238,246,265,267],"stress.":[26],"One":[27],"ofthe":[28],"brain":[29],"regions":[30],"that":[31],"most":[33],"sensitive":[34],"induced":[38,66,275],"ethanol":[40,90,94,116,219],"hippocampus,especially":[42],"its":[43],"CA1":[44,62,242],"region.":[45],"This":[46],"study":[47],"was":[48,82,92,143,151,159,165,203],"aimed":[49],"determine":[51],"the":[52,59,128,141,171,178,190,209,218,226,239,247,272],"neuroprotective":[53,259],"ofvitamin":[55],"preventing":[58],"apoptosis":[60,266],"hippocampal":[63,243],"pyramidal":[64,157,175,214,244,269],"cells":[65,158,176,215,245,270],"ethanol.Fifteen":[68],"male":[69],"Wistar":[70],"rats":[71,129],"(Rattus":[72],"norvegicus)":[73],"were":[74,130,134],"randomly":[75],"divided":[76],"into":[77],"three":[78],"groups.":[79],"The":[80,89,104,161],"controlgroup":[81,227],"given":[83],"daily":[84],"normal":[85],"saline":[86],"solution":[87,95,117],"intraperitoneally.":[88,103],"group":[91,107,180,185,193,220,250],"given20%":[93],"at":[96,118],"a":[97,119,204,258],"dose":[98,120],"of":[99,121,154,174,200,211],"3":[100,122],"g/kg":[101,123],"BW/day":[102,113],"vitamin":[105,109,191,248,255],"wasgiven":[108],"1":[111],"\u03bcg/kg":[112],"20%":[115],"BW/dayintraperitoneally.":[124],"After":[125],"30":[126],"days,":[127],"sacrificed,":[131],"their":[132],"brains":[133],"perfused":[135],"with":[136],"PBSfollowed":[137],"fixative":[139],"and":[140,189],"hippocampus":[142],"dissected":[144],"for":[145,149],"histological":[146],"preparations.Immunohistochemical":[147],"staining":[148],"caspase":[150],"performed.":[152],"Percentage":[153],"apoptotic":[155,212,241],"CA1hippocampal":[156,213,268],"calculated.":[160],"results":[162],"showed":[163],"there":[164,202],"no":[166],"significant":[167,205],"difference(p>":[168],"0.05)":[169],"on":[170],"total":[172],"number":[173],"between":[177],"control":[179],"(20.52":[181],"\u00b1":[182,187,196,222,229,252],"1.31),":[183],"theethanol":[184],"(19.02":[186],"1.60),":[188],"(21.":[194],"06":[195],"0.70)":[197],"per":[198],"field":[199],"view.However":[201],"(p<0.05)":[207,234],"percentage":[210],"(16.09":[221],"0.67%)":[223],"compared":[224],"(10.60":[228],"0.95%).":[230],"significantly":[233],"prevented":[235],"percentageof":[240],"(10.82":[251],"0.64%).":[253],"Inconclusion,":[254],"had":[257],"effect":[260],"prevent":[262],"ethanol.":[277]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}