{"id":"https://openalex.org/W2159418656","doi":"https://doi.org/10.1093/clinchem/34.12.2513","title":"An enzyme immunoassay procedure for cancer antigen 125 evaluated.","display_name":"An enzyme immunoassay procedure for cancer antigen 125 evaluated.","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W2159418656","doi":"https://doi.org/10.1093/clinchem/34.12.2513","mag":"2159418656","pmid":"https://pubmed.ncbi.nlm.nih.gov/3058364"},"language":"en","primary_location":{"id":"doi:10.1093/clinchem/34.12.2513","doi":"https://doi.org/10.1093/clinchem/34.12.2513","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/34.12.2513","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054627251","display_name":"K W Ryder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801551699","display_name":"Sidney & Lois Eskenazi Hospital","ror":"https://ror.org/02fj1x097","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801551699","https://openalex.org/I4210130353","https://openalex.org/I4387930232","https://openalex.org/I4387930283"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K W Ryder","raw_affiliation_strings":["Department of Pathology, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis 46202","institution_ids":["https://openalex.org/I2801551699","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113645183","display_name":"Tjien O. Oei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801551699","display_name":"Sidney & Lois Eskenazi Hospital","ror":"https://ror.org/02fj1x097","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801551699","https://openalex.org/I4210130353","https://openalex.org/I4387930232","https://openalex.org/I4387930283"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T O Oei","raw_affiliation_strings":["Department of Pathology, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis 46202","institution_ids":["https://openalex.org/I2801551699","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110184791","display_name":"Meredith T. Hull","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801551699","display_name":"Sidney & Lois Eskenazi Hospital","ror":"https://ror.org/02fj1x097","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801551699","https://openalex.org/I4210130353","https://openalex.org/I4387930232","https://openalex.org/I4387930283"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M T Hull","raw_affiliation_strings":["Department of Pathology, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis 46202","institution_ids":["https://openalex.org/I2801551699","https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068974121","display_name":"M. Sample","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801551699","display_name":"Sidney & Lois Eskenazi Hospital","ror":"https://ror.org/02fj1x097","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801551699","https://openalex.org/I4210130353","https://openalex.org/I4387930232","https://openalex.org/I4387930283"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M M Sample","raw_affiliation_strings":["Department of Pathology, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis 46202","institution_ids":["https://openalex.org/I2801551699","https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.19086561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"34","issue":"12","first_page":"2513","last_page":"2516"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ca125","display_name":"CA125","score":0.9509999752044678},{"id":"https://openalex.org/keywords/enzyme-immunoassay","display_name":"enzyme immunoassay","score":0.9769999980926514},{"id":"https://openalex.org/keywords/radioimmunoassay","display_name":"radioimmunoassay","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ovarian-carcinoma","display_name":"ovarian carcinoma","score":0.9229999780654907},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.6769999861717224},{"id":"https://openalex.org/keywords/decision-threshold","display_name":"decision threshold","score":0.8889999985694885},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"receiver operating characteristic","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.8494405150413513},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.8083915710449219},{"id":"https://openalex.org/C2992389814","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Cancer antigen","level":3,"score":0.5510415434837341},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5260056257247925},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.5144057869911194},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.47062066197395325},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4705786108970642},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4057103991508484},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.36788880825042725},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.33186811208724976},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3210497498512268},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31484103202819824},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3125513195991516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3098319470882416},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19357562065124512},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.08699455857276917}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015295","descriptor_name":"Antigens, Tumor-Associated, Carbohydrate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/clinchem/34.12.2513","doi":"https://doi.org/10.1093/clinchem/34.12.2513","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/34.12.2513","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:3058364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3058364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2144456543","https://openalex.org/W2414859846","https://openalex.org/W2157615826","https://openalex.org/W2084460934","https://openalex.org/W2077825637","https://openalex.org/W2462367730","https://openalex.org/W2424136326","https://openalex.org/W2027399006","https://openalex.org/W1981448756","https://openalex.org/W2370577165"],"abstract_inverted_index":{"The":[0],"performance":[1],"of":[2,76],"a":[3,34,48,88],"new":[4],"enzyme":[5],"immunoassay":[6],"(EIA)":[7],"procedure":[8,81],"(Abbott":[9],"Labs.)":[10],"for":[11,23,51,92],"cancer":[12],"antigen":[13],"125":[14],"(CA":[15],"125)":[16],"met":[17],"or":[18],"exceeded":[19],"the":[20,41,64,72,77,84,112,130],"manufacturer's":[21],"claims":[22],"all":[24],"analytical":[25],"variables":[26],"examined.":[27],"Overall":[28],"correlation":[29],"with":[30,33,119,125],"results":[31,55],"obtained":[32],"radioimmunoassay":[35],"(RIA)":[36],"were":[37,56],"good.":[38],"However,":[39],"near":[40],"decision":[42,69,85],"thresholds":[43,86],"typically":[44],"chosen":[45],"to":[46,58,116],"define":[47],"positive":[49],"result":[50],"ovarian":[52,121],"carcinoma,":[53],"EIA":[54,78],"10":[57],"20":[59],"arbitrary":[60],"units/mL":[61],"less":[62],"than":[63],"RIA":[65,80],"results.":[66],"At":[67],"specific":[68],"thresholds,":[70],"therefore,":[71],"sensitivities":[73],"and":[74,79],"specificities":[75],"differed.":[82],"Adjusting":[83],"gave":[87],"similar":[89],"optimum":[90],"efficiency":[91],"each":[93],"procedure:":[94],"EIA,":[95],"82.9%":[96],"(decision":[97,103],"threshold,":[98,104],"35":[99],"units/mL);":[100],"RIA,":[101],"83.4%":[102],"54":[105],"units/mL).":[106],"Receiver-operating":[107],"characteristic":[108],"curves":[109],"showed":[110],"that":[111],"two":[113],"procedures'":[114],"ability":[115],"distinguish":[117],"patients":[118],"active":[120],"carcinoma":[122],"from":[123],"those":[124],"disease":[126],"in":[127],"remission":[128],"was":[129],"same.":[131]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}