{"id":"https://openalex.org/W2159397492","doi":"https://doi.org/10.1210/jc.2009-1603","title":"Circulating Fibroblast Growth Factor 23 in Patients with End-Stage Renal Disease Treated by Peritoneal Dialysis Is Intact and Biologically Active","display_name":"Circulating Fibroblast Growth Factor 23 in Patients with End-Stage Renal Disease Treated by Peritoneal Dialysis Is Intact and Biologically Active","publication_year":2009,"publication_date":"2009-12-05","ids":{"openalex":"https://openalex.org/W2159397492","doi":"https://doi.org/10.1210/jc.2009-1603","mag":"2159397492","pmid":"https://pubmed.ncbi.nlm.nih.gov/19965919","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2840849"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2009-1603","doi":"https://doi.org/10.1210/jc.2009-1603","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2009-1603","pdf_url":"https://academic.oup.com/jcem/article-pdf/95/2/578/9065479/jcem0578.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jcem/article-pdf/95/2/578/9065479/jcem0578.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101557061","display_name":"Takashi Shimada","orcid":"https://orcid.org/0000-0001-7182-7003","observed_orcids":["https://orcid.org/0000-0001-7182-7003"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I205823427","display_name":"Kyowa Kirin (Japan)","ror":"https://ror.org/000wej815","country_code":"JP","type":"company","lineage":["https://openalex.org/I205823427"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Takashi Shimada","raw_affiliation_strings":["Endocrine Unit (T.S., H.J.), Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","Innovative Drug Discovery Laboratories (T.S., I.U., Y.Y.), Kyowa Hakko Kirin Co., Ltd., Gunma 370-1295, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Unit (T.S., H.J.), Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Innovative Drug Discovery Laboratories (T.S., I.U., Y.Y.), Kyowa Hakko Kirin Co., Ltd., Gunma 370-1295, Japan","institution_ids":["https://openalex.org/I205823427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010069343","display_name":"Itaru Urakawa","orcid":"https://orcid.org/0000-0003-3838-8461","observed_orcids":["https://orcid.org/0000-0003-3838-8461"]},"institutions":[{"id":"https://openalex.org/I205823427","display_name":"Kyowa Kirin (Japan)","ror":"https://ror.org/000wej815","country_code":"JP","type":"company","lineage":["https://openalex.org/I205823427"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Itaru Urakawa","raw_affiliation_strings":["Innovative Drug Discovery Laboratories (T.S., I.U., Y.Y.), Kyowa Hakko Kirin Co., Ltd., Gunma 370-1295, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovative Drug Discovery Laboratories (T.S., I.U., Y.Y.), Kyowa Hakko Kirin Co., Ltd., Gunma 370-1295, Japan","institution_ids":["https://openalex.org/I205823427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003850042","display_name":"Tamara Isakova","orcid":"https://orcid.org/0000-0002-9763-2367","observed_orcids":["https://orcid.org/0000-0002-9763-2367"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara Isakova","raw_affiliation_strings":["Nephrology Unit (T.I., M.E.), Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Unit (T.I., M.E.), Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuji Yamazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205823427","display_name":"Kyowa Kirin (Japan)","ror":"https://ror.org/000wej815","country_code":"JP","type":"company","lineage":["https://openalex.org/I205823427"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Yamazaki","raw_affiliation_strings":["Innovative Drug Discovery Laboratories (T.S., I.U., Y.Y.), Kyowa Hakko Kirin Co., Ltd., Gunma 370-1295, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovative Drug Discovery Laboratories (T.S., I.U., Y.Y.), Kyowa Hakko Kirin Co., Ltd., Gunma 370-1295, Japan","institution_ids":["https://openalex.org/I205823427"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Epstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Epstein","raw_affiliation_strings":["Nephrology Unit (T.I., M.E.), Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Unit (T.I., M.E.), Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061322949","display_name":"Katherine Wesseling\u2010Perry","orcid":"https://orcid.org/0000-0002-9122-7459","observed_orcids":["https://orcid.org/0000-0002-9122-7459"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Wesseling-Perry","raw_affiliation_strings":["Department of Pediatrics (K.W.-P., I.B.S.), David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics (K.W.-P., I.B.S.), David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008906136","display_name":"Myles Selig Wolf","orcid":"https://orcid.org/0000-0002-1127-1442","observed_orcids":["https://orcid.org/0000-0002-1127-1442"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myles Wolf","raw_affiliation_strings":["Division of Nephrology and Hypertension (M.W.), Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension (M.W.), Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084811951","display_name":"Isidro B. Salusky","orcid":"https://orcid.org/0000-0001-8052-416X","observed_orcids":["https://orcid.org/0000-0001-8052-416X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isidro B. Salusky","raw_affiliation_strings":["Endocrine Unit (T.S., H.J.), Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Unit (T.S., H.J.), Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061211092","display_name":"Harald J\u00fcppner","orcid":"https://orcid.org/0000-0001-7491-0515","observed_orcids":["https://orcid.org/0000-0001-7491-0515"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harald Ju\u0308ppner","raw_affiliation_strings":["Endocrine Unit (T.S., H.J.), Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","Pediatric Nephrology Unit (H.J.), Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Unit (T.S., H.J.), Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Pediatric Nephrology Unit (H.J.), Departments of Medicine and Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":13.7996,"has_fulltext":true,"cited_by_count":228,"citation_normalized_percentile":{"value":0.99120941,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"95","issue":"2","first_page":"578","last_page":"585"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.9990000128746033},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.9330000281333923},{"id":"https://openalex.org/keywords/peritoneal-dialysis","display_name":"peritoneal dialysis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phosphorus-homeostasis","display_name":"phosphorus homeostasis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/vitamin-d-metabolism","display_name":"vitamin D metabolism","score":0.9639999866485596},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.9130718111991882},{"id":"https://openalex.org/C2778049618","wikidata":"https://www.wikidata.org/wiki/Q860395","display_name":"Osteomalacia","level":3,"score":0.8042385578155518},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6886831521987915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6800456047058105},{"id":"https://openalex.org/C2779056158","wikidata":"https://www.wikidata.org/wiki/Q1756474","display_name":"Peritoneal dialysis","level":2,"score":0.6565346121788025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6446619033813477},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5865064263343811},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.5221338868141174},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4793758690357208},{"id":"https://openalex.org/C2776489590","wikidata":"https://www.wikidata.org/wiki/Q183392","display_name":"Rickets","level":3,"score":0.47537389397621155},{"id":"https://openalex.org/C2911197707","wikidata":"https://www.wikidata.org/wiki/Q1779987","display_name":"Hypophosphatemic Rickets","level":4,"score":0.4491094946861267},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.424887090921402},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.17545941472053528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16720378398895264},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0876937210559845},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000089703","descriptor_name":"Fibroblast Growth Factor-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010530","descriptor_name":"Peritoneal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1210/jc.2009-1603","doi":"https://doi.org/10.1210/jc.2009-1603","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2009-1603","pdf_url":"https://academic.oup.com/jcem/article-pdf/95/2/578/9065479/jcem0578.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2840849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2840849","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Endocrinol Metab","raw_type":"Text"},{"id":"pmid:19965919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19965919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/jc.2009-1603","doi":"https://doi.org/10.1210/jc.2009-1603","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2009-1603","pdf_url":"https://academic.oup.com/jcem/article-pdf/95/2/578/9065479/jcem0578.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2109737363","display_name":"Role of FGF23 in Mineral Metabolism Across the Spectrum of Chronic Kidney Disease","funder_award_id":"R01DK076116","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3552353607","display_name":"Hormonal Control of Calcium Metabolism","funder_award_id":"P01DK011794","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5402294149","display_name":"Regulation of Bone Mineralization in Renal Osteodystrophy","funder_award_id":"R01DK035423","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8725662076","display_name":"Role of Parathyroid Hormone in Renal Osteodystrophy","funder_award_id":"R01DK067563","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000012293","display_name":null,"funder_award_id":"PO1-DK11794","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000123378","display_name":null,"funder_award_id":"DK 11794","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320322359","display_name":"Kyowa Hakko Kirin","ror":"https://ror.org/0586k5242"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159397492.pdf","grobid_xml":"https://content.openalex.org/works/W2159397492.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W132615239","https://openalex.org/W1563425273","https://openalex.org/W1965969760","https://openalex.org/W1977645780","https://openalex.org/W1987998131","https://openalex.org/W1993004730","https://openalex.org/W1998100845","https://openalex.org/W2000048959","https://openalex.org/W2000736072","https://openalex.org/W2003490678","https://openalex.org/W2004168425","https://openalex.org/W2012675371","https://openalex.org/W2017219647","https://openalex.org/W2019253822","https://openalex.org/W2021852822","https://openalex.org/W2022604691","https://openalex.org/W2023446262","https://openalex.org/W2028563969","https://openalex.org/W2038640758","https://openalex.org/W2042318994","https://openalex.org/W2051959338","https://openalex.org/W2060108666","https://openalex.org/W2063765502","https://openalex.org/W2068226571","https://openalex.org/W2079730042","https://openalex.org/W2091948921","https://openalex.org/W2094262605","https://openalex.org/W2095948376","https://openalex.org/W2098828778","https://openalex.org/W2099379221","https://openalex.org/W2101903081","https://openalex.org/W2107207648","https://openalex.org/W2109177164","https://openalex.org/W2112631592","https://openalex.org/W2115596685","https://openalex.org/W2127560186","https://openalex.org/W2143098590","https://openalex.org/W2146666133","https://openalex.org/W2150640826","https://openalex.org/W2157448600","https://openalex.org/W2164533721","https://openalex.org/W2164952534","https://openalex.org/W2170092490","https://openalex.org/W2170351820","https://openalex.org/W2171100097","https://openalex.org/W2172200321","https://openalex.org/W2328615536","https://openalex.org/W2403949875","https://openalex.org/W2527550773","https://openalex.org/W3037275937"],"related_works":["https://openalex.org/W2159278721","https://openalex.org/W131810085","https://openalex.org/W2062466028","https://openalex.org/W3094599174","https://openalex.org/W2000048959","https://openalex.org/W2332113435","https://openalex.org/W7095077573","https://openalex.org/W1968658067","https://openalex.org/W2364286235","https://openalex.org/W7009914334"],"abstract_inverted_index":{"CONTEXT:":[0],"Fibroblast":[1],"growth":[2],"factor":[3],"23":[4],"(FGF23)":[5],"regulates":[6],"phosphorus":[7],"homeostasis":[8],"and":[9,20,64,136,143,194,200,254],"vitamin":[10],"D":[11],"metabolism.":[12],"Circulating":[13],"FGF23":[14,34,47,80,98,117,126,172,183,196,205,233,248],"levels":[15,77,118,169],"are":[16,35],"elevated":[17,76],"in":[18,37,44,81,99,155,175,249],"inherited":[19],"acquired":[21],"hypophosphatemic":[22],"disorders":[23],"that":[24,173,244],"can":[25],"cause":[26],"rickets":[27],"or":[28,93,133],"osteomalacia.":[29],"Particularly":[30],"increased":[31,46,65],"concentrations":[32],"of":[33,60,78,85,170,192,204,212],"observed":[36],"patients":[38,103,145,214,251],"with":[39,50,121,124,146,151,207],"chronic":[40],"kidney":[41],"disease":[42,53,149],"(CKD),":[43],"which":[45,222],"is":[48,252],"associated":[49],"more":[51],"rapid":[52],"progression,":[54],"improved":[55],"bone":[56],"mineralization,":[57],"the":[58,74,156,242],"development":[59],"left":[61],"ventricular":[62],"hypertrophy,":[63],"mortality.":[66],"OBJECTIVE:":[67],"Our":[68,236],"objective":[69],"was":[70,108,185,223],"to":[71,177],"determine":[72],"whether":[73],"markedly":[75],"immunoreactive":[79,195],"CKD":[82,102],"represent":[83],"accumulation":[84],"intact,":[86],"biologically":[87,255],"active":[88,97],"hormone,":[89],"C-terminal":[90,137],"cleavage":[91],"fragments,":[92],"both.":[94],"DESIGN:":[95],"Biologically":[96],"plasma":[100,211],"from":[101,210,225],"treated":[104,150],"by":[105,187],"peritoneal":[106,152],"dialysis":[107,153,213,250],"quantified":[109],"using":[110],"a":[111,159,217],"cell-based":[112],"Egr-1":[113],"reporter":[114],"assay;":[115],"bioactive":[116,171,193],"were":[119,197],"compared":[120],"those":[122],"measured":[123],"immunometric":[125],"assays":[127],"detecting":[128],"either":[129],"intact":[130,134,227,253],"hormone":[131,135],"alone":[132],"fragments.":[138,234],"SETTING":[139],"AND":[140],"PATIENTS:":[141],"Adult":[142],"pediatric":[144],"end-stage":[147],"renal":[148],"participated":[154],"study":[157],"at":[158],"tertiary":[160],"referral":[161],"center.":[162],"RESULTS:":[163],"Serially":[164],"diluted":[165],"patient":[166],"samples":[167],"revealed":[168,215],"ran":[174],"parallel":[176],"CHO":[178],"cell-derived":[179],"recombinant":[180,226],"human":[181],"FGF23.":[182],"bioactivity":[184],"inhibited":[186],"an":[188],"anti-FGF23":[189,208],"antibody.":[190],"Levels":[191],"tightly":[198],"correlated,":[199],"Western":[201],"blot":[202],"analysis":[203],"immunoprecipitated":[206],"antibodies":[209],"only":[216],"single":[218],"prominent":[219],"protein":[220],"band,":[221],"indistinguishable":[224],"FGF23,":[228],"without":[229],"clear":[230],"evidence":[231,240],"for":[232,241],"CONCLUSIONS:":[235],"results":[237],"provide":[238],"strong":[239],"conclusion":[243],"virtually":[245],"all":[246],"circulating":[247],"active.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}