{"id":"https://openalex.org/W2159397133","doi":"https://doi.org/10.1161/hypertensionaha.109.130443","title":"Deficiency of Nectin-2 Leads to Cardiac Fibrosis and Dysfunction Under Chronic Pressure Overload","display_name":"Deficiency of Nectin-2 Leads to Cardiac Fibrosis and Dysfunction Under Chronic Pressure Overload","publication_year":2009,"publication_date":"2009-08-11","ids":{"openalex":"https://openalex.org/W2159397133","doi":"https://doi.org/10.1161/hypertensionaha.109.130443","mag":"2159397133","pmid":"https://pubmed.ncbi.nlm.nih.gov/19667252"},"language":"en","primary_location":{"id":"doi:10.1161/hypertensionaha.109.130443","doi":"https://doi.org/10.1161/hypertensionaha.109.130443","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.109.130443","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.109.130443","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.109.130443","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082647122","display_name":"Seimi Satomi\u2010Kobayashi","orcid":"https://orcid.org/0000-0003-4656-260X","observed_orcids":["https://orcid.org/0000-0003-4656-260X"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Seimi Satomi-Kobayashi","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054125226","display_name":"Tomomi Ueyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Tomomi Ueyama","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steffen Mueller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Steffen Mueller","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087872679","display_name":"Ryuji Toh","orcid":"https://orcid.org/0000-0002-7204-6695","observed_orcids":["https://orcid.org/0000-0002-7204-6695"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Ryuji Toh","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111623284","display_name":"Tomoya Masano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Tomoya Masano","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111733886","display_name":"Tsuyoshi Sakoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Sakoda","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003538048","display_name":"Yoshiyuki Rikitake","orcid":"https://orcid.org/0000-0001-7207-4656","observed_orcids":["https://orcid.org/0000-0001-7207-4656"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yoshiyuki Rikitake","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013105441","display_name":"Jun Miyoshi","orcid":"https://orcid.org/0000-0002-6883-1930","observed_orcids":["https://orcid.org/0000-0002-6883-1930"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Jun Miyoshi","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088800086","display_name":"Hiroaki Matsubara","orcid":"https://orcid.org/0000-0002-8408-4234","observed_orcids":["https://orcid.org/0000-0002-8408-4234"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hiroaki Matsubara","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101929657","display_name":"Hidemasa Oh","orcid":"https://orcid.org/0000-0002-9643-6073","observed_orcids":["https://orcid.org/0000-0002-9643-6073"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hidemasa Oh","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050600382","display_name":"Seinosuke Kawashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Seinosuke Kawashima","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101620749","display_name":"Ken\u2010ichi Hirata","orcid":"https://orcid.org/0000-0002-6782-3031","observed_orcids":["https://orcid.org/0000-0002-6782-3031"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Ken-ichi Hirata","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042331400","display_name":"Yoshimi Takai","orcid":"https://orcid.org/0000-0003-1338-1327","observed_orcids":["https://orcid.org/0000-0003-1338-1327"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]},{"id":"https://openalex.org/I4210150196","display_name":"Kyoto University Hospital","ror":"https://ror.org/04k6gr834","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210150196"]},{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yoshimi Takai","raw_affiliation_strings":["From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Cardiovascular Medicine, Department of Internal Medicine (S.S-K., R.T., T.M., S.K., K-i.H.), and Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology (Y.R., Y.T.), Kobe University Graduate School of Medicine, Kobe, Japan; Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I40677808","https://openalex.org/I65837984"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine (T.U., H.M.), Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Experimental Therapeutics (T.U., H.M., H.O.), Translational Research Center, Kyoto University Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210150196"]},{"raw_affiliation_string":"Department of Molecular Biology (J.M.), Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry (Y.T.), Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology (S.M.), State University of New York at Stony Brook, Stony Brook, NY","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]},{"raw_affiliation_string":"Division of Coronary Heart Disease (T.S.), Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6919,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.84783171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"54","issue":"4","first_page":"825","last_page":"831"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nectin-2","display_name":"nectin-2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/intercalated-discs","display_name":"intercalated discs","score":0.8629999756813049},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pressure-overload","display_name":"pressure overload","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.8560000061988831},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.9739999771118164},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9729999899864197},{"id":"https://openalex.org/keywords/aortic-banding","display_name":"aortic banding","score":0.7749999761581421},{"id":"https://openalex.org/keywords/nectin-4","display_name":"nectin-4","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C23327873","wikidata":"https://www.wikidata.org/wiki/Q6985829","display_name":"Nectin","level":4,"score":0.827523946762085},{"id":"https://openalex.org/C2781175142","wikidata":"https://www.wikidata.org/wiki/Q6045608","display_name":"Intercalated disc","level":4,"score":0.8086466789245605},{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.7870639562606812},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.74630206823349},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49927425384521484},{"id":"https://openalex.org/C91682701","wikidata":"https://www.wikidata.org/wiki/Q41797304","display_name":"Immunoglobulin superfamily","level":3,"score":0.4741605818271637},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.4588108956813812},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4455380141735077},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.41646355390548706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41153693199157715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4105367958545685},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4008691608905792},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3454556167125702},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2872411608695984},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.2872108817100525},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25872287154197693},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.2527965307235718},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.2519770562648773},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.10177525877952576},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09157922863960266},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08892378211021423},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.0},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000075983","descriptor_name":"Nectins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022005","descriptor_name":"Adherens Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/hypertensionaha.109.130443","doi":"https://doi.org/10.1161/hypertensionaha.109.130443","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.109.130443","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.109.130443","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:19667252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19667252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/hypertensionaha.109.130443","doi":"https://doi.org/10.1161/hypertensionaha.109.130443","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.109.130443","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.109.130443","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323467","display_name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","ror":"https://ror.org/045p8e908"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159397133.pdf","grobid_xml":"https://content.openalex.org/works/W2159397133.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W196745860","https://openalex.org/W1980953487","https://openalex.org/W1989950796","https://openalex.org/W1992266959","https://openalex.org/W2000537144","https://openalex.org/W2001535302","https://openalex.org/W2024306318","https://openalex.org/W2029654767","https://openalex.org/W2031217240","https://openalex.org/W2041421272","https://openalex.org/W2041550708","https://openalex.org/W2043198887","https://openalex.org/W2043395027","https://openalex.org/W2067837318","https://openalex.org/W2068291993","https://openalex.org/W2068671266","https://openalex.org/W2071881835","https://openalex.org/W2082078624","https://openalex.org/W2088055307","https://openalex.org/W2091719398","https://openalex.org/W2097767970","https://openalex.org/W2099117877","https://openalex.org/W2107359871","https://openalex.org/W2109485370","https://openalex.org/W2113175417","https://openalex.org/W2115013104","https://openalex.org/W2117596573","https://openalex.org/W2117919604","https://openalex.org/W2118567467","https://openalex.org/W2122742614","https://openalex.org/W2124042926","https://openalex.org/W2126750826","https://openalex.org/W2131678721","https://openalex.org/W2136070250","https://openalex.org/W2141623014","https://openalex.org/W2148475161","https://openalex.org/W2148819836","https://openalex.org/W4237863787","https://openalex.org/W4255767289"],"related_works":["https://openalex.org/W2011439262","https://openalex.org/W2056550364","https://openalex.org/W2118567467","https://openalex.org/W2996281628","https://openalex.org/W2561796143","https://openalex.org/W1157518776","https://openalex.org/W2156673413","https://openalex.org/W4313396973","https://openalex.org/W1539662574","https://openalex.org/W2133223516"],"abstract_inverted_index":{"The":[0,159],"intercalated":[1,34,47,83,99,163,237],"disc,":[2,48],"a":[3],"cell-cell":[4,43,63],"contact":[5],"site":[6],"between":[7],"neighboring":[8],"cardiac":[9,77,108,123,145,151,179,245],"myocytes,":[10],"plays":[11],"an":[12],"important":[13],"role":[14,73],"in":[15,29,39,45,53,68,76,101,128,170,183],"maintaining":[16],"the":[17,20,30,33,46,72,82,88,98,102,120,162,175,188,236,241],"homeostasis":[18,78],"of":[19,32,74,81,90,119,144,161,177,190,220,235],"heart":[21,242],"by":[22],"transmitting":[23,57],"electric":[24],"and":[25,56,79,93,110,138,165,209,233,239],"mechanical":[26],"signals.":[27],"Changes":[28],"architecture":[31],"disc":[35,84,100,238],"have":[36],"been":[37],"observed":[38,169],"dilated":[40],"cardiomyopathy.":[41],"Among":[42,87],"junctions":[44,50],"adherens":[49,69],"are":[51,60,85],"involved":[52],"anchoring":[54],"myofibrils":[55,167],"force.":[58],"Nectins":[59],"Ca(2+)-independent,":[61],"immunoglobulin-like":[62],"adhesion":[64],"molecules":[65],"that":[66,226],"exist":[67],"junctions.":[70],"However,":[71],"nectins":[75],"integrity":[80],"unknown.":[86],"isoforms":[89],"nectins,":[91],"nectin-2":[92,227],"-4":[94],"were":[95,168,214],"expressed":[96],"at":[97,196],"heart.":[103],"Nectin-2-knockout":[104],"mice":[105,130,140,149],"showed":[106],"normal":[107],"structure":[109,232],"function":[111,124,234],"under":[112],"physiological":[113],"conditions.":[114],"Four":[115],"weeks":[116,202],"after":[117,203],"banding":[118],"ascending":[121],"aorta,":[122],"was":[125,181],"significantly":[126],"impaired":[127],"nectin-2-knockout":[129,137,148,172,185,192],"compared":[131,217],"with":[132,218],"wild-type":[133,139,157,221],"mice,":[134,193],"although":[135],"both":[136],"developed":[141],"similar":[142],"degrees":[143],"hypertrophy.":[146],"Banded":[147],"displayed":[150],"fibrosis":[152],"more":[153],"evidently":[154],"than":[155],"banded":[156,171,184,191],"mice.":[158,173,186,222],"disruption":[160],"discs":[164],"disorganized":[166],"Furthermore,":[174],"number":[176],"apoptotic":[178],"myocytes":[180],"increased":[182],"In":[187],"hearts":[189],"Akt":[194],"remained":[195],"lower":[197],"phosphorylation":[198],"levels":[199],"until":[200],"2":[201],"banding,":[204],"whereas":[205],"c-Jun":[206],"N-terminal":[207],"kinase":[208,213],"p38":[210],"mitogen-activated":[211],"protein":[212],"highly":[215],"phosphorylated":[216],"those":[219],"These":[223],"results":[224],"indicate":[225],"is":[228],"required":[229],"to":[230],"maintain":[231],"protects":[240],"from":[243],"pressure-overload-induced":[244],"dysfunction.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}