{"id":"https://openalex.org/W2159346017","doi":"https://doi.org/10.1085/jgp.200809961","title":"Mathematical Model of Mouse Embryonic Cardiomyocyte Excitation\u2013Contraction Coupling","display_name":"Mathematical Model of Mouse Embryonic Cardiomyocyte Excitation\u2013Contraction Coupling","publication_year":2008,"publication_date":"2008-09-15","ids":{"openalex":"https://openalex.org/W2159346017","doi":"https://doi.org/10.1085/jgp.200809961","mag":"2159346017","pmid":"https://pubmed.ncbi.nlm.nih.gov/18794378","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2553388"},"language":"en","primary_location":{"id":"doi:10.1085/jgp.200809961","doi":"https://doi.org/10.1085/jgp.200809961","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.200809961","pdf_url":"https://rupress.org/jgp/article-pdf/132/4/407/1224125/jgp_200809961.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of General Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jgp/article-pdf/132/4/407/1224125/jgp_200809961.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111972869","display_name":"Topi Korhonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Topi Korhonen","raw_affiliation_strings":["Institute of Biomedicine, Department of Physiology and Biocenter Oulu, University of Oulu, 90014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Department of Physiology and Biocenter Oulu, University of Oulu, 90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084097059","display_name":"Risto Rapila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Risto Rapila","raw_affiliation_strings":["Institute of Biomedicine, Department of Physiology and Biocenter Oulu, University of Oulu, 90014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Department of Physiology and Biocenter Oulu, University of Oulu, 90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081578056","display_name":"Pasi Tavi","orcid":"https://orcid.org/0000-0003-2563-3616","observed_orcids":["https://orcid.org/0000-0003-2563-3616"]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Pasi Tavi","raw_affiliation_strings":["Institute of Biomedicine, Department of Physiology and Biocenter Oulu, University of Oulu, 90014 Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Department of Physiology and Biocenter Oulu, University of Oulu, 90014 Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081578056"],"corresponding_institution_ids":["https://openalex.org/I98381234"],"apc_list":null,"apc_paid":null,"fwci":2.3327,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.88617834,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"132","issue":"4","first_page":"407","last_page":"419"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/embryonic-cardiomyocytes","display_name":"embryonic cardiomyocytes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium-release","display_name":"sarcoplasmic reticulum calcium release","score":0.8659999966621399},{"id":"https://openalex.org/keywords/na-ca2-exchanger","display_name":"Na+/Ca2+ exchanger","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cytosolic-calcium-dynamics","display_name":"cytosolic calcium dynamics","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hyperpolarization-activated-current","display_name":"hyperpolarization-activated current","score":0.9430000185966492},{"id":"https://openalex.org/keywords/calreticulin","display_name":"calreticulin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cardiac-action-potential","display_name":"cardiac action potential","score":0.5180000066757202},{"id":"https://openalex.org/keywords/mouse-heart-development","display_name":"mouse heart development","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2777837822","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Embryonic heart","level":4,"score":0.5894472599029541},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5872858762741089},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.5335894823074341},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5291562080383301},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5235190987586975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4566073417663574},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.451985239982605},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44558656215667725},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.44426971673965454},{"id":"https://openalex.org/C13852961","wikidata":"https://www.wikidata.org/wiki/Q17021880","display_name":"Heartbeat","level":2,"score":0.43333151936531067},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.42582976818084717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3257559537887573},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.12466269731521606},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12310326099395752},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12287673354148865},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10752400755882263},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019831","descriptor_name":"Sodium-Calcium Exchanger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019831","descriptor_name":"Sodium-Calcium Exchanger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D037282","descriptor_name":"Calreticulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037282","descriptor_name":"Calreticulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1085/jgp.200809961","doi":"https://doi.org/10.1085/jgp.200809961","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.200809961","pdf_url":"https://rupress.org/jgp/article-pdf/132/4/407/1224125/jgp_200809961.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of General Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1413048","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2553388","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:18794378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18794378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2553388","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2553388/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gen Physiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1085/jgp.200809961","doi":"https://doi.org/10.1085/jgp.200809961","is_oa":true,"landing_page_url":"https://doi.org/10.1085/jgp.200809961","pdf_url":"https://rupress.org/jgp/article-pdf/132/4/407/1224125/jgp_200809961.pdf","source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of General Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159346017.pdf","grobid_xml":"https://content.openalex.org/works/W2159346017.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1597285101","https://openalex.org/W1661761832","https://openalex.org/W1965371036","https://openalex.org/W1977643020","https://openalex.org/W1982140992","https://openalex.org/W1986783128","https://openalex.org/W1988792839","https://openalex.org/W1991546805","https://openalex.org/W1996022889","https://openalex.org/W1998672281","https://openalex.org/W2005264220","https://openalex.org/W2005865511","https://openalex.org/W2010068969","https://openalex.org/W2013072110","https://openalex.org/W2032756882","https://openalex.org/W2045065489","https://openalex.org/W2049655628","https://openalex.org/W2054799212","https://openalex.org/W2055521852","https://openalex.org/W2058607911","https://openalex.org/W2068162188","https://openalex.org/W2070631962","https://openalex.org/W2075401648","https://openalex.org/W2077847058","https://openalex.org/W2080308056","https://openalex.org/W2082722322","https://openalex.org/W2085071477","https://openalex.org/W2087693277","https://openalex.org/W2088659629","https://openalex.org/W2102767470","https://openalex.org/W2108383919","https://openalex.org/W2111867044","https://openalex.org/W2112960344","https://openalex.org/W2128720297","https://openalex.org/W2129103251","https://openalex.org/W2130478482","https://openalex.org/W2132561989","https://openalex.org/W2139133121","https://openalex.org/W2141283808","https://openalex.org/W2156407866","https://openalex.org/W2157757193","https://openalex.org/W2158644069","https://openalex.org/W2159329774","https://openalex.org/W2159999909","https://openalex.org/W2163269686","https://openalex.org/W2165627388","https://openalex.org/W2171437709","https://openalex.org/W2411440828","https://openalex.org/W2977097895","https://openalex.org/W3196492948"],"related_works":["https://openalex.org/W2379407471","https://openalex.org/W1982880087","https://openalex.org/W2162960464","https://openalex.org/W2770119731","https://openalex.org/W2912495091","https://openalex.org/W2076273945","https://openalex.org/W2156407866","https://openalex.org/W2290087062","https://openalex.org/W2141283808","https://openalex.org/W6922521425"],"abstract_inverted_index":{"Excitation-contraction":[0],"(E-C)":[1],"coupling":[2,90,150],"is":[3],"the":[4,8,48,56,61,76,84,114,125,142,160,166,171,180,192,202,213,217,222,225,228],"mechanism":[5,220],"that":[6,188],"connects":[7],"electrical":[9],"excitation":[10],"with":[11,95],"cardiomyocyte":[12,86],"contraction.":[13],"Embryonic":[14],"cardiomyocytes":[15],"are":[16],"not":[17],"only":[18],"capable":[19],"of":[20,83,108,147,162,205,227],"generating":[21],"action":[22],"potential":[23],"(AP)-induced":[24],"Ca(2+)":[25,45,73,131,136,173],"signals":[26],"and":[27,70,80,88,133,151,170,196,224],"contractions":[28],"(E-C":[29],"coupling),":[30],"but":[31],"they":[32],"also":[33],"can":[34,111],"induce":[35],"spontaneous":[36,40,44],"pacemaking":[37,87],"activity.":[38],"The":[39,138],"activity":[41],"originates":[42],"from":[43,47],"releases":[46],"sarcoplasmic":[49],"reticulum":[50],"(SR),":[51],"which":[52],"trigger":[53],"APs":[54],"via":[55],"Na(+)/Ca(2+)":[57],"exchanger":[58],"(NCX).":[59],"In":[60,118,177,208],"AP-driven":[62],"mode,":[63],"an":[64,68],"external":[65],"stimulus":[66],"triggers":[67],"AP":[69],"activates":[71],"voltage-activated":[72],"intrusion":[74],"to":[75,120,187],"cell.":[77],"These":[78],"complex":[79],"unique":[81],"features":[82,146],"embryonic":[85,116,232],"E-C":[89,149],"have":[91],"never":[92],"been":[93],"assessed":[94],"mathematical":[96,103],"modeling.":[97],"Here,":[98],"we":[99],"suggest":[100],"a":[101,183],"novel":[102,128],"model":[104,126,139,157,181,215],"explaining":[105,216],"how":[106],"both":[107,148],"these":[109,178,206],"mechanisms":[110],"coexist":[112],"in":[113,191,230],"same":[115],"cardiomyocytes.":[117,233],"addition":[119],"experimentally":[121,143],"characterized":[122],"ion":[123],"currents,":[124],"includes":[127],"heterogeneous":[129],"cytosolic":[130],"dynamics":[132],"oscillatory":[134],"SR":[135,172],"handling.":[137],"reproduces":[140],"faithfully":[141],"observed":[144,189],"fundamental":[145],"pacemaking.":[152],"We":[153],"further":[154],"validate":[155],"our":[156],"by":[158],"simulating":[159],"effect":[161],"genetic":[163],"modifications":[164],"on":[165],"hyperpolarization-activated":[167],"current,":[168],"NCX,":[169],"buffer":[174],"protein":[175],"calreticulin.":[176],"simulations,":[179],"produces":[182],"similar":[184],"functional":[185],"alteration":[186],"previously":[190],"genetically":[193],"engineered":[194],"mice,":[195],"thus":[197],"provides":[198],"mechanistic":[199],"explanations":[200],"for":[201,221],"cardiac":[203],"phenotypes":[204],"animals.":[207],"general,":[209],"this":[210],"study":[211],"presents":[212],"first":[214],"underlying":[218],"cellular":[219],"origin":[223],"regulation":[226],"heartbeat":[229],"early":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
