{"id":"https://openalex.org/W2159283549","doi":"https://doi.org/10.1093/intimm/dxh206","title":"A distinct role for ICOS-mediated co-stimulatory signaling in CD4+ and CD8+ T cell subsets","display_name":"A distinct role for ICOS-mediated co-stimulatory signaling in CD4+ and CD8+ T cell subsets","publication_year":2005,"publication_date":"2005-01-25","ids":{"openalex":"https://openalex.org/W2159283549","doi":"https://doi.org/10.1093/intimm/dxh206","mag":"2159283549","pmid":"https://pubmed.ncbi.nlm.nih.gov/15668466"},"language":"en","primary_location":{"id":"doi:10.1093/intimm/dxh206","doi":"https://doi.org/10.1093/intimm/dxh206","is_oa":false,"landing_page_url":"https://doi.org/10.1093/intimm/dxh206","pdf_url":null,"source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053914726","display_name":"Masashi Watanabe","orcid":"https://orcid.org/0000-0003-1741-8748","observed_orcids":["https://orcid.org/0000-0003-1741-8748"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]},{"id":"https://openalex.org/I4405286273","display_name":"Research Institute for Biomedical Sciences, Tokyo University of Science","ror":"https://ror.org/01peck770","country_code":"JP","type":"facility","lineage":["https://openalex.org/I161296585","https://openalex.org/I4405286273"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"M. Watanabe","raw_affiliation_strings":["Division of Immunobiology, Research Institute for Biological Sciences, Tokyo University of Science, Noda, Chiba, Japan","Division of Immunobiology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunobiology, Research Institute for Biological Sciences, Tokyo University of Science, Noda, Chiba, Japan","institution_ids":["https://openalex.org/I161296585","https://openalex.org/I4405286273"]},{"raw_affiliation_string":"Division of Immunobiology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053914726"],"corresponding_institution_ids":["https://openalex.org/I161296585","https://openalex.org/I4405286273"],"apc_list":{"value":3530,"currency":"USD","value_usd":3530},"apc_paid":null,"fwci":1.024,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.75059536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"17","issue":"3","first_page":"269","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inducible-t-cell-costimulator","display_name":"ICOS","score":0.8080000281333923},{"id":"https://openalex.org/keywords/costimulation","display_name":"costimulation","score":0.890999972820282},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.746999979019165},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/il-2-receptor-beta-chain","display_name":"IL-2 receptor beta chain","score":0.906000018119812},{"id":"https://openalex.org/keywords/cd122","display_name":"CD122","score":0.996999979019165},{"id":"https://openalex.org/keywords/t-cell-expansion","display_name":"T cell expansion","score":0.7429999709129333},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5202720761299133},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4917652904987335},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49153241515159607},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4588002562522888},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.435332715511322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4243176579475403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3231624960899353},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30899542570114136},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.24054419994354248},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1279691755771637},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015375","descriptor_name":"Receptors, Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060889","descriptor_name":"Inducible T-Cell Co-Stimulator Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/intimm/dxh206","doi":"https://doi.org/10.1093/intimm/dxh206","is_oa":false,"landing_page_url":"https://doi.org/10.1093/intimm/dxh206","pdf_url":null,"source":{"id":"https://openalex.org/S5544371","display_name":"International Immunology","issn_l":"0953-8178","issn":["0953-8178","1460-2377"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Immunology","raw_type":"journal-article"},{"id":"pmid:15668466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15668466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International immunology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1011.3067","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1011.3067","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://intimm.oxfordjournals.org/content/early/2005/01/24/intimm.dxh206.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.561.9056","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.561.9056","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://intimm.oxfordjournals.org/content/17/3/269.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1491154613","https://openalex.org/W1495421840","https://openalex.org/W1514881432","https://openalex.org/W1542262758","https://openalex.org/W1548331405","https://openalex.org/W1564765245","https://openalex.org/W1581138690","https://openalex.org/W1604334489","https://openalex.org/W1613769575","https://openalex.org/W1626388077","https://openalex.org/W1628992377","https://openalex.org/W1661441964","https://openalex.org/W1667545291","https://openalex.org/W1733558371","https://openalex.org/W1898621392","https://openalex.org/W1923661714","https://openalex.org/W2008773262","https://openalex.org/W2010660594","https://openalex.org/W2013624346","https://openalex.org/W2022986271","https://openalex.org/W2026893575","https://openalex.org/W2037708347","https://openalex.org/W2052077392","https://openalex.org/W2069904188","https://openalex.org/W2070552972","https://openalex.org/W2077021157","https://openalex.org/W2083706418","https://openalex.org/W2084201164","https://openalex.org/W2084841253","https://openalex.org/W2091783976","https://openalex.org/W2093785165","https://openalex.org/W2104136109","https://openalex.org/W2113287758","https://openalex.org/W2116169737","https://openalex.org/W2118175246","https://openalex.org/W2118953824","https://openalex.org/W2130594577","https://openalex.org/W2133866843","https://openalex.org/W2135133819","https://openalex.org/W2140066663","https://openalex.org/W2151157466","https://openalex.org/W2158291190","https://openalex.org/W2160242825","https://openalex.org/W2160915452","https://openalex.org/W2162380170","https://openalex.org/W2171026458","https://openalex.org/W2321413400","https://openalex.org/W2955504961","https://openalex.org/W4232759851","https://openalex.org/W4244103648"],"related_works":["https://openalex.org/W7095463812","https://openalex.org/W2128810183","https://openalex.org/W1823273132","https://openalex.org/W1564765245","https://openalex.org/W2073574551","https://openalex.org/W2112602239","https://openalex.org/W45145161","https://openalex.org/W1985082545","https://openalex.org/W1667545291","https://openalex.org/W1661441964"],"abstract_inverted_index":{"While":[0],"the":[1,27,51,54,63,99,109,139,161,240,249],"ligand":[2],"of":[3,29,50,53,66,88,101,141,148,164,180,208,251],"inducible":[4],"co-stimulator":[5],"(ICOS),":[6],"B7":[7],"homologous":[8],"protein,":[9],"is":[10,20,119,219,226],"widely":[11],"expressed":[12],"in":[13,40,58,98,108,248],"somatic":[14],"cells,":[15,104],"B7-1":[16],"and":[17,91,105,150,253],"B7-2":[18],"expression":[19,162],"mainly":[21],"limited":[22,136],"to":[23,45,69,155,198],"lymphoid":[24],"organs.":[25],"Thus,":[26],"activation":[28],"T":[30,67,103,111,124,143,152,170,184,194,202,223,231,255],"cells":[31,68,185,195,203],"through":[32],"ICOS":[33,55,94,129,241],"without":[34],"a":[35,47,135,175,205,245],"CD28-mediated":[36],"signal":[37,57,243],"may":[38],"occur":[39],"physiological":[41],"situations.":[42],"In":[43],"order":[44],"gain":[46],"better":[48],"understanding":[49],"role":[52,247],"co-stimulatory":[56,242],"immune":[59,257],"responses,":[60],"we":[61,173],"studied":[62],"cellular":[64],"response":[65],"beads":[70],"coated":[71],"with":[72,160,212],"anti-ICOS":[73],"or":[74],"anti-CD28,":[75],"plus":[76],"sub-optimal":[77],"anti-CD3":[78],"mAb.":[79],"We":[80],"demonstrate":[81],"that":[82,117,186,216,239],"while":[83,191],"CD28":[84],"ligation":[85,95],"induced":[86,106],"expansion":[87,100,126,140],"both":[89],"CD4+":[90,110,142,149,183,193,252],"CD8+":[92,102,123,151,222,254],"populations,":[93],"only":[96,134],"resulted":[97],"apoptosis":[107],"cell":[112,125,153,224,232],"population.":[113,233],"It":[114],"was":[115],"found":[116],"IL-2":[118,157,165,209],"critically":[120],"required":[121],"for":[122,221],"triggered":[127],"by":[128,210,228],"ligation,":[130],"whereas":[131],"it":[132],"had":[133],"effect":[137],"on":[138,169],"cells.":[144,171],"This":[145],"distinct":[146,178,246],"reactivity":[147],"populations":[154],"exogenous":[156],"strongly":[158],"correlates":[159],"level":[163],"receptor":[166],"beta-chain,":[167],"CD122,":[168],"Furthermore,":[172],"defined":[174],"small":[176],"but":[177],"population":[179],"memory":[181],"phenotype":[182],"constitutively":[187],"express":[188],"ICOS.":[189],"Interestingly,":[190],"naive":[192],"were":[196],"unable":[197],"produce":[199],"IL-2,":[200,217],"ICOS-expressing":[201,230],"produced":[204,227],"substantial":[206],"amount":[207],"stimulation":[211],"anti-ICOS/CD3":[213],"beads,":[214],"suggesting":[215],"which":[218],"indispensable":[220],"expansion,":[225],"this":[229],"These":[234],"results":[235],"provide":[236],"evidence":[237],"indicating":[238],"plays":[244],"development":[250],"cell-mediated":[256],"responses.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}