{"id":"https://openalex.org/W2159274404","doi":"https://doi.org/10.1186/1471-2407-13-184","title":"Expressional alterations in functional ultra-conserved non-coding rnas in response to all-transretinoic acid - induced differentiation in neuroblastoma cells","display_name":"Expressional alterations in functional ultra-conserved non-coding rnas in response to all-transretinoic acid - induced differentiation in neuroblastoma cells","publication_year":2013,"publication_date":"2013-04-08","ids":{"openalex":"https://openalex.org/W2159274404","doi":"https://doi.org/10.1186/1471-2407-13-184","mag":"2159274404","pmid":"https://pubmed.ncbi.nlm.nih.gov/23565812","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3626850"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2407-13-184","doi":"https://doi.org/10.1186/1471-2407-13-184","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-13-184","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-13-184","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-13-184","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024265298","display_name":"Karen M. Watters","orcid":"https://orcid.org/0000-0002-8260-0098","observed_orcids":["https://orcid.org/0000-0002-8260-0098"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Karen M Watters","raw_affiliation_strings":["Cancer Genetics, Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. kwatters@bsd.uchicago.edu","Cancer Genetics, Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genetics, Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland. kwatters@bsd.uchicago.edu","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Cancer Genetics, Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044144357","display_name":"Kenneth R. Bryan","orcid":"https://orcid.org/0000-0002-9550-8354","observed_orcids":["https://orcid.org/0000-0002-9550-8354"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I3017411684","display_name":"Children's Health Ireland at Crumlin","ror":"https://ror.org/025qedy81","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I3017411684"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Kenneth Bryan","raw_affiliation_strings":["Cancer Genetics, Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","Children\u2019s Research Centre, Our Lady\u2019s Children\u2019s Hospital Crumlin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genetics, Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Children\u2019s Research Centre, Our Lady\u2019s Children\u2019s Hospital Crumlin, Dublin, Ireland","institution_ids":["https://openalex.org/I3017411684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052099004","display_name":"Niamh H. Foley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I3017411684","display_name":"Children's Health Ireland at Crumlin","ror":"https://ror.org/025qedy81","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I3017411684"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Niamh H Foley","raw_affiliation_strings":["Cancer Genetics, Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","Children\u2019s Research Centre, Our Lady\u2019s Children\u2019s Hospital Crumlin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genetics, Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Children\u2019s Research Centre, Our Lady\u2019s Children\u2019s Hospital Crumlin, Dublin, Ireland","institution_ids":["https://openalex.org/I3017411684"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Meehan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I3017411684","display_name":"Children's Health Ireland at Crumlin","ror":"https://ror.org/025qedy81","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I3017411684"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Maria Meehan","raw_affiliation_strings":["Cancer Genetics, Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","Children\u2019s Research Centre, Our Lady\u2019s Children\u2019s Hospital Crumlin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genetics, Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Children\u2019s Research Centre, Our Lady\u2019s Children\u2019s Hospital Crumlin, Dublin, Ireland","institution_ids":["https://openalex.org/I3017411684"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109866643","display_name":"Raymond L. Stallings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I3017411684","display_name":"Children's Health Ireland at Crumlin","ror":"https://ror.org/025qedy81","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I3017411684"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Raymond L Stallings","raw_affiliation_strings":["Cancer Genetics, Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","Children\u2019s Research Centre, Our Lady\u2019s Children\u2019s Hospital Crumlin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genetics, Department of Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Children\u2019s Research Centre, Our Lady\u2019s Children\u2019s Hospital Crumlin, Dublin, Ireland","institution_ids":["https://openalex.org/I3017411684"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024265298"],"corresponding_institution_ids":["https://openalex.org/I142762351"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":2.7502,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.90542254,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"184","last_page":"184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.1225999966263771,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.871999979019165},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.972000002861023},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.703000009059906},{"id":"https://openalex.org/keywords/non-coding-rna-expression","display_name":"non-coding RNA expression","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.546999990940094},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.8820000290870667},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.8080000281333923},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.9151501655578613},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.6674641966819763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6563791036605835},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5930549502372742},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5282948017120361},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5265493988990784},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.525604248046875},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5200005173683167},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.48575833439826965},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4801068603992462},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.47310519218444824},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43569236993789673},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.42789649963378906},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4198697805404663},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4104998707771301},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.38323503732681274},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33115291595458984}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022661","descriptor_name":"RNA, Untranslated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2407-13-184","doi":"https://doi.org/10.1186/1471-2407-13-184","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-13-184","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-13-184","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2626668","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3626850","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3626850","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3626850","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmid:23565812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23565812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:epubs.rcsi.ie:cangenart-1007","doi":null,"is_oa":false,"landing_page_url":"https://epubs.rcsi.ie/cangenart/7","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Genetics Articles","raw_type":"text"},{"id":"pmh:oai:figshare.com:article/10768034","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Expressional_alterations_in_functional_ultra-conserved_non-coding_rnas_in_response_to_all-trans_retinoic_acid_-_induced_differentiation_in_neuroblastoma_cells_/10768034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:www.lenus.ie:10147/283216","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10147/283216","pdf_url":null,"source":{"id":"https://openalex.org/S4306401756","display_name":"Lenus, The Irish Health Repository (Dr Steevens Hospital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/1471-2407-13-184","doi":"https://doi.org/10.1186/1471-2407-13-184","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-13-184","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-13-184","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F8766430056","display_name":"Research Ireland","ror":"https://ror.org/010t7sr36"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159274404.pdf","grobid_xml":"https://content.openalex.org/works/W2159274404.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1951244372","https://openalex.org/W1967703437","https://openalex.org/W1969951398","https://openalex.org/W1972316849","https://openalex.org/W1977703159","https://openalex.org/W1988993069","https://openalex.org/W1996394817","https://openalex.org/W2007179439","https://openalex.org/W2007199559","https://openalex.org/W2009300653","https://openalex.org/W2035987806","https://openalex.org/W2038287336","https://openalex.org/W2042720937","https://openalex.org/W2047416562","https://openalex.org/W2050740079","https://openalex.org/W2059341976","https://openalex.org/W2064428081","https://openalex.org/W2067410483","https://openalex.org/W2067606868","https://openalex.org/W2071086080","https://openalex.org/W2074469807","https://openalex.org/W2076406596","https://openalex.org/W2085432002","https://openalex.org/W2089122694","https://openalex.org/W2100990361","https://openalex.org/W2106713259","https://openalex.org/W2116236561","https://openalex.org/W2120865735","https://openalex.org/W2122906783","https://openalex.org/W2133810641","https://openalex.org/W2136245178","https://openalex.org/W2139017293","https://openalex.org/W2142808522","https://openalex.org/W2146573461","https://openalex.org/W2146843027","https://openalex.org/W2149243226","https://openalex.org/W2150283054","https://openalex.org/W2160188982","https://openalex.org/W2160558870","https://openalex.org/W2164318029","https://openalex.org/W2170989872","https://openalex.org/W2171873561","https://openalex.org/W2322168752"],"related_works":["https://openalex.org/W2317021931","https://openalex.org/W7100278486","https://openalex.org/W2009300653","https://openalex.org/W1996394817","https://openalex.org/W2971428971","https://openalex.org/W2949020864","https://openalex.org/W2623751874","https://openalex.org/W2037385985","https://openalex.org/W4280650964","https://openalex.org/W1224760034"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ultra-conserved":[1],"regions":[2],"(UCRs)":[3],"are":[4,265],"segments":[5],"of":[6,73,84,98,121,168,191,201,206,228,241,282,294,296],"the":[7,63,71,81,96,165,186,223,252,280,292],"genome":[8],"(\u2265":[9],"200":[10],"bp)":[11],"that":[12,217,238,255,279],"exhibit":[13],"100%":[14],"DNA":[15],"sequence":[16],"conservation":[17],"between":[18],"human,":[19],"mouse":[20],"and":[21,56,79,103,111,131,189,216,226,268,291],"rat.":[22],"Transcribed":[23],"UCRs":[24],"(T-UCRs)":[25],"have":[26,243],"been":[27],"shown":[28],"to":[29,53,58,94,136,232,249,301],"be":[30],"differentially":[31,123,151],"expressed":[32,124,152],"in":[33,42,62,101,109,185,222,247,259,262],"cancers":[34],"versus":[35],"normal":[36,263],"tissue,":[37],"indicating":[38],"a":[39,59,90,204,220],"possible":[40,166],"role":[41,167,221],"carcinogenesis.":[43],"All-trans-retinoic":[44],"acid":[45],"(ATRA)":[46],"causes":[47],"some":[48],"neuroblastoma":[49,113,297],"(NB)":[50],"cell":[51,114,160,193,298],"lines":[52,115,299],"undergo":[54],"differentiation":[55,295],"leads":[57],"significant":[60,239],"decrease":[61],"oncogenic":[64],"transcription":[65],"factor":[66],"MYCN.":[67],"Here,":[68],"we":[69,126],"examine":[70],"impact":[72],"ATRA":[74,178,302],"treatment":[75],"on":[76],"T-UCR":[77],"expression":[78,97,133,174,196,209,245],"investigate":[80,137],"biological":[82],"significance":[83],"these":[85],"changes.":[86],"METHODS:":[87],"We":[88],"designed":[89],"custom":[91],"tiling":[92],"microarray":[93,134,197],"profile":[95],"481":[99],"T-UCRs":[100,149,242,256],"sense":[102],"anti-sense":[104],"orientation":[105],"(962":[106],"potential":[107],"transcripts)":[108],"untreated":[110],"ATRA-treated":[112],"(SH-SY5Y,":[116],"SK-N-BE,":[117],"LAN-5).":[118],"Following":[119,145],"identification":[120],"significantly":[122],"T-UCRs,":[125],"carried":[127],"out":[128],"siRNA":[129,182],"knockdown":[130,200],"gene":[132],"analysis":[135,198],"putative":[138],"functional":[139],"roles":[140,254],"for":[141,272],"selected":[142],"T-UCRs.":[143],"RESULTS:":[144],"ATRA-induced":[146],"differentiation,":[147],"32":[148],"were":[150],"(16":[153],"up-regulated,":[154],"16":[155],"down-regulated)":[156],"across":[157],"all":[158],"three":[159],"lines.":[161,194],"Further":[162],"insight":[163],"into":[164],"T-UC.300A,":[169],"an":[170,269],"independent":[171],"transcript":[172],"whose":[173,208],"is":[175,286],"down-regulated":[176],"following":[177,199],"was":[179,210],"achieved":[180],"by":[181,212],"knockdown,":[183],"resulting":[184],"decreased":[187],"viability":[188],"invasiveness":[190],"ATRA-responsive":[192],"Gene":[195],"T-UC.300A":[202,214,285],"revealed":[203],"number":[205],"genes":[207],"altered":[211,244],"changing":[213],"levels":[215,246],"might":[218,257],"play":[219,258],"increased":[224],"proliferation":[225],"invasion":[227,290],"NB":[229],"cells":[230],"prior":[231,300],"ATRA-treatment.":[233],"CONCLUSIONS:":[234],"Our":[235],"results":[236],"indicate":[237,278],"numbers":[240],"response":[248],"ATRA.":[250],"While":[251],"precise":[253],"cancer":[260],"or":[261],"development":[264],"largely":[266],"unknown":[267],"important":[270],"area":[271],"future":[273],"study,":[274],"our":[275],"findings":[276],"strongly":[277],"function":[281],"non-coding":[283],"RNA":[284],"connected":[287],"with":[288],"proliferation,":[289],"inhibition":[293],"treatment.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
