{"id":"https://openalex.org/W2159249780","doi":"https://doi.org/10.1089/10799900050198444","title":"Differences in Lymphocyte-Regulatory Activity Among Variants of Ovine IFN-\u03c4","display_name":"Differences in Lymphocyte-Regulatory Activity Among Variants of Ovine IFN-\u03c4","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W2159249780","doi":"https://doi.org/10.1089/10799900050198444","mag":"2159249780","pmid":"https://pubmed.ncbi.nlm.nih.gov/11096457"},"language":"en","primary_location":{"id":"doi:10.1089/10799900050198444","doi":"https://doi.org/10.1089/10799900050198444","is_oa":false,"landing_page_url":"https://doi.org/10.1089/10799900050198444","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon &amp; Cytokine Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080667753","display_name":"\u015eaban Teki\u0307n","orcid":"https://orcid.org/0000-0003-2641-6293","observed_orcids":["https://orcid.org/0000-0003-2641-6293"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"\u015eaban Tekin","raw_affiliation_strings":["Department of Animal Sciences, University of Florida, Gainesville, FL 32611-0920"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, University of Florida, Gainesville, FL 32611-0920","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013806038","display_name":"Alan D. Ealy","orcid":"https://orcid.org/0000-0002-8507-6578","observed_orcids":["https://orcid.org/0000-0002-8507-6578"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan D. Ealy","raw_affiliation_strings":["Department of Animal Sciences, University of Missouri, Columbia, MO 65211. (Present address: Department of Dairy and Animal Science, Pennsylvania State University, University Park, PA 16802.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, University of Missouri, Columbia, MO 65211. (Present address: Department of Dairy and Animal Science, Pennsylvania State University, University Park, PA 16802.)","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046392099","display_name":"Shu-Zong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu-Zong Wang","raw_affiliation_strings":["Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028606515","display_name":"Peter James Hansen","orcid":"https://orcid.org/0000-0003-3061-9333","observed_orcids":["https://orcid.org/0000-0003-3061-9333"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Hansen","raw_affiliation_strings":["Department of Animal Sciences, University of Florida, Gainesville, FL 32611-0920"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, University of Florida, Gainesville, FL 32611-0920","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2223,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.5282319,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"20","issue":"11","first_page":"1001","last_page":"1005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.27320000529289246,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.09880000352859497,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-tau","display_name":"interferon-tau","score":0.9409999847412109},{"id":"https://openalex.org/keywords/lymphocyte-proliferation-inhibition","display_name":"lymphocyte proliferation inhibition","score":0.8339999914169312},{"id":"https://openalex.org/keywords/phytohemagglutinin","display_name":"phytohemagglutinin","score":0.8330000042915344},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C32253518","wikidata":"https://www.wikidata.org/wiki/Q5158447","display_name":"Conceptus","level":4,"score":0.7467286586761475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6791205406188965},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6060408353805542},{"id":"https://openalex.org/C2777330693","wikidata":"https://www.wikidata.org/wiki/Q1136340","display_name":"Luteolysis","level":4,"score":0.5894982814788818},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5184390544891357},{"id":"https://openalex.org/C32300475","wikidata":"https://www.wikidata.org/wiki/Q18027992","display_name":"IRF1","level":4,"score":0.4754098057746887},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.45497915148735046},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4285346567630768},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3251129984855652},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2693333029747009},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.21215662360191345},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20799332857131958},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17080479860305786},{"id":"https://openalex.org/C143228043","wikidata":"https://www.wikidata.org/wiki/Q2363481","display_name":"Luteal phase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010835","descriptor_name":"Phytohemagglutinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/10799900050198444","doi":"https://doi.org/10.1089/10799900050198444","is_oa":false,"landing_page_url":"https://doi.org/10.1089/10799900050198444","pdf_url":null,"source":{"id":"https://openalex.org/S109620152","display_name":"Journal of Interferon & Cytokine Research","issn_l":"1079-9907","issn":["1079-9907","1557-7465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interferon &amp; Cytokine Research","raw_type":"journal-article"},{"id":"pmid:11096457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11096457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2953851034","display_name":null,"funder_award_id":"HD 21896","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W217208040","https://openalex.org/W1510533289","https://openalex.org/W1537634427","https://openalex.org/W1543974858","https://openalex.org/W1642082766","https://openalex.org/W1871479351","https://openalex.org/W1967789891","https://openalex.org/W1971451280","https://openalex.org/W1984434785","https://openalex.org/W1986858563","https://openalex.org/W1989807793","https://openalex.org/W2003143551","https://openalex.org/W2004498358","https://openalex.org/W2006234567","https://openalex.org/W2009854766","https://openalex.org/W2013379487","https://openalex.org/W2017587668","https://openalex.org/W2022889607","https://openalex.org/W2023613067","https://openalex.org/W2047116971","https://openalex.org/W2049324321","https://openalex.org/W2054656162","https://openalex.org/W2058840288","https://openalex.org/W2070208341","https://openalex.org/W2080026635","https://openalex.org/W2086585721","https://openalex.org/W2097684766","https://openalex.org/W2108229547","https://openalex.org/W2113525695","https://openalex.org/W2116770595","https://openalex.org/W2117875219","https://openalex.org/W2118879316","https://openalex.org/W2125732575","https://openalex.org/W2144596191","https://openalex.org/W2150208430","https://openalex.org/W2181852091","https://openalex.org/W2199320236","https://openalex.org/W2340535391","https://openalex.org/W2418599405","https://openalex.org/W2911598539","https://openalex.org/W4313331172"],"related_works":["https://openalex.org/W2058840288","https://openalex.org/W2047116971","https://openalex.org/W2082412805","https://openalex.org/W7098615982","https://openalex.org/W2166312050","https://openalex.org/W1995594619","https://openalex.org/W2168537274","https://openalex.org/W2165170394","https://openalex.org/W2181852091","https://openalex.org/W1963482933"],"abstract_inverted_index":{"Interferon-tau":[0],"(IFN-tau)":[1],"is":[2],"secreted":[3],"from":[4],"trophectoderm":[5,127,147],"of":[6,24,41,60,92,130,142,145,157],"the":[7,125,143,146,154],"ruminant":[8],"preimplantation":[9],"conceptus":[10],"and":[11,29,68],"functions":[12],"during":[13],"pregnancy":[14],"to":[15,50,82,89,136],"prevent":[16,51],"luteolysis.":[17],"In":[18],"addition,":[19],"IFN-tau":[20,35,116,131],"can":[21],"inhibit":[22,58,90],"proliferation":[23,91],"peripheral":[25],"blood":[26],"lymphocytes":[27,150],"(PBL)":[28],"other":[30],"cells.":[31],"Several":[32],"distinct":[33],"ovine":[34],"(OvIFN-tau)":[36],"gene":[37],"variants":[38,84,117,129],"exist;":[39],"three":[40],"these":[42],"(IFN-tau4,":[43],"IFN-tau6d,":[44,103],"IFN-tau11)":[45],"differ":[46,133],"in":[47,87,111,134],"their":[48],"ability":[49,88,135],"luteolysis":[52],"(IFN-tau4":[53,63,73],">":[54,56,64,66,74],"IFN-tau6d":[55,65,75],"IFN-tau11),":[57,67],"growth":[59],"Daudi":[61],"cells":[62],"induce":[69],"an":[70,106],"antiviral":[71,122],"state":[72],"=":[76],"IFN-tau11).":[77],"The":[78,140],"present":[79],"objective":[80],"was":[81,99],"compare":[83],"for":[85],"differences":[86,110],"phytohemagglutinin-stimulated":[93],"PBL.":[94],"At":[95],"equal":[96,121],"concentrations,":[97],"IFN-tau4":[98],"more":[100],"inhibitory":[101],"than":[102],"IFN-tau11,":[104],"or":[105],"IFN-omega":[107],"control.":[108],"Similar":[109],"potency":[112],"were":[113,118],"seen":[114],"when":[115],"tested":[119],"at":[120],"concentrations.":[123],"Thus,":[124],"sheep":[126],"secretes":[128],"that":[132],"regulate":[137],"lymphocyte":[138],"function.":[139],"nature":[141],"effect":[144],"on":[148,153],"endometrial":[149],"may":[151],"depend":[152],"relative":[155],"amount":[156],"each":[158],"variant":[159],"produced.":[160]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
