{"id":"https://openalex.org/W2159236358","doi":"https://doi.org/10.1146/annurev-cellbio-100109-104042","title":"Presentation Counts: Microenvironmental Regulation of Stem Cells by Biophysical and Material Cues","display_name":"Presentation Counts: Microenvironmental Regulation of Stem Cells by Biophysical and Material Cues","publication_year":2010,"publication_date":"2010-10-07","ids":{"openalex":"https://openalex.org/W2159236358","doi":"https://doi.org/10.1146/annurev-cellbio-100109-104042","mag":"2159236358","pmid":"https://pubmed.ncbi.nlm.nih.gov/20590452","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5989312"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-cellbio-100109-104042","doi":"https://doi.org/10.1146/annurev-cellbio-100109-104042","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-cellbio-100109-104042","pdf_url":null,"source":{"id":"https://openalex.org/S93285647","display_name":"Annual Review of Cell and Developmental Biology","issn_l":"1081-0706","issn":["1081-0706","1530-8995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5989312","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091603416","display_name":"Albert J. Keung","orcid":"https://orcid.org/0000-0001-8958-1232","observed_orcids":["https://orcid.org/0000-0001-8958-1232"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert J. Keung","raw_affiliation_strings":["Department of Chemical Engineering, University of California, Berkeley, California, 94720;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of California, Berkeley, California, 94720;","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048305189","display_name":"Sanjay Kumar","orcid":"https://orcid.org/0000-0002-9996-4883","observed_orcids":["https://orcid.org/0000-0002-9996-4883"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay Kumar","raw_affiliation_strings":["Department of Bioengineering, University of California, Berkeley, California, 94720;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, Berkeley, California, 94720;","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013729741","display_name":"David V. Schaffer","orcid":"https://orcid.org/0000-0002-9625-0121","observed_orcids":["https://orcid.org/0000-0002-9625-0121"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David V. Schaffer","raw_affiliation_strings":["Department of Bioengineering, University of California, Berkeley, California, 94720;","Department of Chemical Engineering, University of California, Berkeley, California, 94720;","Helen Wills Neuroscience Institute, University of California, Berkeley, California, 94720;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, Berkeley, California, 94720;","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of California, Berkeley, California, 94720;","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Helen Wills Neuroscience Institute, University of California, Berkeley, California, 94720;,","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":1.4379,"has_fulltext":false,"cited_by_count":172,"citation_normalized_percentile":{"value":0.82785808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"26","issue":"1","first_page":"533","last_page":"556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.824999988079071},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.8930000066757202},{"id":"https://openalex.org/keywords/biophysical-cues","display_name":"biophysical cues","score":0.8489999771118164},{"id":"https://openalex.org/keywords/biochemical-cues","display_name":"biochemical cues","score":0.7369999885559082},{"id":"https://openalex.org/keywords/mechanical-cues","display_name":"mechanical cues","score":0.5189999938011169},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cell-fate-regulation","display_name":"cell fate regulation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/engineered-materials","display_name":"engineered materials","score":0.8029999732971191},{"id":"https://openalex.org/keywords/histogenesis","display_name":"histogenesis","score":0.578000009059906},{"id":"https://openalex.org/keywords/tissue-homeostasis","display_name":"tissue homeostasis","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8808475136756897},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7656452059745789},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5652459859848022},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5560391545295715},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5084847211837769},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48319756984710693},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.47853168845176697},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.45949462056159973},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.4417569637298584},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17532172799110413},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1540488600730896},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0697350800037384}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1146/annurev-cellbio-100109-104042","doi":"https://doi.org/10.1146/annurev-cellbio-100109-104042","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-cellbio-100109-104042","pdf_url":null,"source":{"id":"https://openalex.org/S93285647","display_name":"Annual Review of Cell and Developmental Biology","issn_l":"1081-0706","issn":["1081-0706","1530-8995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmid:20590452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20590452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4943804","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5989312","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5989312","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5989312","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Cell Dev Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4943804","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5989312","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2484136824","display_name":null,"funder_award_id":"R21 DE018044","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G329800440","display_name":"Cellular mechanobiology: Biophysics and therapeutics","funder_award_id":"1dp2od004213-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4692362935","display_name":"Fundamental Mechanobiology of Tumor Progression","funder_award_id":"U54CA143836","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6208209756","display_name":null,"funder_award_id":"R21EB007295","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309411","display_name":"University of California Berkeley","ror":"https://ror.org/01an7q238"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333566","display_name":"National Defense Science and Engineering Graduate","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":156,"referenced_works":["https://openalex.org/W1488252042","https://openalex.org/W1549544590","https://openalex.org/W1554690897","https://openalex.org/W1576773659","https://openalex.org/W1584141172","https://openalex.org/W1616421194","https://openalex.org/W1861988602","https://openalex.org/W1954994954","https://openalex.org/W1965180167","https://openalex.org/W1966462125","https://openalex.org/W1968541478","https://openalex.org/W1971091133","https://openalex.org/W1974365381","https://openalex.org/W1975718597","https://openalex.org/W1976632391","https://openalex.org/W1977962361","https://openalex.org/W1978968660","https://openalex.org/W1980867815","https://openalex.org/W1982316160","https://openalex.org/W1982765286","https://openalex.org/W1984223272","https://openalex.org/W1984417662","https://openalex.org/W1988391064","https://openalex.org/W1991237283","https://openalex.org/W1998777645","https://openalex.org/W2000060150","https://openalex.org/W2000328495","https://openalex.org/W2000430191","https://openalex.org/W2001675896","https://openalex.org/W2003873431","https://openalex.org/W2004947110","https://openalex.org/W2005505636","https://openalex.org/W2006508505","https://openalex.org/W2007004974","https://openalex.org/W2008067928","https://openalex.org/W2008370035","https://openalex.org/W2009219431","https://openalex.org/W2009393065","https://openalex.org/W2011874994","https://openalex.org/W2013650960","https://openalex.org/W2015890343","https://openalex.org/W2015979204","https://openalex.org/W2017042997","https://openalex.org/W2018244125","https://openalex.org/W2021312689","https://openalex.org/W2021488944","https://openalex.org/W2022480787","https://openalex.org/W2023687572","https://openalex.org/W2025667574","https://openalex.org/W2025695637","https://openalex.org/W2026652581","https://openalex.org/W2026917510","https://openalex.org/W2028916867","https://openalex.org/W2032275376","https://openalex.org/W2032828027","https://openalex.org/W2032936734","https://openalex.org/W2038929699","https://openalex.org/W2040184402","https://openalex.org/W2042408662","https://openalex.org/W2044193480","https://openalex.org/W2044484847","https://openalex.org/W2046713135","https://openalex.org/W2047608367","https://openalex.org/W2049387285","https://openalex.org/W2053121568","https://openalex.org/W2055419484","https://openalex.org/W2055604817","https://openalex.org/W2057564766","https://openalex.org/W2058258523","https://openalex.org/W2058500387","https://openalex.org/W2060475101","https://openalex.org/W2061285112","https://openalex.org/W2061315835","https://openalex.org/W2062362393","https://openalex.org/W2062945727","https://openalex.org/W2063145905","https://openalex.org/W2067064279","https://openalex.org/W2068437602","https://openalex.org/W2068506802","https://openalex.org/W2071033251","https://openalex.org/W2073795835","https://openalex.org/W2075580305","https://openalex.org/W2076681174","https://openalex.org/W2079762668","https://openalex.org/W2081452775","https://openalex.org/W2081858053","https://openalex.org/W2082292567","https://openalex.org/W2084694780","https://openalex.org/W2085144002","https://openalex.org/W2086265207","https://openalex.org/W2086641148","https://openalex.org/W2088473349","https://openalex.org/W2089204174","https://openalex.org/W2089822668","https://openalex.org/W2090063730","https://openalex.org/W2090890518","https://openalex.org/W2091523930","https://openalex.org/W2093723806","https://openalex.org/W2098737512","https://openalex.org/W2099052265","https://openalex.org/W2101904950","https://openalex.org/W2105300288","https://openalex.org/W2108855259","https://openalex.org/W2109538565","https://openalex.org/W2111724224","https://openalex.org/W2112618608","https://openalex.org/W2113964043","https://openalex.org/W2116767628","https://openalex.org/W2118453722","https://openalex.org/W2119708685","https://openalex.org/W2122238986","https://openalex.org/W2123914902","https://openalex.org/W2125862744","https://openalex.org/W2126326508","https://openalex.org/W2126409708","https://openalex.org/W2128681786","https://openalex.org/W2130606072","https://openalex.org/W2131256178","https://openalex.org/W2131404238","https://openalex.org/W2132817489","https://openalex.org/W2132936019","https://openalex.org/W2132997123","https://openalex.org/W2133943800","https://openalex.org/W2134208433","https://openalex.org/W2134812776","https://openalex.org/W2134834074","https://openalex.org/W2135395238","https://openalex.org/W2135447662","https://openalex.org/W2136334987","https://openalex.org/W2137809380","https://openalex.org/W2137825287","https://openalex.org/W2138900954","https://openalex.org/W2139719464","https://openalex.org/W2140395408","https://openalex.org/W2141593635","https://openalex.org/W2143723854","https://openalex.org/W2143889930","https://openalex.org/W2144023435","https://openalex.org/W2146649239","https://openalex.org/W2146776050","https://openalex.org/W2148625728","https://openalex.org/W2150798197","https://openalex.org/W2151170075","https://openalex.org/W2153027227","https://openalex.org/W2153338840","https://openalex.org/W2154214070","https://openalex.org/W2156416422","https://openalex.org/W2160839395","https://openalex.org/W2162716266","https://openalex.org/W2167243609","https://openalex.org/W2168811660","https://openalex.org/W2169327044","https://openalex.org/W2223011189","https://openalex.org/W2275190818","https://openalex.org/W2906916700","https://openalex.org/W4213141530"],"related_works":["https://openalex.org/W1963822296","https://openalex.org/W2900783112","https://openalex.org/W2278485442","https://openalex.org/W2146758639","https://openalex.org/W2122176403","https://openalex.org/W3208527475","https://openalex.org/W1988432563","https://openalex.org/W1820936244","https://openalex.org/W61732521","https://openalex.org/W4401634616"],"abstract_inverted_index":{"Stem":[0],"cells":[1,48],"reside":[2],"in":[3,8,128,136],"adult":[4],"and":[5,15,17,35,50,54,70,85,87,121,126,132,139,160,173],"embryonic":[6],"tissues":[7],"a":[9,129],"broad":[10],"spectrum":[11],"of":[12,33,75,141,157],"developmental":[13],"stages":[14],"lineages,":[16],"they":[18],"are":[19],"thus":[20],"naturally":[21],"exposed":[22],"to":[23,65,94,104],"diverse":[24],"microenvironments":[25],"or":[26,39,62],"niches":[27],"that":[28],"modulate":[29],"their":[30,88],"hallmark":[31],"behaviors":[32],"self-renewal":[34],"differentiation":[36],"into":[37],"one":[38],"more":[40],"mature":[41],"lineages.":[42],"Within":[43],"each":[44],"such":[45,142],"microenvironment,":[46],"stem":[47,151,169],"sense":[49],"process":[51],"multiple":[52],"biochemical":[53,120,162],"biophysical":[55,122],"cues,":[56,123],"which":[57],"can":[58,91,101],"exert":[59],"redundant,":[60],"competing,":[61],"orthogonal":[63],"influences":[64],"collectively":[66],"regulate":[67],"cell":[68,108,152,170],"fate":[69],"function.":[71],"The":[72],"proper":[73],"presentation":[74],"these":[76,97],"myriad":[77],"regulatory":[78,99,148],"signals":[79],"is":[80],"required":[81],"for":[82,118,167],"tissue":[83],"development":[84,138],"homeostasis,":[86],"improper":[89],"appearance":[90],"potentially":[92],"lead":[93],"disease.":[95],"Whereas":[96],"complex":[98],"cues":[100],"be":[102],"challenging":[103],"dissect":[105],"using":[106],"traditional":[107],"culture":[109],"paradigms,":[110],"recently":[111],"developed":[112],"engineered":[113],"material":[114],"systems":[115,143],"offer":[116],"advantages":[117],"investigating":[119],"both":[124],"static":[125],"dynamic,":[127],"controlled,":[130],"modular,":[131],"quantitative":[133],"fashion.":[134],"Advances":[135],"the":[137,155],"use":[140],"have":[144],"helped":[145],"elucidate":[146],"novel":[147],"mechanisms":[149],"controlling":[150],"behavior,":[153],"particularly":[154],"importance":[156],"solid-phase":[158],"mechanical":[159],"immobilized":[161],"microenvironmental":[163],"signals,":[164],"with":[165],"implications":[166],"basic":[168],"biology,":[171],"disease,":[172],"therapeutics.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":18}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}