{"id":"https://openalex.org/W2159232889","doi":"https://doi.org/10.1212/wnl.44.6.1015","title":"Progressive supranuclear palsy","display_name":"Progressive supranuclear palsy","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W2159232889","doi":"https://doi.org/10.1212/wnl.44.6.1015","mag":"2159232889","pmid":"https://pubmed.ncbi.nlm.nih.gov/8208392"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.44.6.1015","doi":"https://doi.org/10.1212/wnl.44.6.1015","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.44.6.1015","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002149196","display_name":"Maria Gearing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Gearing","raw_affiliation_strings":["Veterans Affairs Medical Center and the Department of Pathology and Laboratory Medicine (Drs. Gearing and Mirra) and the Department of Neurology (Drs. Olson and Watts), Emory University School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center and the Department of Pathology and Laboratory Medicine (Drs. Gearing and Mirra) and the Department of Neurology (Drs. Olson and Watts), Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I150468666","https://openalex.org/I2799886695","https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David A. Olson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Olson","raw_affiliation_strings":["Veterans Affairs Medical Center and the Department of Pathology and Laboratory Medicine (Drs. Gearing and Mirra) and the Department of Neurology (Drs. Olson and Watts), Emory University School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center and the Department of Pathology and Laboratory Medicine (Drs. Gearing and Mirra) and the Department of Neurology (Drs. Olson and Watts), Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I150468666","https://openalex.org/I2799886695","https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075498105","display_name":"Ray L. Watts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ray L. Watts","raw_affiliation_strings":["Veterans Affairs Medical Center and the Department of Pathology and Laboratory Medicine (Drs. Gearing and Mirra) and the Department of Neurology (Drs. Olson and Watts), Emory University School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center and the Department of Pathology and Laboratory Medicine (Drs. Gearing and Mirra) and the Department of Neurology (Drs. Olson and Watts), Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I150468666","https://openalex.org/I2799886695","https://openalex.org/I4210152539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062983762","display_name":"Suzanne Samuels Mirra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne S. Mirra","raw_affiliation_strings":["Veterans Affairs Medical Center and the Department of Pathology and Laboratory Medicine (Drs. Gearing and Mirra) and the Department of Neurology (Drs. Olson and Watts), Emory University School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center and the Department of Pathology and Laboratory Medicine (Drs. Gearing and Mirra) and the Department of Neurology (Drs. Olson and Watts), Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I150468666","https://openalex.org/I2799886695","https://openalex.org/I4210152539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.0961,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.97478871,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"44","issue":"6","first_page":"1015","last_page":"1015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.09239999949932098,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progressive-supranuclear-palsy","display_name":"progressive supranuclear palsy","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7620000243186951},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/clinical-heterogeneity","display_name":"clinical heterogeneity","score":0.6769999861717224},{"id":"https://openalex.org/keywords/underdiagnosis","display_name":"underdiagnosis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/differential-diagnosis-of-dementia","display_name":"differential diagnosis of dementia","score":0.9490000009536743},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.9823895692825317},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.976351261138916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5484994649887085},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.5448132157325745},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5195212960243225},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5158523917198181},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.44241607189178467}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013494","descriptor_name":"Supranuclear Palsy, Progressive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013494","descriptor_name":"Supranuclear Palsy, Progressive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.44.6.1015","doi":"https://doi.org/10.1212/wnl.44.6.1015","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.44.6.1015","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:8208392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8208392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1054070016","display_name":"EMORY ALZHEIMERS DISEASE CENTER","funder_award_id":"P30AG010130","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1086794002","display_name":null,"funder_award_id":"AG-10130","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1561180953","display_name":null,"funder_award_id":"AG06790","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3477990590","display_name":"CONSORTIUM--ESTABLISH A REGISTRY FOR ALZHEIMERS DISEASE","funder_award_id":"U01AG006790","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2102961539","https://openalex.org/W2335656920","https://openalex.org/W4389460334","https://openalex.org/W1496232636","https://openalex.org/W2415591512","https://openalex.org/W4403416895","https://openalex.org/W2037446427","https://openalex.org/W99777439","https://openalex.org/W4386070754","https://openalex.org/W4410220221"],"abstract_inverted_index":{"To":[0],"investigate":[1],"potential":[2],"heterogeneity":[3,91],"in":[4,24,36,77,92,108],"progressive":[5],"supranuclear":[6],"palsy":[7],"(PSP),":[8],"we":[9],"examined":[10],"13":[11,48],"patients":[12,49,82],"with":[13,74],"neuropathologically":[14],"diagnosed":[15],"PSP.":[16],"The":[17],"clinical":[18,88],"diagnosis":[19,35,111],"of":[20,26,46,55,81,87,112],"PSP":[21,43,75,100],"was":[22,32],"made":[23],"eight":[25],"these":[27],"individuals,":[28],"whereas":[29],"probable":[30],"AD":[31,69],"the":[33,37,47,109],"primary":[34],"remaining":[38],"five.":[39],"In":[40],"addition":[41],"to":[42],"neuropathology,":[44],"seven":[45],"(54%)":[50],"showed":[51],"concomitant":[52],"pathologic":[53],"changes":[54,72],"Alzheimer's":[56],"disease":[57,60],"(AD),":[58],"Parkinson's":[59],"(PD),":[61],"or":[62],"both":[63],"disorders.":[64,94],"These":[65],"observations":[66],"indicate":[67],"that":[68,99],"and":[70,83,89,104],"PD":[71],"coexist":[73],"neuropathology":[76],"a":[78],"substantive":[79],"proportion":[80],"provide":[84],"further":[85],"evidence":[86],"neuropathologic":[90],"neurodegenerative":[93],"Moreover,":[95],"our":[96],"results":[97],"suggest":[98],"may":[101],"be":[102],"underdiagnosed":[103],"deserves":[105],"more":[106],"prominence":[107],"differential":[110],"dementing":[113],"illness.":[114]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}