{"id":"https://openalex.org/W2159226459","doi":"https://doi.org/10.1111/j.1365-2516.2009.02137.x","title":"Bernard Soulier syndrome in pregnancy: a systematic review","display_name":"Bernard Soulier syndrome in pregnancy: a systematic review","publication_year":2010,"publication_date":"2010-01-12","ids":{"openalex":"https://openalex.org/W2159226459","doi":"https://doi.org/10.1111/j.1365-2516.2009.02137.x","mag":"2159226459","pmid":"https://pubmed.ncbi.nlm.nih.gov/20070385"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2516.2009.02137.x","doi":"https://doi.org/10.1111/j.1365-2516.2009.02137.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2516.2009.02137.x","pdf_url":null,"source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091537176","display_name":"Panagiotis Peitsidis","orcid":"https://orcid.org/0000-0001-9772-4133","observed_orcids":["https://orcid.org/0000-0001-9772-4133"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. PEITSIDIS","raw_affiliation_strings":["Royal Free Hospital, Obstetrics and Gynaecology, London, UK","Royal Free Hospital, Obstetrics and Gynaecology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Free Hospital, Obstetrics and Gynaecology, London, UK","institution_ids":["https://openalex.org/I2801138448"]},{"raw_affiliation_string":"Royal Free Hospital, Obstetrics and Gynaecology","institution_ids":["https://openalex.org/I2801138448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087362116","display_name":"T Datta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. DATTA","raw_affiliation_strings":["Royal Free Hospital, Obstetrics and Gynaecology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Free Hospital, Obstetrics and Gynaecology","institution_ids":["https://openalex.org/I2801138448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001103102","display_name":"I. Pafilis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I. PAFILIS","raw_affiliation_strings":["Royal Free Hospital, Obstetrics and Gynaecology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Free Hospital, Obstetrics and Gynaecology","institution_ids":["https://openalex.org/I2801138448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009053444","display_name":"O. OTOMEWO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100063501","display_name":"Brighton and Sussex Medical School","ror":"https://ror.org/01qz7fr76","country_code":"GB","type":"education","lineage":["https://openalex.org/I100063501","https://openalex.org/I162608824","https://openalex.org/I71637028"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"O. OTOMEWO","raw_affiliation_strings":["Brighton and Sussex Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brighton and Sussex Medical School","institution_ids":["https://openalex.org/I100063501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029562668","display_name":"Edward G. D. Tuddenham","orcid":"https://orcid.org/0000-0001-8955-2909","observed_orcids":["https://orcid.org/0000-0001-8955-2909"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E. G. D. TUDDENHAM","raw_affiliation_strings":["Royal Free Hospital, Haemophilia Centre and Thrombosis Unit, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Free Hospital, Haemophilia Centre and Thrombosis Unit, London, UK","institution_ids":["https://openalex.org/I2801138448"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091326245","display_name":"Rezan A. Kadir","orcid":"https://orcid.org/0000-0002-2684-1006","observed_orcids":["https://orcid.org/0000-0002-2684-1006"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"R. A. KADIR","raw_affiliation_strings":["Royal Free Hospital, Haemophilia Centre and Thrombosis Unit, London, UK","Royal Free Hospital, Obstetrics and Gynaecology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Free Hospital, Haemophilia Centre and Thrombosis Unit, London, UK","institution_ids":["https://openalex.org/I2801138448"]},{"raw_affiliation_string":"Royal Free Hospital, Obstetrics and Gynaecology","institution_ids":["https://openalex.org/I2801138448"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091326245"],"corresponding_institution_ids":["https://openalex.org/I2801138448"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":1.3037,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.74831964,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"16","issue":"4","first_page":"584","last_page":"591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bernard-soulier-syndrome","display_name":"Bernard-Soulier syndrome","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9580000042915344},{"id":"https://openalex.org/keywords/bleeding-disorders","display_name":"bleeding disorders","score":0.5249999761581421},{"id":"https://openalex.org/keywords/postpartum-hemorrhage","display_name":"postpartum hemorrhage","score":0.9710000157356262},{"id":"https://openalex.org/keywords/alloimmune-thrombocytopenia","display_name":"alloimmune thrombocytopenia","score":0.9259999990463257},{"id":"https://openalex.org/keywords/neonatal-outcomes","display_name":"neonatal outcomes","score":0.7149999737739563},{"id":"https://openalex.org/keywords/giant-platelets","display_name":"giant platelets","score":0.6430000066757202},{"id":"https://openalex.org/keywords/rare-bleeding-disorders","display_name":"rare bleeding disorders","score":0.5019999742507935},{"id":"https://openalex.org/keywords/multidisciplinary-management","display_name":"multidisciplinary management","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C2778212984","wikidata":"https://www.wikidata.org/wiki/Q822228","display_name":"Bernard\u2013Soulier syndrome","level":3,"score":0.9179685115814209},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9125615358352661},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6027710437774658},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5182704329490662},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.46600350737571716},{"id":"https://openalex.org/C3020341036","wikidata":"https://www.wikidata.org/wiki/Q3454555","display_name":"Autosomal recessive trait","level":3,"score":0.4193934202194214},{"id":"https://openalex.org/C3020501284","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary team","level":2,"score":0.41067758202552795},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32540833950042725},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.19226670265197754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13475945591926575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001606","descriptor_name":"Bernard-Soulier Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006473","descriptor_name":"Postpartum Hemorrhage","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007044","descriptor_name":"Hysterectomy","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011256","descriptor_name":"Pregnancy Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054098","descriptor_name":"Thrombocytopenia, Neonatal Alloimmune","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2516.2009.02137.x","doi":"https://doi.org/10.1111/j.1365-2516.2009.02137.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2516.2009.02137.x","pdf_url":null,"source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},{"id":"pmid:20070385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20070385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia : the official journal of the World Federation of Hemophilia","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1489331","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1489331/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HAEMOPHILIA , 16 (4) pp. 584-591. (2010)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W24454078","https://openalex.org/W1842780236","https://openalex.org/W1963794929","https://openalex.org/W1984387193","https://openalex.org/W1988095542","https://openalex.org/W1994071781","https://openalex.org/W2021325476","https://openalex.org/W2045266388","https://openalex.org/W2060837247","https://openalex.org/W2063210490","https://openalex.org/W2072480723","https://openalex.org/W2085727695","https://openalex.org/W2085983093","https://openalex.org/W2088424387","https://openalex.org/W2102758202","https://openalex.org/W2105033197","https://openalex.org/W2111673450","https://openalex.org/W2117009464","https://openalex.org/W2141160700","https://openalex.org/W2273829467","https://openalex.org/W2316549542","https://openalex.org/W2404503839","https://openalex.org/W2426322905","https://openalex.org/W2472143865","https://openalex.org/W2474257538","https://openalex.org/W3028535359","https://openalex.org/W4241306296","https://openalex.org/W4247924714"],"related_works":["https://openalex.org/W2072480723","https://openalex.org/W2318032071","https://openalex.org/W4323539346","https://openalex.org/W2900931545","https://openalex.org/W2102758202","https://openalex.org/W2426322905","https://openalex.org/W1994071781","https://openalex.org/W2085983093","https://openalex.org/W2011672414","https://openalex.org/W2472143865"],"abstract_inverted_index":{"Bernard":[0,60,137],"Soulier":[1,61,138],"syndrome":[2,62,139],"(BSS)":[3],"is":[4,18,63,142,177],"a":[5,74,145],"rare":[6,188],"disorder":[7],"of":[8,25,45,55,77,107,148],"platelets,":[9],"inherited":[10],"mainly":[11],"as":[12],"an":[13,118],"autosomal":[14],"recessive":[15],"trait.":[16],"It":[17],"characterised":[19],"by":[20],"qualitative":[21],"and":[22,42,53,79,102,133,154,161],"quantitative":[23],"defects":[24],"the":[26,43,50,152,155],"platelet":[27],"membrane":[28],"glycoprotein":[29],"(GP)":[30],"Ib-IX-V":[31],"complex.":[32],"The":[33],"main":[34],"clinical":[35,51],"characteristics":[36],"are":[37,168],"thrombocytopenia,":[38],"prolonged":[39],"bleeding":[40,150],"time":[41],"presence":[44],"giant":[46],"platelets.":[47],"Data":[48],"on":[49],"course":[52],"outcome":[54],"pregnancy":[56,141],"in":[57,65,99,104,112,126,140,183],"women":[58,116,167,185],"with":[59,129,144,186],"scattered":[64],"individual":[66],"case":[67,85],"reports.":[68],"In":[69],"this":[70,187],"paper,":[71],"we":[72],"performed":[73],"systematic":[75],"review":[76],"literature":[78],"identified":[80],"16":[81],"relevant":[82],"articles;":[83],"all":[84],"reports":[86],"that":[87],"included":[88],"30":[89],"pregnancies":[90],"among":[91],"18":[92],"women.":[93],"Primary":[94],"postpartum":[95],"haemorrhage":[96],"was":[97,124],"reported":[98,125],"10":[100],"(33%)":[101],"secondary":[103],"12":[105],"(40%)":[106],"pregnancies,":[108],"requiring":[109],"blood":[110],"transfusion":[111],"15":[113],"pregnancies.":[114],"Two":[115],"had":[117],"emergency":[119],"obstetric":[120],"hysterectomy.":[121],"Alloimmune":[122],"thrombocytopenia":[123],"6":[127],"neonates,":[128],"one":[130,134],"intrauterine":[131],"death":[132],"neonatal":[135],"death.":[136],"associated":[143],"high":[146],"risk":[147],"serious":[149],"for":[151,165],"mother":[153],"neonate.":[156],"A":[157],"multidisciplinary":[158],"team":[159],"approach":[160],"individualised":[162],"management":[163],"plan":[164],"such":[166],"required":[169],"to":[170,179],"minimise":[171],"these":[172],"risks.":[173],"An":[174],"international":[175],"registry":[176],"recommended":[178],"obtain":[180],"further":[181],"knowledge":[182],"managing":[184],"disorder.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}