{"id":"https://openalex.org/W2159202152","doi":"https://doi.org/10.1186/1744-8069-8-13","title":"Minocycline Markedly Reduces Acute Visceral Nociception via Inhibiting Neuronal ERK Phosphorylation","display_name":"Minocycline Markedly Reduces Acute Visceral Nociception via Inhibiting Neuronal ERK Phosphorylation","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2159202152","doi":"https://doi.org/10.1186/1744-8069-8-13","mag":"2159202152","pmid":"https://pubmed.ncbi.nlm.nih.gov/22364340","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3342906"},"language":"en","primary_location":{"id":"doi:10.1186/1744-8069-8-13","doi":"https://doi.org/10.1186/1744-8069-8-13","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1744-8069-8-13","pdf_url":null,"source":{"id":"https://openalex.org/S49886757","display_name":"Molecular Pain","issn_l":"1744-8069","issn":["1744-8069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/1744-8069-8-13","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070294890","display_name":"Ik\u2010Hyun Cho","orcid":"https://orcid.org/0000-0002-1036-0494","observed_orcids":["https://orcid.org/0000-0002-1036-0494","https://orcid.org/0000-0002-3868-7384"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Ik-Hyun Cho","raw_affiliation_strings":["Department of Anatomy, College of Oriental Medicine, and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Oriental Medicine, and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100768169","display_name":"Min Jung Lee","orcid":"https://orcid.org/0000-0001-9090-5863","observed_orcids":["https://orcid.org/0000-0001-9090-5863","https://orcid.org/0000-0002-9759-0355"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Jung Lee","raw_affiliation_strings":["Department of Anatomy, College of Oriental Medicine, and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Oriental Medicine, and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049722450","display_name":"Minhee Jang","orcid":"https://orcid.org/0000-0003-1441-1217","observed_orcids":["https://orcid.org/0000-0003-1441-1217"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minhee Jang","raw_affiliation_strings":["Department of Anatomy, College of Oriental Medicine, and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Oriental Medicine, and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085877656","display_name":"Nam-Gil Gwak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nam Gil Gwak","raw_affiliation_strings":["Department of Anatomy, College of Oriental Medicine, and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Oriental Medicine, and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008749792","display_name":"Ka Yeon Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ka Yeon Lee","raw_affiliation_strings":["Department of Anatomy, College of Oriental Medicine, and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Oriental Medicine, and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017605603","display_name":"Hyuk\u2010Sang Jung","orcid":"https://orcid.org/0000-0002-7256-9672","observed_orcids":["https://orcid.org/0000-0002-7256-9672"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyuk-Sang Jung","raw_affiliation_strings":["Department of Anatomy, College of Oriental Medicine, and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, College of Oriental Medicine, and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, South Korea","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017605603","https://openalex.org/A5070294890"],"corresponding_institution_ids":["https://openalex.org/I35928602"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":2.6267,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.88289169,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":null,"first_page":"13","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/minocycline","display_name":"minocycline","score":1.0},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/acetic-acid-induced-pain","display_name":"acetic acid-induced pain","score":0.6869999766349792},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.47200000286102295},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.8299999833106995},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.8240000009536743},{"id":"https://openalex.org/keywords/abdominal-pain","display_name":"abdominal pain","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2778275353","wikidata":"https://www.wikidata.org/wiki/Q415336","display_name":"Minocycline","level":3,"score":0.951270341873169},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.7578338980674744},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6702849864959717},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6334034204483032},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6293057203292847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.591205894947052},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5108280181884766},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.5047651529312134},{"id":"https://openalex.org/C2779794527","wikidata":"https://www.wikidata.org/wiki/Q4116360","display_name":"Visceral pain","level":4,"score":0.4680582880973816},{"id":"https://openalex.org/C2776673659","wikidata":"https://www.wikidata.org/wiki/Q47512","display_name":"Acetic acid","level":2,"score":0.4602760970592499},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.33829355239868164},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3061547875404358},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21578019857406616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2114349603652954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20827123522758484},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.05724826455116272},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059225","descriptor_name":"Nociception","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059265","descriptor_name":"Visceral Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1744-8069-8-13","doi":"https://doi.org/10.1186/1744-8069-8-13","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1744-8069-8-13","pdf_url":null,"source":{"id":"https://openalex.org/S49886757","display_name":"Molecular Pain","issn_l":"1744-8069","issn":["1744-8069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pain","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3342906","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3342906/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3342906/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Pain","raw_type":"Text"},{"id":"pmid:22364340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22364340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pain","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c986648b7f3445399c0efb8304f50216","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c986648b7f3445399c0efb8304f50216","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Pain, Vol 8, Iss 1, p 13 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1744-8069-8-13","doi":"https://doi.org/10.1186/1744-8069-8-13","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1744-8069-8-13","pdf_url":null,"source":{"id":"https://openalex.org/S49886757","display_name":"Molecular Pain","issn_l":"1744-8069","issn":["1744-8069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321332","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159202152.pdf","grobid_xml":"https://content.openalex.org/works/W2159202152.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1530030261","https://openalex.org/W1537685381","https://openalex.org/W1599631170","https://openalex.org/W1916850619","https://openalex.org/W1919059205","https://openalex.org/W1964849585","https://openalex.org/W1965102171","https://openalex.org/W1967880641","https://openalex.org/W1968151350","https://openalex.org/W1971063834","https://openalex.org/W1975398455","https://openalex.org/W1980636359","https://openalex.org/W1981575902","https://openalex.org/W1984861197","https://openalex.org/W1990203556","https://openalex.org/W1991762055","https://openalex.org/W1996052504","https://openalex.org/W1998574964","https://openalex.org/W2000254352","https://openalex.org/W2001026574","https://openalex.org/W2001641196","https://openalex.org/W2001686828","https://openalex.org/W2009182920","https://openalex.org/W2011727049","https://openalex.org/W2013134748","https://openalex.org/W2013186124","https://openalex.org/W2015264121","https://openalex.org/W2016448869","https://openalex.org/W2025278422","https://openalex.org/W2032882491","https://openalex.org/W2033402363","https://openalex.org/W2036717742","https://openalex.org/W2038948844","https://openalex.org/W2040088974","https://openalex.org/W2043323520","https://openalex.org/W2047059900","https://openalex.org/W2050310406","https://openalex.org/W2054513110","https://openalex.org/W2058363339","https://openalex.org/W2061216048","https://openalex.org/W2065558719","https://openalex.org/W2068760451","https://openalex.org/W2071391649","https://openalex.org/W2078565430","https://openalex.org/W2083762779","https://openalex.org/W2084300785","https://openalex.org/W2084591387","https://openalex.org/W2085911193","https://openalex.org/W2087454739","https://openalex.org/W2088163920","https://openalex.org/W2091324444","https://openalex.org/W2098719212","https://openalex.org/W2113426565","https://openalex.org/W2122516991","https://openalex.org/W2125266565","https://openalex.org/W2133132296","https://openalex.org/W2139698257","https://openalex.org/W2140193821","https://openalex.org/W2142769493","https://openalex.org/W2148726772","https://openalex.org/W2158230836","https://openalex.org/W2162730620","https://openalex.org/W2165284393","https://openalex.org/W2166622977","https://openalex.org/W2170809837","https://openalex.org/W2278365557","https://openalex.org/W2286903127","https://openalex.org/W2328347586","https://openalex.org/W4211154552","https://openalex.org/W4246253704","https://openalex.org/W4292820908","https://openalex.org/W4407196861"],"related_works":["https://openalex.org/W2006701781","https://openalex.org/W1981575902","https://openalex.org/W2070312747","https://openalex.org/W2142769493","https://openalex.org/W2072449546","https://openalex.org/W1990882591","https://openalex.org/W2082699543","https://openalex.org/W2005092208","https://openalex.org/W2171396145","https://openalex.org/W1974055192"],"abstract_inverted_index":{"BACKGROUND:":[0],"Minocycline":[1,62],"prevents":[2],"the":[3,77,80,87,97,127,146,153],"development":[4],"of":[5,47,82,99,118,148],"neuropathic":[6],"and":[7,14,76,156],"inflammatory":[8],"pain":[9,23,42,130],"by":[10,92,107,112],"inhibiting":[11],"microglial":[12],"activation":[13],"postsynaptic":[15],"currents.":[16],"But,":[17],"how":[18],"minocycline":[19,31,50,113,137,158],"obviates":[20],"acute":[21,40,142,165],"visceral":[22],"is":[24],"unclear.":[25],"The":[26],"present":[27],"study":[28],"investigated":[29],"whether":[30],"had":[32],"an":[33,120],"any":[34],"antinociceptive":[35],"effect":[36],"on":[37],"acetic":[38,54,70,93,108,128,140],"acid-induced":[39,71,141],"abdominal":[41,143,166],"after":[43],"intraperitoneal":[44],"(i.p.)":[45],"administration":[46],"saline":[48],"or":[49,65],"1":[51],"hour":[52],"before":[53],"acid":[55,94,109],"injection":[56],"(1.0%,":[57],"250":[58],"\u03bcl,":[59],"i.p.).":[60],"RESULTS:":[61],"(4,":[63],"10,":[64],"40":[66],"mg/kg)":[67],"significantly":[68],"decreased":[69],"nociception":[72,144],"(0-60":[73],"minutes":[74],"post-injection)":[75],"enhancement":[78],"in":[79,86,152,163],"number":[81],"c-Fos":[83],"positive":[84],"cells":[85],"T5-L2":[88],"spinal":[89,100,154],"cord":[90],"induced":[91,106],"injection.":[95],"Also,":[96],"expression":[98,151],"phosphorylated":[101],"extracellular":[102],"signal-regulated":[103],"kinase":[104,123],"(p-ERK)":[105],"was":[110],"reduced":[111],"pre-administration.":[114],"Interestingly,":[115],"intrathecal":[116],"introduction":[117],"PD98059,":[119],"ERK":[121],"upstream":[122],"inhibitor,":[124],"markedly":[125],"blocked":[126],"acid-stimulated":[129],"responses.":[131],"CONCLUSIONS:":[132],"These":[133],"results":[134],"demonstrate":[135],"that":[136,157],"effectively":[138],"inhibits":[139],"via":[145],"inhibition":[147],"neuronal":[149],"p-ERK":[150],"cord,":[155],"may":[159],"have":[160],"therapeutic":[161],"potential":[162],"suppressing":[164],"pain.":[167]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}