{"id":"https://openalex.org/W2159118796","doi":"https://doi.org/10.1158/1078-0432.ccr-04-1749","title":"Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression","display_name":"Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2159118796","doi":"https://doi.org/10.1158/1078-0432.ccr-04-1749","mag":"2159118796","pmid":"https://pubmed.ncbi.nlm.nih.gov/16397019"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-04-1749","doi":"https://doi.org/10.1158/1078-0432.ccr-04-1749","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-04-1749","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068094202","display_name":"Nills Diaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nills Diaz","raw_affiliation_strings":["1Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111541235","display_name":"Susan E. Minton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Minton","raw_affiliation_strings":["2Comprehensive Breast Cancer,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Comprehensive Breast Cancer,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110399289","display_name":"Charles Cox","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Cox","raw_affiliation_strings":["2Comprehensive Breast Cancer,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Comprehensive Breast Cancer,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051955482","display_name":"Tammy L. Bowman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150208","display_name":"Molecular Oncology (United States)","ror":"https://ror.org/04rtkc841","country_code":"US","type":"company","lineage":["https://openalex.org/I4210150208"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy Bowman","raw_affiliation_strings":["3Molecular Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Molecular Oncology,","institution_ids":["https://openalex.org/I4210150208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046522184","display_name":"Tanya Gritsko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150208","display_name":"Molecular Oncology (United States)","ror":"https://ror.org/04rtkc841","country_code":"US","type":"company","lineage":["https://openalex.org/I4210150208"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanya Gritsko","raw_affiliation_strings":["3Molecular Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Molecular Oncology,","institution_ids":["https://openalex.org/I4210150208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112790298","display_name":"Roy Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150208","display_name":"Molecular Oncology (United States)","ror":"https://ror.org/04rtkc841","country_code":"US","type":"company","lineage":["https://openalex.org/I4210150208"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy Garcia","raw_affiliation_strings":["3Molecular Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Molecular Oncology,","institution_ids":["https://openalex.org/I4210150208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024605593","display_name":"Ibrahim Eweis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150208","display_name":"Molecular Oncology (United States)","ror":"https://ror.org/04rtkc841","country_code":"US","type":"company","lineage":["https://openalex.org/I4210150208"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ibrahim Eweis","raw_affiliation_strings":["3Molecular Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Molecular Oncology,","institution_ids":["https://openalex.org/I4210150208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037161167","display_name":"Marek Wloch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marek Wloch","raw_affiliation_strings":["1Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085404362","display_name":"Sandy Livingston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandy Livingston","raw_affiliation_strings":["1Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088558538","display_name":"Edward Seijo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ed Seijo","raw_affiliation_strings":["1Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017675148","display_name":"Alan B Cantor","orcid":"https://orcid.org/0000-0002-5136-028X","observed_orcids":["https://orcid.org/0000-0002-5136-028X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan Cantor","raw_affiliation_strings":["4Biostatistics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Biostatistics, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413485","display_name":"Ji\u2010Hyun Lee","orcid":"https://orcid.org/0000-0001-6420-5150","observed_orcids":["https://orcid.org/0000-0001-6420-5150","https://orcid.org/0000-0003-0450-2879"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji-Hyun Lee","raw_affiliation_strings":["4Biostatistics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Biostatistics, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074737861","display_name":"Craig A. Beam","orcid":"https://orcid.org/0000-0002-8772-7661","observed_orcids":["https://orcid.org/0000-0002-8772-7661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig A. Beam","raw_affiliation_strings":["4Biostatistics, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Biostatistics, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102841436","display_name":"Daniel M. Sullivan","orcid":"https://orcid.org/0009-0003-0951-9781","observed_orcids":["https://orcid.org/0009-0003-0951-9781","https://orcid.org/0000-0002-2183-1773"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Sullivan","raw_affiliation_strings":["5Experimental Therapeutics Programs, H. Lee Moffitt Cancer Center and Research Institute, Department of Interdisciplinary Oncology, University of South Florida College of Medicine, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Experimental Therapeutics Programs, H. Lee Moffitt Cancer Center and Research Institute, Department of Interdisciplinary Oncology, University of South Florida College of Medicine, Tampa, Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022795218","display_name":"Richard Jove","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150208","display_name":"Molecular Oncology (United States)","ror":"https://ror.org/04rtkc841","country_code":"US","type":"company","lineage":["https://openalex.org/I4210150208"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Jove","raw_affiliation_strings":["3Molecular Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Molecular Oncology,","institution_ids":["https://openalex.org/I4210150208"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032179414","display_name":"Carlos Muro\u2010Cacho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos A. Muro-Cacho","raw_affiliation_strings":["1Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.1862,"has_fulltext":false,"cited_by_count":242,"citation_normalized_percentile":{"value":0.98691498,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"20","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3-activation","display_name":"STAT3 activation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.7059999704360962},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.8080000281333923},{"id":"https://openalex.org/keywords/high-risk-breast-cancer","display_name":"high-risk breast cancer","score":0.9290000200271606},{"id":"https://openalex.org/keywords/invasive-breast-cancer","display_name":"invasive breast cancer","score":0.8600000143051147},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.8349999785423279},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.8980000019073486},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pathological-response","display_name":"pathological response","score":0.8389999866485596},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.765999972820282},{"id":"https://openalex.org/keywords/molecular-biomarkers","display_name":"molecular biomarkers","score":0.722000002861023},{"id":"https://openalex.org/keywords/stat3-inhibitor","display_name":"STAT3 inhibitor","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.9129746556282043},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6069849729537964},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5847207307815552},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5672852396965027},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5316131114959717},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5121614933013916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49740245938301086},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4940688908100128},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4453066885471344},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.44366657733917236},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36837953329086304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3234905004501343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31044667959213257},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.30514949560165405},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077022","descriptor_name":"Survivin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017322","descriptor_name":"Clinical Trials, Phase II as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051034","descriptor_name":"Inhibitor of Apoptosis Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-04-1749","doi":"https://doi.org/10.1158/1078-0432.ccr-04-1749","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-04-1749","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:16397019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16397019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1727770634","display_name":"Molecular Signatures of STAT Regulated Genes in Cancer","funder_award_id":"R01CA055652","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1764731817","display_name":null,"funder_award_id":"CA 82533","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2191264009","display_name":null,"funder_award_id":"CA-55652","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6667071792","display_name":"MOLECULAR ONCOLOGY PROGRAM PROJECT","funder_award_id":"P01CA082533","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1483520515","https://openalex.org/W1499232625","https://openalex.org/W1540079092","https://openalex.org/W1548640328","https://openalex.org/W1550156431","https://openalex.org/W1563819414","https://openalex.org/W1590471414","https://openalex.org/W1821858011","https://openalex.org/W1851243469","https://openalex.org/W1854123316","https://openalex.org/W1869455305","https://openalex.org/W1913007537","https://openalex.org/W1960171220","https://openalex.org/W1968292745","https://openalex.org/W1970727241","https://openalex.org/W1971381959","https://openalex.org/W1973460244","https://openalex.org/W1977681992","https://openalex.org/W1979107436","https://openalex.org/W1980480652","https://openalex.org/W1991498850","https://openalex.org/W2016116775","https://openalex.org/W2020140319","https://openalex.org/W2020508063","https://openalex.org/W2022215206","https://openalex.org/W2024282024","https://openalex.org/W2026318599","https://openalex.org/W2032674547","https://openalex.org/W2035523654","https://openalex.org/W2035701756","https://openalex.org/W2037297522","https://openalex.org/W2040712355","https://openalex.org/W2050544424","https://openalex.org/W2051638902","https://openalex.org/W2056961869","https://openalex.org/W2058288437","https://openalex.org/W2062222985","https://openalex.org/W2064580048","https://openalex.org/W2069657245","https://openalex.org/W2070831760","https://openalex.org/W2074356752","https://openalex.org/W2078802143","https://openalex.org/W2101443436","https://openalex.org/W2119005247","https://openalex.org/W2129432262","https://openalex.org/W2156872475","https://openalex.org/W2159730182","https://openalex.org/W2171451993","https://openalex.org/W2318017968","https://openalex.org/W2330829715","https://openalex.org/W4233166725","https://openalex.org/W4245483584"],"related_works":["https://openalex.org/W2385376067","https://openalex.org/W2062129127","https://openalex.org/W2598665255","https://openalex.org/W2373660605","https://openalex.org/W2361318567","https://openalex.org/W2366221595","https://openalex.org/W2037680161","https://openalex.org/W2027017617","https://openalex.org/W3097064806","https://openalex.org/W2392241107"],"abstract_inverted_index":{"PURPOSE:":[0],"Constitutive":[1],"activation":[2,65],"of":[3,8,20,35,40,63,91,123,142,167,172,177,209,221],"signal":[4],"transducer":[5],"and":[6,25,57,66,84,107,116,128,145,174,211],"activator":[7],"transcription":[9],"3":[10],"(Stat3)":[11],"protein":[12],"has":[13],"been":[14],"observed":[15],"in":[16,31,48,71,109,126,153,157,181,186,218],"a":[17,38,49],"wide":[18],"variety":[19],"tumors,":[21,164],"including":[22],"breast":[23,45,73,222,250],"cancer,":[24],"contributes":[26],"to":[27,247],"oncogenesis":[28],"at":[29],"least":[30],"part":[32],"by":[33,148],"prevention":[34],"apoptosis.":[36],"In":[37,163,190],"study":[39],"45":[41],"patients":[42,248],"with":[43,55,76,170,197,230,249],"high-risk":[44],"cancer":[46],"enrolled":[47],"phase":[50],"II":[51],"neoadjuvant":[52],"chemotherapy":[53],"trial":[54],"docetaxel":[56],"doxorubicin,":[58],"we":[59,87],"evaluated":[60],"the":[61,89],"levels":[62,90,122,166,195],"Stat3":[64,210,226,239],"potentially":[67],"associated":[68],"molecular":[69,124],"biomarkers":[70,125],"invasive":[72,114,154],"carcinoma":[74,155],"compared":[75],"matched":[77],"nonneoplastic":[78,119,127,158],"tissues.":[79],"EXPERIMENTAL":[80],"DESIGN:":[81],"Using":[82],"immunohistochemistry":[83,149],"image":[85],"analysis,":[86],"quantified":[88],"phospho-Stat3":[92],"(pY-Stat3),":[93],"phospho-Src":[94],"(pY-Src),":[95],"epidermal":[96],"growth":[97],"factor":[98],"receptor,":[99,103],"HER2/neu,":[100],"Ki-67,":[101],"estrogen":[102],"Bcl-2,":[104],"Bcl-xL,":[105],"Survivin,":[106],"apoptosis":[108],"formalin-fixed,":[110],"paraffin-embedded":[111],"sections":[112],"from":[113],"carcinomas":[115],"their":[117],"paired":[118],"parenchyma.":[120],"The":[121],"tumor":[129],"tissues":[130],"were":[131,150,179],"analyzed":[132],"as":[133,213,215],"continuous":[134],"variables":[135],"for":[136,206],"statistically":[137],"significant":[138],"correlations.":[139],"RESULTS:":[140],"Levels":[141,176],"activated":[143],"pY-Stat3":[144,168,178,194],"pY-Src":[146,173],"measured":[147],"significantly":[151],"higher":[152,180],"than":[156,185],"tissue":[159],"(P":[160],"<":[161],"0.001).":[162],"elevated":[165,207,225],"correlated":[169,196],"those":[171],"Survivin.":[175],"partial":[182,191],"pathologic":[183,188,192,232],"responders":[184],"complete":[187,231],"responders.":[189],"responders,":[193],"Survivin":[198,216],"expression.":[199],"CONCLUSIONS:":[200],"Our":[201],"findings":[202,235],"suggest":[203,236],"important":[204],"roles":[205],"activities":[208],"Src,":[212],"well":[214],"expression,":[217],"malignant":[219],"progression":[220],"cancer.":[223,251],"Furthermore,":[224],"activity":[227],"correlates":[228],"inversely":[229],"response.":[233],"These":[234],"that":[237],"specific":[238],"or":[240],"Src":[241],"inhibitors":[242],"could":[243],"offer":[244],"clinical":[245],"benefits":[246]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}