{"id":"https://openalex.org/W2159102438","doi":"https://doi.org/10.1186/cc12842","title":"Clinical and biological role of secretory phospholipase A2 in acute respiratory distress syndrome infants","display_name":"Clinical and biological role of secretory phospholipase A2 in acute respiratory distress syndrome infants","publication_year":2013,"publication_date":"2013-07-24","ids":{"openalex":"https://openalex.org/W2159102438","doi":"https://doi.org/10.1186/cc12842","mag":"2159102438","pmid":"https://pubmed.ncbi.nlm.nih.gov/23883784","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4057254"},"language":"en","primary_location":{"id":"doi:10.1186/cc12842","doi":"https://doi.org/10.1186/cc12842","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc12842","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc12842","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc12842","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035973300","display_name":"Dani\u00e8le De Luca","orcid":"https://orcid.org/0000-0002-3846-4834","observed_orcids":["https://orcid.org/0000-0002-3846-4834","https://orcid.org/0000-0002-1639-9138"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Daniele De Luca","raw_affiliation_strings":["Laboratory of Clinical Molecular Biology, Dept of Laboratory Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome, 00168, Italy","Pediatric Intensive Care Unit, Dept of Anesthesiology and Intensive Care, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, Gemelli 8, Rome, 00168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Molecular Biology, Dept of Laboratory Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome, 00168, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]},{"raw_affiliation_string":"Pediatric Intensive Care Unit, Dept of Anesthesiology and Intensive Care, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, Gemelli 8, Rome, 00168, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080624016","display_name":"Elena L\u00f3pez-Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-1549-8150","observed_orcids":["https://orcid.org/0000-0002-1549-8150"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Lopez-Rodriguez","raw_affiliation_strings":["Dept of Biochemistry, Faculty of Biology, Complutense University, av. Complutense s/n, Madrid, 28040, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Biochemistry, Faculty of Biology, Complutense University, av. Complutense s/n, Madrid, 28040, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079985047","display_name":"Angelo Minucci","orcid":"https://orcid.org/0000-0002-0833-4334","observed_orcids":["https://orcid.org/0000-0002-0833-4334"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelo Minucci","raw_affiliation_strings":["Laboratory of Clinical Molecular Biology, Dept of Laboratory Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome, 00168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Molecular Biology, Dept of Laboratory Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome, 00168, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023328829","display_name":"Francesca Vendittelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Vendittelli","raw_affiliation_strings":["Laboratory of Clinical Molecular Biology, Dept of Laboratory Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome, 00168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Molecular Biology, Dept of Laboratory Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome, 00168, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103022066","display_name":"Leonarda Gentile","orcid":"https://orcid.org/0000-0002-5491-6925","observed_orcids":["https://orcid.org/0000-0002-5491-6925"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Leonarda Gentile","raw_affiliation_strings":["Laboratory of Clinical Molecular Biology, Dept of Laboratory Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome, 00168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Molecular Biology, Dept of Laboratory Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome, 00168, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061598707","display_name":"Eleonora Stival","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eleonora Stival","raw_affiliation_strings":["Pediatric Intensive Care Unit, Dept of Anesthesiology and Intensive Care, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, Gemelli 8, Rome, 00168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Intensive Care Unit, Dept of Anesthesiology and Intensive Care, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, Gemelli 8, Rome, 00168, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070677134","display_name":"Giorgio Conti","orcid":"https://orcid.org/0000-0002-8566-9365","observed_orcids":["https://orcid.org/0000-0002-8566-9365","https://orcid.org/0000-0003-4307-8310"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Conti","raw_affiliation_strings":["Pediatric Intensive Care Unit, Dept of Anesthesiology and Intensive Care, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, Gemelli 8, Rome, 00168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Intensive Care Unit, Dept of Anesthesiology and Intensive Care, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, Gemelli 8, Rome, 00168, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029313151","display_name":"Marco Piastra","orcid":"https://orcid.org/0000-0002-3144-8970","observed_orcids":["https://orcid.org/0000-0002-3144-8970"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Piastra","raw_affiliation_strings":["Pediatric Intensive Care Unit, Dept of Anesthesiology and Intensive Care, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, Gemelli 8, Rome, 00168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Intensive Care Unit, Dept of Anesthesiology and Intensive Care, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, Gemelli 8, Rome, 00168, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030961669","display_name":"Massimo M. Antonelli","orcid":"https://orcid.org/0000-0003-3007-1670","observed_orcids":["https://orcid.org/0000-0003-3007-1670"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Antonelli","raw_affiliation_strings":["Pediatric Intensive Care Unit, Dept of Anesthesiology and Intensive Care, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, Gemelli 8, Rome, 00168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Intensive Care Unit, Dept of Anesthesiology and Intensive Care, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, Gemelli 8, Rome, 00168, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007334693","display_name":"Mercedes Echaide","orcid":"https://orcid.org/0000-0002-0836-0858","observed_orcids":["https://orcid.org/0000-0002-0836-0858"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mercedes Echaide","raw_affiliation_strings":["Dept of Biochemistry, Faculty of Biology, Complutense University, av. Complutense s/n, Madrid, 28040, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Biochemistry, Faculty of Biology, Complutense University, av. Complutense s/n, Madrid, 28040, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046250168","display_name":"Jes\u00fas P\u00e9rez\u2010Gil","orcid":"https://orcid.org/0000-0003-3587-7147","observed_orcids":["https://orcid.org/0000-0003-3587-7147"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jesus Perez-Gil","raw_affiliation_strings":["Dept of Biochemistry, Faculty of Biology, Complutense University, av. Complutense s/n, Madrid, 28040, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Biochemistry, Faculty of Biology, Complutense University, av. Complutense s/n, Madrid, 28040, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073293203","display_name":"Ettore Capoluongo","orcid":"https://orcid.org/0000-0003-4402-8403","observed_orcids":["https://orcid.org/0000-0003-4402-8403"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ettore D Capoluongo","raw_affiliation_strings":["Laboratory of Clinical Molecular Biology, Dept of Laboratory Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome, 00168, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Molecular Biology, Dept of Laboratory Medicine, University Hospital 'A. Gemelli', Catholic University of the Sacred Heart, L.go A. Gemelli 8, Rome, 00168, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035973300"],"corresponding_institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":2.9789,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.91476197,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"17","issue":"4","first_page":"R163","last_page":"R163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.8769999742507935,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.11720000207424164,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretory-phospholipase-a2","display_name":"secretory phospholipase A2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9670000076293945},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.7289999723434448},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.7149999737739563},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7860000133514404},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.968999981880188},{"id":"https://openalex.org/keywords/pulmonary-surfactant","display_name":"pulmonary surfactant","score":0.7509999871253967},{"id":"https://openalex.org/keywords/phospholipids","display_name":"phospholipids","score":0.8090000152587891},{"id":"https://openalex.org/keywords/surface-tension","display_name":"surface tension","score":0.7770000100135803},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.6859999895095825},{"id":"https://openalex.org/keywords/prism-iii","display_name":"PRISM III","score":0.5770000219345093},{"id":"https://openalex.org/keywords/icu-length-of-stay","display_name":"ICU length of stay","score":0.4699999988079071},{"id":"https://openalex.org/keywords/lung-injury-biomarkers","display_name":"lung injury biomarkers","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8928455114364624},{"id":"https://openalex.org/C2909621147","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"Acute respiratory distress","level":3,"score":0.7530165910720825},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.6398261785507202},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5673954486846924},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4443340003490448},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34956789016723633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2632337808609009},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.13589465618133545},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.11888954043388367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012121","descriptor_name":"Respiration, Artificial","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012127","descriptor_name":"Respiratory Distress Syndrome, Newborn","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013500","descriptor_name":"Surface Tension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018893","descriptor_name":"Bronchoalveolar Lavage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D054497","descriptor_name":"Phospholipases A2, Secretory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/cc12842","doi":"https://doi.org/10.1186/cc12842","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc12842","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc12842","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3030067","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4057254","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4057254","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4057254","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crit Care","raw_type":"Text"},{"id":"pmid:23883784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23883784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:publicatt.unicatt.it:10807/57416","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10807/57416","pdf_url":null,"source":{"id":"https://openalex.org/S4306400564","display_name":"PubliCatt (Universit\u00e0 Cattolica del Sacro Cuore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/cc12842","doi":"https://doi.org/10.1186/cc12842","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc12842","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc12842","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1953797129","display_name":null,"funder_award_id":"S-0505/MAT/0283","funder_id":"https://openalex.org/F4320313831","funder_display_name":"Comunidad de Madrid"}],"funders":[{"id":"https://openalex.org/F4320313831","display_name":"Comunidad de Madrid","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159102438.pdf","grobid_xml":"https://content.openalex.org/works/W2159102438.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W105869727","https://openalex.org/W622786078","https://openalex.org/W1513419514","https://openalex.org/W1516337467","https://openalex.org/W1966129095","https://openalex.org/W1975753141","https://openalex.org/W1975787340","https://openalex.org/W1976477866","https://openalex.org/W1976959056","https://openalex.org/W1987587436","https://openalex.org/W1989363851","https://openalex.org/W2010671112","https://openalex.org/W2012061254","https://openalex.org/W2012880570","https://openalex.org/W2016890843","https://openalex.org/W2020498024","https://openalex.org/W2022375046","https://openalex.org/W2022806475","https://openalex.org/W2029268245","https://openalex.org/W2030480577","https://openalex.org/W2030922074","https://openalex.org/W2037421391","https://openalex.org/W2041597679","https://openalex.org/W2061805206","https://openalex.org/W2066633485","https://openalex.org/W2075236864","https://openalex.org/W2084445380","https://openalex.org/W2087307517","https://openalex.org/W2090177710","https://openalex.org/W2090864499","https://openalex.org/W2092276820","https://openalex.org/W2094596421","https://openalex.org/W2097788458","https://openalex.org/W2099210873","https://openalex.org/W2100565859","https://openalex.org/W2103738507","https://openalex.org/W2105122487","https://openalex.org/W2110874551","https://openalex.org/W2113128753","https://openalex.org/W2118583447","https://openalex.org/W2120919525","https://openalex.org/W2122579655","https://openalex.org/W2123013484","https://openalex.org/W2126554704","https://openalex.org/W2128635872","https://openalex.org/W2146982175","https://openalex.org/W2161177126","https://openalex.org/W2161328469","https://openalex.org/W2166443939","https://openalex.org/W2176076708","https://openalex.org/W2313065649","https://openalex.org/W2469578780","https://openalex.org/W2797576027","https://openalex.org/W2917055535","https://openalex.org/W6808289518"],"related_works":["https://openalex.org/W2022806475","https://openalex.org/W7098742891","https://openalex.org/W7098655431","https://openalex.org/W2090864499","https://openalex.org/W2031703200","https://openalex.org/W2469578780","https://openalex.org/W2009052968","https://openalex.org/W2333204039","https://openalex.org/W1975753141","https://openalex.org/W2410890521"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Secretory":[1,285,311],"phospholipase":[2,101,286,312],"A2":[3,102,287,313],"is":[4,27,289],"supposed":[5],"to":[6,52,61,72,106],"play":[7],"a":[8,316],"role":[9],"in":[10,84,179,182,187,190,210,213,221,291,320],"acute":[11,21],"lung":[12,94],"injury":[13],"but":[14],"no":[15,93],"data":[16,121],"are":[17,33,39,185],"available":[18],"for":[19,99],"pediatric":[20,292,321],"respiratory":[22],"distress":[23],"syndrome":[24],"(ARDS).":[25],"It":[26],"not":[28],"clear":[29],"which":[30],"enzyme":[31,41,55,74,139,202,227],"subtypes":[32,59,203],"secreted":[34],"and":[35,44,47,56,60,65,89,103,109,113,162,238,275,294,307],"what":[36],"the":[37,54],"relationships":[38],"between":[40,226],"activity,":[42,228],"biophysical":[43,66],"biochemical":[45,64],"parameters,":[46],"clinical":[48,77,309],"outcomes.":[49,310],"We":[50],"aimed":[51],"measure":[53],"identify":[57],"its":[58,63,107],"study":[62],"effect.":[67],"The":[68],"secondary":[69],"aim":[70],"was":[71,82,218],"correlate":[73],"activity":[75,108,140,288],"with":[76,87,92,250,301],"outcome.":[78],"METHODS:":[79],"Bronchoalveolar":[80],"lavage":[81],"performed":[83],"24":[85],"infants":[86],"ARDS":[88,180,188,293],"14":[90],"controls":[91,191],"disease.":[95],"Samples":[96],"were":[97,117,122,177,204],"assayed":[98],"secretory":[100],"molecules":[104],"related":[105],"expression.":[110],"Western":[111],"blotting":[112],"captive":[114],"bubble":[115],"surfactometry":[116],"also":[118,248],"performed.":[119],"Clinical":[120],"real":[123],"time":[124],"downloaded.":[125],"RESULTS:":[126],"Tumor":[127],"necrosis":[128],"factor-\u03b1":[129],"(814":[130],"(506-2,499)":[131],"vs.":[132,143,155,169,194],"287":[133],"(111-1,315)":[134],"pg/mL;":[135],"P":[136,147,159,174,198,235,244,257,272,281],"=":[137,148,160,175,199,233,242,255,258,262,270,273,279,282],"0.04),":[138],"(430":[141],"(253-600)":[142],"149":[144],"(61-387)":[145],"IU/mL;":[146],"0.01),":[149],"free":[150,229],"fatty":[151,230],"acids":[152,231],"(4.3":[153],"(2.8-8.6)":[154],"2":[156],"(0.8-4.6)":[157],"mM;":[158],"0.026),":[161],"minimum":[163],"surface":[164,239,305],"tension":[165,240],"(25.6":[166],"\u00b1":[167,171],"6.1":[168],"18":[170],"1.8":[172],"mN/m;":[173],"0.006)":[176],"higher":[178],"than":[181,189],"controls.":[183],"Phospholipids":[184],"lower":[186,211],"(76.5":[192],"(54-100)":[193],"1,094":[195],"(536-2,907)":[196],"\u03bcg/mL;":[197],"0.0001).":[200],"Three":[201],"identified":[205],"(-IIA,":[206],"-V,":[207],"-X),":[208],"although":[209],"quantities":[212],"controls;":[214],"another":[215],"subtype":[216],"(-IB)":[217],"mainly":[219],"detected":[220],"ARDS.":[222,322],"Significant":[223],"correlations":[224],"exist":[225,249],"(\u03c1":[232,241,254,261,269,278],"0.823;":[234],"<":[236,245],"0.001),":[237,259,265],"0.55;":[243],"0.028).":[246],"Correlations":[247],"intensive":[251],"care":[252],"stay":[253],"0.54;":[256,280],"PRISM-III24":[260],"0.79;":[263],"P<":[264],"duration":[266],"of":[267,296],"ventilation":[268],"0.53;":[271],"0.002),":[274],"oxygen":[276],"therapy":[277],"0.001).":[283],"CONCLUSIONS:":[284],"raised":[290],"constituted":[295],"four":[297],"subtypes.":[298],"Enzyme":[299],"correlates":[300],"some":[302],"inflammatory":[303],"mediators,":[304],"tension,":[306],"major":[308],"may":[314],"be":[315],"clinically":[317],"relevant":[318],"target":[319]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}