{"id":"https://openalex.org/W2159101101","doi":"https://doi.org/10.1016/s1473-3099(13)70297-4","title":"Efficacy and safety of a patch vaccine containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase 3, randomised, double-blind, placebo-controlled field trial in travellers from Europe to Mexico and Guatemala","display_name":"Efficacy and safety of a patch vaccine containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase 3, randomised, double-blind, placebo-controlled field trial in travellers from Europe to Mexico and Guatemala","publication_year":2013,"publication_date":"2013-11-28","ids":{"openalex":"https://openalex.org/W2159101101","doi":"https://doi.org/10.1016/s1473-3099(13)70297-4","mag":"2159101101","pmid":"https://pubmed.ncbi.nlm.nih.gov/24291168"},"language":"en","primary_location":{"id":"doi:10.1016/s1473-3099(13)70297-4","doi":"https://doi.org/10.1016/s1473-3099(13)70297-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1473-3099(13)70297-4","pdf_url":null,"source":{"id":"https://openalex.org/S23772524","display_name":"The Lancet Infectious Diseases","issn_l":"1473-3099","issn":["1473-3099","1474-4457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010921017","display_name":"R.H. Behrens","orcid":"https://orcid.org/0000-0002-8166-2633","observed_orcids":["https://orcid.org/0000-0002-8166-2633"]},"institutions":[{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]},{"id":"https://openalex.org/I4210091134","display_name":"Hospital for Tropical Diseases","ror":"https://ror.org/00fdbgx35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210091134"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ronald H Behrens","raw_affiliation_strings":["Hospital for Tropical Diseases, London, UK; London School of Hygiene & Tropical Medicine, London, UK","Hospital for Tropical Diseases, London, UK","London School of Hygiene & Tropical Medicine, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital for Tropical Diseases, London, UK; London School of Hygiene & Tropical Medicine, London, UK","institution_ids":["https://openalex.org/I4210089966","https://openalex.org/I4210091134"]},{"raw_affiliation_string":"Hospital for Tropical Diseases, London, UK","institution_ids":["https://openalex.org/I4210091134"]},{"raw_affiliation_string":"London School of Hygiene & Tropical Medicine, London, UK","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113048405","display_name":"Jakob P. Cramer","orcid":"https://orcid.org/0009-0005-1268-5750","observed_orcids":["https://orcid.org/0009-0005-1268-5750"]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jakob P Cramer","raw_affiliation_strings":["Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078353739","display_name":"Tom\u00e1\u0161 Jel\u0131\u0301nek","orcid":"https://orcid.org/0000-0002-5467-9253","observed_orcids":["https://orcid.org/0000-0002-5467-9253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomas Jelinek","raw_affiliation_strings":["Berlin Center for Travel & Tropical Medicine, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berlin Center for Travel & Tropical Medicine, Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022476540","display_name":"Hilary Shaw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hilary Shaw","raw_affiliation_strings":["Synexus Thames Valley Clinical Research Centre, Reading, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synexus Thames Valley Clinical Research Centre, Reading, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105415599","display_name":"Frank von Sonnenburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank von Sonnenburg","raw_affiliation_strings":["Department for Infectious Disease and Tropical Medicine, University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Infectious Disease and Tropical Medicine, University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110083011","display_name":"Darren Wilbraham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Darren Wilbraham","raw_affiliation_strings":["Guy's Drug Research Unit, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy's Drug Research Unit, London, UK","institution_ids":["https://openalex.org/I1298207432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112788548","display_name":"Thomas Weinke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Weinke","raw_affiliation_strings":["Clinics for Gastroenterology & Infectious Disease, Potsdam, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinics for Gastroenterology & Infectious Disease, Potsdam, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113524657","display_name":"David Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107895","display_name":"BioKinetic Europe (United Kingdom)","ror":"https://ror.org/01hp17k95","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210107895"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J Bell","raw_affiliation_strings":["Bio-Kinetic Europe, Belfast, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Kinetic Europe, Belfast, UK","institution_ids":["https://openalex.org/I4210107895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034976745","display_name":"Edwin J. Asturias","orcid":"https://orcid.org/0000-0002-1275-0787","observed_orcids":["https://orcid.org/0000-0002-1275-0787"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin Asturias","raw_affiliation_strings":["School of Medicine, University of Colorado, Denver, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Colorado, Denver, CO, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030686835","display_name":"Hermann L Enkerlin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hermann L Enkerlin Pauwells","raw_affiliation_strings":["Mexican Institute of Clinical Research, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mexican Institute of Clinical Research, Mexico City, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Roberto Maxwell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Maxwell","raw_affiliation_strings":["Insurgentes, Guanajuato, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insurgentes, Guanajuato, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019826224","display_name":"Mercedes Paredes\u2010Paredes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mercedes Paredes-Paredes","raw_affiliation_strings":["The University of Texas Health Science Center at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas Health Science Center at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032295889","display_name":"Gregory M. Glenn","orcid":"https://orcid.org/0000-0002-2030-8665","observed_orcids":["https://orcid.org/0000-0002-2030-8665"]},"institutions":[{"id":"https://openalex.org/I4210100774","display_name":"Novavax (United States)","ror":"https://ror.org/01bhs6g30","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100774"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory M Glenn","raw_affiliation_strings":["Novavax, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novavax, Rockville, MD, USA","institution_ids":["https://openalex.org/I4210100774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027821519","display_name":"Shailesh Dewasthaly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127539","display_name":"Intercell (Austria)","ror":"https://ror.org/038kx6574","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210127539","https://openalex.org/I4210151340"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Shailesh Dewasthaly","raw_affiliation_strings":["Intercell AG, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intercell AG, Vienna, Austria","institution_ids":["https://openalex.org/I4210127539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110494051","display_name":"Donald M. Stablein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115849","display_name":"Emmes (United States)","ror":"https://ror.org/027fvqp63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210115849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald M Stablein","raw_affiliation_strings":["Mexican Institute of Clinical Research, Mexico City, Mexico; EMMES Corporation, Rockville, MD, USA","EMMES Corporation, Rockville, MD, USA","Mexican Institute of Clinical Research, Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mexican Institute of Clinical Research, Mexico City, Mexico; EMMES Corporation, Rockville, MD, USA","institution_ids":["https://openalex.org/I4210115849"]},{"raw_affiliation_string":"EMMES Corporation, Rockville, MD, USA","institution_ids":["https://openalex.org/I4210115849"]},{"raw_affiliation_string":"Mexican Institute of Clinical Research, Mexico City, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107501521","display_name":"Zhi\u2010Dong Jiang","orcid":"https://orcid.org/0000-0003-3225-9079","observed_orcids":["https://orcid.org/0000-0003-3225-9079"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhi-Dong Jiang","raw_affiliation_strings":["Houston School of Public Health, University of Texas, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston School of Public Health, University of Texas, Houston, TX, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022890061","display_name":"Herbert L. DuPont","orcid":"https://orcid.org/0000-0003-1652-7168","observed_orcids":["https://orcid.org/0000-0003-1652-7168"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Herbert L DuPont","raw_affiliation_strings":["Houston School of Public Health, University of Texas, Houston, TX, USA. Electronic address: herbert.l.dupont@uth.tmc.edu","Houston School of Public Health, University of Texas, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston School of Public Health, University of Texas, Houston, TX, USA. Electronic address: herbert.l.dupont@uth.tmc.edu","institution_ids":[]},{"raw_affiliation_string":"Houston School of Public Health, University of Texas, Houston, TX, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5022890061"],"corresponding_institution_ids":[],"apc_list":{"value":7280,"currency":"USD","value_usd":7280},"apc_paid":null,"fwci":14.2787,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.9933232,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"14","issue":"3","first_page":"197","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12402","display_name":"Travel-related health issues","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12402","display_name":"Travel-related health issues","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.047600001096725464,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterotoxigenic-escherichia-coli","display_name":"enterotoxigenic Escherichia coli","score":0.9190000295639038},{"id":"https://openalex.org/keywords/heat-labile-toxin","display_name":"heat-labile toxin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/traveler-s-diarrhea","display_name":"traveler's diarrhea","score":0.9760000109672546},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.7699999809265137},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.9449999928474426},{"id":"https://openalex.org/keywords/heat-stable-enterotoxin","display_name":"heat-stable enterotoxin","score":0.8759999871253967},{"id":"https://openalex.org/keywords/guatemala","display_name":"Guatemala","score":1.0},{"id":"https://openalex.org/keywords/pre-travel-vaccination","display_name":"pre-travel vaccination","score":0.6060000061988831},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.4830000102519989},{"id":"https://openalex.org/keywords/diarrhea-prevention","display_name":"diarrhea prevention","score":0.44999998807907104},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6473311185836792},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5229252576828003},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.5059015154838562},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.48097217082977295},{"id":"https://openalex.org/C2779565104","wikidata":"https://www.wikidata.org/wiki/Q5447138","display_name":"Field trial","level":2,"score":0.45418089628219604},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4269939363002777},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4250609576702118},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3220319151878357},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2087731659412384},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.1107049286365509},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07755863666534424},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06726610660552979},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003906","descriptor_name":"Developing Countries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006166","descriptor_name":"Guatemala","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008800","descriptor_name":"Mexico","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014195","descriptor_name":"Travel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022361","descriptor_name":"Escherichia coli Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D022361","descriptor_name":"Escherichia coli Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1473-3099(13)70297-4","doi":"https://doi.org/10.1016/s1473-3099(13)70297-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1473-3099(13)70297-4","pdf_url":null,"source":{"id":"https://openalex.org/S23772524","display_name":"The Lancet Infectious Diseases","issn_l":"1473-3099","issn":["1473-3099","1474-4457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:24291168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24291168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet. Infectious diseases","raw_type":"Clinical Trial, Phase III"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1509067395","https://openalex.org/W1898358747","https://openalex.org/W1973190168","https://openalex.org/W1974957348","https://openalex.org/W2011695334","https://openalex.org/W2038968137","https://openalex.org/W2040313647","https://openalex.org/W2053243345","https://openalex.org/W2063917212","https://openalex.org/W2085889988","https://openalex.org/W2098838566","https://openalex.org/W2105433670","https://openalex.org/W2124974796","https://openalex.org/W2136244213","https://openalex.org/W2141579433","https://openalex.org/W2150056219","https://openalex.org/W2153992666","https://openalex.org/W2163335613","https://openalex.org/W2167700118"],"related_works":["https://openalex.org/W2105433670","https://openalex.org/W2053243345","https://openalex.org/W4367059418","https://openalex.org/W1509067395","https://openalex.org/W2085889988","https://openalex.org/W1898358747","https://openalex.org/W2043397952","https://openalex.org/W7095687762","https://openalex.org/W4237550209","https://openalex.org/W7220727415"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}