{"id":"https://openalex.org/W2159096663","doi":"https://doi.org/10.1136/hrt.52.5.530","title":"Captopril in heart failure. A double blind controlled trial.","display_name":"Captopril in heart failure. A double blind controlled trial.","publication_year":1984,"publication_date":"1984-11-01","ids":{"openalex":"https://openalex.org/W2159096663","doi":"https://doi.org/10.1136/hrt.52.5.530","mag":"2159096663","pmid":"https://pubmed.ncbi.nlm.nih.gov/6388612","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/481676"},"language":"en","primary_location":{"id":"doi:10.1136/hrt.52.5.530","doi":"https://doi.org/10.1136/hrt.52.5.530","is_oa":true,"landing_page_url":"https://doi.org/10.1136/hrt.52.5.530","pdf_url":"https://heart.bmj.com/content/heartjnl/52/5/530.full.pdf","source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://heart.bmj.com/content/heartjnl/52/5/530.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017160240","display_name":"John G.F. Cleland","orcid":"https://orcid.org/0000-0002-1471-7016","observed_orcids":["https://orcid.org/0000-0002-1471-7016","https://orcid.org/0000-0002-8635-1009"]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J G Cleland","raw_affiliation_strings":["Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow","Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","Department of Cardiology, Western Infirmary, Glasgow GIl 6NT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","institution_ids":["https://openalex.org/I2801120601","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","institution_ids":["https://openalex.org/I2801120601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108211078","display_name":"Henry J. Dargie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H J Dargie","raw_affiliation_strings":["Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","institution_ids":["https://openalex.org/I2801120601","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","institution_ids":["https://openalex.org/I2801120601"]},{"raw_affiliation_string":"Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042148457","display_name":"G. Peter Hodsman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G P Hodsman","raw_affiliation_strings":["Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow","Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","Department of Cardiology, Western Infirmary, Glasgow GIl 6NT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","institution_ids":["https://openalex.org/I2801120601","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","institution_ids":["https://openalex.org/I2801120601"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S G Ball","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S G Ball","raw_affiliation_strings":["Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","institution_ids":["https://openalex.org/I2801120601","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","institution_ids":["https://openalex.org/I2801120601"]},{"raw_affiliation_string":"Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113608817","display_name":"J. I. S. Robertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J I Robertson","raw_affiliation_strings":["Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","institution_ids":["https://openalex.org/I2801120601","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","institution_ids":["https://openalex.org/I2801120601"]},{"raw_affiliation_string":"Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J J Morton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J J Morton","raw_affiliation_strings":["Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow","Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","Department of Cardiology, Western Infirmary, Glasgow GIl 6NT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","institution_ids":["https://openalex.org/I2801120601","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","institution_ids":["https://openalex.org/I2801120601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045982685","display_name":"Brian W. East","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B W East","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"I Robertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I Robertson","raw_affiliation_strings":["Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","institution_ids":["https://openalex.org/I2801120601","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","institution_ids":["https://openalex.org/I2801120601"]},{"raw_affiliation_string":"Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007401350","display_name":"Gordon D. Murray","orcid":"https://orcid.org/0000-0001-9866-4734","observed_orcids":["https://orcid.org/0000-0001-9866-4734"]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G D Murray","raw_affiliation_strings":["Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","institution_ids":["https://openalex.org/I2801120601","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","institution_ids":["https://openalex.org/I2801120601"]},{"raw_affiliation_string":"Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":null,"display_name":"G Gillen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120601","display_name":"Western Infirmary","ror":"https://ror.org/02e22bh87","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I2801120601"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G Gillen","raw_affiliation_strings":["Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and the Medical Research Council Blood Pressure Unit, Western Infirmnary; the","institution_ids":["https://openalex.org/I2801120601","https://openalex.org/I90344618"]},{"raw_affiliation_string":"Department of Cardiology, Western Infirmary, Glasgow GIl 6NT","institution_ids":["https://openalex.org/I2801120601"]},{"raw_affiliation_string":"Scottish Universities Research and Reactor Centre; the Department ofStatistics, The University; and the Department of Clinical Physics and Bioengineering, West ofScotland Health Boards, Glasgow","institution_ids":["https://openalex.org/I7882870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.2513,"has_fulltext":true,"cited_by_count":377,"citation_normalized_percentile":{"value":0.99488055,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"52","issue":"5","first_page":"530","last_page":"535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/captopril","display_name":"captopril","score":1.0},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.8349999785423279},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8769999742507935},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.8859999775886536},{"id":"https://openalex.org/keywords/renal-plasma-flow","display_name":"renal plasma flow","score":0.7490000128746033},{"id":"https://openalex.org/keywords/renal-vascular-resistance","display_name":"renal vascular resistance","score":0.8059999942779541},{"id":"https://openalex.org/keywords/serum-potassium","display_name":"serum potassium","score":0.7689999938011169},{"id":"https://openalex.org/keywords/exercise-tolerance","display_name":"exercise tolerance","score":0.7129999995231628},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7289999723434448},{"id":"https://openalex.org/keywords/long-term-treatment","display_name":"long-term treatment","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C2779479957","wikidata":"https://www.wikidata.org/wiki/Q421119","display_name":"Captopril","level":3,"score":0.960273265838623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.694075882434845},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6171093583106995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5732442736625671},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.536439061164856},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.48623982071876526},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4585973024368286},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4493091106414795},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3985682725906372},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2926054000854492},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.2718706727027893}],"mesh":[{"descriptor_ui":"D002216","descriptor_name":"Captopril","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006334","descriptor_name":"Heart Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1136/hrt.52.5.530","doi":"https://doi.org/10.1136/hrt.52.5.530","is_oa":true,"landing_page_url":"https://doi.org/10.1136/hrt.52.5.530","pdf_url":"https://heart.bmj.com/content/heartjnl/52/5/530.full.pdf","source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},{"id":"pmid:6388612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6388612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British heart journal","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:481676","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC481676/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br Heart J","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.825.42","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.825.42","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://heart.bmj.com/content/52/5/530.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1136/hrt.52.5.530","doi":"https://doi.org/10.1136/hrt.52.5.530","is_oa":true,"landing_page_url":"https://doi.org/10.1136/hrt.52.5.530","pdf_url":"https://heart.bmj.com/content/heartjnl/52/5/530.full.pdf","source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159096663.pdf","grobid_xml":"https://content.openalex.org/works/W2159096663.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W125318081","https://openalex.org/W1515631712","https://openalex.org/W1974235653","https://openalex.org/W1977173164","https://openalex.org/W1990919233","https://openalex.org/W2000911265","https://openalex.org/W2004105502","https://openalex.org/W2051165221","https://openalex.org/W2063484017","https://openalex.org/W2068033616","https://openalex.org/W2080972575","https://openalex.org/W2096073058","https://openalex.org/W2108219991","https://openalex.org/W2156403936","https://openalex.org/W2166168086","https://openalex.org/W2305919962","https://openalex.org/W2312231629","https://openalex.org/W2365268540","https://openalex.org/W2413695779","https://openalex.org/W4210336424","https://openalex.org/W7116926305"],"related_works":["https://openalex.org/W1963598699","https://openalex.org/W2014659345","https://openalex.org/W2045360765","https://openalex.org/W2413092187","https://openalex.org/W1999022133","https://openalex.org/W2337944938","https://openalex.org/W2063484017","https://openalex.org/W2071652114","https://openalex.org/W2413400495","https://openalex.org/W2120525089"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,31,87,187,195],"the":[3,153,172,191],"converting":[4],"enzyme":[5],"inhibitor":[6],"captopril":[7,134],"as":[8],"long":[9,77,192],"term":[10,78,193],"treatment":[11,194],"was":[12,91,110,135,155,162,178],"investigated":[13],"in":[14,22,40,80,114,130,146,166,190],"14":[15],"patients":[16,132,139,148],"with":[17,36],"severe":[18,196],"congestive":[19],"heart":[20],"failure":[21],"a":[23,37,158,163],"double":[24],"blind":[25],"trial.":[26],"Captopril":[27,182],"reduced":[28],"plasma":[29,46],"concentrations":[30,64],"angiotensin":[32],"II":[33],"and":[34,49,62,68,94,96,103,125,137],"noradrenaline,":[35],"converse":[38],"increase":[39],"active":[41],"renin":[42],"concentration.":[43],"Effective":[44],"renal":[45,50],"flow":[47],"increased":[48],"vascular":[51],"resistance":[52],"fell;":[53],"glomerular":[54],"filtration":[55],"rate":[56],"did":[57,149],"not":[58,150],"change.":[59],"Serum":[60],"urea":[61],"creatinine":[63],"rose.":[65],"Both":[66],"serum":[67,81],"total":[69,84],"body":[70,85],"potassium":[71],"contents":[72],"increased;":[73],"there":[74,161],"were":[75,107,121,128],"no":[76],"changes":[79],"concentration":[82],"or":[83],"content":[86],"sodium.":[88],"Exercise":[89],"tolerance":[90],"appreciably":[92],"improved,":[93],"dyspnoea":[95],"fatigue":[97],"lessened.":[98],"Left":[99],"ventricular":[100,116],"end":[101,104],"systolic":[102],"diastolic":[105],"dimensions":[106],"reduced.":[108],"There":[109],"an":[111],"appreciable":[112],"reduction":[113,165],"complex":[115],"ectopic":[117],"rhythms.":[118],"Adverse":[119],"effects":[120],"few:":[122],"weight":[123],"gain":[124],"fluid":[126],"retention":[127],"evident":[129],"five":[131],"when":[133,152],"introduced":[136],"two":[138,147],"initially":[140],"experienced":[141],"mild":[142],"postural":[143],"dizziness;":[144],"rashes":[145],"recur":[151],"drug":[154],"reintroduced":[156],"at":[157],"lower":[159],"dose;":[160],"significant":[164],"white":[167,175],"cell":[168,176],"count":[169,177],"overall,":[170],"but":[171],"lowest":[173],"individual":[174],"4000":[179],"X":[180],"10(6)/l.":[181],"thus":[183],"seemed":[184],"to":[185],"be":[186],"considerable":[188],"value":[189],"cardiac":[197],"failure.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}