{"id":"https://openalex.org/W2159078978","doi":"https://doi.org/10.1084/jem.129.4.757","title":"CELLS INVOLVED IN THE IMMUNE RESPONSE","display_name":"CELLS INVOLVED IN THE IMMUNE RESPONSE","publication_year":1969,"publication_date":"1969-04-01","ids":{"openalex":"https://openalex.org/W2159078978","doi":"https://doi.org/10.1084/jem.129.4.757","mag":"2159078978","pmid":"https://pubmed.ncbi.nlm.nih.gov/5766947","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2138626"},"language":"en","primary_location":{"id":"doi:10.1084/jem.129.4.757","doi":"https://doi.org/10.1084/jem.129.4.757","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.129.4.757","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2138626/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103367253","display_name":"Nabih I. Abdou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088756","display_name":"Royal Victoria Hospital","ror":"https://ror.org/00arwy491","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210088756","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nabih I. Abdou","raw_affiliation_strings":["From The Harry Webster Thorp Laboratories for The Division of Immunochemistry and Allergy, McGill University Clinic, Royal Victoria Hospital, Montreal 2, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Harry Webster Thorp Laboratories for The Division of Immunochemistry and Allergy, McGill University Clinic, Royal Victoria Hospital, Montreal 2, Quebec, Canada","institution_ids":["https://openalex.org/I4210088756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113643245","display_name":"Maxwell Richter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088756","display_name":"Royal Victoria Hospital","ror":"https://ror.org/00arwy491","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210088756","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Maxwell Richter","raw_affiliation_strings":["From The Harry Webster Thorp Laboratories for The Division of Immunochemistry and Allergy, McGill University Clinic, Royal Victoria Hospital, Montreal 2, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Harry Webster Thorp Laboratories for The Division of Immunochemistry and Allergy, McGill University Clinic, Royal Victoria Hospital, Montreal 2, Quebec, Canada","institution_ids":["https://openalex.org/I4210088756"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210088756"],"apc_list":null,"apc_paid":null,"fwci":4.9993,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.95217778,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"129","issue":"4","first_page":"757","last_page":"774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/allogeneic-bone-marrow","display_name":"allogeneic bone marrow","score":0.8560000061988831},{"id":"https://openalex.org/keywords/sheep-red-blood-cells","display_name":"sheep red blood cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/antibody-production","display_name":"antibody production","score":0.6570000052452087},{"id":"https://openalex.org/keywords/blastogenesis","display_name":"blastogenesis","score":0.6549999713897705},{"id":"https://openalex.org/keywords/thymidine-incorporation","display_name":"thymidine incorporation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/donor-sensitization","display_name":"donor sensitization","score":0.5460000038146973},{"id":"https://openalex.org/keywords/antigen-specific-immune-response","display_name":"antigen-specific immune response","score":0.5059999823570251},{"id":"https://openalex.org/keywords/antibody-producing-cells","display_name":"antibody-forming cells","score":0.6940000057220459},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7644426822662354},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6690382361412048},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6429858803749084},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6264107823371887},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6052461862564087},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.5828685760498047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5181311964988708},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5017595291137695},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32122603058815}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011830","descriptor_name":"Radiation Effects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1084/jem.129.4.757","doi":"https://doi.org/10.1084/jem.129.4.757","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.129.4.757","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2138626","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2138626/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2138626/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:5766947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5766947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.274.988","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.274.988","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1f/9b/J_Exp_Med_1969_Mar_31_129(4)_757-774.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2138626","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2138626/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2138626/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159078978.pdf","grobid_xml":"https://content.openalex.org/works/W2159078978.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W294906880","https://openalex.org/W1502047136","https://openalex.org/W1965619929","https://openalex.org/W1977351444","https://openalex.org/W2001276827","https://openalex.org/W2006894378","https://openalex.org/W2008692873","https://openalex.org/W2011199268","https://openalex.org/W2064008537","https://openalex.org/W2071722434","https://openalex.org/W2081567534","https://openalex.org/W2103169500","https://openalex.org/W2105564783","https://openalex.org/W2114258661","https://openalex.org/W2124503773","https://openalex.org/W2129214400","https://openalex.org/W2141099453","https://openalex.org/W2141155302","https://openalex.org/W2158901501","https://openalex.org/W2165698236","https://openalex.org/W2198496683","https://openalex.org/W2412425743","https://openalex.org/W2424941616","https://openalex.org/W2611762303","https://openalex.org/W2740645735","https://openalex.org/W4242765117"],"related_works":["https://openalex.org/W7095876631","https://openalex.org/W7095372349","https://openalex.org/W7095822277","https://openalex.org/W7100449023","https://openalex.org/W2516226942","https://openalex.org/W1985931383","https://openalex.org/W2086617842","https://openalex.org/W1496809378","https://openalex.org/W7096988101","https://openalex.org/W1524150978"],"abstract_inverted_index":{"Irradiated":[0],"rabbits":[1,64,72],"given":[2],"allogeneic":[3,67],"bone":[4,68,105,138,164],"marrow":[5,69,106,139,165],"cells":[6,19,26,78,148,166,191],"from":[7,71,107],"normal":[8],"adult":[9],"donors":[10,109,140],"responded":[11],"to":[12,56,82,124,145,153,167,171,183],"an":[13,90],"injection":[14],"of":[15,30,44,50,88,101,120,136,162,178,186],"sheep":[16,75,96,146,172],"red":[17,76,97,130,147,173],"blood":[18,77,131,174],"by":[20,103],"forming":[21,31],"circulating":[22],"antibodies.":[23],"Their":[24],"spleen":[25],"were":[27,41,86],"also":[28,42],"capable":[29,43],"many":[32],"plaques":[33],"using":[34],"the":[35,57,104,113,117,121,128,137,184,187,193],"hemolysis":[36],"in":[37,60,158,192],"gel":[38],"technique,":[39],"and":[40,47,49,189],"undergoing":[45],"blastogenesis":[46],"mitosis":[48],"incorporating":[51],"tritiated":[52],"thymidine":[53],"upon":[54],"exposure":[55],"specific":[58,111,143],"antigen":[59,114],"vitro.":[61],"However,":[62],"irradiated":[63,122],"injected":[65,73],"with":[66,74,95,141,181],"obtained":[70],"24":[79,150],"hr":[80,151],"prior":[81,152],"sacrifice":[83,154],"(primed":[84],"donors)":[85],"incapable":[87],"mounting":[89],"immune":[91,118],"response":[92,119],"after":[93],"stimulation":[94],"cells.":[98,175],"This":[99],"loss":[100],"reactivity":[102],"primed":[108],"is":[110,133,195],"for":[112,149],"injected,":[115],"since":[116],"recipients":[123],"a":[125],"non-cross-reacting":[126],"antigen,":[127],"horse":[129],"cell,":[132],"unimpaired.":[134],"Treatment":[135],"high-titered":[142],"antiserum":[144],"did":[155],"not":[156],"result":[157],"any":[159],"diminished":[160],"ability":[161],"their":[163],"transfer":[168],"antibody-forming":[169,190],"capacity":[170],"The":[176],"significance":[177],"these":[179],"results,":[180],"respect":[182],"origin":[185],"antigen-reactive":[188],"rabbit,":[194],"discussed.":[196]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
