{"id":"https://openalex.org/W2159030596","doi":null,"title":"The MEF2A 39Untranslated Region Functions as acis-Acting Translational Repressor","display_name":"The MEF2A 39Untranslated Region Functions as acis-Acting Translational Repressor","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2159030596","mag":"2159030596"},"language":"en","primary_location":{"id":"mag:2159030596","doi":null,"is_oa":false,"landing_page_url":"https://mcb.asm.org/content/17/5/2756.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064800933","display_name":"Brian L. Black","orcid":"https://orcid.org/0000-0002-6664-8913","observed_orcids":["https://orcid.org/0000-0002-6664-8913"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian L. Black","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6664-8913","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010556512","display_name":"Jianrong Lu","orcid":"https://orcid.org/0000-0002-4969-6040","observed_orcids":["https://orcid.org/0000-0002-4969-6040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianrong Lu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4969-6040","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043827002","display_name":"Anderic N. Olson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anderic N. Olson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1520628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.20350000262260437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mef2a","display_name":"MEF2A","score":0.9980000257492065},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.8880000114440918},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.9729999899864197},{"id":"https://openalex.org/keywords/muscle-cell-differentiation","display_name":"muscle cell differentiation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.7350000143051147},{"id":"https://openalex.org/keywords/chloramphenicol-acetyltransferase-reporter","display_name":"chloramphenicol acetyltransferase reporter","score":0.8360000252723694},{"id":"https://openalex.org/keywords/reticulocyte-lysate-translation","display_name":"reticulocyte lysate translation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.6419378519058228},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.6054022312164307},{"id":"https://openalex.org/C2780730277","wikidata":"https://www.wikidata.org/wiki/Q24744759","display_name":"Chloramphenicol acetyltransferase","level":5,"score":0.6003780364990234},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.5770387649536133},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.5708601474761963},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5416666865348816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.526648998260498},{"id":"https://openalex.org/C51183755","wikidata":"https://www.wikidata.org/wiki/Q83166919","display_name":"Mef2","level":5,"score":0.5030524134635925},{"id":"https://openalex.org/C12464233","wikidata":"https://www.wikidata.org/wiki/Q937624","display_name":"Five prime untranslated region","level":5,"score":0.48641538619995117},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.47270986437797546},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4503452181816101},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.38657325506210327},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3685344457626343},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.3632477819919586},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.2856227159500122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27116405963897705},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13347575068473816}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2159030596","doi":null,"is_oa":false,"landing_page_url":"https://mcb.asm.org/content/17/5/2756.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W347512548","https://openalex.org/W1479824186","https://openalex.org/W1492171676","https://openalex.org/W1775749144","https://openalex.org/W1867816903","https://openalex.org/W1947596099","https://openalex.org/W1978995496","https://openalex.org/W1988162020","https://openalex.org/W1992879938","https://openalex.org/W1993857983","https://openalex.org/W2015999110","https://openalex.org/W2018467507","https://openalex.org/W2023947760","https://openalex.org/W2032220086","https://openalex.org/W2035760322","https://openalex.org/W2051258900","https://openalex.org/W2055217734","https://openalex.org/W2056427097","https://openalex.org/W2058267750","https://openalex.org/W2064864270","https://openalex.org/W2070293940","https://openalex.org/W2077921152","https://openalex.org/W2078680074","https://openalex.org/W2088124858","https://openalex.org/W2106438297","https://openalex.org/W2106468261","https://openalex.org/W2107844605","https://openalex.org/W2112431248","https://openalex.org/W2116345841","https://openalex.org/W2122967431","https://openalex.org/W2124608824","https://openalex.org/W2142549149","https://openalex.org/W2171741953"],"related_works":["https://openalex.org/W1849689813","https://openalex.org/W2002680630","https://openalex.org/W1992879938","https://openalex.org/W2013602440","https://openalex.org/W2113861670","https://openalex.org/W2122967431","https://openalex.org/W4236931735","https://openalex.org/W1569747416","https://openalex.org/W2299104974","https://openalex.org/W2160487610"],"abstract_inverted_index":{"Myocyte":[0],"enhancer":[1],"factor":[2],"2":[3],"(MEF2)":[4],"proteins":[5,36],"serve":[6],"as":[7,198],"important":[8,67],"muscle":[9,16,48,170,174],"transcription":[10],"factors.":[11],"In":[12,73],"addition,":[13],"MEF2proteinshavebeenshowntopotentiatetheactivityofothercell-type-specifictranscriptionfactorsfound":[14],"in":[15,28,69,119,148,150,176,203,206],"and":[17,33,37,46,49,57,94,121,205,208,219],"brain":[18],"tissue.":[19],"While":[20],"transcripts":[21],"for":[22],"MEF2":[23,35,55,71],"factors":[24],"are":[25,40],"widely":[26],"expressed":[27],"a":[29],"variety":[30],"of":[31,140,165,222],"cells":[32,175],"tissues,":[34],"binding":[38,220],"activity":[39,133,221],"largely":[41],"restricted":[42],"to":[43,50,76,97,127,144,215],"skeletal,":[44],"smooth,":[45],"cardiac":[47],"brain.":[51],"This":[52],"disparity":[53],"between":[54],"protein":[56],"mRNA":[58],"expression":[59,118,218],"suggests":[60],"that":[61,110,122,157,193,210],"translational":[62,136,159,180,200],"control":[63,84],"may":[64,213],"play":[65],"an":[66,74,128],"role":[68],"regulating":[70],"expression.":[72],"effort":[75],"identify":[77],"sequences":[78],"within":[79],"the":[80,88,98,111,141,158,163,179,184,194,216],"MEF2A":[81,90,112,142,166,185,195],"message":[82],"which":[83],"translation,":[85],"we":[86,105],"isolated":[87],"mouse":[89],"3*untranslated":[91],"region":[92,130],"(UTR)":[93],"fused":[95],"it":[96],"chloramphenicol":[99],"acetyltransferase":[100],"(CAT)":[101],"reporter":[102],"gene.":[103],"Here,":[104],"show":[106,156],"by":[107,162,183],"CAT":[108,116,145],"assay":[109],"3*UTR":[113,143,164,196],"dramatically":[114],"inhibits":[115],"gene":[117],"vivo":[120,207],"this":[123,211],"inhibition":[124,181],"is":[125,167,188],"due":[126],"internal":[129],"withinthehighlyconserved3*UTR.RNaseprotectionanalysesdemonstratedthatthesteady-statelevelofCAT":[131],"mRNAproducedinvivowasnotaffectedbyfusionoftheMEF2A3*UTR,indicatingthattheinhibitionofCAT":[132],"resulted":[134],"from":[135],"repression.":[137],"Furthermore,":[138],"fusion":[139],"inhibited":[146],"translation":[147],"vitro":[149,204],"rabbit":[151],"reticulocyte":[152],"lysates.":[153],"We":[154],"also":[155],"repression":[160,212],"mediated":[161],"regulated":[168],"during":[169],"cell":[171],"differentiation.":[172],"As":[173],"culture":[177],"differentiate,":[178],"caused":[182],"3*":[186],"UTR":[187],"relaxed.":[189],"These":[190],"results":[191],"demonstrate":[192],"functions":[197],"acis-acting":[199],"repressor":[201],"both":[202],"suggest":[209],"contribute":[214],"tissue-restricted":[217],"MEF2A.":[223]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
