{"id":"https://openalex.org/W2158993550","doi":"https://doi.org/10.1517/14712598.2013.761969","title":"Antibody-based candidate therapeutics against HIV-1: implications for virus eradication and vaccine design","display_name":"Antibody-based candidate therapeutics against HIV-1: implications for virus eradication and vaccine design","publication_year":2013,"publication_date":"2013-01-07","ids":{"openalex":"https://openalex.org/W2158993550","doi":"https://doi.org/10.1517/14712598.2013.761969","mag":"2158993550","pmid":"https://pubmed.ncbi.nlm.nih.gov/23293858","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6953398"},"language":"en","primary_location":{"id":"doi:10.1517/14712598.2013.761969","doi":"https://doi.org/10.1517/14712598.2013.761969","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14712598.2013.761969","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6953398","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067025401","display_name":"Weizao Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Weizao Chen","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Frederick National Laboratory for Cancer Research, Protein Interactions Group, Miller Drive, Building 469, Room 144, Frederick, MD 21702, USA. chenw3@mail.nih.gov","+1 301 846 5598","National Cancer Institute, National Institutes of Health, Frederick National Laboratory for Cancer Research, Protein Interactions Group,\nMiller Drive, Building 469, Room 144, Frederick, MD 21702, USA +1 301 846 1770"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Frederick National Laboratory for Cancer Research, Protein Interactions Group, Miller Drive, Building 469, Room 144, Frederick, MD 21702, USA. chenw3@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"+1 301 846 5598","institution_ids":[]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Frederick National Laboratory for Cancer Research, Protein Interactions Group,\nMiller Drive, Building 469, Room 144, Frederick, MD 21702, USA +1 301 846 1770","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073076889","display_name":"Tianlei Ying","orcid":"https://orcid.org/0000-0002-9597-2843","observed_orcids":["https://orcid.org/0000-0002-9597-2843"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianlei Ying","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Frederick National Laboratory for Cancer Research, Protein Interactions Group, Miller Drive, Building 469, Room 144, Frederick, MD 21702, USA +1 301 846 1770; +1 301 846 5598; chenw3@mail.nih.gov","+1 301 846 5598","National Cancer Institute, National Institutes of Health, Frederick National Laboratory for Cancer Research, Protein Interactions Group,\nMiller Drive, Building 469, Room 144, Frederick, MD 21702, USA +1 301 846 1770"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Frederick National Laboratory for Cancer Research, Protein Interactions Group, Miller Drive, Building 469, Room 144, Frederick, MD 21702, USA +1 301 846 1770; +1 301 846 5598; chenw3@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"+1 301 846 5598","institution_ids":[]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Frederick National Laboratory for Cancer Research, Protein Interactions Group,\nMiller Drive, Building 469, Room 144, Frederick, MD 21702, USA +1 301 846 1770","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089862290","display_name":"Dimiter Stanchev Dimitrov","orcid":"https://orcid.org/0000-0002-2258-1024","observed_orcids":["https://orcid.org/0000-0002-2258-1024"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dimiter S Dimitrov","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Frederick National Laboratory for Cancer Research, Protein Interactions Group, Miller Drive, Building 469, Room 144, Frederick, MD 21702, USA +1 301 846 1770; +1 301 846 5598; chenw3@mail.nih.gov","+1 301 846 5598","National Cancer Institute, National Institutes of Health, Frederick National Laboratory for Cancer Research, Protein Interactions Group,\nMiller Drive, Building 469, Room 144, Frederick, MD 21702, USA +1 301 846 1770"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Frederick National Laboratory for Cancer Research, Protein Interactions Group, Miller Drive, Building 469, Room 144, Frederick, MD 21702, USA +1 301 846 1770; +1 301 846 5598; chenw3@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"+1 301 846 5598","institution_ids":[]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Frederick National Laboratory for Cancer Research, Protein Interactions Group,\nMiller Drive, Building 469, Room 144, Frederick, MD 21702, USA +1 301 846 1770","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067025401"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":1.6805,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.84627774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"5","first_page":"657","last_page":"671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/broadly-neutralizing-antibodies","display_name":"broadly neutralizing antibodies","score":0.890999972820282},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hiv-1-eradication","display_name":"HIV-1 eradication","score":0.8659999966621399},{"id":"https://openalex.org/keywords/hiv-1-vaccine-design","display_name":"HIV-1 vaccine design","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hiv-1-envelope-glycoprotein","display_name":"HIV-1 envelope glycoprotein","score":0.8730000257492065},{"id":"https://openalex.org/keywords/bispecific-fusion-protein","display_name":"bispecific fusion protein","score":0.9049999713897705},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/antibody-maturation","display_name":"antibody maturation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/germline-antibodies","display_name":"germline antibodies","score":0.777999997138977},{"id":"https://openalex.org/keywords/prophylactics","display_name":"prophylactics","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6170185208320618},{"id":"https://openalex.org/C2780195530","wikidata":"https://www.wikidata.org/wiki/Q1479804","display_name":"HIV vaccine","level":4,"score":0.5465547442436218},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5389493107795715},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5167345404624939},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4897003471851349},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44901391863822937},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4388638734817505},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4156753122806549},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.383891224861145},{"id":"https://openalex.org/C2778190748","wikidata":"https://www.wikidata.org/wiki/Q7907956","display_name":"Vaccine trial","level":3,"score":0.21459656953811646}],"mesh":[{"descriptor_ui":"D004197","descriptor_name":"Disease Reservoirs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015700","descriptor_name":"HIV Envelope Protein gp41","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1517/14712598.2013.761969","doi":"https://doi.org/10.1517/14712598.2013.761969","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14712598.2013.761969","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},{"id":"pmid:23293858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23293858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on biological therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6953398","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6953398","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Expert Opin Biol Ther","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6953398","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6953398","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Expert Opin Biol Ther","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5511856655","display_name":"Human Monoclonal Antibodies and Antibody-Guided Nanoparticles","funder_award_id":"Z01BC010701","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5970235536","display_name":"Ligand-receptor-antibody interactions in transmembrane s","funder_award_id":"Z01BC010257","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W20946563","https://openalex.org/W1491954563","https://openalex.org/W1497870368","https://openalex.org/W1503491996","https://openalex.org/W1557952727","https://openalex.org/W1571416991","https://openalex.org/W1607012924","https://openalex.org/W1842798465","https://openalex.org/W1969156908","https://openalex.org/W1969305630","https://openalex.org/W1971158720","https://openalex.org/W1972527396","https://openalex.org/W1973123797","https://openalex.org/W1977849687","https://openalex.org/W1977929936","https://openalex.org/W1980322325","https://openalex.org/W1983539618","https://openalex.org/W1983551402","https://openalex.org/W1985534966","https://openalex.org/W1986291311","https://openalex.org/W1990152283","https://openalex.org/W1990971245","https://openalex.org/W1993084727","https://openalex.org/W1993366615","https://openalex.org/W1996538960","https://openalex.org/W1996604523","https://openalex.org/W2001235690","https://openalex.org/W2001419705","https://openalex.org/W2012362118","https://openalex.org/W2014626333","https://openalex.org/W2016180326","https://openalex.org/W2016364569","https://openalex.org/W2016453064","https://openalex.org/W2029804942","https://openalex.org/W2030844138","https://openalex.org/W2030987189","https://openalex.org/W2035450675","https://openalex.org/W2035867359","https://openalex.org/W2036741092","https://openalex.org/W2038673095","https://openalex.org/W2040681869","https://openalex.org/W2044293862","https://openalex.org/W2044863954","https://openalex.org/W2051364248","https://openalex.org/W2051611676","https://openalex.org/W2052277371","https://openalex.org/W2054392131","https://openalex.org/W2055796578","https://openalex.org/W2056661571","https://openalex.org/W2058066573","https://openalex.org/W2060880470","https://openalex.org/W2070086938","https://openalex.org/W2075032293","https://openalex.org/W2077494233","https://openalex.org/W2077977162","https://openalex.org/W2078913377","https://openalex.org/W2080089116","https://openalex.org/W2081224837","https://openalex.org/W2081313987","https://openalex.org/W2083094268","https://openalex.org/W2083726777","https://openalex.org/W2083791326","https://openalex.org/W2085528829","https://openalex.org/W2088493593","https://openalex.org/W2089216532","https://openalex.org/W2092019330","https://openalex.org/W2093442592","https://openalex.org/W2093582005","https://openalex.org/W2093985842","https://openalex.org/W2097386513","https://openalex.org/W2097594050","https://openalex.org/W2103178838","https://openalex.org/W2104887267","https://openalex.org/W2109229894","https://openalex.org/W2110669507","https://openalex.org/W2110787025","https://openalex.org/W2111294827","https://openalex.org/W2112782031","https://openalex.org/W2113236498","https://openalex.org/W2113963476","https://openalex.org/W2116715603","https://openalex.org/W2118274231","https://openalex.org/W2118820599","https://openalex.org/W2119711460","https://openalex.org/W2120399100","https://openalex.org/W2120876680","https://openalex.org/W2122043122","https://openalex.org/W2124058652","https://openalex.org/W2126977955","https://openalex.org/W2128461524","https://openalex.org/W2129922258","https://openalex.org/W2132109712","https://openalex.org/W2135151522","https://openalex.org/W2137677704","https://openalex.org/W2142337547","https://openalex.org/W2146520916","https://openalex.org/W2150051713","https://openalex.org/W2151622733","https://openalex.org/W2152048324","https://openalex.org/W2153178346","https://openalex.org/W2154277357","https://openalex.org/W2154575731","https://openalex.org/W2155379930","https://openalex.org/W2156123588","https://openalex.org/W2162546635","https://openalex.org/W2166859411","https://openalex.org/W2166861522","https://openalex.org/W2167283896","https://openalex.org/W2171106047","https://openalex.org/W2177434887","https://openalex.org/W2917571037","https://openalex.org/W4235232179","https://openalex.org/W4243952253","https://openalex.org/W4298022270"],"related_works":["https://openalex.org/W2001419705","https://openalex.org/W2884875339","https://openalex.org/W2083791326","https://openalex.org/W2129922258","https://openalex.org/W4290975583","https://openalex.org/W2027633663","https://openalex.org/W7155070731","https://openalex.org/W2895982607","https://openalex.org/W3217081325","https://openalex.org/W2170584620"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1],"currently":[2],"available":[3],"anti-HIV-1":[4],"drugs":[5],"can":[6,19],"control":[7],"the":[8,14,31,69,104],"infection":[9],"but":[10],"do":[11],"not":[12],"eradicate":[13,178],"virus.":[15],"Their":[16],"long-term":[17],"use":[18,102],"lead":[20],"to":[21,26,51,156],"side":[22],"effects":[23],"and":[24,80,86,135,140,153,167],"resistance":[25],"therapy.":[27],"Therefore,":[28],"eradication":[29,109],"of":[30,38,65,126,128,148,165,181,185],"virus":[32],"has":[33,151],"been":[34],"a":[35,192],"major":[36],"goal":[37],"research.":[39],"Biological":[40],"therapeutics":[41,87,175],"including":[42],"broadly":[43],"neutralizing":[44],"monoclonal":[45],"antibodies":[46],"(bnAbs)":[47],"are":[48],"promising":[49],"tools":[50],"reach":[52],"this":[53],"goal.":[54],"They":[55],"could":[56,176],"also":[57,98],"help":[58,177],"design":[59,121],"novel":[60,163],"vaccine":[61,120,130,182],"immunogens":[62,131,183],"potentially":[63],"capable":[64,184],"eliciting":[66,186],"bnAbs":[67,79,134,150,188],"targeting":[68],"HIV-1":[70,78,108,149],"envelope":[71],"glycoproteins":[72],"(Envs).":[73],"AREAS":[74],"COVERED:":[75],"We":[76,97],"review":[77],"their":[81,100,136],"potential":[82,101],"as":[83,93,116,118],"candidate":[84,129,174],"prophylactics":[85],"used":[88],"individually,":[89],"in":[90,103,110,189],"combination,":[91],"or":[92],"bispecific":[94],"fusion":[95],"proteins.":[96],"discuss":[99],"'activation-elimination'":[105],"approach":[106],"for":[107],"infected":[111],"patients":[112],"receiving":[113],"antiretroviral":[114],"treatment":[115],"well":[117],"current":[119],"efforts":[122],"based":[123],"on":[124],"understanding":[125],"interactions":[127],"with":[132],"matured":[133],"putative":[137],"germline":[138],"predecessors,":[139],"related":[141],"antibody":[142],"maturation":[143],"pathways.":[144],"EXPERT":[145],"OPINION:":[146],"Exploration":[147],"provided":[152],"will":[154],"continue":[155],"provide":[157],"useful":[158],"knowledge":[159],"that":[160,172],"helps":[161],"develop":[162],"types":[164],"biotherapeutics":[166],"vaccines.":[168],"It":[169],"is":[170],"possible":[171],"bnAb-based":[173],"HIV-1.":[179],"Development":[180],"potent":[187],"humans":[190],"remains":[191],"fundamental":[193],"challenge.":[194]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}