{"id":"https://openalex.org/W2158991964","doi":null,"title":"Implanon. A review of clinical studies.","display_name":"Implanon. A review of clinical studies.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2158991964","mag":"2158991964","pmid":"https://pubmed.ncbi.nlm.nih.gov/10068281"},"language":"en","primary_location":{"id":"pmid:10068281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10068281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of family planning","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111887372","display_name":"Jayne E. Edwards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J E Edwards","raw_affiliation_strings":["Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, OX3 7LJ UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, OX3 7LJ UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":null,"display_name":"A Moore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.5259,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.97768752,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"24","issue":"4 Suppl","first_page":"3","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13242","display_name":"Male Reproductive Health Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/implanon","display_name":"Implanon","score":1.0},{"id":"https://openalex.org/keywords/norplant","display_name":"Norplant","score":0.9580000042915344},{"id":"https://openalex.org/keywords/contraceptive-implants","display_name":"contraceptive implants","score":0.828000009059906},{"id":"https://openalex.org/keywords/contraceptive-efficacy","display_name":"contraceptive efficacy","score":0.6579999923706055},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6759999990463257},{"id":"https://openalex.org/keywords/menstrual-bleeding-patterns","display_name":"menstrual bleeding patterns","score":0.703000009059906},{"id":"https://openalex.org/keywords/patient-acceptability","display_name":"patient acceptability","score":0.7039999961853027},{"id":"https://openalex.org/keywords/pregnancy-rate","display_name":"pregnancy rate","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9631612300872803},{"id":"https://openalex.org/C2780186607","wikidata":"https://www.wikidata.org/wiki/Q416950","display_name":"Levonorgestrel","level":5,"score":0.7699116468429565},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7149237394332886},{"id":"https://openalex.org/C2779441745","wikidata":"https://www.wikidata.org/wiki/Q415304","display_name":"Desogestrel","level":5,"score":0.6829593777656555},{"id":"https://openalex.org/C2777548101","wikidata":"https://www.wikidata.org/wiki/Q3149432","display_name":"Contraceptive implant","level":5,"score":0.5570959448814392},{"id":"https://openalex.org/C2779076696","wikidata":"https://www.wikidata.org/wiki/Q1280670","display_name":"Family planning","level":4,"score":0.5231881737709045},{"id":"https://openalex.org/C2781197234","wikidata":"https://www.wikidata.org/wiki/Q3733839","display_name":"Etonogestrel","level":5,"score":0.5144396424293518},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4719366729259491},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44544002413749695},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42779260873794556},{"id":"https://openalex.org/C502991105","wikidata":"https://www.wikidata.org/wiki/Q5133849","display_name":"Clinical research","level":2,"score":0.42253512144088745},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41508570313453674},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4055919647216797},{"id":"https://openalex.org/C2986817661","wikidata":"https://www.wikidata.org/wiki/Q185698","display_name":"Research methodology","level":3,"score":0.3394092917442322},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22733330726623535},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07715925574302673},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003271","descriptor_name":"Contraceptive Agents, Female","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003271","descriptor_name":"Contraceptive Agents, Female","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004412","descriptor_name":"Dysmenorrhea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014753","descriptor_name":"Vinyl Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014753","descriptor_name":"Vinyl Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016912","descriptor_name":"Levonorgestrel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017135","descriptor_name":"Desogestrel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10068281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10068281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of family planning","raw_type":"Comparative Study"},{"id":"mag:2158991964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10068281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2413981935","https://openalex.org/W2353953376","https://openalex.org/W2041735629","https://openalex.org/W1948918988","https://openalex.org/W7098217628","https://openalex.org/W2398274941","https://openalex.org/W4299366543","https://openalex.org/W2065233273","https://openalex.org/W2052415534","https://openalex.org/W4245115380"],"abstract_inverted_index":{"This":[0],"paper":[1],"compares":[2],"current":[3],"clinical":[4,53],"trials":[5,25,54],"experience":[6],"of":[7,11,23,26,32,46,51,63,71,79,90,120,125,147,152,167,190,199,220],"Implanon":[8,27,33,64,99,108,121,139,182,213],"with":[9,69,98,163],"that":[10],"Norplant":[12,101,126,153],"the":[13,58,91,203,217],"other":[14,210],"implantable":[15],"progestogen":[16],"available":[17],"in":[18,38,102,130,145],"UK.":[19],"A":[21],"number":[22],"noncomparative":[24],"and":[28,34,60,65,85,115,202,223,228],"open":[29],"randomized":[30],"comparisons":[31],"Norplant-6":[35],"were":[36,128,157],"conducted":[37],"healthy":[39],"female":[40,104],"volunteers":[41],"requiring":[42],"a":[43,94,174,188,197],"long-term":[44],"method":[45],"contraception.":[47],"The":[49,73,88],"aim":[50],"these":[52],"was":[55,75,140],"to":[56,66,110,113,150,209,215,225],"examine":[57],"efficacy":[59,221],"adverse":[61,86,160,200],"effects":[62],"compare":[67],"them":[68],"those":[70,178],"Norplant.":[72],"comparison":[74],"based":[76],"on":[77,82,169],"ease":[78],"use":[80,183],"effect":[81],"bleeding":[83],"patterns":[84],"experiences.":[87],"results":[89],"studies":[92],"gave":[93],"zero":[95],"pregnancy":[96],"rate":[97],"or":[100],"1458":[103],"volunteers.":[105],"However":[107],"proved":[109],"be":[111],"faster":[112],"insert":[114],"remove":[116],"than":[117,132,142,165],"Norplant;":[118],"90%":[119],"insertions":[122,127],"versus":[123],"37%":[124],"done":[129],"less":[131,141],"3":[133],"minutes.":[134],"Furthermore":[135],"removal":[136],"time":[137],"for":[138],"5":[143],"minutes":[144],"83%":[146],"instances":[148],"compared":[149],"36%":[151],"removals.":[154],"There":[156],"no":[158],"recorded":[159],"event":[161],"rates":[162],"fewer":[164],"3%":[166],"women":[168,179],"either":[170],"treatment":[171],"withdrawing":[172],"as":[173,187,196],"result.":[175],"Of":[177],"who":[180],"terminated":[181],"57%":[184],"did":[185,194,206],"so":[186,195,207],"result":[189,198],"menstrual":[191],"irregularity":[192],"25%":[193],"events":[201],"remaining":[204],"18%":[205],"due":[208],"reasons.":[211],"appears":[214],"offer":[216],"necessary":[218],"combination":[219],"compliance":[222],"acceptability":[224],"both":[226],"doctors":[227],"patient.":[229]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}